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PD 144418 oxalate

Catalog #: 2606
2 Citations Datasheet / COA / SDS

Discontinued Product

2606 has been discontinued.
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PD 144418 oxalate | CAS No. 1794760-28-3 | Sigma1 Receptor Ligands
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Description: High affinity, selective σ1 ligand

Chemical Name: 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PD 144418 oxalate is a high affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.

Technical Data

M.Wt:
372.42
Formula:
C18H22N2O.C2H2O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1794760-28-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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Citations for PD 144418 oxalate

The citations listed below are publications that use Tocris products. Selected citations for PD 144418 oxalate include:

2 Citations: Showing 1 - 2

  1. Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol  2018;21:938
  2. Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
    Authors: Navarro Et al.
    Autophagy  2015;35:6639

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