pep2-SVKI
Biological Activity
pep2-SVKI is an inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD).Control Peptide also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Functional roles of protein interactions with AMPA and kainate receptors.
Collingridge and Isaac
Neurosci.Res., 2003;47:3 -
PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
Daw et al.
Neuron, 2000;28:873 -
Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
Kim et al.
Proc.Natl.Acad.Sci.U.S.A., 2001;98:11725 -
AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.
Li et al.
Nat.Neurosci., 1999;2:972
Product Datasheets
Citations for pep2-SVKI
The citations listed below are publications that use Tocris products. Selected citations for pep2-SVKI include:
4 Citations: Showing 1 - 4
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Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress.
Authors: McElligott Et al.
J Neurosci 2010;107:2271
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Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases.
Authors: Grey and Burrell
J Neurophysiol 2010;103:2737
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A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha.
Authors: Dickinson Et al.
Mol Brain 2009;2:18
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Activity-dependent synaptic plasticity in retinal ganglion cells.
Authors: Xia Et al.
J Neurosci 2007;27:12221
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