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PD 168568 dihydrochloride

Catalog #: 3529
1 Citation Datasheet / COA / SDS
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3529/50
PD 168568 dihydrochloride | CAS No. 1782532-06-2 | Dopamine D4 Receptor Antagonists
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Description: Potent and selective D4 antagonist

Chemical Name: 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PD 168568 dihydrochloride is a potent and selective dopamine D4 receptor antagonist (Ki values are 8.8 and 1842 nM at D4 and D2 receptors respectively). Reverses amphetamine-stimulated locomotion in vivo and is orally active.

Technical Data

M.Wt:
422.39
Formula:
C22H27N3O.2HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1782532-06-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Isoindolinone enantiomers having affinity for the DA D4 receptor.
    Belliotti et al.
    Bioorg.Med.Chem.Lett., 1998;8:1499

Product Datasheets

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Citation for PD 168568 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PD 168568 dihydrochloride include:

1 Citation: Showing 1 - 1

  1. Intravitreally-administered DA D2-like (and D4), but not D1-like, receptor agonists reduce form-deprivation myopia in tree shrews.
    Authors: Ward Et al.
    Vis Neurosci  2017;34:E003

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