Home / Kinase Assay Kits / Proteome Profiler Human Phospho-Kinase Array Kit

Proteome Profiler Human Phospho-Kinase Array Kit

Catalog #: ARY003C
389 Citations 10 Reviews Datasheet / COA / SDS
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
Catalog # Availability Size / Price Qty
ARY003C
Best Seller
Detection of human protein kinase phosphorylation in A549 Cell Line.
4 Images
Product Details
Citations (389)
FAQs
Reviews (10)
Summary Product Datasheets Data Images Background

Proteome Profiler Human Phospho-Kinase Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of human protein kinase phosphorylation. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 37 human kinases and total amounts of 2 related proteins simultaneously
  • Requires no specialized equipment

 

Principle of the Assay

The Proteome Profiler Human Phospho-Kinase Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Captured proteins are detected with biotinylated detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents

Each Human Phospho-Kinase Antibody Array Kit contains most of the necessary components for a ready-to-run assay without the need for specialized equipment.

  • 8 Array Membranes (4 of membrane A and 4 of membrane B)
  • 8-Well Multi-dish
  • Lysis Buffer
  • Array Buffers
  • Wash Buffer
  • Detection Antibody Cocktail A
  • Detection Antibody Cocktail B
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed product datasheet with protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these proteins in a single sample.
Akt 1/2/3 (S473) HSP60 PRAS40 (T246)
Akt 1/2/3 (T308) JNK 1/2/3 (T183/Y185, T221/Y223) Pyk2 (Y402)
beta-Catenin Lck (Y394) RSK1/2 (S221/S227)
Chk-2 (T68) Lyn (Y397) RSK1/2/3 (S380/S386/S377)
c-Jun (S63) MSK1/2 (S376/S360) Src (Y419)
CREB (S133) p38 alpha (T180/Y182) STAT1 (Y701)
EGF R (Y1086) p53 (S15) STAT2 (Y690)
eNOS (S1177) p53 (S392) STAT3 (S727)
ERK1/2 (T202/Y204, T185/Y187) p53 (S46) STAT3 (Y705)
Fgr (Y412) P70 S6 Kinase (T389) STAT5a/b (Y699)
GSK-3 alpha/beta (S21/S9) p70 S6 Kinase (T421/S424) STAT6 (Y641)
GSK-3 beta (S9) PDGF R beta (Y751) WNK-1 (T60)
HSP27 (S78/S82) PLC gamma-1 (Y783) Yes (Y426)

 

Assays for analytes represented in the Human Phospho-Kinase Array Kit

 

Analyte DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA
Development Systems (Phospho)		 Quantikine®
ELISA Kits
Akt (S473)   DYC887B  
Akt (T308)      
beta-Catenin DYC1329    
Chk2 (T68)   DYC1626  
c-Jun (S63)      
CREB (S133)   DYC2510  
EGF R (Y1086) DYC1854   DEGFR0
eNOS (S1177)      
ERK1/2 (T202/Y204, T185/Y187)   DYC1018B  
Fgr (Y412)      
GSK-3 beta (S9)      
GSK-3 alpha/beta (S21/S9) DYC2157 DYC2630  
HSP27 (S78/S82) DYC1580 DYC2314  
HSP60 DYC1800    
JNK pan (T183/Y185, T221/Y223) DYC1205 DYC1387  
Lck (Y394)      
Lyn (Y397)   DYC3936  
MSK1/2 (S376/S360)      
p38 alpha (T180/Y182) DYC8691B DYC869B  
p53 (S15) DYC1043 DYC1839  
p53 (S46) DYC1043 DYC1489  
p53 (S392) DYC1043 DYC2996  
p70 S6 Kinase (T389)   DYC896  
p70 S6 Kinase (T421/S424) DYC8962 DYC8965  
PDGF R beta (Y751) DYC385 DYC3096  
PLC gamma-1 (Y783)      
PRAS40 (T246)   DYC6890  
PYK2 (Y402)      
RSK1/2 (S221/S227)      
RSK1/2/3 (S380/S386/S377)   DYC889B  
Src (Y419)   DYC2685  
STAT1 (Y701)      
STAT2 (Y690)      
STAT3 (S727)      
STAT3 (Y705)   DYC4607B  
STAT5a/b (Y694/Y699)      
STAT6 (Y641)      
WNK-1(T60)   DYC4720  
Yes (Y426)   DYC3929  

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

Product Datasheets

You must select a language.

x
Product Datasheet
COA
SDS

Scientific Data

N/A Detection of human protein kinase phosphorylation in A549 Cell Line. View Larger

Detection of Human Protein Kinase Phosphorylation in A549 Cell Line. A549 human lung adenocarcinoma cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 24 hour recovery before lysis.

N/A Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line. View Larger

Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line. Daudi human B cell lymphoma cells were either left untreated or treated with 500 U/ml Recombinant Human IFN-alpha 2a (R&D Systems, Catalog # 11100-1) for 5 minutes.

N/A Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line. View Larger

Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line. Jurkat human acute T cell leukemia cells were either left untreated or treated with 100 ng/mL PMA and 0.5 mM Ionomycin for 20 minutes.

N/A Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line. View Larger

Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line. MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of recombinant human IGF-1 (R&D Systems®, Catalog # 291-G1) for 1 hour.

Citations for Proteome Profiler Human Phospho-Kinase Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

389 Citations: Showing 1 - 10
Filter your results:

Filter by:

