Phospho-p38 alpha (T180/Y182) Surveyor IC

Phospho-p38 alpha (T180/Y182) Surveyor IC Summary

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Background: p38 alpha

The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses. All four p38 family members, alpha, beta, gamma, and delta, are phosphorylated by MKK3 and/or MKK6 at dual Thr and Tyr positions within the phosphoacceptor sequence Thr-Gly-Tyr. Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max.

The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. Ubiquitously expressed, p38 alpha is dually phosphorylated by MKK3 and MKK6 at Thr180 and Tyr182. Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases.

Related Research Areas

• Airway Inflammation and Remodeling
• Apoptosis Intracellular Kinases
• Chemokine Receptor Intracellular Signaling
• C-type Lectin Receptors
• Diabetic Peripheral Neuropathy
• GDNF Family
• IL-1 Family
• IL-10 Family
• IL-17 Family
• Interferons
• Intracellular Kinases
• Intracellular Kinases in the Akt Pathway
• Intracellular Signaling Molecules in Angiogenesis
• Neurofibrillary Tangle Formation
• Neurotrophin/Trk Family
• NOD-like Receptors and the Inflammasome
• Platelet Signaling
• Positive Regulators of the Jak/STAT Pathway
• Search Kinases and Phosphatases
• TNF Superfamily Regulators
• Toll-Like Receptors
• VEGF Family