Perlapine
Chemical Name: 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
Purity: ≥99%
Biological Activity
Perlapine is a potent muscarinic DREADD agonist (pEC50 values are 8.38, 8.08 and 7.27 for hM1Dq, hM3Dq and hM4Di in vitro, respectively). Exhibits >10,000-fold selectivity for hM3Dq over hM3 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.
Chen et al.
ACS Chem.Neurosci., 2015;18:476 -
DREADD agonist 21 (C21) is an effective agonist for muscarinic-based DREADDs in vitro and in vivo.
Thompson et al.
ACS Pharmacol.Transl.Sci., 2018;1:61
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Citation for Perlapine
The citations listed below are publications that use Tocris products. Selected citations for Perlapine include:
1 Citation: Showing 1 - 1
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Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics.
Authors: Weston Et al.
Sci Adv. 2019;5
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