  1. Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain
    Authors: Jones, K;Keddy, C;Jenkins, C;Nicholson, K;Shinde, U;Davare, MA;
    Scientific reports  2024-09-27
  2. PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression
    Authors: Ross, MO;Xie, Y;Owyang, RC;Ye, C;Zbihley, ONP;Lyu, R;Wu, T;Wang, P;Karginova, O;Olopade, OI;Zhao, M;He, C;
    Nature communications  2024-08-13
  3. Comprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer
    Authors: Rodríguez-Sarmiento, DY;Rondón-Villarreal, P;Scarpelli-Pereira, PH;Bouvier, M;
    Biomolecules  2024-07-29
  4. APG-1252 combined with Cabozantinib inhibits hepatocellular carcinoma by suppressing MEK/ERK and CREB/Bcl-xl pathways
    Authors: Di, T;Luo, QY;Song, JT;Yan, XL;Zhang, L;Pan, WT;Guo, Y;Lu, FT;Sun, YT;Xia, ZF;Yang, LQ;Qiu, MZ;Yang, DJ;Sun, J;
    International immunopharmacology  2024-07-19
  5. Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma
    Authors: Yu, L;Deng, Y;Wang, X;Santos, C;Davis, IJ;Earp, HS;Liu, P;
    Nature communications  2024-06-21
  6. Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer
    Authors: Standing, D;Dandawate, P;Gunewardena, S;Covarrubias-Zambrano, O;Roby, KF;Khabele, D;Jewell, A;Tawfik, O;Bossmann, SH;Godwin, AK;Weir, SJ;Jensen, RA;Anant, S;
    Cell death & disease  2024-05-25
  7. Novel Glycomimetics Protect against Glycated Low-Density Lipoprotein-Induced Vascular Calcification In Vitro via Attenuation of the RAGE/ERK/CREB Pathway
    Authors: Sidgwick, GP;Weston, R;Mahmoud, AM;Schiro, A;Serracino-Inglott, F;Tandel, SM;Skeoch, S;Bruce, IN;Jones, AM;Alexander, MY;Wilkinson, FL;
    Cells  2024-02-08
  8. DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts
    Authors: Shumliakivska, M;Luxán, G;Hemmerling, I;Scheller, M;Li, X;Müller-Tidow, C;Schuhmacher, B;Sun, Z;Dendorfer, A;Debes, A;Glaser, SF;Muhly-Reinholz, M;Kirschbaum, K;Hoffmann, J;Nagel, E;Puntmann, VO;Cremer, S;Leuschner, F;Abplanalp, WT;John, D;Zeiher, AM;Dimmeler, S;
    Nature communications  2024-01-19
  9. Brain-targeted delivery of neuroprotective survival gene minimizing hematopoietic cell contamination: implications for Parkinson's disease treatment
    Authors: Lee, MH;Kang, S;Um, KH;Lee, SW;Hwang, H;Baek, K;Choi, JW;
    Journal of translational medicine  2024-01-13
  10. ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy
    Authors: Soumoy, L;Genbauffe, A;Mouchart, L;Sperone, A;Trelcat, A;Mukeba-Harchies, L;Wells, M;Blankert, B;Najem, A;Ghanem, G;Saussez, S;Journe, F;
    Cancer cell international  2024-01-04
  11. GRB7 plays a promoting role in the progression of gastric cancer
    Authors: Zhu, G;Cai, H;Xiao, Q;Zeng, S;Jiang, X;Liu, D;
    BMC cancer  2023-12-21
  12. Phenol-Soluble Modulin ?3 Stimulates Autophagy in HaCaT Keratinocytes
    Authors: Dernovics, Á;Seprényi, G;Rázga, Z;Ayaydin, F;Veréb, Z;Megyeri, K;
    Biomedicines  2023-11-10
  13. EGCG inhibits the inflammation and senescence inducing properties of MDA-MB-231 triple-negative breast cancer (TNBC) cells-derived extracellular vesicles in human adipose-derived mesenchymal stem cells
    Authors: Gonzalez Suarez, N;Fernandez-Marrero, Y;Hébert, MPA;Roy, ME;Boudreau, LH;Annabi, B;
    Cancer cell international  2023-10-13
  14. Fumarate hydratase functions as a tumor suppressor in endometrial cancer by inactivating EGFR signaling
    Authors: Wang, YY;Vadhan, A;Wu, CH;Hsu, CY;Chen, YC;Chen, YK;Chen, PY;Nguyen, HDH;Chang, YC;Yuan, SF;
    Oncology reports  2023-10-01
  15. Identification of a miRNA multi-targeting therapeutic strategy in glioblastoma
    Authors: Bassot, A;Dragic, H;Haddad, SA;Moindrot, L;Odouard, S;Corlazzoli, F;Marinari, E;Bomane, A;Brassens, A;Marteyn, A;Hibaoui, Y;Petty, TJ;Chalabi-Dchar, M;Larrouquere, L;Zdobnov, EM;Legrand, N;Tamburini, J;Lincet, H;Castets, M;Yebra, M;Migliorini, D;Dutoit, V;Walker, PR;Preynat-Seauve, O;Dietrich, PY;Cosset, É;
    Cell death & disease  2023-09-25
  16. PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia
    Authors: Pun, SH;O'Neill, KM;Edgar, KS;Gill, EK;Moez, A;Naderi-Meshkin, H;Malla, SB;Hookham, MB;Alsaggaf, M;Madishetti, VV;Botezatu, B;King, W;Brunssen, C;Morawietz, H;Dunne, PD;Brazil, DP;Medina, RJ;Watson, CJ;Grieve, DJ;
    Cells  2023-09-06
  17. Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma
    Authors: Pang, L;Dunterman, M;Guo, S;Khan, F;Liu, Y;Taefi, E;Bahrami, A;Geula, C;Hsu, WH;Horbinski, C;James, CD;Chen, P;
    Nature immunology  2023-09-04
  18. PTPN2 copper-sensing rapidly relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression
    Authors: Ross, MO;Xie, Y;Owyang, RC;Ye, C;Zbihley, ONP;Lyu, R;Wu, T;Wang, P;Karginova, O;Olopade, OI;Zhao, M;He, C;
    bioRxiv : the preprint server for biology  2023-08-29
  19. Epithelial Galectin-3 Induced the Mitochondrial Complex Inhibition and Cell Cycle Arrest of CD8+ T Cells in Severe/Critical COVID-19
    Authors: Wang, Y;Yang, C;Wang, Z;Wang, Y;Yan, Q;Feng, Y;Liu, Y;Huang, J;Zhou, J;
    International journal of molecular sciences  2023-08-14
  20. Cannabidiol Enhances Cabozantinib-Induced Apoptotic Cell Death via Phosphorylation of p53 Regulated by ER Stress in Hepatocellular Carcinoma
    Authors: Jeon, Y;Kim, T;Kwon, H;Kim, JK;Park, YT;Ham, J;Kim, YJ;
    Cancers  2023-08-05
  21. Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer
    Authors: Zhou, Q;Peng, Y;Ji, F;Chen, H;Kang, W;Chan, LS;Gou, H;Lin, Y;Huang, P;Chen, D;Wei, Q;Su, H;Liang, C;Zhang, X;Yu, J;Wong, CC;
    Nature communications  2023-08-04
  22. Identification of Glucocorticoid Receptor Target Genes That Potentially Inhibit Collagen Synthesis in Human Dermal Fibroblasts
    Authors: Choi, D;Kang, W;Park, S;Son, B;Park, T;
    Biomolecules  2023-06-11
  23. Long-chain polyphosphates inhibit type I interferon signaling and augment LPS-induced cytokine secretion in human leukocytes
    Authors: Pirttiniemi, A;Adeshara, K;Happonen, N;Einarsdottir, E;Katayama, S;Salmenkari, H;H�rkk�, S;Kere, J;Groop, PH;Lehto, M;
    Journal of leukocyte biology  2023-05-24
  24. The role of KNTC1 in the regulation of proliferation, migration and tumorigenesis in colorectal cancer
    Authors: Wang, J;Ding, Z;Shu, W;Zhuge, Y;
    Cellular signalling  2023-05-23
  25. FGF-trapping hampers cancer stem-like cells in uveal melanoma
    Authors: Loda, A;Calza, S;Giacomini, A;Ravelli, C;Krishna Chandran, AM;Tobia, C;Tabellini, G;Parolini, S;Semeraro, F;Ronca, R;Rezzola, S;
    Cancer cell international  2023-05-11
  26. Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma
    Authors: Balasubramanian, B;Yacqub-Usman, K;Venkatraman, S;Myint, KZ;Juengsamarn, J;Sarkhampee, P;Lertsawatvicha, N;Sripa, J;Kuakpaetoon, T;Suriyonplengsaeng, C;Wongprasert, K;Grabowska, AM;Bates, DO;Janvilisri, T;Tohtong, R;
    Cancers  2023-04-28
  27. Galectin-3 promotes secretion of proteases that decrease epithelium integrity in human colon cancer cells
    Authors: S Li, DM Pritchard, LG Yu
    Cell Death & Disease, 2023-04-13;14(4):268.  2023-04-13
  28. Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema
    Authors: JJ Park, K Oh, GW Lee, G Bang, JH Park, HB Kim, JY Kim, EY Shin, EG Kim
    Experimental & Molecular Medicine, 2023-04-03;0(0):.  2023-04-03
  29. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis
    Authors: W Lin, R Niu, SM Park, Y Zou, SS Kim, X Xia, S Xing, Q Yang, X Sun, Z Yuan, S Zhou, D Zhang, HJ Kwon, S Park, C Il Kim, H Koo, Y Liu, H Wu, M Zheng, H Yoo, B Shi, JB Park, J Yin
    Nature Communications, 2023-03-22;14(1):1578.  2023-03-22
  30. Venetoclax-Resistant T-ALL Cells Display Distinct Cancer Stem Cell Signatures and Enrichment of Cytokine Signaling
    Authors: K Shah, L Al Ashiri, A Nasimian, M Ahmed, JU Kazi
    International Journal of Molecular Sciences, 2023-03-05;24(5):.  2023-03-05
  31. Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade
    Authors: CH Chang, BJ Lin, CH Chen, NL Nguyen, TH Hsieh, JH Su, MC Chen
    Marine Drugs, 2023-01-21;21(2):.  2023-01-21
  32. EGFR and Lyn inhibition augments regorafenib induced cell death in sorafenib resistant 3D tumor spheroid model
    Authors: E Sar?yar, O Karpat, S Sezan, SM Baylan, A K?pçak, K Guven, E Erdal, ZF Karagonlar
    Cellular Signalling, 2023-01-21;0(0):110608.  2023-01-21
  33. HIF-1alpha accumulation in response to transient hypoglycemia may worsen diabetic eye disease
    Authors: C Guo, M Deshpande, Y Niu, I Kachwala, M Flores-Bel, H Megarity, T Nuse, S Babapoor-F, M Ramada, J Sanchez, N Inamdar, TV Johnson, MV Canto-Sole, S Montaner, A Sodhi
    Cell Reports, 2023-01-10;42(1):111976.  2023-01-10
  34. IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway
    Authors: Yuan, S;Wang, Y;Chan, L;Hung, A;Nguyen, H;Chen, Y;Hu, S;Lo, S;Wang, Y;
    Research Square  2023-01-01
  35. CCL4 Regulates Eosinophil Activation in Eosinophilic Airway Inflammation
    Authors: HH Chu, Y Kobayashi, DV Bui, Y Yun, LM Nguyen, A Mitani, K Suzuki, M Asako, A Kanda, H Iwai
    International Journal of Molecular Sciences, 2022-12-18;23(24):.  2022-12-18
  36. Oxidized Proteins Differentially Affect Maturation and Activation of Human Monocyte-Derived Cells
    Authors: R Clemen, K Arlt, L Miebach, T von Woedtk, S Bekeschus
    Cells, 2022-11-18;11(22):.  2022-11-18
  37. BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes
    Authors: H Takahashi, WM Kühtreiber, RC Keefe, AH Lee, A Aristarkho, HF Dias, N Ng, KJ Nelson, S Bien, D Scheffey, DL Faustman
    Science Advances, 2022-11-16;8(46):eabq7240.  2022-11-16
  38. Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
    Authors: M Schmitt, F Ceteci, J Gupta, M Pesic, TW Böttger, AM Nicolas, KB Kennel, E Engel, M Schewe, A Callak Kir, V Petrocelli, Y Dabiri, J Varga, M Ramakrishn, M Karimova, A Ablasser, T Sato, MC Arkan, FJ de Sauvage, FR Greten
    Nature, 2022-11-16;0(0):.  2022-11-16
  39. Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells
    Authors: T Chernova, S Grosso, XM Sun, AR Tenor, JZ Cabeza, A Craxton, EL Self, A Nakas, K Cain, M MacFarlane, AE Willis
    International Journal of Molecular Sciences, 2022-10-18;23(20):.  2022-10-18
  40. Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion
    Authors: J Ablain, A Al Mahi, H Rothschild, M Prasad, S Aires, S Yang, ME Dokukin, S Xu, M Dang, I Sokolov, CG Lian, LI Zon
    Nature Genetics, 2022-10-13;0(0):.  2022-10-13
  41. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation
    Authors: P Marona, J Górka, O Kwapisz, J Jura, J Rys, RM Hoffman, K Miekus
    Cell Death & Disease, 2022-09-22;13(9):814.  2022-09-22
  42. Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma
    Authors: MV Barbolina
    Cancers, 2022-09-19;14(18):.  2022-09-19
  43. Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele
    Authors: M Flück, D Vaughan, J Rittweger, MN Giraud
    Frontiers in Physiology, 2022-09-06;13(0):933792.  2022-09-06
  44. An in vivo model of glioblastoma radiation resistance identifies long non-coding RNAs and targetable kinases
    Authors: CT Stackhouse, JC Anderson, Z Yue, T Nguyen, NJ Eustace, CP Langford, J Wang, JR Rowland Iv, C Xing, FM Mikhail, X Cui, H Alrefai, RE Bash, KJ Lee, ES Yang, AB Hjelmeland, CR Miller, JY Chen, GY Gillespie, CD Willey
    JCI Insight, 2022-08-22;0(0):.  2022-08-22
  45. Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice
    Authors: W Jiang, C Ma, J Bai, X Du
    Redox Biology, 2022-08-13;56(0):102432.  2022-08-13
  46. PTEN inhibits AMPK to control collective migration
    Authors: F Peglion, L Capuana, I Perfettini, L Boucontet, B Braithwait, E Colucci-Gu, E Quissac, K Forsberg-N, F Llense, S Etienne-Ma
    Nature Communications, 2022-08-11;13(1):4528.  2022-08-11
  47. p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells
    Authors: S Pietrobono, R De Paolo, D Mangiameli, A Marranci, I Battisti, C Franchin, G Arrigoni, D Melisi, L Poliseno, B Stecca
    The Journal of Biological Chemistry, 2022-08-07;298(9):102353.  2022-08-07
  48. Angiotensin II Exaggerates SARS-CoV-2 Specific T-Cell Response in Convalescent Individuals following COVID-19
    Authors: M Almutlaq, FA Mansour, J Alghamdi, Y Alhendi, AA Alamro, AA Alghamdi, HS Alamri, F Alroqi, T Barhoumi
    International Journal of Molecular Sciences, 2022-08-04;23(15):.  2022-08-04
  49. Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion
    Authors: A Jouida, M O'Callagha, C Mc Carthy, A Fabre, P Nadarajan, MP Keane
    Cancers, 2022-08-03;14(15):.  2022-08-03
  50. Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma
    Authors: C Xu, L Yan, X Guan, Z Wang, J Wu, A Lv, D Liu, F Liu, B Dong, M Zhao, L Jia, X Tian, C Hao
    International journal of biological sciences, 2022-08-01;18(13):5038-5055.  2022-08-01
  51. The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells
    Authors: D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz
    Elife, 2022-07-11;11(0):.  2022-07-11
  52. Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells
    Authors: C He, C Wang, H Liu, B Shan
    BMC Cancer, 2022-07-02;22(1):724.  2022-07-02
  53. Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer
    Authors: K Kamat, V Krishnan, O Dorigo
    British Journal of Cancer, 2022-06-24;0(0):.  2022-06-24
  54. Peroxiredoxin IV plays a critical role in cancer cell growth and radioresistance through the activation of the Akt/GSK3 signaling pathways
    Authors: N Ding, H Jiang, P Thapa, Y Hao, A Alshahrani, D Allison, T Izumi, VM Rangnekar, X Liu, Q Wei
    The Journal of Biological Chemistry, 2022-06-10;0(0):102123.  2022-06-10
  55. GSK3beta palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis
    Authors: C Zhao, H Yu, X Fan, W Niu, J Fan, S Sun, M Gong, B Zhao, Z Fang, X Chen
    Oncogenesis, 2022-05-23;11(1):28.  2022-05-23
  56. Idelalisib activates AKT via increased recruitment of PI3Kdelta/PI3Kbeta to BCR signalosome while reducing PDK1 in post-therapy CLL cells
    Authors: MK Mamidi, H Mahmud, GP Maiti, MT Mendez, SM Fernandes, SK Vesely, J Holter-Cha, JR Brown, AK Ghosh
    Leukemia, 2022-05-14;0(0):.  2022-05-14
  57. m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer
    Authors: JX Lin, NZ Lian, YX Gao, QL Zheng, YH Yang, YB Ma, ZS Xiu, QZ Qiu, HG Wang, CH Zheng, P Li, JW Xie, J Lu, QY Chen, LL Cao, M Lin, JB Wang, CM Huang
    Cell Death & Disease, 2022-05-14;13(5):463.  2022-05-14
  58. Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer
    Authors: M Kakarla, S ChallaSiva, MF Dufficy, V Gil, Y Filipovich, R Vickman, SE Crawford, SW Hayward, OE Franco
    Cancers, 2022-05-09;14(9):.  2022-05-09
  59. Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells
    Authors: C Alonso-Gon, C González-A, J Menéndez-M, A González-G, V Álvarez-Ga, A González-C, C Martínez-C, S Cos
    Biomedicines, 2022-05-07;10(5):.  2022-05-07
  60. Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia
    Authors: T Braun, J Stachelsch, N Bley, S Oberbeck, M Otte, TA Müller, L Wahnschaff, M Gla beta, K Ommer, M Franitza, B Gathof, J Altmüller, M Hallek, D Auguin, S Hüttelmaie, A Schrader, M Herling
    Cancer Research, 2022-05-03;0(0):.  2022-05-03
  61. ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer
    Authors: EJ Lim, JH Kang, YJ Kim, S Kim, SJ Lee
    Cell Death & Disease, 2022-04-29;13(4):417.  2022-04-29
  62. The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway
    Authors: S Bini, V Pecce, A Di Costanz, L Polito, A Ghadiri, I Minicocci, F Tambaro, S Covino, M Arca, L D'Erasmo
    Biomolecules, 2022-04-16;12(4):.  2022-04-16
  63. Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
    Authors: Y Huang, E Motta, C Nanvuma, LD Kuhrt, Y Yuan, P Xia, M Lubas, S Zhu, M Schnauss, N Qazi, F Hu, H Zhang, T Lei, M Synowitz, C Flüh, H Kettenmann
    Cell Reports, 2022-04-12;39(2):110670.  2022-04-12
  64. Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion
