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Prostaglandin E2

Catalog #: 2296
20 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2296/10
Prostaglandin E2 | CAS No. 363-24-6 | Prostanoid Receptor Agonists
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Description: Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
Alternative Names: PGE2

Chemical Name: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid

Purity: ≥98%

Product Details
Citations (20)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Prostaglandin E2 is an endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Prostaglandin E2 binds with high affinity to EP1, EP2, EP3 and EP4 receptors (Kd values range between ~ 1 - 10 nM). Prostaglandin E2 influences a wide range of processes including inflammation, vasodilation, smooth muscle relaxation, fertility, gastric mucosal integrity and platelet aggregation. Prostaglandin E2 regulates vertebrate hematopoietic stem cell (HSC) homeostasis, acts as viral transduction enhancer and is tumorigenic in some cancers.

Technical Data

M.Wt:
352.47
Formula:
C20H32O5
Solubility:
Soluble to 100 mM in DMSO and to 45 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
363-24-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Prediction of DNA Repair Inhibitor Response in Short Term Patient-Derived Ovarian Cancer Organoids
    SJ Hill, B Decker, EA Roberts, NS Horowitz, MG Muto, MJ Worley, CM Feltmate, MR Nucci, EM Swisher, H Nguyen, C Yang, R Morizane, BS Kochupurak, KT Do, PA Konstantin, JF Liu, JV Bonventre, UA Matulonis, GI Shapiro, RS Berkowitz, CP Crum, AD D'Andrea
    Cancer Discov, 2018;0(0):.
  2. Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor
    LC Dutton, J Dudhia, B Catchpole, H Hodgkiss-G, D Werling, DJ Connolly
    Sci Rep, 2018;8(1):13351.
  3. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
    L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
    Autophagy, 2017;0(0):0.
  4. IgE receptor-mediated mast-cell renin release.
    Aldi S, Robador P, Tomita K, Di Lorenzo A, Levi R
    Am J Pathol, 2014;184(2):376-81.
  5. Patient derived organoids to model rare prostate cancer phenotypes
    L Puca, R Bareja, D Prandi, R Shaw, M Benelli, WR Karthaus, J Hess, M Sigouros, A Donoghue, M Kossai, D Gao, J Cyrta, V Sailer, A Vosoughi, C Pauli, Y Churakova, C Cheung, LD Deonarine, TJ McNary, R Rosati, ST Tagawa, DM Nanus, JM Mosquera, CL Sawyers, Y Chen, G Inghirami, RA Rao, C Grandori, O Elemento, A Sboner, F Demichelis, MA Rubin, H Beltran
    Nat Commun, 2018;9(1):2404.
  6. Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
    Coleman et al.
    Pharmacol.Rev., 1994;46:205
  7. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
    North et al.
    Nature., 2007;447:1007
  8. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation.
    Hata and Breyer
    Pharm.Ther., 2004;103:147
  9. Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
    Karthaus et al.
    Cell, 2014;159:163
  10. SnapShot: Growing Organoids from Stem Cells.
    Sato et al.
    Cell, 2015;161:1700
  11. Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells.
    Heffner et al.
    Mol.Ther, 2018;26:320
  12. New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses
    A Gutjahr, L Papagno, F Vernejoul, T Lioux, F Jospin, B Chanut, E Perouzel, N Rochereau, V Appay, B Verrier, S Paul
    EBioMedicine, 2020;58(0):102922.
  13. RSPO3 is important for trabecular bone and fracture risk in mice and humans
    KH Nilsson, P Henning, ME Shahawy, M Nethander, TL Andersen, C Ejersted, J Wu, KL Gustafsson, A Koskela, J Tuukkanen, PPC Souza, J Tuckermann, M Lorentzon, LE Ruud, T Lehtimäki, JH Tobias, S Zhou, UH Lerner, JB Richards, S Movérare-S, C Ohlsson
    Nature Communications, 2021;12(1):4923.
  14. Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function
    H Gassmann, K Schneider, V Evdokimova, P Ruzanov, SJ Schober, B Xue, K von Heykin, M Thiede, GHS Richter, MW Pfaffl, E Noessner, LD Stein, PH Sorensen, SEG Burdach, U Thiel
    Cells, 2021;10(8):.

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Citations for Prostaglandin E2

The citations listed below are publications that use Tocris products. Selected citations for Prostaglandin E2 include:

20 Citations: Showing 1 - 10

  1. Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
    Authors: He Et al.
    Cell Stem Cell  2022;29:1333
  2. Snake venom gland organoids.
    Authors: Post Et al.
    Cell  2020;180:233
  3. IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
    Authors: Colomer Et al.
    Mol Cell  2019;75:669
  4. A Novel Three-Dimensional Immune Oncology Model for High-Throughput Testing of Tumoricidal Activity.
    Authors: Sherman Et al.
    Front Immunol  2018;9:857
  5. Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients.
    Authors: Zhu
    Oncotarget  2018;9(1):982
  6. Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset.
    Authors: Sachamitr Et al.
    Front Immunol  2018;8:1935
  7. Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses.
    Authors: Ye Et al.
    Endocr Connect  2018;7:749
  8. Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC).
    Authors: Senger Et al.
    Cell Mol Gastroenterol Hepatol  2018;5:549
  9. TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
    Authors: Somerville Et al.
    Cell Rep  2018;25:1741
  10. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer.
    Authors: Al-Taei Et al.
    Oncoimmunology  2017;6:e1268308

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Organoids culture
By MARIA PINNA on 09/22/2023
Species: Human

Prostaglandin E2 supplementation for organoids media is paramount for some organoid model growth and viability.

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