PD 407824

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family.
   Pouliot L, Chen Y, Bai J, Guha R, Martin S, Gottesman M, Hall M
   Cancer Res, 2012;72(22):5945-55.
2. Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model
   S Liu, Y Liu, K Minami, A Chen, Q Wan, Y Yin, L Gan, A Xu, N Matsuura, M Koizumi, Y Liu, S Na, J Li, H Nakshatri, BY Li, H Yokota
   Oncotarget, 2018;9(10):9364-9378.
3. Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation.
   Squire et al.
   Structure, 2005;13:541
4. 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenylring substitutions.
   Palmer et al.
   J.Med.Chem., 2006;49:4896
5. Discovery of a small-molecule BMP sensitizer for human embryonic stem cell differentiation.
   Feng et al.
   Cell Rep., 2016;15:2063

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