    Authors: C Gaiteiro, J Soares, M Relvas-San, A Peixoto, D Ferreira, P Paulo, A Brandão, E Fernandes, R Azevedo, C Palmeira, R Freitas, A Miranda, H Osório, J Prieto, L Lima, AMN Silva, LL Santos, JA Ferreira
    Theranostics, 2022-03-28;12(7):3150-3177.  2022-03-28
  65. SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway
    Authors: Z Liu, Q Wang, G Zhai, S Ke, X Yu, J Guo
    Cancer Cell International, 2022-03-19;22(1):127.  2022-03-19
  66. ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers
    Authors: J Mooz, K Riegel, H Ps, A Sadanandam, F Marini, M Klein, U Werner, W Roth, A Wilken-Sch, I Tegeder, K Rajalingam
    Science Advances, 2022-03-18;8(11):eabk1538.  2022-03-18
  67. DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6
    Authors: X Zhang, Y Hu, Y Pan, Y Xiong, Y Zhang, M Han, K Dong, J Song, H Liang, Z Ding, X Zhang, H Zhu, Q Liu, X Lu, Y Feng, X Chen, Z Zhang, B Zhang
    Oncogene, 2022-02-09;0(0):.  2022-02-09
  68. DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3
    Authors: CM Borza, G Bolas, F Bock, X Zhang, FC Akabogu, MZ Zhang, M de Caestec, M Yang, HC Yang, E Lee, L Gewin, AB Fogo, WH McDonald, R Zent, A Pozzi
    JCI Insight, 2022-02-08;0(0):.  2022-02-08
  69. Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability
    Authors: RS Smith, I Odintsov, Z Liu, AJ Lui, T Hayashi, M Vojnic, Y Suehara, L Delasos, MS Mattar, J Hmeljak, HA Ramirez, M Shaw, G Bui, AB Hartono, E Gladstone, S Kunte, H Magnan, I Khodos, E De Stanchi, MP La Quaglia, J Yao, M Laé, SB Lee, L Spraggon, CA Pratilas, M Ladanyi, R Somwar
    Disease Models & Mechanisms, 2022-01-27;0(0):.  2022-01-27
  70. Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma
    Authors: E Shimada, Y Matsumoto, M Nakagawa, Y Susuki, M Endo, N Setsu, T Fujiwara, K Iida, A Nabeshima, K Yahiro, A Kimura, T Hirose, M Kanahori, R Oyama, Y Oda, Y Nakashima
    British Journal of Cancer, 2022-01-11;0(0):.  2022-01-11
  71. Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants
    Authors: MT Khayat, AM Omar, F Ahmed, MI Khan, SM Ibrahim, YA Muhammad, AM Malebari, T Neamatalla, ME El-Araby
    Frontiers in Pharmacology, 2022-01-05;12(0):794325.  2022-01-05
  72. SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
    Authors: Y Cha, T Kim, J Jeon, Y Jang, PB Kim, C Lopes, P Leblanc, BM Cohen, KS Kim
    Cell Reports, 2021-12-28;37(13):110155.  2021-12-28
  73. Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma
    Authors: I Berestjuk, M Lecacheur, A Carminati, S Diazzi, C Rovera, V Prod'homme, M Ohanna, A Popovic, A Mallaviall, F Larbret, S Pisano, S Audebert, T Passeron, C Gaggioli, CA Girard, M Deckert, S Tartare-De
    Embo Molecular Medicine, 2021-12-27;0(0):e11814.  2021-12-27
  74. Therapeutic potential of the PI3K inhibitor LY294002 and PARP inhibitor Talazoparib combination in BRCA-deficient triple negative breast cancer cells
    Authors: G Guney Eski, M Ozturk
    Cellular Signalling, 2021-12-24;91(0):110229.  2021-12-24
  75. Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells
    Authors: K Marunaka, S Shu, M Kobayashi, M Goto, Y Katsuta, Y Yoshino, A Ikari
    International Journal of Molecular Sciences, 2021-12-22;23(1):.  2021-12-22
  76. GPR87 Promotes Metastasis through the AKT-eNOS-NO Axis in Lung Adenocarcinoma
    Authors: HM Ahn, EY Choi, YJ Kim
    Cancers, 2021-12-21;14(1):.  2021-12-21
  77. SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase
    Authors: Y Ounoughene, E Fourgous, Y Boublik, E Saland, N Guiraud, C Recher, S Urbach, P Fort, JE Sarry, D Fesquet, S Roche
    Cancers, 2021-12-17;13(24):.  2021-12-17
  78. Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence
    Authors: D Bakhshinya, AA Adile, J Liu, WD Gwynne, Y Suk, S Custers, I Burns, M Singh, N McFarlane, MK Subapandit, MA Qazi, P Vora, MM Kameda-Smi, N Savage, KL Desmond, N Tatari, D Tran, M Seyfrid, K Hope, NA Bock, C Venugopal, GD Bader, SK Singh
    Science Advances, 2021-12-08;7(50):eabi5568.  2021-12-08
  79. Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer
    Authors: YZ Mazzu, YR Liao, S Nandakumar, LE Jehane, RP Koche, SH Rajanala, R Li, H Zhao, TA Gerke, G Chakrabort, GM Lee, GJ Nanjangud, A Gopalan, Y Chen, PW Kantoff
    Oncogene, 2021-11-20;0(0):.  2021-11-20
  80. Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer
    Authors: L Yin, Y Zeng, R Zeng, Y Chen, TL Wang, KJ Rodabaugh, F Yu, A Natarajan, AR Karpf, J Dong
    Oncogene, 2021-11-19;0(0):.  2021-11-19
  81. The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis
    Authors: N Stoup, M Liberelle, C Schulz, S Cavdarli, R Vasseur, R Magnez, F Lahdaoui, N Skrypek, F Peretti, F Frénois, X Thuru, P Melnyk, N Renault, N Jonckheere, N Lebègue, I Van Seunin
    Cancers, 2021-11-16;13(22):.  2021-11-16
  82. Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells
    Authors: D Chauss, T Freiwald, R McGregor, B Yan, L Wang, E Nova-Lampe, D Kumar, Z Zhang, H Teague, EE West, KM Vannella, MJ Ramos-Beni, J Bibby, A Kelly, A Malik, AF Freeman, DM Schwartz, D Portilla, DS Chertow, S John, P Lavender, C Kemper, G Lombardi, NN Mehta, N Cooper, MS Lionakis, A Laurence, M Kazemian, B Afzali
    Nature Immunology, 2021-11-11;0(0):.  2021-11-11
  83. The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation
    Authors: V Vorstandle, M Laggner, D Copic, K Klas, M Direder, Y Chen, B Golabi, W Haslik, C Radtke, E Tschachler, K Hötzenecke, HJ Ankersmit, M Mildner
    Nature Communications, 2021-10-29;12(1):6242.  2021-10-29
  84. Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation
    Authors: J Kim, YJ Jeon, SC Lim, J Ryu, JH Lee, IY Chang, HJ You
    Cell Death & Disease, 2021-10-28;12(11):1013.  2021-10-28
  85. IL-36alpha and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling
    Authors: ZII Al-Luhaibi, Á Dernovics, G Seprényi, F Ayaydin, Z Boldogk?i, Z Veréb, K Megyeri
    Biomedicines, 2021-10-26;9(11):.  2021-10-26
  86. Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation
    Authors: A Quintanal-, H Taniguchi, YA Zhan, MM Hasan, SS Chavan, F Meng, F Uddin, V Allaj, P Manoj, NS Shah, JM Chan, M Ciampricot, A Chow, M Offin, J Ray-Kirton, JD Egger, UK Bhanot, I Linkov, M Asher, MH Roehrl, K Ventura, J Qiu, E de Stanchi, JC Chang, N Rekhtman, B Houck-Loom, RP Koche, HA Yu, T Sen, CM Rudin
    Journal of hematology & oncology, 2021-10-16;14(1):170.  2021-10-16
  87. Tyrosine kinase independent actions of DDR2 in tumor cells and CAFs influence tumor invasion, migration, and metastasis
    Authors: CE Barcus, PY Hwang, V Morikis, A Brenot, P Pence, M Clarke, GD Longmore
    Journal of Cell Science, 2021-10-13;0(0):.  2021-10-13
  88. Combinatorial Effect of PLK1 Inhibition with Temozolomide and Radiation in Glioblastoma
    Authors: A Pandey, SC Tripathi, J Mai, SM Hanash, H Shen, S Mitra, RC Rostomily
    Cancers, 2021-10-12;13(20):.  2021-10-12
  89. Androgen Receptor Activation in Glioblastoma Can Be Achieved by Ligand-Independent Signaling through EGFR-A Potential Therapeutic Target
    Authors: N Zalcman, M Gutreiman, T Shahar, M Weller, I Lavon
    International Journal of Molecular Sciences, 2021-10-11;22(20):.  2021-10-11
  90. Preclinical development of a bispecific TNFalpha/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease
    Authors: KJ Roberts, MF Cubitt, TM Carlton, L Rodrigues-, L Maggiore, R Chai, S Clare, K Harcourt, TT MacDonald, KP Ray, A Vossenkämp, MR West, JS Crowe
    Scientific Reports, 2021-09-30;11(1):19422.  2021-09-30
  91. CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
    Authors: S Ma, LS Mangala, W Hu, E Bayaktar, A Yokoi, W Hu, S Pradeep, S Lee, PD Piehowski, A Villar-Pra, SY Wu, MH McGuire, OD Lara, C Rodriguez-, CJ LaFargue, NB Jennings, KD Rodland, T Liu, V Kundra, PT Ram, S Ramakrishn, G Lopez-Bere, RL Coleman, AK Sood
    Cell Reports, 2021-08-17;36(7):109549.  2021-08-17
  92. Gemcitabine and APG-1252, a novel small molecule inhibitor of BCL-2/BCL-XL, display a synergistic antitumor effect in nasopharyngeal carcinoma through the JAK-2/STAT3/MCL-1 signaling pathway
    Authors: F Luo, FT Lu, MZ Qiu, T Zhou, WJ Ma, M Luo, KM Zeng, QY Luo, WT Pan, L Zhang, ZF Xia, ZH Zhang, JX Cao, HY Zhao, L Zhang, DJ Yang
    Cell Death & Disease, 2021-08-05;12(8):772.  2021-08-05
  93. PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance
    Authors: C Yoon, J Lu, SW Ryeom, MC Simon, SS Yoon
    Cell Death & Disease, 2021-07-29;12(8):749.  2021-07-29
  94. Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration
    Authors: P Ebner-Peki, L Krisch, M Wolf, S Hochmann, A Hoog, B Vári, K Muigg, R Poupardin, C Scharler, S Schmidhube, E Russe, H Stachelsch, A Schneeberg, K Schallmose, D Strunk
    Theranostics, 2021-07-25;11(17):8430-8447.  2021-07-25
  95. CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1
    Authors: S Durlanik, K Fundel-Cle, C Viollet, HJ Huber, M Lenter, K Kitt, S Pflanz
    Scientific Reports, 2021-07-21;11(1):14849.  2021-07-21
  96. TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer
    Authors: J Xu, X Yang, Q Deng, C Yang, D Wang, G Jiang, X Yao, X He, J Ding, J Qiang, J Tu, R Zhang, QY Lei, ZM Shao, X Bian, R Hu, L Zhang, S Liu
    Nature Communications, 2021-07-20;12(1):4413.  2021-07-20
  97. Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling
    Authors: C Stecher, S Marinkov, L Mayr-Harti, A Katic, MT Kastner, FJJ Rieder-Rom, X Lin, S Nekhai, C Steininger
    Frontiers in Microbiology, 2021-07-15;12(0):698603.  2021-07-15
  98. New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRbeta Signaling
    Authors: M Mahdal, J Neradil, P Mudry, S Paukovceko, I Staniczkov, J Urban, P Macsek, L Pazourek, T Tomas, R Veselska
    Cancers, 2021-07-15;13(14):.  2021-07-15
  99. miR-301a-3p induced by endoplasmic reticulum stress mediates the occurrence and transmission of trastuzumab resistance in HER2-positive gastric cancer
    Authors: J Guo, X Zhong, Q Tan, S Yang, J Liao, J Zhuge, Z Hong, Q Deng, Q Zuo
    Cell Death & Disease, 2021-07-13;12(7):696.  2021-07-13
  100. RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells
    Authors: E Demirel, C Arnold, J Garg, MA Jäger, C Sticht, R Li, H Kuk, N Wettschure, M Hecker, T Korff
    Cells, 2021-07-11;10(7):.  2021-07-11
  101. Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells
    Authors: H Sevim, H Çelik, L Dü?ünceli, CS Ceyhan, A Molotkova, K Nakazawa, GT Graham, JR Petro, JA Toretsky, A Üren
    PLoS ONE, 2021-06-16;16(6):e0253170.  2021-06-16
  102. Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis
    Authors: K Andelid, K Öst, A Andersson, E Mohamed, Z Jevnikar, LEGW Vanfletere, M Göransson
    Respiratory Research, 2021-06-07;22(1):172.  2021-06-07
  103. Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes
    Authors: TW Jones, L Eddens, J Kupusarevi, DCM Simoes, MJW Furber, KA van Somere, G Howatson
    Scientific Reports, 2021-05-24;11(1):10785.  2021-05-24
  104. Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail
    Authors: YJ Lai, CH Chao, CC Liao, TA Lee, JM Hsu, WC Chou, J Wang, HC Huang, SJ Chang, YL Lin, CW Li
    American journal of cancer research, 2021-05-15;11(5):2278-2290.  2021-05-15
  105. New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer
    Authors: L Gheysen, L Soumoy, A Trelcat, L Verset, F Journe, S Saussez
    Cells, 2021-05-05;10(5):.  2021-05-05
  106. The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells
    Authors: S Hafner, M Schmiech, SJ Lang
    Frontiers in Pharmacology, 2021-05-05;12(0):611657.  2021-05-05
  107. Glycosyltransferase POMGNT1 deficiency strengthens N-cadherin-mediated cell-cell adhesion
    Authors: SI Noor, M Hoffmann, N Rinis, MF Bartels, PR Winterhalt, C Hoelscher, R Hennig, N Himmelreic, C Thiel, T Ruppert, E Rapp, S Strahl
    The Journal of Biological Chemistry, 2021-02-18;0(0):100433.  2021-02-18
  108. Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines
    Authors: F Benedetti, S Curreli, RC Gallo, D Zella
    Journal of Translational Medicine, 2021-02-09;19(1):60.  2021-02-09
  109. TGF-&beta1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor
    Authors: H Yoon, CM Tang, S Banerjee, AL Delgado, M Yebra, J Davis, JK Sicklick
    Oncogenesis, 2021-02-06;10(2):13.  2021-02-06
  110. mTOR modulates resistance to gemcitabine in lung cancer in an MTORC2 dependent mechanism
    Authors: MA Chawsheen, PR Dash
    Cellular Signalling, 2021-02-03;81(0):109934.  2021-02-03
  111. Identification of Radil as a Ras binding partner and putative activator
    Authors: BH Choi, Z Kou, TM Colon, CH Chen, Y Chen, W Dai
    The Journal of Biological Chemistry, 2021-01-20;0(0):100314.  2021-01-20
  112. S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell-cell interactions with adjacent breast cancer cells
    Authors: SH Jo, WH Heo, HY Son, M Quan, BS Hong, JH Kim, HB Lee, W Han, Y Park, DS Lee, NH Kwon, MC Park, J Chae, JI Kim, DY Noh, HG Moon
    Scientific Reports, 2021-01-14;11(1):1337.  2021-01-14
  113. BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways
    Authors: CY Jiao, QC Feng, CX Li, D Wang, S Han, YD Zhang, WJ Jiang, J Chang, X Wang, XC Li
    Cell Death & Disease, 2021-01-11;12(1):63.  2021-01-11
  114. Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells
    Authors: J Wang, X Lv, X Guo, Y Dong, P Peng, F Huang, P Wang, H Zhang, J Zhou, Y Wang, B Wei, ZF Shang, S Li
    Oncogenesis, 2021-01-05;10(1):8.  2021-01-05
  115. CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3&beta/&beta-catenin/OCT4 axis
    Authors: W Shen, X Zhang, J Tang, Z Zhang, R Du, D Luo, X Liu, Y Xia, Y Li, S Wang, S Yan, W Yang, R Xiang, N Luo, Y Luo, J Li
    Theranostics, 2021-01-01;11(5):2297-2317.  2021-01-01
  116. Schistosoma mansoni eggs induce Wnt/&beta-catenin signaling and activate the protooncogene c-Jun in human and hamster colon
    Authors: J Weglage, F Wolters, L Hehr, J Lichtenber, C Wulz, F Hempel, A Baier, T Quack, K Köhler, T Longerich, G Schramm, K Irungbam, H Mueller, V von Buelow, A Tschuschne, M Odenthal, U Drebber, ME Arousy, LNZ Ramalho, K Bankov, P Wild, J Pons-Kühne, J Tschammer, CG Grevelding, E Roeb, M Roderfeld
    Scientific Reports, 2020-12-23;10(1):22373.  2020-12-23
  117. Extracellular signal-regulated kinase 1/2 is required for complement component C1q and fibronectin dependent enhancement of Fc&gamma- receptor mediated phagocytosis in mouse and human cells
    Authors: EA Willmann, V Pandurovic, A Jokinen, D Beckley, SS Bohlson
    BMC immunology, 2020-12-14;21(1):61.  2020-12-14
  118. Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA
    Authors: Q Hao, P Wang, P Dutta, S Chung, Q Li, K Wang, J Li, W Cao, W Deng, Q Geng, K Schrode, M Shaheen, K Wu, D Zhu, QH Chen, G Chen, Y Elshimali, J Vadgama, Y Wu
    Cell Death & Disease, 2020-12-11;11(12):1052.  2020-12-11
  119. Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines
    Authors: M Fuentes-Ba, MP Ventero, JA Encinar, P García-Mor, M Poveda-Del, E Pérez-Vale, VM Barberá, J Gallego-Pl, Á Rodríguez-, J Martín-Nie, M Saceda
    Cancers, 2020-12-11;12(12):.  2020-12-11
  120. Insight into Cisplatin-Resistance Signaling of W1 Ovarian Cancer Cells Emerges mTOR and HSP27 as Targets for Sensitization Strategies
    Authors: K Wantoch vo, P König, S Henze, M Schlesinge, P Zawierucha, R Januchowsk, G Bendas
    International Journal of Molecular Sciences, 2020-12-03;21(23):.  2020-12-03
  121. Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages
    Authors: YY Wang, HD Chen, S Lo, YK Chen, YC Huang, SC Hu, YC Hsieh, AC Hung, MF Hou, SF Yuan
    Cancers, 2020-11-26;12(12):.  2020-11-26
  122. LIMD2 Regulates Key Steps of Metastasis Cascade in Papillary Thyroid Cancer Cells via MAPK Crosstalk
    Authors: RP Araldi, TC de Melo, D Levy, DM de Souza, B Maurício, GA Colozza-Ga, SP Bydlowski, H Peng, FJ Rauscher, JM Cerutti
    Cells, 2020-11-23;9(11):.  2020-11-23
