PF 04479745

Catalog #: 5755 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
5755/1

PF 04479745 | CAS No. 1065110-43-1 | 5-HT2C Receptor Agonists

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Description: Potent and selective 5-HT2C agonist

Chemical Name: (9S)-6,7,8,9-Tetrahydro-N,9-dimethyl-2-(phenylmethyl)-5H-pyrimido[4,5-d]azepin-4-amine

Purity: ≥98%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PF 04479745 is a potent and selective 5-HT_2C agonist (EC₅₀ = 10 nM). Exhibits > 100-fold selectivity over a panel of 90 receptors, enzymes and ion channels, except for 5-HT_2A (IC₅₀ = 360 nM antagonist), 5-HT_2B (EC₅₀ = 67 nM antagonist), 5-HT_1A and 5-HT₆ (functional activity not tested).

Technical Data

M.Wt:

282.39

Formula:

C₁₇H₂₂N₄

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1065110-43-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from Pfizer Inc.

Background References

Multiparameter optimization in CNS drug discovery: Design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors.
Storer et al.
J.Med.Chem., 2014;57:5258

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