PFM 01
Chemical Name: (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
Purity: ≥98%
Biological Activity
PFM 01 is a MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Customers also Viewed
Background References
-
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.
Shibata et al.
Mol.Cell, 2014;53:7
Product Datasheets
Citations for PFM 01
The citations listed below are publications that use Tocris products. Selected citations for PFM 01 include:
2 Citations: Showing 1 - 2
-
The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1.
Authors: George-Lucian Et al.
Nat Commun 2022;13:5063
-
p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation.
Authors: Benedikt M Et al.
Cell Rep 2021;35:109153
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for PFM 01
There are currently no reviews for this product. Be the first to review PFM 01 and earn rewards!
Have you used PFM 01?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
