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PROTAC®(H-PGDS)-7

Catalog #: 8004 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8004/5
PROTAC®(H-PGDS)-7 | CAS No. 2761281-50-7 | Active Degraders
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Description: Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)

Chemical Name: N-[4-[4-[[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]carbonyl]-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide

Purity: ≥98%

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Biological Activity

PROTAC®(H-PGDS)-7 is a potent Degrader of hematopoietic prostaglandin D2 synthase (H-PGDS; DC50 = 17pM after 24 hours). Comprises the H-PGDS inhibitor TFC-007 (Cat. No. 5108) directly linked to E3 ligase cereblon. Suppresses prostaglandin D2 production in vitro and in vivo.

PROTAC®(H-PGDS)-8 negative control (Cat. No. 8005) also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
742.79
Formula:
C40H38N8O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2761281-50-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from National Institute of Health Sciences, Japan and Tsuzuki Gakuen.

Product Datasheets

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