  123. The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu)
    Authors: A Alghamdi, W Aldossary, S Albahkali, B Alotaibi, BM Alrfaei
    PLoS ONE, 2020-11-10;15(11):e0241902.  2020-11-10
  124. LDOC1 Suppresses Microbe-Induced Production of IL-1&beta in Human Normal and Cancerous Oral Cells through the PI3K/Akt/GSK-3&beta Axis
    Authors: CH Lee, PF Hung, KJ Liu, HL Chung, WC Yang, KC Hsu, TH Fong, HJ Lo, YP Chen, JR Yang, CY Yen
    Cancers (Basel), 2020-10-27;12(11):.  2020-10-27
  125. Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling
    Authors: B Zhou, J Liu, L Zeng, S Zhu, H Wang, TR Billiar, G Kroemer, DJ Klionsky, HJ Zeh, J Jiang, D Tang, R Kang
    Nat Microbiol, 2020-10-19;0(0):.  2020-10-19
  126. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling
    Authors: S Ketterer, J Mitschke, A Ketscher, M Schlimpert, W Reichardt, N Baeuerle, ME Hess, P Metzger, M Boerries, C Peters, B Kammerer, T Brummer, F Steinberg, T Reinheckel
    Nat Commun, 2020-10-12;11(1):5133.  2020-10-12
  127. Design, synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as anti-glioblastoma agents targeting the AKT pathway
    Authors: M Szeliga, M Karpi?ska, R Rola, A Niewiadomy
    Bioorg Chem, 2020-10-09;105(0):104362.  2020-10-09
  128. The role of TRPV1 ion channels in the suppression of gastric cancer development
    Authors: N Gao, F Yang, S Chen, H Wan, X Zhao, H Dong
    J Exp Clin Cancer Res, 2020-10-02;39(1):206.  2020-10-02
  129. Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma
    Authors: K Regan-Fend, D Li, R Reyes, L Yu, NA Wani, P Hu, ST Jacob, K Ghoshal, PRO Payne, T Motiwala
    Cancers (Basel), 2020-09-23;12(10):.  2020-09-23
  130. IL-32&gamma potentiates tumor immunity in melanoma
    Authors: T Gruber, M Kremenovic, H Sadozai, N Rombini, L Baeriswyl, F Maibach, RL Modlin, M Gilliet, D von Werdt, RE Hunger, SM Seyed Jafa, G Parisi, G Abril-Rodr, A Ribas, M Schenk
    JCI Insight, 2020-09-17;5(18):.  2020-09-17
  131. Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer
    Authors: R Wang, T Yamada, K Kita, H Taniguchi, S Arai, K Fukuda, M Terashima, A Ishimura, A Nishiyama, A Tanimoto, S Takeuchi, K Ohtsubo, K Yamashita, T Yamano, A Yoshimura, K Takayama, K Kaira, Y Taniguchi, S Atagi, H Uehara, R Hanayama, I Matsumoto, X Han, K Matsumoto, W Wang, T Suzuki, S Yano
    Nat Commun, 2020-09-14;11(1):4607.  2020-09-14
  132. Anticancer activities of selected Emirati Date (Phoenix dactylifera L.) varieties pits in human triple negative breast cancer MDA-MB-231 cells
    Authors: MNK Khattak, A Shanableh, MI Hussain, AA Khan, M Abdulwahab, W Radeef, MH Samreen
    Saudi journal of biological sciences, 2020-09-06;27(12):3390-3396.  2020-09-06
  133. Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration
    Authors: X Zhang, S Bandyopadh, LP Araujo, K Tong, J Flores, D Laubitz, Y Zhao, G Yap, J Wang, Q Zou, R Ferraris, L Zhang, W Hu, EM Bonder, PR Kiela, R Coffey, MP Verzi, II Ivanov, N Gao
    JCI Insight, 2020-08-20;5(16):.  2020-08-20
  134. Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/beta-catenin/SLUG axis
    Authors: S Bu, Q Wang, J Sun, X Li, T Gu, D Lai
    Cell Death Dis, 2020-08-18;11(8):644.  2020-08-18
  135. The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma
    Authors: A Reszegi, Z Horváth, K Karászi, E Reg?s, V Postniková, P Tátrai, A Kiss, Z Schaff, I Kovalszky, K Baghy
    Biomolecules, 2020-08-18;10(8):.  2020-08-18
  136. TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
    Authors: HK Kim, KR Bhattarai, RP Junjappa, JH Ahn, SH Pagire, HJ Yoo, J Han, D Lee, KW Kim, HR Kim, HJ Chae
    Nat Commun, 2020-08-11;11(1):4012.  2020-08-11
  137. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
    Authors: JMD Grandjean, A Madhavan, L Cech, BO Seguinot, RJ Paxman, E Smith, L Scampavia, ET Powers, CB Cooley, L Plate, TP Spicer, JW Kelly, RL Wiseman
    Nat. Chem. Biol., 2020-07-20;0(0):.  2020-07-20
  138. m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling
    Authors: JW Xie, XB Huang, QY Chen, YB Ma, YJ Zhao, LC Liu, JB Wang, JX Lin, J Lu, LL Cao, M Lin, RH Tu, CH Zheng, CM Huang, P Li
    Mol. Cancer, 2020-07-10;19(1):114.  2020-07-10
  139. Downregulation of RRM2 Attenuates Retroperitoneal Liposarcoma Progression via the Akt/mTOR/4EBP1 Pathway: Clinical, Biological, and Therapeutic Significance
    Authors: S Zhang, L Yan, C Cui, Z Wang, J Wu, A Lv, M Zhao, B Dong, W Zhang, X Guan, X Tian, C Hao
    Onco Targets Ther, 2020-07-03;13(0):6523-6537.  2020-07-03
  140. Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL
    Authors: C Hurtz, GB Wertheim, JP Loftus, D Blumenthal, A Lehman, Y Li, A Bagashev, B Manning, KD Cummins, JK Burkhardt, AE Perl, M Carroll, SK Tasian
    J. Clin. Invest., 2020-07-01;0(0):.  2020-07-01
  141. PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility
    Authors: HW Jen, DL Gu, YD Lang, YS Jou
    Cells, 2020-06-18;9(6):.  2020-06-18
  142. Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells
    Authors: SJ Lang, M Schmiech, S Hafner, C Paetz, K Werner, M El Gaafary, CQ Schmidt, T Syrovets, T Simmet
    Int J Mol Sci, 2020-06-08;21(11):.  2020-06-08
  143. Oncogenic Potential of Bisphenol A and Common Environmental Contaminants in Human Mammary Epithelial Cells
    Authors: VA Nair, S Valo, P Peltomäki, K Bajbouj, WM Abdel-Rahm
    Int J Mol Sci, 2020-05-25;21(10):.  2020-05-25
  144. Immuno-metabolic impact of the multiple sclerosis patients' sera on endothelial cells of the blood-brain barrier
    Authors: MH Sheikh, SM Henson, RA Loiola, S Mercurio, A Colamatteo, GT Maniscalco, V De Rosa, S McArthur, E Solito
    J Neuroinflammation, 2020-05-09;17(1):153.  2020-05-09
  145. SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway
    Authors: J Zhang, XH Liu, C Li, XX Wu, YL Chen, WW Li, X Li, F Gong, Q Tang, D Jiang
    J. Exp. Clin. Cancer Res., 2020-05-07;39(1):79.  2020-05-07
  146. The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells
    Authors: A Douida, F Batista, A Robaszkiew, P Boto, A Aladdin, M Szenykiv, R Czinege, L Virág, K Tar
    J. Cell. Mol. Med., 2020-05-05;0(0):.  2020-05-05
  147. FGF2 Induces Resistance to Nilotinib through MAPK Pathway Activation in KIT Mutated Melanoma
    Authors: P Tétu, J Delyon, J André, C Reger de M, M Sabbah, GE Ghanem, M Battistell, S Mourah, C Lebbé, N Dumaz
    Cancers (Basel), 2020-04-25;12(5):.  2020-04-25
  148. Circulating Neutrophils Predict Poor Survival for HCC and Promote HCC Progression Through p53 and STAT3 Signaling Pathway
    Authors: Y Wang, R Yao, D Zhang, R Chen, Z Ren, L Zhang
    J Cancer, 2020-04-06;11(13):3736-3744.  2020-04-06
  149. A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
    Authors: LR Kong, NAB Mohamed Sa, RW Ong, TZ Tan, NL Syn, RM Goh, CW Fhu, DSW Tan, NG Iyer, S Kannan, CS Verma, YC Lim, R Soo, J Ho, Y Huang, JSJ Lim, BJ Yan, ME Nga, SG Lim, HP Koeffler, SC Lee, D Kappei, HT Hung, BC Goh
    Nat Commun, 2020-03-25;11(1):1556.  2020-03-25
  150. Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma
    Authors: ES Grassi, V Pantazopou, A Pietras
    Oncogene, 2020-03-24;0(0):.  2020-03-24
  151. The Lipid Virulence Factors of Mycobacterium tuberculosis Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages
    Authors: A Bah, M Sanicas, J Nigou, C Guilhot, C Astarie-De, I Vergne
    Cells, 2020-03-09;9(3):.  2020-03-09
  152. Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma
    Authors: M Pruss, A Dwucet, M Tanriover, M Hlavac, RE Kast, KM Debatin, CR Wirtz, ME Halatsch, MD Siegelin, MA Westhoff, G Karpel-Mas
    Br. J. Cancer, 2020-03-02;0(0):.  2020-03-02
  153. Glycosaminoglycans as Tools to Decipher the Platelet Tumor Cell Interaction: A Focus on P-Selectin
    Authors: S Schwarz, LM Gockel, A Naggi, U Barash, M Gobec, G Bendas, M Schlesinge
    Molecules, 2020-02-26;25(5):.  2020-02-26
  154. FGF trapping inhibits multiple myeloma growth through c-Myc degradation-induced mitochondrial oxidative stress
    Authors: R Ronca, GC Ghedini, F Maccarinel, A Sacco, SL Locatelli, E Foglio, S Taranto, E Grillo, S Matarazzo, R Castelli, G Paganini, V Desantis, N Cattane, A Cattaneo, M Mor, C Carlo-Stel, A Belotti, A Roccaro, M Presta, A Giacomini
    Cancer Res., 2020-02-24;0(0):.  2020-02-24
  155. Porphyromonas gingivalis triggers the shedding of inflammatory endothelial microvesicles that act as autocrine effectors of endothelial dysfunction
    Authors: IM Bugueno, F Zobairi El, F Batool, H El Itawi, E Anglès-Can, N Benkirane-, F Toti, O Huck
    Sci Rep, 2020-02-04;10(1):1778.  2020-02-04
  156. Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells
    Authors: K Oono, K Ohtake, C Watanabe, S Shiba, T Sekiya, K Kasono
    Lipids Health Dis, 2020-01-31;19(1):15.  2020-01-31
  157. Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3&beta signalling pathway in renal cell carcinoma
    Authors: Q Zhu, AL Zhong, H Hu, JJ Zhao, DS Weng, Y Tang, QZ Pan, ZQ Zhou, MJ Song, JY Yang, JY He, Y Liu, M Li, WM Hu, CP Yang, T Xiang, MY Chen, G Ma, L Guo, JC Xia
    J Hematol Oncol, 2020-01-03;13(1):2.  2020-01-03
  158. Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling
    Authors: P Shahi Thak, M Gupta, S Singh, R Joshi, E Glasgow, A Lekan, S Agarwal, GD Luker, H Tavana
    BMC Cancer, 2020-01-02;20(1):4.  2020-01-02
  159. Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice
    Authors: SA Scarneo, LS Eibschutz, PJ Bendele, KW Yang, J Totzke, P Hughes, DA Fox, TAJ Haystead
    Arthritis Res. Ther., 2019-12-17;21(1):292.  2019-12-17
  160. CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation
    Authors: NL Cook, M Pjanic, AG Emmerich, AS Rao, S Hetty, JW Knowles, T Quertermou, C Castillejo, E Ingelsson
    BMC Endocr Disord, 2019-10-29;19(1):115.  2019-10-29
  161. CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma
    Authors: R Xu, Y Li, H Yan, E Zhang, X Huang, Q Chen, J Chen, J Qu, Y Liu, J He, Q Yi, Z Cai
    Cell Death Dis, 2019-10-14;10(10):781.  2019-10-14
  162. Interleukin-6 mediates resistance to PI3K-pathway-targeted therapy in lymphoma
    Authors: JH Kim, WS Kim, C Park
    BMC Cancer, 2019-10-10;19(1):936.  2019-10-10
  163. Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma
    Authors: J Wurm, SP Behringer, VM Ravi, K Joseph, N Neidert, JP Maier, R Doria-Medi, M Follo, D Delev, D Pfeifer, J Beck, R Sankowski, O Schnell, DH Heiland
    Cancers (Basel), 2019-09-26;11(10):.  2019-09-26
  164. UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling
    Authors: JX Lin, XS Xie, XF Weng, SL Qiu, C Yoon, NZ Lian, JW Xie, JB Wang, J Lu, QY Chen, LL Cao, M Lin, RH Tu, YH Yang, CM Huang, CH Zheng, P Li
    J. Exp. Clin. Cancer Res., 2019-09-18;38(1):410.  2019-09-18
  165. Tyrosine kinase inhibition to improve anthracycline-based chemotherapy efficacy in T-cell lymphoma
    Authors: M Magni, G Biancon, S Rizzitano, A Cavanè, C Paolizzi, M Dugo, P Corradini, C Carniti
    Br. J. Cancer, 2019-09-02;0(0):.  2019-09-02
  166. Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer
    Authors: MJ Jo, S Jeong, HK Yun, DY Kim, BR Kim, JL Kim, YJ Na, SH Park, YA Jeong, BG Kim, H Ashktorab, DT Smoot, JY Heo, J Han, DH Lee, SC Oh
    BMC Cancer, 2019-07-27;19(1):739.  2019-07-27
  167. Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin
    Authors: J Menéndez-M, F Hermida-Pr, R Granda-Día, A González, JM García-Ped, N Del-Río-Ib, A González-G, S Cos, C Alonso-Gon, C Martínez-C
    Cancers (Basel), 2019-07-19;11(7):.  2019-07-19
  168. EPHA2 feedback activation limits the response to PDEdelta inhibition in KRAS-dependent cancer cells
    Authors: YH Chen, H Lv, N Shen, XM Wang, S Tang, B Xiong, J Ding, MY Geng, M Huang
    Acta Pharmacol. Sin., 2019-07-17;41(2):270-277.  2019-07-17
  169. Multilevel defects in the hematopoietic niche in essential thrombocythemia
    Authors: T Sun, M Ju, X Dai, H Dong, W Gu, Y Gao, R Fu, X Liu, Y Huang, W Liu, Y Chi, W Wang, H Li, Y Zhou, L Shi, R Yang, L Zhang
    Haematologica, 2019-07-09;0(0):.  2019-07-09
  170. Kinome expression profiling to target new therapeutic avenues in multiple myeloma
    Authors: H de Boussac, A Bruyer, M Jourdan, A Maes, N Robert, C Gourzones, L Vincent, A Seckinger, G Cartron, D Hose, E De Bruyne, A Kassambara, P Pasero, J Moreaux
    Haematologica, 2019-07-09;0(0):.  2019-07-09
  171. Paired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer
    Authors: PH Su, HC Lai, RL Huang, LY Chen, YC Wang, TI Wu, MWY Chan, CC Liao, CW Chen, WY Lin, CC Chang
    Sci Rep, 2019-06-24;9(1):9195.  2019-06-24
  172. Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide
    Authors: AL Potthoff, DH Heiland, BO Evert, FR Almeida, SP Behringer, A Dolf, Á Güresir, E Güresir, K Joseph, T Pietsch, P Schuss, U Herrlinger, MA Westhoff, H Vatter, A Waha, M Schneider
    Cancers (Basel), 2019-06-20;11(6):.  2019-06-20
  173. Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration
    Authors: S Offer, JA Menard, JE Pérez, KG de Oliveir, VI Chandran, MC Johansson, A Bång-Ruden, P Siesjö, A Ebbesson, I Hedenfalk, PC Sundgren, A Darabi, M Belting
    J. Exp. Clin. Cancer Res., 2019-06-07;38(1):241.  2019-06-07
  174. Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells
    Authors: S Jeong, BG Kim, DY Kim, BR Kim, JL Kim, SH Park, YJ Na, MJ Jo, HK Yun, YA Jeong, HJ Kim, SI Lee, HD Kim, DH Kim, SC Oh, DH Lee
    Cancers (Basel), 2019-06-05;11(6):.  2019-06-05
  175. Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds
    Authors: IA Schepetkin, LN Kirpotina, AI Khlebnikov, N Balasubram, MT Quinn
    Molecules, 2019-05-10;24(9):.  2019-05-10
  176. A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer
    Authors: J Chen, J Bell, BT Lau, T Whittaker, D Stapleton, HP Ji
    Oncogenesis, 2019-05-10;8(5):33.  2019-05-10
  177. The small GTPase ARF6 activates PI3K in melanoma to induce a pro-metastatic state
    Authors: JH Yoo, SW Brady, L Acosta-Alv, A Rogers, J Peng, LK Sorensen, RK Wolff, T Mleynek, D Shin, CP Rich, DA Kircher, A Bild, SJ Odelberg, DY Li, SL Holmen, AH Grossmann
    Cancer Res., 2019-05-02;0(0):.  2019-05-02
  178. Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia-reperfusion injury
    Authors: L Hummitzsch, K Zitta, R Berndt, YL Wong, R Rusch, K Hess, T Wedel, M Gruenewald, J Cremer, M Steinfath, M Albrecht
    J Transl Med, 2019-04-29;17(1):136.  2019-04-29
  179. IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states
    Authors: G Pellizzari, C Hoskin, S Crescioli, S Mele, J Gotovina, G Chiaruttin, R Bianchini, K Ilieva, HJ Bax, S Papa, KE Lacy, E Jensen-Jar, S Tsoka, DH Josephs, JF Spicer, SN Karagianni
    EBioMedicine, 2019-04-05;0(0):.  2019-04-05
  180. Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells
    Authors: DA Ferraro, F Patella, S Zanivan, C Donato, N Aceto, M Giannotta, E Dejana, M Diepenbruc, G Christofor, M Buess
    BMC Cancer, 2019-04-04;19(1):312.  2019-04-04
  181. Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach
    Authors: Z Xiao, B Sperl, S Gärtner, T Nedelko, E Stacher-Pr, A Ullrich, PG Knyazev
    Oncotarget, 2019-04-02;10(26):2546-2560.  2019-04-02
  182. PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway
    Authors: Y Bai, X Liu, X Qi, X Liu, F Peng, H Li, H Fu, S Pei, L Chen, X Chi, L Zhang, X Zhu, Y Song, Y Wang, S Meng, T Jiang, S Shao
    EBioMedicine, 2019-03-25;0(0):.  2019-03-25
  183. Survival/adaptation of Bone Marrow derived Mesenchymal Stem Cells after long term starvation through selective processes
    Authors: F Ferro, R Spelat, G Shaw, N Duffy, MN Islam, PM O'Shea, D O'Toole, L Howard, M Murphy
    Stem Cells, 2019-03-25;0(0):.  2019-03-25
  184. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
    Authors: SP Kennedy, JZR Han, N Portman, M Nobis, JF Hastings, KJ Murphy, SL Latham, AL Cadell, D Miladinovi, GR Marriott, YEI O'Donnell, RF Shearer, JT Williams, AG Munoz, TR Cox, DN Watkins, DN Saunders, P Timpson, E Lim, W Kolch, DR Croucher
