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PIR 3.5

Catalog #: 4212
3 Citations Datasheet / COA / SDS

Discontinued Product

4212 has been discontinued.
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PIR 3.5 | CAS No. 6088-51-3 | PAK Inhibitors
1 Image
Description: Negative control of IPA 3 (Cat. No. 3622)

Chemical Name: 6,6'-Dithiodi-2-naphthtol

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PIR 3.5 is a negative control of IPA 3, a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).

Active Analog also available.

Technical Data

M.Wt:
350.45
Formula:
C20H14O2S2
Solubility:
Soluble to 75 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
6088-51-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.
    Pandolfi A, Stanley R, Yu Y, Bartholdy B, Pendurti G, Gritsman K, Boultwood J, Chernoff J, Verma A, Steidl U
    Blood, 2015;126(9):1118-27.
  2. Endophilin marks and controls a clathrin-independent endocytic pathway.
    Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
    Nature, 2015;517(7535):460-5.
  3. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.
    Deacon et al.
    Chem.Biol., 2008;15:322

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for PIR 3.5

The citations listed below are publications that use Tocris products. Selected citations for PIR 3.5 include:

3 Citations: Showing 1 - 3

  1. Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala.
    Authors: Das Et al.
    Sci Rep  2017;7:13930
  2. Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.
    Authors: Imle Et al.
    MBio  2015;6
  3. Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.
    Authors: Molosh Et al.
    J Biol Chem  2014;17:1583

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