Proteome Profiler Human Phospho-Kinase Array Kit

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts
Authors: Shumliakivska, M;Luxán, G;Hemmerling, I;Scheller, M;Li, X;Müller-Tidow, C;Schuhmacher, B;Sun, Z;Dendorfer, A;Debes, A;Glaser, SF;Muhly-Reinholz, M;Kirschbaum, K;Hoffmann, J;Nagel, E;Puntmann, VO;Cremer, S;Leuschner, F;Abplanalp, WT;John, D;Zeiher, AM;Dimmeler, S;
Nature communications  2024-01-19

Brain-targeted delivery of neuroprotective survival gene minimizing hematopoietic cell contamination: implications for Parkinson's disease treatment
Authors: Lee, MH;Kang, S;Um, KH;Lee, SW;Hwang, H;Baek, K;Choi, JW;
Journal of translational medicine  2024-01-13

ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy
Authors: Soumoy, L;Genbauffe, A;Mouchart, L;Sperone, A;Trelcat, A;Mukeba-Harchies, L;Wells, M;Blankert, B;Najem, A;Ghanem, G;Saussez, S;Journe, F;
Cancer cell international  2024-01-04

GRB7 plays a promoting role in the progression of gastric cancer
Authors: Zhu, G;Cai, H;Xiao, Q;Zeng, S;Jiang, X;Liu, D;
BMC cancer  2023-12-21

Phenol-Soluble Modulin ?3 Stimulates Autophagy in HaCaT Keratinocytes
Authors: Dernovics, Á;Seprényi, G;Rázga, Z;Ayaydin, F;Veréb, Z;Megyeri, K;
Biomedicines  2023-11-10

EGCG inhibits the inflammation and senescence inducing properties of MDA-MB-231 triple-negative breast cancer (TNBC) cells-derived extracellular vesicles in human adipose-derived mesenchymal stem cells
Authors: Gonzalez Suarez, N;Fernandez-Marrero, Y;Hébert, MPA;Roy, ME;Boudreau, LH;Annabi, B;
Cancer cell international  2023-10-13

Fumarate hydratase functions as a tumor suppressor in endometrial cancer by inactivating EGFR signaling
Authors: Wang, YY;Vadhan, A;Wu, CH;Hsu, CY;Chen, YC;Chen, YK;Chen, PY;Nguyen, HDH;Chang, YC;Yuan, SF;
Oncology reports  2023-10-01

Identification of a miRNA multi-targeting therapeutic strategy in glioblastoma
Authors: Bassot, A;Dragic, H;Haddad, SA;Moindrot, L;Odouard, S;Corlazzoli, F;Marinari, E;Bomane, A;Brassens, A;Marteyn, A;Hibaoui, Y;Petty, TJ;Chalabi-Dchar, M;Larrouquere, L;Zdobnov, EM;Legrand, N;Tamburini, J;Lincet, H;Castets, M;Yebra, M;Migliorini, D;Dutoit, V;Walker, PR;Preynat-Seauve, O;Dietrich, PY;Cosset, É;
Cell death & disease  2023-09-25

PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia
Authors: Pun, SH;O'Neill, KM;Edgar, KS;Gill, EK;Moez, A;Naderi-Meshkin, H;Malla, SB;Hookham, MB;Alsaggaf, M;Madishetti, VV;Botezatu, B;King, W;Brunssen, C;Morawietz, H;Dunne, PD;Brazil, DP;Medina, RJ;Watson, CJ;Grieve, DJ;
Cells  2023-09-06

Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma
Authors: Pang, L;Dunterman, M;Guo, S;Khan, F;Liu, Y;Taefi, E;Bahrami, A;Geula, C;Hsu, WH;Horbinski, C;James, CD;Chen, P;
Nature immunology  2023-09-04

PTPN2 copper-sensing rapidly relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression
Authors: Ross, MO;Xie, Y;Owyang, RC;Ye, C;Zbihley, ONP;Lyu, R;Wu, T;Wang, P;Karginova, O;Olopade, OI;Zhao, M;He, C;
bioRxiv : the preprint server for biology  2023-08-29

Epithelial Galectin-3 Induced the Mitochondrial Complex Inhibition and Cell Cycle Arrest of CD8+ T Cells in Severe/Critical COVID-19
Authors: Wang, Y;Yang, C;Wang, Z;Wang, Y;Yan, Q;Feng, Y;Liu, Y;Huang, J;Zhou, J;
International journal of molecular sciences  2023-08-14

Cannabidiol Enhances Cabozantinib-Induced Apoptotic Cell Death via Phosphorylation of p53 Regulated by ER Stress in Hepatocellular Carcinoma
Authors: Jeon, Y;Kim, T;Kwon, H;Kim, JK;Park, YT;Ham, J;Kim, YJ;
Cancers  2023-08-05

Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer
Authors: Zhou, Q;Peng, Y;Ji, F;Chen, H;Kang, W;Chan, LS;Gou, H;Lin, Y;Huang, P;Chen, D;Wei, Q;Su, H;Liang, C;Zhang, X;Yu, J;Wong, CC;
Nature communications  2023-08-04

Identification of Glucocorticoid Receptor Target Genes That Potentially Inhibit Collagen Synthesis in Human Dermal Fibroblasts
Authors: Choi, D;Kang, W;Park, S;Son, B;Park, T;
Biomolecules  2023-06-11

Long-chain polyphosphates inhibit type I interferon signaling and augment LPS-induced cytokine secretion in human leukocytes
Authors: Pirttiniemi, A;Adeshara, K;Happonen, N;Einarsdottir, E;Katayama, S;Salmenkari, H;H�rkk�, S;Kere, J;Groop, PH;Lehto, M;
Journal of leukocyte biology  2023-05-24

The role of KNTC1 in the regulation of proliferation, migration and tumorigenesis in colorectal cancer
Authors: Wang, J;Ding, Z;Shu, W;Zhuge, Y;
Cellular signalling  2023-05-23

FGF-trapping hampers cancer stem-like cells in uveal melanoma
Authors: Loda, A;Calza, S;Giacomini, A;Ravelli, C;Krishna Chandran, AM;Tobia, C;Tabellini, G;Parolini, S;Semeraro, F;Ronca, R;Rezzola, S;
Cancer cell international  2023-05-11

Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma
Authors: Balasubramanian, B;Yacqub-Usman, K;Venkatraman, S;Myint, KZ;Juengsamarn, J;Sarkhampee, P;Lertsawatvicha, N;Sripa, J;Kuakpaetoon, T;Suriyonplengsaeng, C;Wongprasert, K;Grabowska, AM;Bates, DO;Janvilisri, T;Tohtong, R;
Cancers  2023-04-28

Galectin-3 promotes secretion of proteases that decrease epithelium integrity in human colon cancer cells
Authors: S Li, DM Pritchard, LG Yu
Cell Death & Disease, 2023-04-13;14(4):268.  2023-04-13

Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema
Authors: JJ Park, K Oh, GW Lee, G Bang, JH Park, HB Kim, JY Kim, EY Shin, EG Kim
Experimental & Molecular Medicine, 2023-04-03;0(0):.  2023-04-03

IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis
Authors: W Lin, R Niu, SM Park, Y Zou, SS Kim, X Xia, S Xing, Q Yang, X Sun, Z Yuan, S Zhou, D Zhang, HJ Kwon, S Park, C Il Kim, H Koo, Y Liu, H Wu, M Zheng, H Yoo, B Shi, JB Park, J Yin
Nature Communications, 2023-03-22;14(1):1578.  2023-03-22

Venetoclax-Resistant T-ALL Cells Display Distinct Cancer Stem Cell Signatures and Enrichment of Cytokine Signaling
Authors: K Shah, L Al Ashiri, A Nasimian, M Ahmed, JU Kazi
International Journal of Molecular Sciences, 2023-03-05;24(5):.  2023-03-05

Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade
Authors: CH Chang, BJ Lin, CH Chen, NL Nguyen, TH Hsieh, JH Su, MC Chen
Marine Drugs, 2023-01-21;21(2):.  2023-01-21

EGFR and Lyn inhibition augments regorafenib induced cell death in sorafenib resistant 3D tumor spheroid model
Authors: E Sar?yar, O Karpat, S Sezan, SM Baylan, A K?pçak, K Guven, E Erdal, ZF Karagonlar
Cellular Signalling, 2023-01-21;0(0):110608.  2023-01-21

HIF-1alpha accumulation in response to transient hypoglycemia may worsen diabetic eye disease
Authors: C Guo, M Deshpande, Y Niu, I Kachwala, M Flores-Bel, H Megarity, T Nuse, S Babapoor-F, M Ramada, J Sanchez, N Inamdar, TV Johnson, MV Canto-Sole, S Montaner, A Sodhi
Cell Reports, 2023-01-10;42(1):111976.  2023-01-10

IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway
Authors: Yuan, S;Wang, Y;Chan, L;Hung, A;Nguyen, H;Chen, Y;Hu, S;Lo, S;Wang, Y;
Research Square  2023-01-01

CCL4 Regulates Eosinophil Activation in Eosinophilic Airway Inflammation
Authors: HH Chu, Y Kobayashi, DV Bui, Y Yun, LM Nguyen, A Mitani, K Suzuki, M Asako, A Kanda, H Iwai
International Journal of Molecular Sciences, 2022-12-18;23(24):.  2022-12-18

Oxidized Proteins Differentially Affect Maturation and Activation of Human Monocyte-Derived Cells
Authors: R Clemen, K Arlt, L Miebach, T von Woedtk, S Bekeschus
Cells, 2022-11-18;11(22):.  2022-11-18

BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes
Authors: H Takahashi, WM Kühtreiber, RC Keefe, AH Lee, A Aristarkho, HF Dias, N Ng, KJ Nelson, S Bien, D Scheffey, DL Faustman
Science Advances, 2022-11-16;8(46):eabq7240.  2022-11-16

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
Authors: M Schmitt, F Ceteci, J Gupta, M Pesic, TW Böttger, AM Nicolas, KB Kennel, E Engel, M Schewe, A Callak Kir, V Petrocelli, Y Dabiri, J Varga, M Ramakrishn, M Karimova, A Ablasser, T Sato, MC Arkan, FJ de Sauvage, FR Greten
Nature, 2022-11-16;0(0):.  2022-11-16

Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells
Authors: T Chernova, S Grosso, XM Sun, AR Tenor, JZ Cabeza, A Craxton, EL Self, A Nakas, K Cain, M MacFarlane, AE Willis
International Journal of Molecular Sciences, 2022-10-18;23(20):.  2022-10-18

Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion
Authors: J Ablain, A Al Mahi, H Rothschild, M Prasad, S Aires, S Yang, ME Dokukin, S Xu, M Dang, I Sokolov, CG Lian, LI Zon
Nature Genetics, 2022-10-13;0(0):.  2022-10-13

Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation
Authors: P Marona, J Górka, O Kwapisz, J Jura, J Rys, RM Hoffman, K Miekus
Cell Death & Disease, 2022-09-22;13(9):814.  2022-09-22

Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma
Authors: MV Barbolina
Cancers, 2022-09-19;14(18):.  2022-09-19

Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele
Authors: M Flück, D Vaughan, J Rittweger, MN Giraud
Frontiers in Physiology, 2022-09-06;13(0):933792.  2022-09-06

An in vivo model of glioblastoma radiation resistance identifies long non-coding RNAs and targetable kinases
Authors: CT Stackhouse, JC Anderson, Z Yue, T Nguyen, NJ Eustace, CP Langford, J Wang, JR Rowland Iv, C Xing, FM Mikhail, X Cui, H Alrefai, RE Bash, KJ Lee, ES Yang, AB Hjelmeland, CR Miller, JY Chen, GY Gillespie, CD Willey
JCI Insight, 2022-08-22;0(0):.  2022-08-22

Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice
Authors: W Jiang, C Ma, J Bai, X Du
Redox Biology, 2022-08-13;56(0):102432.  2022-08-13

PTEN inhibits AMPK to control collective migration
Authors: F Peglion, L Capuana, I Perfettini, L Boucontet, B Braithwait, E Colucci-Gu, E Quissac, K Forsberg-N, F Llense, S Etienne-Ma
Nature Communications, 2022-08-11;13(1):4528.  2022-08-11

p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells
Authors: S Pietrobono, R De Paolo, D Mangiameli, A Marranci, I Battisti, C Franchin, G Arrigoni, D Melisi, L Poliseno, B Stecca
The Journal of Biological Chemistry, 2022-08-07;298(9):102353.  2022-08-07

Angiotensin II Exaggerates SARS-CoV-2 Specific T-Cell Response in Convalescent Individuals following COVID-19
Authors: M Almutlaq, FA Mansour, J Alghamdi, Y Alhendi, AA Alamro, AA Alghamdi, HS Alamri, F Alroqi, T Barhoumi
International Journal of Molecular Sciences, 2022-08-04;23(15):.  2022-08-04

Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion
Authors: A Jouida, M O'Callagha, C Mc Carthy, A Fabre, P Nadarajan, MP Keane
Cancers, 2022-08-03;14(15):.  2022-08-03

Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma
Authors: C Xu, L Yan, X Guan, Z Wang, J Wu, A Lv, D Liu, F Liu, B Dong, M Zhao, L Jia, X Tian, C Hao
International journal of biological sciences, 2022-08-01;18(13):5038-5055.  2022-08-01

The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells
Authors: D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz
Elife, 2022-07-11;11(0):.  2022-07-11

Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells
Authors: C He, C Wang, H Liu, B Shan
BMC Cancer, 2022-07-02;22(1):724.  2022-07-02

Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer
Authors: K Kamat, V Krishnan, O Dorigo
British Journal of Cancer, 2022-06-24;0(0):.  2022-06-24

Peroxiredoxin IV plays a critical role in cancer cell growth and radioresistance through the activation of the Akt/GSK3 signaling pathways
Authors: N Ding, H Jiang, P Thapa, Y Hao, A Alshahrani, D Allison, T Izumi, VM Rangnekar, X Liu, Q Wei
The Journal of Biological Chemistry, 2022-06-10;0(0):102123.  2022-06-10

GSK3beta palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis
Authors: C Zhao, H Yu, X Fan, W Niu, J Fan, S Sun, M Gong, B Zhao, Z Fang, X Chen
Oncogenesis, 2022-05-23;11(1):28.  2022-05-23

Idelalisib activates AKT via increased recruitment of PI3Kdelta/PI3Kbeta to BCR signalosome while reducing PDK1 in post-therapy CLL cells
Authors: MK Mamidi, H Mahmud, GP Maiti, MT Mendez, SM Fernandes, SK Vesely, J Holter-Cha, JR Brown, AK Ghosh
Leukemia, 2022-05-14;0(0):.  2022-05-14

m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer
Authors: JX Lin, NZ Lian, YX Gao, QL Zheng, YH Yang, YB Ma, ZS Xiu, QZ Qiu, HG Wang, CH Zheng, P Li, JW Xie, J Lu, QY Chen, LL Cao, M Lin, JB Wang, CM Huang
Cell Death & Disease, 2022-05-14;13(5):463.  2022-05-14

Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer
Authors: M Kakarla, S ChallaSiva, MF Dufficy, V Gil, Y Filipovich, R Vickman, SE Crawford, SW Hayward, OE Franco
Cancers, 2022-05-09;14(9):.  2022-05-09

Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells
Authors: C Alonso-Gon, C González-A, J Menéndez-M, A González-G, V Álvarez-Ga, A González-C, C Martínez-C, S Cos
Biomedicines, 2022-05-07;10(5):.  2022-05-07

Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia
Authors: T Braun, J Stachelsch, N Bley, S Oberbeck, M Otte, TA Müller, L Wahnschaff, M Gla beta, K Ommer, M Franitza, B Gathof, J Altmüller, M Hallek, D Auguin, S Hüttelmaie, A Schrader, M Herling
Cancer Research, 2022-05-03;0(0):.  2022-05-03

ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer
Authors: EJ Lim, JH Kang, YJ Kim, S Kim, SJ Lee
Cell Death & Disease, 2022-04-29;13(4):417.  2022-04-29

The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway
Authors: S Bini, V Pecce, A Di Costanz, L Polito, A Ghadiri, I Minicocci, F Tambaro, S Covino, M Arca, L D'Erasmo
Biomolecules, 2022-04-16;12(4):.  2022-04-16

Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
Authors: Y Huang, E Motta, C Nanvuma, LD Kuhrt, Y Yuan, P Xia, M Lubas, S Zhu, M Schnauss, N Qazi, F Hu, H Zhang, T Lei, M Synowitz, C Flüh, H Kettenmann
Cell Reports, 2022-04-12;39(2):110670.  2022-04-12

Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion
Authors: C Gaiteiro, J Soares, M Relvas-San, A Peixoto, D Ferreira, P Paulo, A Brandão, E Fernandes, R Azevedo, C Palmeira, R Freitas, A Miranda, H Osório, J Prieto, L Lima, AMN Silva, LL Santos, JA Ferreira
Theranostics, 2022-03-28;12(7):3150-3177.  2022-03-28

SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway
Authors: Z Liu, Q Wang, G Zhai, S Ke, X Yu, J Guo
Cancer Cell International, 2022-03-19;22(1):127.  2022-03-19

ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers
Authors: J Mooz, K Riegel, H Ps, A Sadanandam, F Marini, M Klein, U Werner, W Roth, A Wilken-Sch, I Tegeder, K Rajalingam
Science Advances, 2022-03-18;8(11):eabk1538.  2022-03-18

DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6
Authors: X Zhang, Y Hu, Y Pan, Y Xiong, Y Zhang, M Han, K Dong, J Song, H Liang, Z Ding, X Zhang, H Zhu, Q Liu, X Lu, Y Feng, X Chen, Z Zhang, B Zhang
Oncogene, 2022-02-09;0(0):.  2022-02-09

DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3
Authors: CM Borza, G Bolas, F Bock, X Zhang, FC Akabogu, MZ Zhang, M de Caestec, M Yang, HC Yang, E Lee, L Gewin, AB Fogo, WH McDonald, R Zent, A Pozzi
JCI Insight, 2022-02-08;0(0):.  2022-02-08

Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability
Authors: RS Smith, I Odintsov, Z Liu, AJ Lui, T Hayashi, M Vojnic, Y Suehara, L Delasos, MS Mattar, J Hmeljak, HA Ramirez, M Shaw, G Bui, AB Hartono, E Gladstone, S Kunte, H Magnan, I Khodos, E De Stanchi, MP La Quaglia, J Yao, M Laé, SB Lee, L Spraggon, CA Pratilas, M Ladanyi, R Somwar
Disease Models & Mechanisms, 2022-01-27;0(0):.  2022-01-27

Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma
Authors: E Shimada, Y Matsumoto, M Nakagawa, Y Susuki, M Endo, N Setsu, T Fujiwara, K Iida, A Nabeshima, K Yahiro, A Kimura, T Hirose, M Kanahori, R Oyama, Y Oda, Y Nakashima
British Journal of Cancer, 2022-01-11;0(0):.  2022-01-11

Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants
Authors: MT Khayat, AM Omar, F Ahmed, MI Khan, SM Ibrahim, YA Muhammad, AM Malebari, T Neamatalla, ME El-Araby
Frontiers in Pharmacology, 2022-01-05;12(0):794325.  2022-01-05

SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
Authors: Y Cha, T Kim, J Jeon, Y Jang, PB Kim, C Lopes, P Leblanc, BM Cohen, KS Kim
Cell Reports, 2021-12-28;37(13):110155.  2021-12-28

Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma
Authors: I Berestjuk, M Lecacheur, A Carminati, S Diazzi, C Rovera, V Prod'homme, M Ohanna, A Popovic, A Mallaviall, F Larbret, S Pisano, S Audebert, T Passeron, C Gaggioli, CA Girard, M Deckert, S Tartare-De
Embo Molecular Medicine, 2021-12-27;0(0):e11814.  2021-12-27

