PNU 37883 hydrochloride
Chemical Name: N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Purity: ≥99%
Biological Activity
PNU 37883 hydrochloride is a novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs.
Humphrey and Ludens
J.Cardiovasc.Pharmacol., 1998;31:894 -
Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.
Cui et al.
Br.J.Pharmacol., 2003;139:122 -
Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.
Kovalev et al.
Br.J.Pharmacol., 2004;141:867
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