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PNU 74654

Catalog #: 3534
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3534/25
3534/5
PNU 74654 | CAS No. 113906-27-7 | beta-Catenin Compounds
1 Image
Description: β-catenin binder; inhibits Wnt signaling

Chemical Name: 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide

Purity: ≥99%

Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Binds to β-catenin (KD = 450 nM). Inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway. Promotes neural differentiation of hPSCs as part of a chemical cocktail.

Technical Data

M.Wt:
320.34
Formula:
C19H16N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
113906-27-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Transcription factor binding dynamics during human ES cell differentiation.
    Tsankov, Alexande, Gu, Hongcang, Akopian, Veronika, Ziller, Michael, Donaghey, Julie, Amit, Ido, Gnirke, Andreas, Meissner, Alexande
    Nature, 2015;518(7539):344-9.
  2. Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis.
    Keats E, Dominguez J, Grant M, Khan Z
    Stem Cells, 2014;32(6):1649-60.
  3. Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.
    Trosset et al.
    Proteins, 2006;64:60
  4. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
    Wells and McClendon
    Nature, 2007;450:1001
  5. Chemically defined neural conversion of human pluripotent stem cells.
    Chen et al.
    Methods Mol.Biol., 2019;1919:59

Product Datasheets

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Citations for PNU 74654

The citations listed below are publications that use Tocris products. Selected citations for PNU 74654 include:

9 Citations: Showing 1 - 9

  1. FSCN1 as a new druggable target in adrenocortical carcinoma.
    Authors: Margaret E Et al.
    Int J Cancer  2023;153:210-223
  2. α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.
    Authors: Juan C Et al.
    J Neurosci  2021;41:2264-2273
  3. Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.
    Authors: Stephen J Et al.
    Genes Dev  2021;35:1527-1547
  4. Chemically defined neural conversion of human pluripotent stem cells.
    Authors: Chen Et al.
    Methods Mol.Biol.  2019;1919:59
  5. Transcription factor binding dynamics during human ES cell differentiation.
    Authors: Tsankov Et al.
    Stem Cells Int  2015;518:344
  6. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
    Authors: Liao Et al.
    Nature  2015;47:469
  7. Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors.
    Authors: Yang Et al.
    Cell Reprogram  2015;2015:270428
  8. β-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion.
    Authors: Corritore Et al.
    Ann Neurol  2014;16:456
  9. Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses.
    Authors: Baril Et al.
    PLoS Pathog  2013;9:e1003416

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