PF 4778574
Chemical Name: N-[(3R,4S)-3-[4-(5-cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl]-2-propanesulfonamide
Purity: ≥98%
Biological Activity
Positive allosteric modulator of AMPA receptors (Ki = 85 nM). Prevents ketamine-induced working memory impairments. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Prevention of KA-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction.
Roberts et al.
Behav.Brain Res., 2010;212:41 -
An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations.
Doran et al.
Drug Metab.Dispos., 2012;40:2162 -
Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574.
Shaffer et al.
J.Pharmacol.Exp.Ther., 2013;347:212
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