Prasugrel
Chemical Name: 2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone
Purity: ≥98%
Biological Activity
Prasugrel is an irreversible P2Y12 antagonist; metabolised to active metabolite R-99224 (IC50 = 45 μM) irreversibly binds platelet P2Y12 receptors, inhibiting platelet activation. Antiplatelet and antithrombotic. Orally active and active in vivo. Note - inactive in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Prasugrel.
Huber et al.
Nat.Rev.Drug Discov., 2009;8:449 -
The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties.
Sugidachi et al.
Br.J.Pharmacol., 2000;129:1439 -
The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of pras. in a mouse model: evidence for specific inhibition of P2Y12 receptors by pras.
Hashimoto
Biochem.Pharmacol., 2007;74:1003
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