    Breast Cancer Res., 2019-03-21;21(1):43.  2019-03-21
  185. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
    Authors: S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis
    JCI Insight, 2019-03-21;0(0):.  2019-03-21
  186. Signal regulatory protein ? protects podocytes through promoting autophagic activity
    Authors: L Li, Y Liu, S Li, Y Yang, C Zeng, W Rong, H Liang, M Zhang, X Zhu, K Kidder, Y Liu, Z Liu, K Zen
    JCI Insight, 2019-03-19;5(0):.  2019-03-19
  187. Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program
    Authors: JH Noh, KM Kim, PR Pandey, NN Hooten, R Munk, G Kundu, S De, JL Martindale, X Yang, MK Evans, K Abdelmohse, M Gorospe
    Nucleic Acids Res., 2019-03-18;0(0):.  2019-03-18
  188. E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms
    Authors: MK Jolly, KE Ware, S Xu, S Gilja, S Shetler, Y Yang, X Wang, RG Austin, D Runyambo, AJ Hish, S Bartholf D, JT George, RT Kreulen, MK Boss, AL Lazarides, DL Kerr, DG Gerber, D Sivaraj, AJ Armstrong, MW Dewhirst, WC Eward, H Levine, JA Somarelli
    Mol. Cancer Res., 2019-03-12;0(0):.  2019-03-12
  189. Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis
    Authors: D Neelakanta, S Dogra, BR Devapatla, P Jaiprasart, MC Mukashyaka, R Janknecht, SKD Dwivedi, R Bhattachar, S Husain, K Ding, S Woo
    Mol. Cancer Res., 2019-03-11;0(0):.  2019-03-11
  190. Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib
    Authors: YC Ko, CY Hu, ZH Liu, HF Tien, DL Ou, HF Chien, LI Lin
    Int J Mol Sci, 2019-03-11;20(5):.  2019-03-11
  191. EPHA2 is a predictive biomarker of resistance and a potential therapeutic target for improving anti-epidermal growth factor receptor therapy in colorectal cancer
    Authors: G Martini, C Cardone, PP Vitiello, V Belli, S Napolitano, T Troiani, D Ciardiello, CM Della Cort, F Morgillo, N Matrone, V Sforza, G Papaccio, V Desiderio, MC Paul, V Moreno-Vie, N Normanno, AM Rachiglio, V Tirino, E Maiello, TP Latiano, D Rizzi, G Signoriell, M Sibilia, F Ciardiello, E Martinelli
    Mol. Cancer Ther., 2019-03-01;0(0):.  2019-03-01
  192. Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway
    Authors: T van Montfo, R van der Sl, G Darcis, D Beaty, K Groen, AO Pasternak, G Pollakis, M Vink, EM Westerhout, M Hamdi, M Bakker, B van der Pu, S Jurriaans, JH Prins, R Jeeninga, AAM Thomas, D Speijer, B Berkhout
    EBioMedicine, 2019-02-26;0(0):.  2019-02-26
  193. Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus
    Authors: ME Nickol, J Ciric, SD Falcinelli, DS Chertow, J Kindrachuk
    Viruses, 2019-01-29;11(2):.  2019-01-29
  194. Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin
    Authors: C Zalfa, P Azmoon, E Mantuano, SL Gonias
    J. Leukoc. Biol., 2019-01-28;0(0):.  2019-01-28
  195. MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma
    Authors: Y Zhao, W Huang, TM Kim, Y Jung, LG Menon, H Xing, H Li, RS Carroll, PJ Park, HW Yang, MD Johnson
    J. Exp. Clin. Cancer Res., 2019-01-25;38(1):36.  2019-01-25
  196. AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
    Authors: H Taniguchi, T Yamada, R Wang, K Tanimura, Y Adachi, A Nishiyama, A Tanimoto, S Takeuchi, LH Araujo, M Boroni, A Yoshimura, S Shiotsu, I Matsumoto, S Watanabe, T Kikuchi, S Miura, H Tanaka, T Kitazaki, H Yamaguchi, H Mukae, J Uchino, H Uehara, K Takayama, S Yano
    Nat Commun, 2019-01-16;10(1):259.  2019-01-16
  197. Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma
    Authors: R Kumar, CN Njauw, BY Reddy, Z Ji, A Rajadurai, N Klebanov, H Tsao
    Oncogene, 2019-01-16;0(0):.  2019-01-16
  198. ?-arrestin 1 regulates ?2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
    Authors: J Kim, CA Grotegut, JW Wisler, T Li, L Mao, M Chen, W Chen, PB Rosenberg, HA Rockman, RJ Lefkowitz
    Skelet Muscle, 2018-12-27;8(1):39.  2018-12-27
  199. Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells
    Authors: G Tornillo, C Knowlson, H Kendrick, J Cooke, H Mirza, I Aurrekoetx, MDM Vivanco, NE Buckley, A Grigoriadi, MJ Smalley
    Cell Rep, 2018-12-26;25(13):3674-3692.e10.  2018-12-26
  200. Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms
    Authors: A Arenas Cor, R Ayala Diaz, P Hernández-, J Gorrochate, D Primo, A Robles, ML Morales, J Ballestero, I Rapado, M Gallardo, M Linares, J Martínez-L
    Haematologica, 2018-12-13;0(0):.  2018-12-13
  201. 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease
    Authors: C Klein, G Roussel, S Brun, C Rusu, C Patte-Mens, M Maitre, AG Mensah-Nya
    Acta Neuropathol Commun, 2018-12-11;6(1):136.  2018-12-11
  202. The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors
    Authors: X Wang, J Ai, H Liu, X Peng, H Chen, Y Chen, Y Su, A Shen, X Huang, J Ding, M Geng
    Mol. Cancer Ther., 2018-12-06;0(0):.  2018-12-06
  203. The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells
    Authors: E Golec, L Lind, M Qayyum, AM Blom, BC King
    J. Immunol., 2018-12-05;0(0):.  2018-12-05
  204. Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
    Authors: MH Kubala, V Punj, VR Placencio-, H Fang, GE Fernandez, R Sposto, YA DeClerck
    Cell Rep, 2018-11-20;25(8):2177-2191.e7.  2018-11-20
  205. NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway
    Authors: L Deng, X Gao, B Liu, X He, J Xu, J Qiang, Q Wu, S Liu
    Cell Death Dis, 2018-11-16;9(12):1143.  2018-11-16
  206. Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin
    Authors: E Narvi, K Vaparanta, A Karrila, D Chakrobort, S Knuutila, A Pulliainen, M Sundvall, K Elenius
    Sci Rep, 2018-11-08;8(1):16579.  2018-11-08
  207. Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
    Authors: TM Totiger, S Srinivasan, VR Jala, P Lamichhane, AR Dosch, AA Gaidarski, C Joshi, S Rangappa, J Castellano, PK Vemula, X Chen, D Kwon, N Kashikar, M VanSaun, NB Merchant, NS Nagathihal
    Mol. Cancer Ther., 2018-11-07;0(0):.  2018-11-07
  208. Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist
    Authors: W Miao, K Sakai, N Ozawa, T Nishiuchi, Y Suzuki, K Ito, T Morioka, M Umitsu, J Takagi, H Suga, K Matsumoto
    Sci Rep, 2018-11-07;8(1):16492.  2018-11-07
  209. Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1
    Authors: TY Wong, WC Juang, CT Tsai, CJ Tseng, WH Lee, SN Chang, PW Cheng
    J Clin Med, 2018-11-02;7(11):.  2018-11-02
  210. WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4
    Authors: K Taniuchi, M Furihata, S Naganuma, T Saibara
    Cancer Med, 2018-10-23;0(0):.  2018-10-23
  211. Lorlatinib treatment elicits multiple on- and off-target mechanisms of resistance in ALK-driven cancer
    Authors: S Redaelli, M Ceccon, M Zappa, GG Sharma, C Mastini, M Mauri, M Nigoghossi, L Massimino, N Cordani, F Farina, R Piazza, C Gambacorti, L Mologni
    Cancer Res., 2018-10-15;0(0):.  2018-10-15
  212. Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation
    Authors: V Pandey, B Wang, CD Mohan, AR Raquib, S Rangappa, V Srinivasa, JE Fuchs, KS Girish, T Zhu, A Bender, L Ma, Z Yin, Basappa, KS Rangappa, PE Lobie
    Proc. Natl. Acad. Sci. U.S.A., 2018-10-11;0(0):.  2018-10-11
  213. Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT
    Authors: Y Zhang, G Ji, S Han, Z Shao, Z Lu, L Huo, J Zhang, R Yang, Q Feng, H Shen, H Wang, X Li
    Cell. Physiol. Biochem., 2018-10-11;50(2):612-628.  2018-10-11
  214. IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells
    Authors: M Shimizu, N Tanaka
    Oncogene, 2018-10-10;0(0):.  2018-10-10
  215. K-Ras lysine-42 is crucial for its signaling, cell migration and invasion
    Authors: BH Choi, MR Philips, Y Chen, L Lu, W Dai
    J. Biol. Chem., 2018-09-18;0(0):.  2018-09-18
  216. Olfactory receptor OR2AT4 regulates human hair growth
    Authors: J Chéret, M Bertolini, L Ponce, J Lehmann, T Tsai, M Alam, H Hatt, R Paus
    Nat Commun, 2018-09-18;9(1):3624.  2018-09-18
  217. WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
    Authors: CS Gonçalves, J Vieira de, M Pojo, EP Martins, S Queirós, E Chautard, R Taipa, MM Pires, AA Pinto, F Pardal, C Custódia, CC Faria, C Clara, RM Reis, N Sousa, BM Costa
    Theranostics, 2018-09-09;8(17):4805-4823.  2018-09-09
  218. Establishment of keratinocyte cell lines from human hair follicles
    Authors: T Wagner, M Gschwandtn, A Strajeriu, A Elbe-Bürge, J Grillari, R Grillari-V, G Greiner, B Golabi, E Tschachler, M Mildner
    Sci Rep, 2018-09-07;8(1):13434.  2018-09-07
  219. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
    Authors: Y Jiang, YY Jiang, JJ Xie, A Mayakonda, M Hazawa, L Chen, JF Xiao, CQ Li, ML Huang, LW Ding, QY Sun, L Xu, D Kanojia, M Jeitany, JW Deng, LD Liao, HJ Soukiasian, BP Berman, JJ Hao, LY Xu, EM Li, MR Wang, XG Bi, DC Lin, HP Koeffler
    Nat Commun, 2018-09-06;9(1):3619.  2018-09-06
  220. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors
    Authors: F Pareja, AH Brandes, T Basili, P Selenica, FC Geyer, D Fan, A Da Cruz Pa, R Kumar, DN Brown, R Gularte-Mé, B Alemar, R Bi, RS Lim, I de Bruijn, S Fujisawa, R Gardner, E Feng, A Li, EM da Silva, JR Lozada, P Blecua, L Cohen-Goul, AA Jungbluth, EA Rakha, IO Ellis, MIA Edelweiss, J Palazzo, L Norton, T Hollmann, M Edelweiss, BP Rubin, B Weigelt, JS Reis-Filho
    Nat Commun, 2018-08-30;9(1):3533.  2018-08-30
  221. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds
    Authors: V Vishwakarm, J New, D Kumar, V Snyder, L Arnold, E Nissen, Q Hu, N Cheng, D Miller, AR Thomas, Y Shnayder, K Kakarala, TT Tsue, DA Girod, SM Thomas
    Sci Rep, 2018-08-15;8(1):12163.  2018-08-15
  222. Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17
    Authors: P Urriola-Mu, R Lagos-Cabr, D Patiño-Gar, JG Reyes, RD Moreno
    Int J Mol Sci, 2018-07-31;19(8):.  2018-07-31
  223. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1? axis to inhibit gastric tumorigenesis
    Authors: W Li, CC Wong, X Zhang, W Kang, G Nakatsu, Q Zhao, H Chen, MYY Go, PWY Chiu, X Wang, J Ji, X Li, Z Cai, EKW Ng, J Yu
    Oncogene, 2018-07-27;0(0):.  2018-07-27
  224. Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo
    Authors: C Li, V Rezov, E Joensuu, V Vartiainen, M Rönty, M Yin, M Myllärniem, K Koli
    Sci Rep, 2018-07-03;8(1):10070.  2018-07-03
  225. Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway
    Authors: Z Fang, KH Jung, HH Yan, SJ Kim, M Rumman, JH Park, B Han, JE Lee, YW Kang, JH Lim, SS Hong
    Cell. Physiol. Biochem., 2018-06-28;47(5):1751-1768.  2018-06-28
  226. Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines
    Authors: MY Gökyildiri, U Grandel, K Hattar, G Dahlem, E Schuetz, FH Leinberger, F Eberle, U Sibelius, F Grimminger, W Seeger, R Engenhart-, E Dikomey, FSB Subtil
    Oncotarget, 2018-06-22;9(48):28976-28988.  2018-06-22
  227. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
    Authors: PD Fan, G Narzisi, AD Jayaprakas, E Venturini, N Robine, P Smibert, S Germer, HA Yu, EJ Jordan, PK Paik, YY Janjigian, JE Chaft, L Wang, AA Jungbluth, S Middha, L Spraggon, H Qiao, CM Lovly, MG Kris, GJ Riely, K Politi, H Varmus, M Ladanyi
    Proc. Natl. Acad. Sci. U.S.A., 2018-06-06;115(26):E6030-E6038.  2018-06-06
  228. WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
    Authors: W Chen, LN Zebaze, J Dong, L Chézeau, P Inquimbert, S Hugel, S Niu, F Bihel, E Boutant, E Réal, P Villa, MP Junier, H Chneiweiss, M Hibert, J Haiech, MC Kilhoffer, M Zeniou
    Oncotarget, 2018-06-05;9(43):27197-27219.  2018-06-05
  229. JDP2 overexpression provokes cardiac dysfunction in mice
    Authors: J Heger, J Bornbaum, A Würfel, C Hill, N Brockmann, R Gáspár, J Pálóczi, ZV Varga, M Sárközy, P Bencsik, T Csont, S Török, B Kojonazaro, RT Schermuly, K Böngler, M Parahuleva, P Ferdinandy, R Schulz, G Euler
    Sci Rep, 2018-05-16;8(1):7647.  2018-05-16
  230. HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis
    Authors: C Hernandez, P Huebener, JP Pradere, DJ Antoine, RA Friedman, RF Schwabe
    J. Clin. Invest., 2018-05-07;0(0):.  2018-05-07
  231. Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
    Authors: X Gong, JR Smith, HM Swanson, LP Rubin
    Molecules, 2018-04-14;23(4):.  2018-04-14
  232. Acquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model
    Authors: BM Ku, MK Choi, JM Sun, SH Lee, JS Ahn, K Park, MJ Ahn
    PLoS ONE, 2018-04-11;13(4):e0194730.  2018-04-11
  233. YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma
    Authors: X Zhang, X Wang, R Xu, J Ji, Y Xu, M Han, Y Wei, B Huang, A Chen, Q Zhang, W Li, J Wang, X Li, C Qiu
    J Transl Med, 2018-03-23;16(1):79.  2018-03-23
  234. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
    Authors: G Xiao, LN Chan, L Klemm, D Braas, Z Chen, H Geng, QC Zhang, A Aghajanire, KN Cosgun, T Sadras, J Lee, T Mirzapoiaz, R Salgia, T Ernst, A Hochhaus, H Jumaa, X Jiang, DM Weinstock, TG Graeber, M Müschen
    Cell, 2018-03-15;0(0):.  2018-03-15
  235. BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling
    Authors: K Taniuchi, M Furihata, S Naganuma, K Dabanaka, K Hanazaki, T Saibara
    Am J Cancer Res, 2018-03-01;8(3):387-404.  2018-03-01
  236. Suppression of the ERK-SRF axis facilitates somatic cell reprogramming
    Authors: S Huh, HR Song, GR Jeong, H Jang, NH Seo, JH Lee, JY Yi, B Lee, HW Choi, JT Do, JS Kim, SH Lee, JW Jung, T Lee, J Shim, MK Han, TH Lee
    Exp. Mol. Med., 2018-02-23;50(2):e448.  2018-02-23
  237. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer
    Authors: U Baumgartne, F Berger, A Hashemi Gh, SS Burgener, K Monastyrsk, E Vassella
    Mol. Cancer, 2018-02-19;17(1):44.  2018-02-19
  238. Low-molecular weight keratins with anti-skin aging activity produced by anaerobic digestion of poultry feathers with Fervidobacterium islandicum AW-1
    Authors: I Yeo, YJ Lee, K Song, HS Jin, JE Lee, D Kim, DW Lee, NJ Kang
    J. Biotechnol., 2018-02-10;0(0):.  2018-02-10
  239. Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines
    Authors: S Heavey, P Dowling, G Moore, MP Barr, N Kelly, SG Maher, S Cuffe, SP Finn, KJ O'Byrne, K Gately
    Sci Rep, 2018-01-26;8(1):1652.  2018-01-26
  240. Human Epididymis Protein 4 Promotes Events Associated with Metastatic Ovarian CancerviaRegulation of the Extracelluar Matrix
    Authors: JR Ribeiro, HM Gaudet, M Khan, C Schorl, NE James, MT Oliver, PA DiSilvestr, RG Moore, N Yano
    Front Oncol, 2018-01-22;7(0):332.  2018-01-22
  241. Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice
    Authors: P Kuppusamy, A Nagalingam, N Muniraj, NK Saxena, D Sharma
    Sci Rep, 2017-12-20;7(1):17943.  2017-12-20
  242. Dysregulation of Mir-196b in Head and Neck Cancers Leads to Pleiotropic Effects in the Tumor Cells and Surrounding Stromal Fibroblasts
    Authors: S Álvarez-Te, ST Menéndez, MÁ Villaronga, JP Rodrigo, L Manterola, L de Villala, JC de Vicente, L Alonso-Dur, MP Fernández, CH Lawrie, JM García-Ped
    Sci Rep, 2017-12-19;7(1):17785.  2017-12-19
  243. Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis
    Authors: S Keller, J Kneissl, V Grabher-Me, S Heindl, J Hasenauer, D Maier, J Mattes, P Winter, B Luber
    BMC Cancer, 2017-12-13;17(1):845.  2017-12-13
  244. Protein C receptor stimulates multiple signaling pathways in breast cancer cells
    Authors: D Wang, C Liu, J Wang, Y Jia, X Hu, H Jiang, ZM Shao, YA Zeng
    J. Biol. Chem., 2017-12-07;0(0):.  2017-12-07
  245. Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.
    Authors: Charalambos Kaittanis, Chrysafis Andreou, Haley Hieronymu, Ninghui Mao, Catherine A Foss, Matthias Eiber, Gregor Weirich, Palak Panchal, Anuradha Gopalan, Juan Zurita, Samuel Achilefu, Gabriela Chiosis, Vladimir Ponomarev, Markus Schwaiger, Brett S Carver, Martin G Pomper, Jan Grimm
    The Journal of Experimental Medicine, 2017-11-15;0(0):1540-9538.  2017-11-15
  246. Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation
    Authors: M Riera-Borr, VD Cuevas, B Alonso, MA Vega, J Joven, E Izquierdo, ÁL Corbí
