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Pomalidomide 4'-alkylC5-acid

Catalog #: 6682 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6682/25
Pomalidomide 4'-alkylC5-acid | CAS No. 2225940-49-6 | Degrader Building Blocks
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Description: Cereblon ligand with alkyl linker and terminal acid for onward chemistry
Alternative Names: Pomalidomide - linker 3

Chemical Name: 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid

Purity: ≥95%

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Biological Activity

Pomalidomide 4'-alkylC5-acid is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC5 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Pomalidomide - linker 3

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
387.39
Formula:
C19H21N3O6
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2225940-49-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Degradation of the BAF complex factor BRD9 by heterobifunctional ligands.
    Remillard et al.
    Angew.Chem.Int.Ed.Engl., 2017;56:5738

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