Therapeutic potential of the PI3K inhibitor LY294002 and PARP inhibitor Talazoparib combination in BRCA-deficient triple negative breast cancer cells
Authors: G Guney Eski, M Ozturk
Cellular Signalling, 2021-12-24;91(0):110229.  2021-12-24

Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells
Authors: K Marunaka, S Shu, M Kobayashi, M Goto, Y Katsuta, Y Yoshino, A Ikari
International Journal of Molecular Sciences, 2021-12-22;23(1):.  2021-12-22

GPR87 Promotes Metastasis through the AKT-eNOS-NO Axis in Lung Adenocarcinoma
Authors: HM Ahn, EY Choi, YJ Kim
Cancers, 2021-12-21;14(1):.  2021-12-21

SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase
Authors: Y Ounoughene, E Fourgous, Y Boublik, E Saland, N Guiraud, C Recher, S Urbach, P Fort, JE Sarry, D Fesquet, S Roche
Cancers, 2021-12-17;13(24):.  2021-12-17

Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence
Authors: D Bakhshinya, AA Adile, J Liu, WD Gwynne, Y Suk, S Custers, I Burns, M Singh, N McFarlane, MK Subapandit, MA Qazi, P Vora, MM Kameda-Smi, N Savage, KL Desmond, N Tatari, D Tran, M Seyfrid, K Hope, NA Bock, C Venugopal, GD Bader, SK Singh
Science Advances, 2021-12-08;7(50):eabi5568.  2021-12-08

Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer
Authors: YZ Mazzu, YR Liao, S Nandakumar, LE Jehane, RP Koche, SH Rajanala, R Li, H Zhao, TA Gerke, G Chakrabort, GM Lee, GJ Nanjangud, A Gopalan, Y Chen, PW Kantoff
Oncogene, 2021-11-20;0(0):.  2021-11-20

Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer
Authors: L Yin, Y Zeng, R Zeng, Y Chen, TL Wang, KJ Rodabaugh, F Yu, A Natarajan, AR Karpf, J Dong
Oncogene, 2021-11-19;0(0):.  2021-11-19

The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis
Authors: N Stoup, M Liberelle, C Schulz, S Cavdarli, R Vasseur, R Magnez, F Lahdaoui, N Skrypek, F Peretti, F Frénois, X Thuru, P Melnyk, N Renault, N Jonckheere, N Lebègue, I Van Seunin
Cancers, 2021-11-16;13(22):.  2021-11-16

Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells
Authors: D Chauss, T Freiwald, R McGregor, B Yan, L Wang, E Nova-Lampe, D Kumar, Z Zhang, H Teague, EE West, KM Vannella, MJ Ramos-Beni, J Bibby, A Kelly, A Malik, AF Freeman, DM Schwartz, D Portilla, DS Chertow, S John, P Lavender, C Kemper, G Lombardi, NN Mehta, N Cooper, MS Lionakis, A Laurence, M Kazemian, B Afzali
Nature Immunology, 2021-11-11;0(0):.  2021-11-11

The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation
Authors: V Vorstandle, M Laggner, D Copic, K Klas, M Direder, Y Chen, B Golabi, W Haslik, C Radtke, E Tschachler, K Hötzenecke, HJ Ankersmit, M Mildner
Nature Communications, 2021-10-29;12(1):6242.  2021-10-29

Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation
Authors: J Kim, YJ Jeon, SC Lim, J Ryu, JH Lee, IY Chang, HJ You
Cell Death & Disease, 2021-10-28;12(11):1013.  2021-10-28

IL-36alpha and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling
Authors: ZII Al-Luhaibi, Á Dernovics, G Seprényi, F Ayaydin, Z Boldogk?i, Z Veréb, K Megyeri
Biomedicines, 2021-10-26;9(11):.  2021-10-26

Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation
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Tyrosine kinase independent actions of DDR2 in tumor cells and CAFs influence tumor invasion, migration, and metastasis
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Combinatorial Effect of PLK1 Inhibition with Temozolomide and Radiation in Glioblastoma
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Cancers, 2021-10-12;13(20):.  2021-10-12

Androgen Receptor Activation in Glioblastoma Can Be Achieved by Ligand-Independent Signaling through EGFR-A Potential Therapeutic Target
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International Journal of Molecular Sciences, 2021-10-11;22(20):.  2021-10-11

Preclinical development of a bispecific TNFalpha/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease
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CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
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Gemcitabine and APG-1252, a novel small molecule inhibitor of BCL-2/BCL-XL, display a synergistic antitumor effect in nasopharyngeal carcinoma through the JAK-2/STAT3/MCL-1 signaling pathway
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PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance
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Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration
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CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1
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TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer
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Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling
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New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRbeta Signaling
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miR-301a-3p induced by endoplasmic reticulum stress mediates the occurrence and transmission of trastuzumab resistance in HER2-positive gastric cancer
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RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells
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Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells
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Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis
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Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail
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New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer
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The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells
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Glycosyltransferase POMGNT1 deficiency strengthens N-cadherin-mediated cell-cell adhesion
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TGF-&beta1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor
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mTOR modulates resistance to gemcitabine in lung cancer in an MTORC2 dependent mechanism
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Identification of Radil as a Ras binding partner and putative activator
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S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell-cell interactions with adjacent breast cancer cells
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BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways
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CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3&beta/&beta-catenin/OCT4 axis
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Extracellular signal-regulated kinase 1/2 is required for complement component C1q and fibronectin dependent enhancement of Fc&gamma- receptor mediated phagocytosis in mouse and human cells
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Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA
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Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines
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Insight into Cisplatin-Resistance Signaling of W1 Ovarian Cancer Cells Emerges mTOR and HSP27 as Targets for Sensitization Strategies
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Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages
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LIMD2 Regulates Key Steps of Metastasis Cascade in Papillary Thyroid Cancer Cells via MAPK Crosstalk
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The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu)
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PLoS ONE, 2020-11-10;15(11):e0241902.  2020-11-10

LDOC1 Suppresses Microbe-Induced Production of IL-1&beta in Human Normal and Cancerous Oral Cells through the PI3K/Akt/GSK-3&beta Axis
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Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling
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Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling
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Design, synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as anti-glioblastoma agents targeting the AKT pathway
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Bioorg Chem, 2020-10-09;105(0):104362.  2020-10-09

The role of TRPV1 ion channels in the suppression of gastric cancer development
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Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma
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Cancers (Basel), 2020-09-23;12(10):.  2020-09-23

IL-32&gamma potentiates tumor immunity in melanoma
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Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer
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Anticancer activities of selected Emirati Date (Phoenix dactylifera L.) varieties pits in human triple negative breast cancer MDA-MB-231 cells
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Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration
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The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma
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Biomolecules, 2020-08-18;10(8):.  2020-08-18

Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/beta-catenin/SLUG axis
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TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
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Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
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m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling
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Downregulation of RRM2 Attenuates Retroperitoneal Liposarcoma Progression via the Akt/mTOR/4EBP1 Pathway: Clinical, Biological, and Therapeutic Significance
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Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL
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PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility
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Cells, 2020-06-18;9(6):.  2020-06-18

Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells
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Int J Mol Sci, 2020-05-25;21(10):.  2020-05-25

Immuno-metabolic impact of the multiple sclerosis patients' sera on endothelial cells of the blood-brain barrier
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SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway
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The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells
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FGF2 Induces Resistance to Nilotinib through MAPK Pathway Activation in KIT Mutated Melanoma
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Cancers (Basel), 2020-04-25;12(5):.  2020-04-25

Circulating Neutrophils Predict Poor Survival for HCC and Promote HCC Progression Through p53 and STAT3 Signaling Pathway
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A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
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Oncogene, 2020-03-24;0(0):.  2020-03-24

The Lipid Virulence Factors of Mycobacterium tuberculosis Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages
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Cells, 2020-03-09;9(3):.  2020-03-09

Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma
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Glycosaminoglycans as Tools to Decipher the Platelet Tumor Cell Interaction: A Focus on P-Selectin
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FGF trapping inhibits multiple myeloma growth through c-Myc degradation-induced mitochondrial oxidative stress
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Porphyromonas gingivalis triggers the shedding of inflammatory endothelial microvesicles that act as autocrine effectors of endothelial dysfunction
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Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells
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Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice
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CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation
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CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma
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Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma
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UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling
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Tyrosine kinase inhibition to improve anthracycline-based chemotherapy efficacy in T-cell lymphoma
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Br. J. Cancer, 2019-09-02;0(0):.  2019-09-02

Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer
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BMC Cancer, 2019-07-27;19(1):739.  2019-07-27

Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin
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Cancers (Basel), 2019-07-19;11(7):.  2019-07-19

EPHA2 feedback activation limits the response to PDEdelta inhibition in KRAS-dependent cancer cells
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Acta Pharmacol. Sin., 2019-07-17;41(2):270-277.  2019-07-17

Kinome expression profiling to target new therapeutic avenues in multiple myeloma
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Haematologica, 2019-07-09;0(0):.  2019-07-09

Multilevel defects in the hematopoietic niche in essential thrombocythemia
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Haematologica, 2019-07-09;0(0):.  2019-07-09

Paired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer
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Sci Rep, 2019-06-24;9(1):9195.  2019-06-24

Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide
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Cancers (Basel), 2019-06-20;11(6):.  2019-06-20

Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration
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Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells
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Cancers (Basel), 2019-06-05;11(6):.  2019-06-05

A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer
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Oncogenesis, 2019-05-10;8(5):33.  2019-05-10

Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds
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Molecules, 2019-05-10;24(9):.  2019-05-10

The small GTPase ARF6 activates PI3K in melanoma to induce a pro-metastatic state
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Cancer Res., 2019-05-02;0(0):.  2019-05-02

Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia-reperfusion injury
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J Transl Med, 2019-04-29;17(1):136.  2019-04-29

IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states
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EBioMedicine, 2019-04-05;0(0):.  2019-04-05

Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells
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BMC Cancer, 2019-04-04;19(1):312.  2019-04-04

Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach
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Oncotarget, 2019-04-02;10(26):2546-2560.  2019-04-02

PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway
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EBioMedicine, 2019-03-25;0(0):.  2019-03-25

Survival/adaptation of Bone Marrow derived Mesenchymal Stem Cells after long term starvation through selective processes
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Stem Cells, 2019-03-25;0(0):.  2019-03-25

CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
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JCI Insight, 2019-03-21;0(0):.  2019-03-21

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
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Breast Cancer Res., 2019-03-21;21(1):43.  2019-03-21

Signal regulatory protein ? protects podocytes through promoting autophagic activity
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JCI Insight, 2019-03-19;5(0):.  2019-03-19

Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program
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Nucleic Acids Res., 2019-03-18;0(0):.  2019-03-18

E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms
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Mol. Cancer Res., 2019-03-12;0(0):.  2019-03-12

Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib
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Int J Mol Sci, 2019-03-11;20(5):.  2019-03-11

Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis
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Mol. Cancer Res., 2019-03-11;0(0):.  2019-03-11

EPHA2 is a predictive biomarker of resistance and a potential therapeutic target for improving anti-epidermal growth factor receptor therapy in colorectal cancer
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Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway
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Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus
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Viruses, 2019-01-29;11(2):.  2019-01-29

Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin
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MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma
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AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
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Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma
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Oncogene, 2019-01-16;0(0):.  2019-01-16

?-arrestin 1 regulates ?2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
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Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells
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Cell Rep, 2018-12-26;25(13):3674-3692.e10.  2018-12-26

Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms
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Haematologica, 2018-12-13;0(0):.  2018-12-13

5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease
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The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors
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Mol. Cancer Ther., 2018-12-06;0(0):.  2018-12-06

The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells
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Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
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Cell Rep, 2018-11-20;25(8):2177-2191.e7.  2018-11-20

NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway
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Cell Death Dis, 2018-11-16;9(12):1143.  2018-11-16

Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin
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Sci Rep, 2018-11-08;8(1):16579.  2018-11-08

Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist
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Sci Rep, 2018-11-07;8(1):16492.  2018-11-07

Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
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Mol. Cancer Ther., 2018-11-07;0(0):.  2018-11-07

Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1
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J Clin Med, 2018-11-02;7(11):.  2018-11-02

WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4
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Cancer Med, 2018-10-23;0(0):.  2018-10-23

Lorlatinib treatment elicits multiple on- and off-target mechanisms of resistance in ALK-driven cancer
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Cancer Res., 2018-10-15;0(0):.  2018-10-15

Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation
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Proc. Natl. Acad. Sci. U.S.A., 2018-10-11;0(0):.  2018-10-11

Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT
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Cell. Physiol. Biochem., 2018-10-11;50(2):612-628.  2018-10-11

IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells
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Oncogene, 2018-10-10;0(0):.  2018-10-10

Olfactory receptor OR2AT4 regulates human hair growth
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Nat Commun, 2018-09-18;9(1):3624.  2018-09-18

K-Ras lysine-42 is crucial for its signaling, cell migration and invasion
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WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
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Theranostics, 2018-09-09;8(17):4805-4823.  2018-09-09

Establishment of keratinocyte cell lines from human hair follicles
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Sci Rep, 2018-09-07;8(1):13434.  2018-09-07

Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
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Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors
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Nat Commun, 2018-08-30;9(1):3533.  2018-08-30

Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds
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Sci Rep, 2018-08-15;8(1):12163.  2018-08-15

Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17
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Int J Mol Sci, 2018-07-31;19(8):.  2018-07-31

CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1? axis to inhibit gastric tumorigenesis
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Oncogene, 2018-07-27;0(0):.  2018-07-27

Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo
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Sci Rep, 2018-07-03;8(1):10070.  2018-07-03

Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway
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Cell. Physiol. Biochem., 2018-06-28;47(5):1751-1768.  2018-06-28

Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines
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Oncotarget, 2018-06-22;9(48):28976-28988.  2018-06-22

YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
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Proc. Natl. Acad. Sci. U.S.A., 2018-06-06;115(26):E6030-E6038.  2018-06-06

WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
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Oncotarget, 2018-06-05;9(43):27197-27219.  2018-06-05

JDP2 overexpression provokes cardiac dysfunction in mice
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HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis
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Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
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Molecules, 2018-04-14;23(4):.  2018-04-14

Acquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model
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PLoS ONE, 2018-04-11;13(4):e0194730.  2018-04-11

YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma
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B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
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BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling
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Suppression of the ERK-SRF axis facilitates somatic cell reprogramming
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miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer
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Low-molecular weight keratins with anti-skin aging activity produced by anaerobic digestion of poultry feathers with Fervidobacterium islandicum AW-1
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Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines
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Human Epididymis Protein 4 Promotes Events Associated with Metastatic Ovarian CancerviaRegulation of the Extracelluar Matrix
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Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice
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Dysregulation of Mir-196b in Head and Neck Cancers Leads to Pleiotropic Effects in the Tumor Cells and Surrounding Stromal Fibroblasts
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Sci Rep, 2017-12-19;7(1):17785.  2017-12-19

Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis
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BMC Cancer, 2017-12-13;17(1):845.  2017-12-13

Protein C receptor stimulates multiple signaling pathways in breast cancer cells
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Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.
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The Journal of Experimental Medicine, 2017-11-15;0(0):1540-9538.  2017-11-15

Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation
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The Transcription Factor HOXB7 Regulates ERK Kinase Activity and Thereby Stimulates the Motility and Invasiveness of Pancreatic Cancer Cells
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J. Biol. Chem., 2017-09-14;0(0):.  2017-09-14

Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy
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Oncotarget, 2017-08-17;9(2):1602-1616.  2017-08-17

Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation
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WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response
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Cell Death Dis, 2017-07-27;8(7):e2955.  2017-07-27

JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non-small cell lung cancer
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Mol. Cancer Ther., 2017-07-20;0(0):.  2017-07-20

Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.
Authors: Chih-Hau Chang, Meng-Chi Yen, Ssu-Hui Liao, Yu-Ling Hsu, Chung-Sheng Lai, Kao-Ping Chang, Ya-Ling Hsu
International Journal of Molecular Sciences, 2017-07-18;0(0):1422-0067.  2017-07-18

Resistance to the antibody-drug conjugate T-DM1 is based in a reduction in lysosomal proteolytic activity
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Cancer Res., 2017-07-07;0(0):.  2017-07-07

Co-targeting of MEK and PDGFR/STAT3 pathways to treat pancreatic ductal adenocar
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Mol. Cancer Ther., 2017-06-15;0(0):.  2017-06-15

Disruption of Aneuploidy and Senescence induced by Aurora inhibition promotes intrinsic Apoptosis in double hit or double expressor Diffuse Large B-cell Lymphomas
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Mol. Cancer Ther., 2017-06-14;0(0):.  2017-06-14

Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.
Authors: Benjamin Y Owusu, Shantasia Thomas, Phanindra Venukadas, Zhenfu Han, James W Janetka, Robert A Galemmo, Lidija Klampfer
Oncotarget, 2017-05-29;0(0):1949-2553.  2017-05-29

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
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Front Neurosci, 2017-05-22;11(0):278.  2017-05-22

Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades
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Int J Mol Sci, 2017-05-19;18(5):.  2017-05-19

Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells
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PLoS ONE, 2017-05-12;12(5):e0177640.  2017-05-12

The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischemia/reperfusion independent from mitochondrial connexin 43
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Br. J. Pharmacol., 2017-05-10;0(0):.  2017-05-10

Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway
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Proc. Natl. Acad. Sci. U.S.A., 2017-05-08;0(0):.  2017-05-08

Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell
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PLoS ONE, 2017-05-03;12(5):e0176501.  2017-05-03

Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas
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The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry
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Mucosal Immunol, 2017-04-26;0(0):.  2017-04-26

FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation
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Arch. Biochem. Biophys., 2017-04-05;0(0):.  2017-04-05

Galectin-3 interacts with the cell surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells
Authors: F Colomb, W Wang, D Simpson, M Zafar, R Beynon, JM Rhodes, LG Yu
J. Biol. Chem., 2017-03-31;0(0):.  2017-03-31

Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer
Authors: K Kalyvianak, V Gebhart, N Peroulis, C Panagiotop, F Kiagiadaki, I Pediaditak, M Aivaliotis, E Moustou, M Tzardi, G Notas, E Castanas, M Kampa
Sci Rep, 2017-03-14;7(0):44418.  2017-03-14

Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
J. Biol. Chem, 2017-02-23;0(0):.  2017-02-23

EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2�
Authors: II Kuan, KH Liang, YP Wang, TW Kuo, YJ Meir, SC Wu, SC Yang, J Lu, HC Wu
Sci Rep, 2017-02-03;7(0):41852.  2017-02-03

Activation of p38 and Erk Mitogen-Activated Protein Kinases Signaling in Ocular Rosacea
Authors: EJ Wladis, S Swamy, A Herrmann, J Yang, JA Carlson, AP Adam
Invest. Ophthalmol. Vis. Sci, 2017-02-01;58(2):843-848.  2017-02-01

Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma
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Tumour Biol, 2017-02-01;39(2):1010428317690.  2017-02-01

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension
Authors: P Yang, C Read, RE Kuc, G Buonincont, M Southwood, R Torella, PD Upton, A Crosby, SJ Sawiak, TA Carpenter, RC Glen, NW Morrell, JJ Maguire, AP Davenport
Circulation, 2017-01-30;135(12):1160-1173.  2017-01-30

Ras-MEK Signaling Mediates a Critical Chk1-dependent DNA Damage Response in Cancer Cells
Authors: HJ Lee, Y Cao, V Pham, E Blackwood, C Wilson, M Evangelist, C Klijn, D Stokoe, J Settleman
Mol. Cancer Ther, 2017-01-30;0(0):.  2017-01-30

Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer
Oncotarget, 2017-01-17;0(0):.  2017-01-17

Induction and Differentiation of IL-10-Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients.
Authors: Banko Z, Pozsgay J, Szili D, Toth M, Gati T, Nagy G, Rojkovich B, Sarmay G
J Immunol, 2017-01-13;198(4):1512-1520.  2017-01-13

Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene
Authors: SA Nadeau, W An, BC Mohapatra, I Mushtaq, TA Bielecki, H Luan, N Zutshi, G Ahmad, MD Storck, M Sanada, S Ogawa, V Band, H Band
J. Biol. Chem, 2017-01-12;292(9):3666-3682.  2017-01-12

Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN
Authors: A Cavazzoni, S La Monica, R Alfieri, A Ravelli, N Van Der St, R Sciarrillo, D Madeddu, CAM Lagrasta, F Quaini, M Bonelli, C Fumarola, D Cretella, G Digiacomo, M Tiseo, GJ Peters, A Ardizzoni, PG Petronini, E Giovannett
Oncotarget, 2017-01-01;0(0):.  2017-01-01

Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs
Authors: Nader Alaridah
J Innate Immun, 2016-12-24;0(0):.  2016-12-24

CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells
Authors: Aki Tanouchi
J. Exp. Clin. Cancer Res, 2016-12-05;35(1):190.  2016-12-05

Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line
Authors: Benjamin Kalbe
Eur. J. Cell Biol, 2016-12-05;0(0):.  2016-12-05

Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.
Authors: Astrid Escudero-E, Michael Bartosche, Chrysostomi Gialeli, Marcin Okroj, Sioned Owen, Karin Jirström, Akira Orimo, Wen G Jiang, Kristian Pietras, Anna M Blom
Oncotarget, 2016-11-22;0(0):1949-2553.  2016-11-22

Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance
Acta Pharmacol. Sin., 2016-11-14;0(0):.  2016-11-14

Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection
MBio, 2016-11-01;7(6):.  2016-11-01

The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2
Authors: Nicola M Heller
J. Biol. Chem., 2016-10-14;291(48):24922-24930.  2016-10-14

Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism
Proc Natl Acad Sci USA, 2016-09-23;0(0):.  2016-09-23

New insights into the Shwachman-Diamond Syndrome-related haematological disorder: hyper-activation of mTOR and STAT3 in leukocytes
Sci Rep, 2016-09-23;6(0):33165.  2016-09-23

Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells
Sci Rep, 2016-09-08;6(0):33132.  2016-09-08

Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase
Authors: Raymond B Birge
Cell Commun. Signal, 2016-09-06;14(1):19.  2016-09-06

Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18
Sci Rep, 2016-08-30;6(0):32255.  2016-08-30

Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells
J Cancer, 2016-08-12;7(13):1824-1832.  2016-08-12

CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells
Oncogene, 2016-08-01;0(0):.  2016-08-01

Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation.
Authors: Barquilla A, Lamberto I, Heynen-Genel S, Brill L, Pasquale E
Mol Biol Cell, 2016-07-06;27(17):2757-70.  2016-07-06

Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
Oncotarget, 2016-06-28;7(26):40531-40545.  2016-06-28

BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine
Authors: Yuexi Gu
Sci Rep, 2016-06-17;6(0):28217.  2016-06-17

Metabolism regulates cellular functions of bone marrow-derived cells used for cardiac therapy
Stem Cells, 2016-05-25;0(0):.  2016-05-25

A Small Molecule Inhibitor of PDK1/PLC?1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion
Authors: C Raimondi, V Calleja, R Ferro, A Fantin, AM Riley, BV Potter, CH Brennan, T Maffucci, B Larijani, M Falasca
Sci Rep, 2016-05-20;6(0):26142.  2016-05-20

Necrotic cells influence migration and invasion of glioblastoma via NF-?B/AP-1-mediated IL-8 regulation
Authors: SH Ahn, H Park, YH Ahn, S Kim, MS Cho, JL Kang, YH Choi
Sci Rep, 2016-04-14;6(0):24552.  2016-04-14

Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling
Authors: L Bénard, JG Oh, M Cacheux, A Lee, M Nonnenmach, DS Matasic, E Kohlbrenne, C Kho, C Pavoine, RJ Hajjar, JS Hulot
Circulation, 2016-03-02;133(15):1458-71; disc.  2016-03-02

Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes.
Authors: Sento S, Sasabe E, Yamamoto T
PLoS ONE, 2016-02-05;11(2):e0148454.  2016-02-05

Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells.
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Cell Commun Signal, 2016-01-12;14(1):4.  2016-01-12

Neutrophils support lung colonization of metastasis-initiating breast cancer cells.
Authors: Wculek S, Malanchi I
Nature, 2015-12-09;528(7582):413-7.  2015-12-09

Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions.
Authors: Purushothaman A, Bandari S, Liu J, Mobley J, Brown E, Sanderson R
J Biol Chem, 2015-11-24;291(4):1652-63.  2015-11-24

Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells.
Authors: Singh A, Ruan Y, Tippett T, Narendran A
J Exp Clin Cancer Res, 2015-09-18;34(0):104.  2015-09-18

Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma.
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Cancer Res, 2015-08-20;75(19):4188-97.  2015-08-20

A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D.
Authors: Eggink L, Spyroulias G, Jones N, Hanson C, Hoober J
PLoS ONE, 2015-06-25;10(6):e0130532.  2015-06-25

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.
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Blood, 2015-06-22;126(9):1106-17.  2015-06-22

The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes.
Authors: Hansen F, Kalle-Brune M, van der Plas M, Stromdahl A, Malmsten M, Morgelin M, Schmidtchen A
J Immunol, 2015-04-24;194(11):5397-406.  2015-04-24

YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway.
Authors: Chang B, Johnson K, LaTocha D, Rowley J, Bryant J, Burke R, Smith R, Loriaux M, Muschen M, Mullighan C, Druker B, Tyner J
J Hematol Oncol, 2015-04-22;8(0):39.  2015-04-22

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.
Authors: Mailly L, Xiao F, Lupberger J, Wilson G, Aubert P, Duong F, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lutgehetmann M, Volz T, Davis C, Harris H, Mee C, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim M, Neunlist M, Zeisel M, Dandri M, McKeating J, Robinet E, Baumert T
Nat Biotechnol, 2015-03-23;33(5):549-54.  2015-03-23

Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.
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PLoS ONE, 2015-03-09;10(3):e0121441.  2015-03-09

Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling.
Authors: Man J, Shoemake J, Ma T, Rizzo A, Godley A, Wu Q, Mohammadi A, Bao S, Rich J, Yu J
Cancer Res, 2015-02-20;75(8):1760-9.  2015-02-20

Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation.
Authors: Zhao D, Besser A, Wander S, Sun J, Zhou W, Wang B, Ince T, Durante M, Guo W, Mills G, Theodorescu D, Slingerland J
Oncogene, 2015-02-16;34(43):5447-59.  2015-02-16

Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.
Authors: Atefi M, Titz B, Avramis E, Ng C, Wong D, Lassen A, Cerniglia M, Escuin-Ordinas H, Foulad D, Comin-Anduix B, Graeber T, Ribas A
Mol Cancer, 2015-02-03;14(0):27.  2015-02-03