    J. Immunol., 2017-10-23;0(0):.  2017-10-23
  247. The Transcription Factor HOXB7 Regulates ERK Kinase Activity and Thereby Stimulates the Motility and Invasiveness of Pancreatic Cancer Cells
    Authors: M Tsuboi, K Taniuchi, T Shimizu, M Saito, T Saibara
    J. Biol. Chem., 2017-09-14;0(0):.  2017-09-14
  248. Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy
    Authors: JM Santiago-O, ES Kleinerman, MG Hollomon, A Livingston, WL Wang, JW Tsai, NB Gordon
    Oncotarget, 2017-08-17;9(2):1602-1616.  2017-08-17
  249. Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation
    Authors: S Curcic, M Holzer, L Pasterk, E Knuplez, TO Eichmann, S Frank, R Zimmermann, R Schicho, A Heinemann, G Marsche
    Sci Rep, 2017-08-14;7(1):8030.  2017-08-14
  250. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response
    Authors: S Janczar, J Nautiyal, Y Xiao, E Curry, M Sun, E Zanini, AJ Paige, H Gabra
    Cell Death Dis, 2017-07-27;8(7):e2955.  2017-07-27
  251. JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non-small cell lung cancer
    Authors: K Shien, VA Papadimitr, D Ruder, C Behrens, L Shen, N Kalhor, J Song, JJ Lee, J Wang, X Tang, RS Herbst, S Toyooka, L Girard, JD Minna, JM Kurie, II Wistuba, JG Izzo
    Mol. Cancer Ther., 2017-07-20;0(0):.  2017-07-20
  252. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.
    Authors: Chih-Hau Chang, Meng-Chi Yen, Ssu-Hui Liao, Yu-Ling Hsu, Chung-Sheng Lai, Kao-Ping Chang, Ya-Ling Hsu
    International Journal of Molecular Sciences, 2017-07-18;0(0):1422-0067.  2017-07-18
  253. Resistance to the antibody-drug conjugate T-DM1 is based in a reduction in lysosomal proteolytic activity
    Authors: C Ríos-Luci, S García-Alo, E Díaz-Rodrí, M Nadal-Serr, J Arribas, A Ocaña, A Pandiella
    Cancer Res., 2017-07-07;0(0):.  2017-07-07
  254. Co-targeting of MEK and PDGFR/STAT3 pathways to treat pancreatic ductal adenocar
    Authors: N Sahu, E Chan, F Chu, T Pham, H Koeppen, W Forrest, M Merchant, J Settleman
    Mol. Cancer Ther., 2017-06-15;0(0):.  2017-06-15
  255. Disruption of Aneuploidy and Senescence induced by Aurora inhibition promotes intrinsic Apoptosis in double hit or double expressor Diffuse Large B-cell Lymphomas
    Authors: D Mahadevan, S Islam, W Qi, C Morales, L Cooke, C Spier, E Weterings
    Mol. Cancer Ther., 2017-06-14;0(0):.  2017-06-14
  256. Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.
    Authors: Benjamin Y Owusu, Shantasia Thomas, Phanindra Venukadas, Zhenfu Han, James W Janetka, Robert A Galemmo, Lidija Klampfer
    Oncotarget, 2017-05-29;0(0):1949-2553.  2017-05-29
  257. Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
    Authors: M Mustapic, E Eitan, JK Werner, ST Berkowitz, MP Lazaropoul, J Tran, EJ Goetzl, D Kapogianni
    Front Neurosci, 2017-05-22;11(0):278.  2017-05-22
  258. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades
    Authors: H Lee, SH Baek, JH Lee, C Kim, JH Ko, SG Lee, A Chinnatham, SA Alharbi, WM Yang, JY Um, G Sethi, KS Ahn
    Int J Mol Sci, 2017-05-19;18(5):.  2017-05-19
  259. Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells
    Authors: GM Pio, Y Xia, MM Piaseczny, JE Chu, AL Allan
    PLoS ONE, 2017-05-12;12(5):e0177640.  2017-05-12
  260. The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischemia/reperfusion independent from mitochondrial connexin 43
    Authors: K Boengler, M Bulic, R Schreckenb, KD Schlueter, R Schulz
    Br. J. Pharmacol., 2017-05-10;0(0):.  2017-05-10
  261. Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway
    Authors: TO Cri?an, MCP Cleophas, B Novakovic, K Erler, FL van de Vee, HG Stunnenber, MG Netea, CA Dinarello, LAB Joosten
    Proc. Natl. Acad. Sci. U.S.A., 2017-05-08;0(0):.  2017-05-08
  262. Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell
    Authors: S Chen, J Tao, F Zhong, Y Jiao, J Xu, Q Shen, H Wang, S Fan, Y Zhang
    PLoS ONE, 2017-05-03;12(5):e0176501.  2017-05-03
  263. Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas
    Authors: MV Carriero, K Bifulco, V Ingangi, S Costantini, G Botti, C Ragone, M Minopoli, ML Motti, D Rea, G Scognamigl, G Botti, C Arra, G Ciliberto, A Pessi
    Sci Rep, 2017-05-02;7(1):1312.  2017-05-02
  264. The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry
    Authors: Z Zhou, L Xu, A Sennepin, C Federici, Y Ganor, D Tudor, D Damotte, N Barry Delo, M Zerbib, M Bomsel
    Mucosal Immunol, 2017-04-26;0(0):.  2017-04-26
  265. FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation
    Authors: FR Teixeira, AO Manfiolli, NA Vieira, AC Medeiros, PO Coelho, D Santiago G, D Schechtman, MD Gomes
    Arch. Biochem. Biophys., 2017-04-05;0(0):.  2017-04-05
  266. Galectin-3 interacts with the cell surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells
    Authors: F Colomb, W Wang, D Simpson, M Zafar, R Beynon, JM Rhodes, LG Yu
    J. Biol. Chem., 2017-03-31;0(0):.  2017-03-31
  267. Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer
    Authors: K Kalyvianak, V Gebhart, N Peroulis, C Panagiotop, F Kiagiadaki, I Pediaditak, M Aivaliotis, E Moustou, M Tzardi, G Notas, E Castanas, M Kampa
    Sci Rep, 2017-03-14;7(0):44418.  2017-03-14
  268. Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
    Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
    J. Biol. Chem, 2017-02-23;0(0):.  2017-02-23
  269. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2�
    Authors: II Kuan, KH Liang, YP Wang, TW Kuo, YJ Meir, SC Wu, SC Yang, J Lu, HC Wu
    Sci Rep, 2017-02-03;7(0):41852.  2017-02-03
  270. Activation of p38 and Erk Mitogen-Activated Protein Kinases Signaling in Ocular Rosacea
    Authors: EJ Wladis, S Swamy, A Herrmann, J Yang, JA Carlson, AP Adam
    Invest. Ophthalmol. Vis. Sci, 2017-02-01;58(2):843-848.  2017-02-01
  271. Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma
    Authors: Y Mo, Y Lu, P Wang, S Huang, L He, D Li, F Li, J Huang, X Lin, X Li, S Che, Q Chen
    Tumour Biol, 2017-02-01;39(2):1010428317690.  2017-02-01
  272. Ras-MEK Signaling Mediates a Critical Chk1-dependent DNA Damage Response in Cancer Cells
    Authors: HJ Lee, Y Cao, V Pham, E Blackwood, C Wilson, M Evangelist, C Klijn, D Stokoe, J Settleman
    Mol. Cancer Ther, 2017-01-30;0(0):.  2017-01-30
  273. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension
    Authors: P Yang, C Read, RE Kuc, G Buonincont, M Southwood, R Torella, PD Upton, A Crosby, SJ Sawiak, TA Carpenter, RC Glen, NW Morrell, JJ Maguire, AP Davenport
    Circulation, 2017-01-30;135(12):1160-1173.  2017-01-30
  274. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer
    Oncotarget, 2017-01-17;0(0):.  2017-01-17
  275. Induction and Differentiation of IL-10-Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients.
    Authors: Banko Z, Pozsgay J, Szili D, Toth M, Gati T, Nagy G, Rojkovich B, Sarmay G
    J Immunol, 2017-01-13;198(4):1512-1520.  2017-01-13
  276. Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene
    Authors: SA Nadeau, W An, BC Mohapatra, I Mushtaq, TA Bielecki, H Luan, N Zutshi, G Ahmad, MD Storck, M Sanada, S Ogawa, V Band, H Band
    J. Biol. Chem, 2017-01-12;292(9):3666-3682.  2017-01-12
  277. Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN
    Authors: A Cavazzoni, S La Monica, R Alfieri, A Ravelli, N Van Der St, R Sciarrillo, D Madeddu, CAM Lagrasta, F Quaini, M Bonelli, C Fumarola, D Cretella, G Digiacomo, M Tiseo, GJ Peters, A Ardizzoni, PG Petronini, E Giovannett
    Oncotarget, 2017-01-01;0(0):.  2017-01-01
  278. Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs
    Authors: Nader Alaridah
    J Innate Immun, 2016-12-24;0(0):.  2016-12-24
  279. Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line
    Authors: Benjamin Kalbe
    Eur. J. Cell Biol, 2016-12-05;0(0):.  2016-12-05
  280. CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells
    Authors: Aki Tanouchi
    J. Exp. Clin. Cancer Res, 2016-12-05;35(1):190.  2016-12-05
  281. Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.
    Authors: Astrid Escudero-E, Michael Bartosche, Chrysostomi Gialeli, Marcin Okroj, Sioned Owen, Karin Jirström, Akira Orimo, Wen G Jiang, Kristian Pietras, Anna M Blom
    Oncotarget, 2016-11-22;0(0):1949-2553.  2016-11-22
  282. Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance
    Acta Pharmacol. Sin., 2016-11-14;0(0):.  2016-11-14
  283. Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection
    MBio, 2016-11-01;7(6):.  2016-11-01
  284. The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2
    Authors: Nicola M Heller
    J. Biol. Chem., 2016-10-14;291(48):24922-24930.  2016-10-14
  285. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism
    Proc Natl Acad Sci USA, 2016-09-23;0(0):.  2016-09-23
  286. New insights into the Shwachman-Diamond Syndrome-related haematological disorder: hyper-activation of mTOR and STAT3 in leukocytes
    Sci Rep, 2016-09-23;6(0):33165.  2016-09-23
  287. Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells
    Sci Rep, 2016-09-08;6(0):33132.  2016-09-08
  288. Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase
    Authors: Raymond B Birge
    Cell Commun. Signal, 2016-09-06;14(1):19.  2016-09-06
  289. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18
    Sci Rep, 2016-08-30;6(0):32255.  2016-08-30
  290. Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells
    J Cancer, 2016-08-12;7(13):1824-1832.  2016-08-12
  291. CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells
    Oncogene, 2016-08-01;0(0):.  2016-08-01
  292. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation.
    Authors: Barquilla A, Lamberto I, Heynen-Genel S, Brill L, Pasquale E
    Mol Biol Cell, 2016-07-06;27(17):2757-70.  2016-07-06
  293. Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
    Oncotarget, 2016-06-28;7(26):40531-40545.  2016-06-28
  294. BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine
    Authors: Yuexi Gu
    Sci Rep, 2016-06-17;6(0):28217.  2016-06-17
  295. Metabolism regulates cellular functions of bone marrow-derived cells used for cardiac therapy
    Stem Cells, 2016-05-25;0(0):.  2016-05-25
  296. A Small Molecule Inhibitor of PDK1/PLC?1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion
    Authors: C Raimondi, V Calleja, R Ferro, A Fantin, AM Riley, BV Potter, CH Brennan, T Maffucci, B Larijani, M Falasca
    Sci Rep, 2016-05-20;6(0):26142.  2016-05-20
  297. Necrotic cells influence migration and invasion of glioblastoma via NF-?B/AP-1-mediated IL-8 regulation
    Authors: SH Ahn, H Park, YH Ahn, S Kim, MS Cho, JL Kang, YH Choi
    Sci Rep, 2016-04-14;6(0):24552.  2016-04-14
  298. Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling
    Authors: L Bénard, JG Oh, M Cacheux, A Lee, M Nonnenmach, DS Matasic, E Kohlbrenne, C Kho, C Pavoine, RJ Hajjar, JS Hulot
    Circulation, 2016-03-02;133(15):1458-71; disc.  2016-03-02
  299. Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes.
    Authors: Sento S, Sasabe E, Yamamoto T
    PLoS ONE, 2016-02-05;11(2):e0148454.  2016-02-05
  300. Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells.
    Authors: Skolekova S, Matuskova M, Bohac M, Toro L, Demkova L, Gursky J, Kucerova L
    Cell Commun Signal, 2016-01-12;14(1):4.  2016-01-12
  301. Neutrophils support lung colonization of metastasis-initiating breast cancer cells.
    Authors: Wculek S, Malanchi I
    Nature, 2015-12-09;528(7582):413-7.  2015-12-09
  302. Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions.
    Authors: Purushothaman A, Bandari S, Liu J, Mobley J, Brown E, Sanderson R
    J Biol Chem, 2015-11-24;291(4):1652-63.  2015-11-24
  303. Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells.
    Authors: Singh A, Ruan Y, Tippett T, Narendran A
    J Exp Clin Cancer Res, 2015-09-18;34(0):104.  2015-09-18
  304. Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma.
    Authors: Yamada T, Amann J, Fukuda K, Takeuchi S, Fujita N, Uehara H, Iwakiri S, Itoi K, Shilo K, Yano S, Carbone D
    Cancer Res, 2015-08-20;75(19):4188-97.  2015-08-20
  305. A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D.
    Authors: Eggink L, Spyroulias G, Jones N, Hanson C, Hoober J
    PLoS ONE, 2015-06-25;10(6):e0130532.  2015-06-25
  306. Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.
    Authors: Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim Y, Adam J, Lichter P, Solary E, Berchem G, Moussay E
    Blood, 2015-06-22;126(9):1106-17.  2015-06-22
  307. The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes.
    Authors: Hansen F, Kalle-Brune M, van der Plas M, Stromdahl A, Malmsten M, Morgelin M, Schmidtchen A
    J Immunol, 2015-04-24;194(11):5397-406.  2015-04-24
  308. YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway.
    Authors: Chang B, Johnson K, LaTocha D, Rowley J, Bryant J, Burke R, Smith R, Loriaux M, Muschen M, Mullighan C, Druker B, Tyner J
    J Hematol Oncol, 2015-04-22;8(0):39.  2015-04-22
  309. Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.
    Authors: Mailly L, Xiao F, Lupberger J, Wilson G, Aubert P, Duong F, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lutgehetmann M, Volz T, Davis C, Harris H, Mee C, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim M, Neunlist M, Zeisel M, Dandri M, McKeating J, Robinet E, Baumert T
    Nat Biotechnol, 2015-03-23;33(5):549-54.  2015-03-23
  310. Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.
    Authors: Laukkanen, Mikko O, Cammarota, Francesc, Esposito, Tiziana, Salvatore, Marco, Castellone, Maria D
    PLoS ONE, 2015-03-09;10(3):e0121441.  2015-03-09
  311. Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling.
    Authors: Man J, Shoemake J, Ma T, Rizzo A, Godley A, Wu Q, Mohammadi A, Bao S, Rich J, Yu J
    Cancer Res, 2015-02-20;75(8):1760-9.  2015-02-20
  312. Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation.
    Authors: Zhao D, Besser A, Wander S, Sun J, Zhou W, Wang B, Ince T, Durante M, Guo W, Mills G, Theodorescu D, Slingerland J
    Oncogene, 2015-02-16;34(43):5447-59.  2015-02-16
  313. Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.
    Authors: Atefi M, Titz B, Avramis E, Ng C, Wong D, Lassen A, Cerniglia M, Escuin-Ordinas H, Foulad D, Comin-Anduix B, Graeber T, Ribas A
    Mol Cancer, 2015-02-03;14(0):27.  2015-02-03
  314. Loss of DGKepsilon induces endothelial cell activation and death independently of complement activation.
    Authors: Bruneau S, Neel M, Roumenina L, Frimat M, Laurent L, Fremeaux-Bacchi V, Fakhouri F
    Blood, 2014-12-10;125(6):1038-46.  2014-12-10
  315. An increase in integrin-linked kinase non-canonically confers NF- inverted question markB-mediated growth advantages to gastric cancer cells by activating ERK1/2.
    Authors: Tseng P, Chen C, Shan Y, Chang W, Liu H, Hong T, Hsieh C, Lin S, Lin C
    Cell Commun Signal, 2014-11-15;12(1):69.  2014-11-15
  316. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation.
    Authors: Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, Won M, Ha K, Jeoung D, Han S, Ryoo S, Lee H, Min J, Kwon Y, Kim D, Kim Y
    J Biol Chem, 2014-11-12;290(1):467-77.  2014-11-12
  317. Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy.
    Authors: Iida, Mari, Brand, Toni M, Starr, Megan M, Huppert, Evan J, Luthar, Neha, Bahrar, Harsh, Coan, John P, Pearson, Hannah E, Salgia, Ravi, Wheeler, Deric L
    Mol Cancer, 2014-10-24;13(0):242.  2014-10-24
  318. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naive to primed cell transition.
    Authors: Speakman C, Domke T, Wongpaiboonwattana W, Sanders K, Mudaliar M, van Aalten D, Barton G, Stavridis M
    Stem Cells, 2014-10-01;32(10):2605-15.  2014-10-01
  319. EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line.
    Authors: Ranayhossaini D, Lu J, Mabus J, Gervais A, Lingham R, Fursov N
    Int J Mol Sci, 2014-09-30;15(10):17686-704.  2014-09-30
