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PKUMDL WQ 2201

Catalog #: 6581 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6581/5
6581/25
PKUMDL WQ 2201 | CAS No. 592474-91-4 | Dehydrogenase Inhibitors
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Description: Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)

Chemical Name: 2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid

Purity: ≥98%

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Biological Activity

PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.

Technical Data

M.Wt:
351.81
Formula:
C15H14ClN3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
592474-91-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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