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Pilocarpine hydrochloride

Catalog #: 0694
3 Citations Datasheet / COA / SDS
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0694/100
Pilocarpine hydrochloride | CAS No. 54-71-7 | Non-selective mAChR Agonists
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Description: Muscarinic agonist

Chemical Name: (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone hydrochloride

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

Pilocarpine hydrochloride is an M3 muscarinic acetycholine receptor agonist.

Technical Data

M.Wt:
244.72
Formula:
C11H16N2O2.HCl
Solubility:
Soluble to 75 mM in DMSO and to 100 mM in water
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
54-71-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. PilC modulates the cellular electrical properties of mammalian hearts by activating a cardiac M3 receptor and a K+ current.
    Wang et al.
    Br.J.Pharmacol., 1999;126:1725
  3. Muscarinic receptor agonists and antagonists.
    Brown and Taylor
    The Pharmacological Basis of Therapeutics. Eds Goo, 1996;:Chapter 7, p147
  4. Differences in the prejunctional effects of methach. and PilC on the release of endogenous acetylcholine from guinea-pig trachea.
    ten Berge et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1996;354:606

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Citations for Pilocarpine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Pilocarpine hydrochloride include:

3 Citations: Showing 1 - 3

  1. The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of PilC on outflow facility in mice.
    Authors: Overby Et al.
    Nat Chem Biol  2014;55:3727
  2. Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors.
    Authors: Deng Et al.
    J Pharmacol Toxicol Methods  2013;68:323
  3. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
    Authors: Tallarida Et al.
    Amino Acids  2012;42:2521

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