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Poly(ADP-ribose) Polymer/pADPr

Catalog #: 4336-100-01
13 Citations 2 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4336-100-01
Product Details
Citations (13)
FAQs
Reviews (2)
Summary Product Datasheets

Poly(ADP-ribose) Polymer/pADPr Summary

PAR Polymer was first synthesized using poly(ADP-ribose) polymerase (PARP) in the presence of NAD+, cleaved from PARP, and subsequently purified. The PAR Polymer is recognized by Trevigen's anti-PAR monoclonal and polyclonal antibodies.

Specifications

Shipping Conditions
The product is shipped with ice packs or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
N/A

Limitations

For research use only. Not for diagnostic use.

Product Datasheets

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Citations for Poly(ADP-ribose) Polymer/pADPr

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

13 Citations: Showing 1 - 10
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  1. PARG is essential for Pol?-mediated DNA end-joining by removing repressive poly-ADP-ribose marks
    Authors: Vekariya, U;Minakhin, L;Chandramouly, G;Tyagi, M;Kent, T;Sullivan-Reed, K;Atkins, J;Ralph, D;Nieborowska-Skorska, M;Kukuyan, AM;Tang, HY;Pomerantz, RT;Skorski, T;
    Nature communications  2024-07-11
  2. SNM1A is crucial for efficient repair of complex DNA breaks in human cells
    Authors: Swift, LP;Lagerholm, BC;Henderson, LR;Ratnaweera, M;Baddock, HT;Sengerova, B;Lee, S;Cruz-Migoni, A;Waithe, D;Renz, C;Ulrich, HD;Newman, JA;Schofield, CJ;McHugh, PJ;
    Nature communications  2024-06-25
  3. A mechanism for oxidative damage repair at gene regulatory elements
    Authors: S Ray, AA Abugable, J Parker, K Liversidge, NM Palminha, C Liao, AE Acosta-Mar, CDS Souza, M Jurga, I Sudbery, SF El-Khamisy
    Nature, 2022-09-28;609(7929):1038-1047.  2022-09-28
  4. BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
    Authors: Y Zhang, M Fang, S Li, H Xu, J Ren, L Tu, B Zuo, W Yao, G Liang
    Molecular Cancer, 2022-08-02;21(1):158.  2022-08-02
  5. PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair
    Authors: B Peng, R Shi, J Bian, Y Li, P Wang, H Wang, J Liao, WG Zhu, X Xu
    Nucleic Acids Research, 2021-07-21;49(13):7554-7570.  2021-07-21
  6. RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3&alpha Co-localization
    Authors: J Wang, YT Oh, Z Li, J Dou, S Tang, X Wang, H Wang, S Takeda, Y Wang
    Cell Reports, 2021-01-12;34(2):108625.  2021-01-12
  7. The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
    Authors: M Gatti, R Imhof, Q Huang, M Baudis, M Altmeyer
    Cell Rep, 2020-08-04;32(5):107985.  2020-08-04
  8. Genetically Encoded Fluorescent Sensor for Poly-ADP-Ribose
    Authors: EO Serebrovsk, NM Podvalnaya, VV Dudenkova, AS Efremova, NG Gurskaya, DA Gorbachev, AV Luzhin, OL Kantidze, EV Zagaynova, SI Shram, KA Lukyanov
    Int J Mol Sci, 2020-07-15;21(14):.  2020-07-15
  9. Poly(ADP-ribose): A Dynamic Trigger for Biomolecular Condensate Formation
    Authors: AKL Leung
    Trends Cell Biol., 2020-02-20;30(5):370-383.  2020-02-20
  10. PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA
    Authors: AS Singatulin, L Hamon, MV Sukhanova, B Desforges, V Joshi, A Bouhss, OI Lavrik, D Pastré
    Cell Rep, 2019-05-07;27(6):1809-1821.e5.  2019-05-07
  11. How the location of superoxide generation influences the beta-cell response to nitric oxide.
    Authors: Broniowska K, Oleson B, McGraw J, Naatz A, Mathews C, Corbett J
    J Biol Chem, 2015-02-03;290(12):7952-60.  2015-02-03
  12. DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal.
    Authors: Britton S, Dernoncourt E, Delteil C, Froment C, Schiltz O, Salles B, Frit P, Calsou P
    Nucleic Acids Res, 2014-07-16;42(14):9047-62.  2014-07-16
  13. PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.
    Authors: Rulten S, Rotheray A, Green R, Grundy G, Moore D, Gomez-Herreros F, Hafezparast M, Caldecott K
    Nucleic Acids Res, 2013-09-18;42(1):307-14.  2013-09-18

FAQs

  1. What is the concentration of this polymer in units of mass/volume?

    • The concentration of poly(ADP-ribose) Polymer/pADPr is determined by measuring light absorbance at 258 nm using the molar extinction coefficient of PAR. This measurement yields concentration in units of μM. The chain length of this polymer ranges between 2 and 300 ADP-ribose units. Because we are unable to evaluate the variation in polymer length and polymer branching, we are unable to calculate a concentration based on mass. As such, this product is bottled and sold by the concentration in molarity.

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Reviews for Poly(ADP-ribose) Polymer/pADPr

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Poly(ADP-ribose) Polymer/pADPr
By Anonymous on 07/28/2021

works good

Poly(ADP-ribose) Polymer/pADPr
By Anonymous on 12/15/2020