PSB 0474
Chemical Name: 3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphate disodium salt
Purity: ≥98%
Biological Activity
PSB 0474 is a potent and selective P2Y6 receptor agonist (EC50 values are 70, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively). Induces contractions of rat isolated intrapulmonary arteries in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors.
El-Tayeb et al.
J.Med.Chem., 2006;49:7076 -
Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands.
Mitchell et al.
J.Pharmacol.Exp.Ther., 2012;343:755
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Citations for PSB 0474
The citations listed below are publications that use Tocris products. Selected citations for PSB 0474 include:
5 Citations: Showing 1 - 5
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Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.
Authors: Carneiro Et al.
Br J Pharmacol 2014;171:3404
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Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis.
Authors: Quintas Et al.
J Neuroinflammation 2014;11:141
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Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells.
Authors: Barragán-Iglesias Et al.
Mol Pain 2014;10:29
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The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
Authors: Gao Et al.
Exp Eye Res 2013;9:31
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Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways.
Authors: Kataoka Et al.
Purinergic Signal 2011;7:403
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in vitro brain slices, 100 nM concentration