Loss of DGKepsilon induces endothelial cell activation and death independently of complement activation.
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Blood, 2014-12-10;125(6):1038-46.  2014-12-10

An increase in integrin-linked kinase non-canonically confers NF- inverted question markB-mediated growth advantages to gastric cancer cells by activating ERK1/2.
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Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation.
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Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy.
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Mol Cancer, 2014-10-24;13(0):242.  2014-10-24

Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naive to primed cell transition.
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Stem Cells, 2014-10-01;32(10):2605-15.  2014-10-01

EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line.
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Int J Mol Sci, 2014-09-30;15(10):17686-704.  2014-09-30

Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling.
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Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
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Nat Commun, 2014-09-02;5(0):4715.  2014-09-02

Adenosine inhibits tumor cell invasion via receptor-independent mechanisms.
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Mol Cancer Res, 2014-07-30;12(12):1863-74.  2014-07-30

IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.
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Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.
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Proc Natl Acad Sci U S A, 2014-06-30;111(28):10299-304.  2014-06-30

The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.
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Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo.
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PLoS ONE, 2014-06-06;9(6):e98641.  2014-06-06

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.
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J Exp Med, 2014-05-26;211(6):1167-83.  2014-05-26

Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.
Authors: Jokela T, Karna R, Makkonen K, Laitinen J, Tammi R, Tammi M
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Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.
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Cancer Res, 2014-04-14;74(9):2617-29.  2014-04-14

Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells.
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PLoS ONE, 2014-04-07;9(4):e94079.  2014-04-07

The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells.
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Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells.
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JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer.
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Cancer Res, 2014-03-07;74(9):2444-54.  2014-03-07

Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation.
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Histamine contributes to tissue remodeling via periostin expression.
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J Invest Dermatol, 2014-02-27;134(8):2105-13.  2014-02-27

Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells.
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Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response.
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PLoS ONE, 2014-01-28;9(1):e86466.  2014-01-28

A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
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Oncogene, 2014-01-27;34(4):531-6.  2014-01-27

Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.
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PLoS ONE, 2014-01-20;9(1):e85296.  2014-01-20

Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells.
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Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.
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The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
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PLoS ONE, 2013-12-13;8(12):e83687.  2013-12-13

Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation.
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J Biol Chem, 2013-12-11;289(6):3138-47.  2013-12-11

Soft matrix is a natural stimulator for cellular invasiveness.
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Mol Biol Cell, 2013-12-11;25(4):457-69.  2013-12-11

Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.
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Proc Natl Acad Sci U S A, 2013-11-18;110(49):E4762-9.  2013-11-18

Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML.
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Leukemia, 2013-11-18;28(3):589-99.  2013-11-18

The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
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PLoS Pathog, 2013-11-07;9(11):e1003737.  2013-11-07

Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.
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Mol Cancer, 2013-11-05;12(1):133.  2013-11-05

Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner.
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Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy.
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Autophagy, 2013-09-04;9(10):1566-78.  2013-09-04

Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein.
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Virol J, 2013-03-07;10(0):79.  2013-03-07

Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584.
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Mol Cancer Res, 2013-02-07;11(4):339-48.  2013-02-07

Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.
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Oncogene, 2013-02-04;33(7):823-31.  2013-02-04

Sunlight UV-induced skin cancer relies upon activation of the p38alpha signaling pathway.
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Cancer Res, 2013-02-04;73(7):2181-8.  2013-02-04

CALHM1 controls the Ca(2)(+)-dependent MEK, ERK, RSK and MSK signaling cascade in neurons.
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J Cell Sci, 2013-01-23;126(0):1199-206.  2013-01-23

Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
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Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy.
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PLoS ONE, 2012-10-02;7(10):e44372.  2012-10-02

Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia.
BMC Cancer, 2012-09-26;12(0):431.  2012-09-26

Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ss-estradiol-BSA.
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PLoS ONE, 2012-09-19;7(9):e45529.  2012-09-19

Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y.
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Neoplasia, 2012-09-01;14(9):813-22.  2012-09-01

Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
EMBO J., 2012-07-06;31(17):3513-23.  2012-07-06

Concomitant targeting of EGF receptor, tgf-Beta and SRC points to a novel therapeutic approach in pancreatic cancer.
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PLoS ONE, 2012-06-27;7(6):e39684.  2012-06-27

A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer.
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J. Leukoc. Biol., 2012-01-18;91(4):591-8.  2012-01-18

EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.
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J. Immunol., 2011-10-28;187(11):5983-94.  2011-10-28

Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.
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Cancer Prev Res (Phila), 2011-07-26;4(8):1190-7.  2011-07-26

DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma.
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Cancer Gene Ther., 2011-06-10;18(7):520-30.  2011-06-10

Proteome profiling reveals potential toxicity and detoxification pathways following exposure of BEAS-2B cells to engineered nanoparticle titanium dioxide.
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Proteomics, 2011-05-18;11(12):2406-22.  2011-05-18

IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis.
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PLoS ONE, 2011-05-17;6(5):e19846.  2011-05-17

Influence of leucine on protein metabolism, phosphokinase expression, and cell proliferation in human duodenum1,3.
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Am. J. Clin. Nutr., 2011-04-20;93(6):1255-62.  2011-04-20

Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.
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Proc. Natl. Acad. Sci. U.S.A., 2011-04-12;108(17):7004-9.  2011-04-12

BH3 mimetics activate multiple pro-autophagic pathways.
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Oncogene, 2011-04-04;30(37):3918-29.  2011-04-04

Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells.
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J. Bone Miner. Res., 2011-04-01;26(4):730-8.  2011-04-01

Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer.
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Am. J. Pathol., 2011-03-01;178(3):1340-9.  2011-03-01

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.
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Cancer Cell, 2011-01-06;19(1):58-71.  2011-01-06

Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation.
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Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab.
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Oncogene, 2010-10-18;30(5):561-74.  2010-10-18

Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome.
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Cell. Mol. Life Sci., 2010-10-16;68(11):1983-2002.  2010-10-16

Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
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Am. J. Pathol., 2010-10-01;177(5):2379-86.  2010-10-01

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation.
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FASEB J., 2010-09-17;25(1):219-31.  2010-09-17

Coactivated platelet-derived growth factor receptor alpha and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma.
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Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
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Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
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Cancer Cell, 2010-06-15;17(0):547-59.  2010-06-15

Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice.
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Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation.
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Oncogene, 2010-02-15;29(17):2517-27.  2010-02-15

VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
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Eur. J. Cancer, 2010-01-22;46(5):974-82.  2010-01-22

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.
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A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
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J. Cell. Biochem., 2009-07-01;107(4):785-96.  2009-07-01

The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.
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Kaposi's sarcoma-associated herpesvirus-G protein-coupled receptor-expressing endothelial cells exhibit reduced migration and stimulated chemotaxis by chemokine inverse agonists.
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