Proglumide sodium salt
Chemical Name: 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt
Purity: ≥98%
Biological Activity
Proglumide sodium salt is a non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini.
Iwamoto et al.
Gastroenterol.Jpn., 1984;19:53 -
Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human colon carcinoma cells.
Mauss et al.
Anticancer Res., 1994;14:215 -
Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists.
Hahne et al.
Proc.Natl.Acad.Sci.U.S.A., 1981;78:6304
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Citation for Proglumide sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Proglumide sodium salt include:
1 Citation: Showing 1 - 1
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Treatment with a Cholecystokinin Receptor Antagonist, Proglumide, Improves Efficacy of Immune Checkpoint Antibodies in Hepatocellular Carcinoma
Authors: Shivapurkar Et al.
Int J Mol Sci 2023;24:3625
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