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Pentylenetetrazole

Catalog #: 2687
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2687/1G
Pentylenetetrazole | CAS No. 54-95-5 | Additional GABA Compounds
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Description: CNS stimulant
Alternative Names: PTZ

Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Pentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.

Technical Data

M.Wt:
138.17
Formula:
C6H10N4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
54-95-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.
    Hartman A, Santos P, Dolce A, Hardwick J
    PLoS ONE, 2012;7(9):e45156.
  2. Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems.
    Rocha et al.
    Epilepsy Res., 1996;26:105
  3. Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density.
    Walsh et al.
    J.Pharmacol.Exp.Ther., 1999;289:1626
  4. Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action.
    Dhir et al.
    Prog.Neuro-Psychopharm.Biol.Psychiat., 2006;30:1478

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Citation for Pentylenetetrazole

The citations listed below are publications that use Tocris products. Selected citations for Pentylenetetrazole include:

1 Citation: Showing 1 - 1

  1. 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors.
    Authors: Karim Et al.
    Br J Pharmacol  2012;165:880

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