PD 102807
Chemical Name: 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester
Purity: ≥98%
Biological Activity
PD 102807 is a selective M4 muscarinic receptor antagonist. IC50 values are 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively. Promotes self-renewal of erythroid progenitors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Synthesis and pharmacology of benzoxazines as highly selective antagonists at M4 muscarinic receptors.
Bohme et al.
J.Med.Chem., 2002;45:3094 -
Identification and characterization of m4 selective muscarinic antagonists.
Augelli-Szafran et al.
Bioorg.Med.Chem.Lett., 1998;8:1991 -
A novel muscarinic M4 receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M2 receptor sub-type.
Kitaichi et al.
Eur.J.Pharmacol., 1999;383:53 -
Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors.
Trivedi et al.
Sci.Transl.Med., 2019;11
Product Datasheets
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Citations for PD 102807
The citations listed below are publications that use Tocris products. Selected citations for PD 102807 include:
4 Citations: Showing 1 - 4
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Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors.
Authors: Trivedi Et al.
Sci.Transl.Med. 2019;11
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Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
Authors: Thomson Et al.
Neuron 2017;95:550
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Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Authors: Zhu Et al.
Nat Commun 2017;8:1676
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Cholinergic innervation of the guinea-pig isolated vas deferens.
Authors: Solanki Et al.
Naunyn Schmiedebergs Arch Pharmacol 2007;376:265
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