  320. Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling.
    Authors: Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, Limame R, Mestdagh P, Vandesompele J, Vanhove C, Maynard D, Lehuede C, Muller C, Valet P, Gespach C, Bracke M, Cocquyt V, Denys H, De Wever O
    Cancer Res, 2014-09-24;74(23):6806-19.  2014-09-24
  321. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
    Authors: Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
    Nat Commun, 2014-09-02;5(0):4715.  2014-09-02
  322. Adenosine inhibits tumor cell invasion via receptor-independent mechanisms.
    Authors: Virtanen S, Kukkonen-Macchi A, Vainio M, Elima K, Harkonen P, Jalkanen S, Yegutkin G
    Mol Cancer Res, 2014-07-30;12(12):1863-74.  2014-07-30
  323. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.
    Authors: Sinkevicius, Kerstin, Kriegel, Christin, Bellaria, Kelly J, Lee, Jaewon, Lau, Allison, Leeman, Kristen, Zhou, Pengchen, Beede, Alexande, Fillmore, Christin, Caswell, Deborah, Barrios, Juliana, Wong, Kwok-Kin, Sholl, Lynette, Schlaeger, Thorsten, Bronson, Roderick, Chirieac, Lucian R, Winslow, Monte M, Haigis, Marcia C, Kim, Carla F
    Proc Natl Acad Sci U S A, 2014-06-30;111(28):10299-304.  2014-06-30
  324. IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.
    Authors: Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A, Tutt A
    Cancer Res, 2014-06-30;74(17):4908-21.  2014-06-30
  325. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.
    Authors: Large M, Wetendorf M, Lanz R, Hartig S, Creighton C, Mancini M, Kovanci E, Lee K, Threadgill D, Lydon J, Jeong J, DeMayo F
    2014-06-19;0(0):.  2014-06-19
  326. Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo.
    Authors: Naspi A, Panasiti V, Abbate F, Roberti V, Devirgiliis V, Curzio M, Borghi M, Lozupone F, Carotti S, Morini S, Gaudio E, Calvieri S, Londei P
    PLoS ONE, 2014-06-06;9(6):e98641.  2014-06-06
  327. Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.
    Authors: Raimondi C, Fantin A, Lampropoulou A, Denti L, Chikh A, Ruhrberg C
    J Exp Med, 2014-05-26;211(6):1167-83.  2014-05-26
  328. Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.
    Authors: Jokela T, Karna R, Makkonen K, Laitinen J, Tammi R, Tammi M
    J Biol Chem, 2014-05-20;289(26):18569-81.  2014-05-20
  329. Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.
    Authors: Nagalingam A, Kuppusamy P, Singh S, Sharma D, Saxena N
    Cancer Res, 2014-04-14;74(9):2617-29.  2014-04-14
  330. Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells.
    Authors: Li, Wenjuan, Liu, Joan, Jackson, Kasey, Shi, Runhua, Zhao, Yunfeng
    PLoS ONE, 2014-04-07;9(4):e94079.  2014-04-07
  331. The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells.
    Authors: Kim, Ji Hye, Kim, Wang-Kyu, Sung, Young Kw, Kwack, Mi Hee, Song, Seung Yo, Choi, Joon-Seo, Park, Sang Gyu, Yi, TacGhee, Lee, Hyun-Joo, Kim, Dae-Duk, Seo, Hyun Min, Song, Sun U, Sung, Jong-Hyu
    Stem Cells Dev, 2014-03-21;23(12):1364-76.  2014-03-21
  332. Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells.
    Authors: Golubkov V, Strongin A
    Cell Commun Signal, 2014-03-11;12(0):15.  2014-03-11
  333. JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer.
    Authors: Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J
    Cancer Res, 2014-03-07;74(9):2444-54.  2014-03-07
  334. Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation.
    Authors: Spary L, Al-Taei S, Salimu J, Cook A, Ager A, Watson H, Clayton A, Staffurth J, Mason M, Tabi Z
    J Immunol, 2014-03-05;192(7):3101-10.  2014-03-05
  335. Histamine contributes to tissue remodeling via periostin expression.
    Authors: Yang, Lingli, Murota, Hiroyuki, Serada, Satoshi, Fujimoto, Minoru, Kudo, Akira, Naka, Tetsuji, Katayama, Ichiro
    J Invest Dermatol, 2014-02-27;134(8):2105-13.  2014-02-27
  336. Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells.
    Authors: Wang L, Chen P, Hsu L, Hsu W, Liu D, Chang C, Hsu Y, Lee J
    Am J Pathol, 2014-02-01;184(2):418-30.  2014-02-01
  337. Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response.
    Authors: Lutay N, Hakansson G, Alaridah N, Hallgren O, Westergren-Thorsson G, Godaly G
    PLoS ONE, 2014-01-28;9(1):e86466.  2014-01-28
  338. A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
    Authors: Bajpe, P K, Prahallad, A, Horlings, H, Nagtegaal, I, Beijersbergen, R, Bernards, R
    Oncogene, 2014-01-27;34(4):531-6.  2014-01-27
  339. Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.
    Authors: Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z, Chen X, Qin N, Zhang X
    PLoS ONE, 2014-01-20;9(1):e85296.  2014-01-20
  340. Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells.
    Authors: Victoni T, Gleonnec F, Lanzetti M, Tenor H, Valenca S, Porto L, Lagente V, Boichot E
    PLoS ONE, 2014-01-08;9(1):e85243.  2014-01-08
  341. The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
    Authors: Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D, Krum H, Kompa A
    PLoS ONE, 2013-12-13;8(12):e83687.  2013-12-13
  342. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.
    Authors: Davies, Kurtis D, Mahale, Sakshi, Astling, David P, Aisner, Dara L, Le, Anh T, Hinz, Trista K, Vaishnavi, Aria, Bunn, Paul A J, Heasley, Lynn E, Tan, Aik-Choo, Camidge, D Ross, Varella-Garcia, Marileil, Doebele, Robert C
    PLoS ONE, 2013-12-13;8(12):e82236.  2013-12-13
  343. Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation.
    Authors: Huck, Bettina, Duss, Stephan, Hausser, Angelika, Olayioye, Monilola
    J Biol Chem, 2013-12-11;289(6):3138-47.  2013-12-11
  344. Soft matrix is a natural stimulator for cellular invasiveness.
    Authors: Gu, Zhizhan, Liu, Fei, Tonkova, Elina A, Lee, Soo Youn, Tschumperlin, Daniel J, Brenner, Michael
    Mol Biol Cell, 2013-12-11;25(4):457-69.  2013-12-11
  345. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.
    Authors: Drake J, Graham N, Lee J, Stoyanova T, Faltermeier C, Sud S, Titz B, Huang J, Pienta K, Graeber T, Witte O
    Proc Natl Acad Sci U S A, 2013-11-18;110(49):E4762-9.  2013-11-18
  346. Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML.
    Authors: Kampen, K R, Ter Elst, A, Mahmud, H, Scherpen, F J G, Diks, S H, Peppelenbosch, M P, de Haas, V, Guryev, V, de Bont, E S J M
    Leukemia, 2013-11-18;28(3):589-99.  2013-11-18
  347. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
    Authors: Haas D, Bala K, Busche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Ruckert J, Varga Z, Keri G, Schulz T
    PLoS Pathog, 2013-11-07;9(11):e1003737.  2013-11-07
  348. Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.
    Authors: Stegeman H, Kaanders J, Verheijen M, Peeters W, Wheeler D, Iida M, Grenman R, van der Kogel A, Span P, Bussink J
    Mol Cancer, 2013-11-05;12(1):133.  2013-11-05
  349. Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner.
    Authors: Polajeva J, Bergstrom T, Edqvist P, Lundequist A, Sjosten A, Nilsson G, Smits A, Bergqvist M, Ponten F, Westermark B, Pejler G, Forsberg Nilsson K, Tchougounova E
    Mol Oncol, 2013-09-18;8(1):50-8.  2013-09-18
  350. Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy.
    Authors: Mir, Shakeel, Schwarze, Steven R, Jin, Ling, Zhang, Jinling, Friend, Woodrow, Miriyala, Sumitra, St Clair, Daret, Craven, Rolf J
    Autophagy, 2013-09-04;9(10):1566-78.  2013-09-04
  351. Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein.
    Authors: Szalmas A, Gyongyosi E, Ferenczi A, Laszlo B, Karosi T, Csomor P, Gergely L, Veress G, Konya J
    Virol J, 2013-03-07;10(0):79.  2013-03-07
  352. Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584.
    Authors: Weidenaar A, Ter Elst A, Kampen K, Meeuwsen-de Boer T, Kamps W, Schuringa J, de Bont E
    Mol Cancer Res, 2013-02-07;11(4):339-48.  2013-02-07
  353. Sunlight UV-induced skin cancer relies upon activation of the p38alpha signaling pathway.
    Authors: Liu K, Yu D, Cho Y, Bode A, Ma W, Yao K, Li S, Li J, Bowden G, Dong Z, Dong Z
    Cancer Res, 2013-02-04;73(7):2181-8.  2013-02-04
  354. Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.
    Authors: Ray, K C, Moss, M E, Franklin, J L, Weaver, C J, Higginbotham, J, Song, Y, Revetta, F L, Blaine, S A, Bridges, L R, Guess, K E, Coffey, R J, Crawford, H C, Washington, M K, Means, A L
    Oncogene, 2013-02-04;33(7):823-31.  2013-02-04
  355. CALHM1 controls the Ca(2)(+)-dependent MEK, ERK, RSK and MSK signaling cascade in neurons.
    Authors: Dreses-Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P
    J Cell Sci, 2013-01-23;126(0):1199-206.  2013-01-23
  356. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
    Authors: Shimizu A, Nakayama H, Wang P, Konig C, Akino T, Sandlund J, Coma S, Italiano J, Mammoto A, Bielenberg D, Klagsbrun M
    J Biol Chem, 2012-11-29;288(4):2210-22.  2012-11-29
  357. Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy.
    Authors: Joshi, Avadhut, Loilome, Watchari, Siu, I-Mei, Tyler, Betty, Gallia, Gary L, Riggins, Gregory
    PLoS ONE, 2012-10-02;7(10):e44372.  2012-10-02
  358. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia.
    BMC Cancer, 2012-09-26;12(0):431.  2012-09-26
  359. Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ss-estradiol-BSA.
    Authors: Cheng W, Chen L, Yang S, Han J, Zhai D, Ni J, Yu C, Cai Z
    PLoS ONE, 2012-09-19;7(9):e45529.  2012-09-19
  360. Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y.
    Authors: Olszewski U, Deally A, Tacke M, Hamilton G
    Neoplasia, 2012-09-01;14(9):813-22.  2012-09-01
  361. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
    EMBO J., 2012-07-06;31(17):3513-23.  2012-07-06
  362. Concomitant targeting of EGF receptor, tgf-Beta and SRC points to a novel therapeutic approach in pancreatic cancer.
    Authors: Deharvengt S, Marmarelis M, Korc M
    PLoS ONE, 2012-06-27;7(6):e39684.  2012-06-27
  363. A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer.
    Authors: Dumitru CA, Fechner MK, Hoffmann TK
    J. Leukoc. Biol., 2012-01-18;91(4):591-8.  2012-01-18
  364. EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.
    Authors: Maddigan A, Truitt L, Arsenault R
    J. Immunol., 2011-10-28;187(11):5983-94.  2011-10-28
  365. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.
    Authors: Li J, Cho YY, Langfald A
    Cancer Prev Res (Phila), 2011-07-26;4(8):1190-7.  2011-07-26
  366. DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma.
    Authors: Singhal G, Akhter MZ, Stern DF
    Cancer Gene Ther., 2011-06-10;18(7):520-30.  2011-06-10
  367. Proteome profiling reveals potential toxicity and detoxification pathways following exposure of BEAS-2B cells to engineered nanoparticle titanium dioxide.
    Authors: Ge Y, Bruno M, Wallace K, Winnik W, Prasad RY
    Proteomics, 2011-05-18;11(12):2406-22.  2011-05-18
  368. IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis.
    Authors: Martins AS, Ordonez JL, Amaral AT, Prins F, Floris G, Debiec-Rychter M, Hogendoorn PC, de Alava E
    PLoS ONE, 2011-05-17;6(5):e19846.  2011-05-17
  369. Influence of leucine on protein metabolism, phosphokinase expression, and cell proliferation in human duodenum1,3.
    Authors: Coeffier M, Claeyssens S, Bensifi M, Lecleire S, Boukhettala N, Maurer B, Donnadieu N, Lavoinne A, Cailleux AF, Dechelotte P
    Am. J. Clin. Nutr., 2011-04-20;93(6):1255-62.  2011-04-20
  370. Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.
    Authors: Wei Q, Jiang H, Xiao Z
    Proc. Natl. Acad. Sci. U.S.A., 2011-04-12;108(17):7004-9.  2011-04-12
  371. BH3 mimetics activate multiple pro-autophagic pathways.
    Authors: Malik SA, Orhon I, Morselli E, Criollo A, Shen S, Marino G, BenYounes A, Benit P, Rustin P, Maiuri MC, Kroemer G
    Oncogene, 2011-04-04;30(37):3918-29.  2011-04-04
  372. Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells.
    Authors: Shih YR, Tseng KF, Lai HY, Lin CH, Lee OK
    J. Bone Miner. Res., 2011-04-01;26(4):730-8.  2011-04-01
  373. Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer.
    Authors: Li A, King J, Moro A, Sugi MD, Dawson DW, Kaplan J, Li G, Lu X, Strieter RM, Burdick M, Go VL, Reber HA, Eibl G, Hines OJ
    Am. J. Pathol., 2011-03-01;178(3):1340-9.  2011-03-01
  374. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.
    Authors: Chandarlapaty, Sarat, Sawai, Ayana, Scaltriti, Maurizio, Rodrik-Outmezguine, Vanessa, Grbovic-Huezo, Olivera, Serra, Violeta, Majumder, Pradip K, Baselga, Jose, Rosen, Neal
    Cancer Cell, 2011-01-06;19(1):58-71.  2011-01-06
  375. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation.
    Authors: Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R
    J. Clin. Invest., 2010-12-01;120(12):4353-65.  2010-12-01
  376. Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab.
    Authors: Dunn EF, Iida M, Myers RA, Campbell DA, Hintz KA, Armstrong EA, Li C, Wheeler DL
    Oncogene, 2010-10-18;30(5):561-74.  2010-10-18
  377. Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome.
    Authors: Guo T, Lee SS, Ng WH
    Cell. Mol. Life Sci., 2010-10-16;68(11):1983-2002.  2010-10-16
  378. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
    Authors: Tomlinson DC, Knowles MA
    Am. J. Pathol., 2010-10-01;177(5):2379-86.  2010-10-01
  379. Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation.
    Authors: Vingtdeux V, Chandakkar P, Zhao H, d'Abramo C, Davies P, Marambaud P
    FASEB J., 2010-09-17;25(1):219-31.  2010-09-17
  380. Coactivated platelet-derived growth factor receptor alpha and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma.
    Authors: Dewaele B, Floris G, Finalet-Ferreiro J, Fletcher CD, Coindre JM, Guillou L, Hogendoorn PC, Wozniak A, Vanspauwen V, Schoffski P, Marynen P, Vandenberghe P, Sciot R, Debiec-Rychter M
    Cancer Res., 2010-08-04;70(18):7304-14.  2010-08-04
  381. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
    Authors: Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villen J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ
    Proc. Natl. Acad. Sci. U.S.A., 2010-08-04;107(34):15299-304.  2010-08-04
  382. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
    Authors: Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, Garcia-Echeverria C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK
    Cancer Cell, 2010-06-15;17(0):547-59.  2010-06-15
  383. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice.
    Authors: Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avances C, Allory Y, de la Taille A, Culine S, Blancou H, Cristol JP, Michel F, Sardet C, Fajas L
    Mol. Cancer Ther., 2010-06-08;9(0):1740-54.  2010-06-08
  384. Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation.
    Authors: Zhang H, Fagan DH, Zeng X
    Oncogene, 2010-02-15;29(17):2517-27.  2010-02-15
  385. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
    Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
    Eur. J. Cancer, 2010-01-22;46(5):974-82.  2010-01-22
  386. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.
    Authors: Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzzi MG, Davies P, Marambaud P
    J. Biol. Chem., 2010-01-14;285(12):9100-13.  2010-01-14
  387. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
    Authors: Cailleteau C, Liagre B, Beneytout JL
    J. Cell. Biochem., 2009-07-01;107(4):785-96.  2009-07-01
  388. The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.
    Authors: Smith NJ, Stoddart LA, Devine NM, Jenkins L, Milligan G
    J. Biol. Chem., 2009-04-27;284(26):17527-39.  2009-04-27
  389. Kaposi's sarcoma-associated herpesvirus-G protein-coupled receptor-expressing endothelial cells exhibit reduced migration and stimulated chemotaxis by chemokine inverse agonists.
    Authors: Couty JP, Lupu-Meiri M, Oron Y, Gershengorn MC
    J. Pharmacol. Exp. Ther., 2009-03-03;329(3):1142-7.  2009-03-03

FAQs

  1. Why are there 8 membranes provided in ARY003C?

    • ARY003C contains 8 membranes because it is divided into parts A and B with 4 membranes each. Both parts are spotted with different antibodies to avoid interference and cross reactivity as well as maximize sensitivity. Parts A and B each contain 39 different capture antibodies printed in duplicate and should be used together for optimal analysis efficiency. A total of four samples can be run with this kit. 

View all Proteome Profiler Antibody Array FAQs

Reviews for Proteome Profiler Human Phospho-Kinase Array Kit

Average Rating: 4.7 (Based on 10 Reviews)

5 Star
80%
4 Star
10%
3 Star
10%
2 Star
0%
1 Star
0%

Have you used Proteome Profiler Human Phospho-Kinase Array Kit?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/24/2023
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/02/2022

Used human lymphoma samples! Worked fine!

Proteome Profiler Human Phospho-Kinase Array Kit ARY003C
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/02/2022

Used this kit with mouse lymphoma cell lines and it worked!

Proteome Profiler Human Phospho-Kinase Array Kit ARY003C
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 09/16/2021
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 07/15/2021
Proteome Profiler Human Phospho-Kinase Array Kit ARY003C
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/21/2021
Proteome Profiler Human Phospho-Kinase Array Kit ARY003C
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/27/2021
Proteome Profiler Human Phospho-Kinase Array Kit ARY003C
Proteome Profiler Human Phospho-Kinase Array Kit
By APK Inmunometabolismo on 11/06/2020
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/18/2020

Some of the antibodies lack sensitivity. Independent comprobation using the exact same protocol (lysis buffer, etc) and conventional WB rendered higher activation than the kit's

Proteome Profiler Human Phospho-Kinase Array Kit ARY003C
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/21/2020
Proteome Profiler Human Phospho-Kinase Array Kit ARY003C