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PSB 0777 ammonium salt

Catalog #: 4334
2 Citations Datasheet / COA / SDS
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4334/10
4334/50
PSB 0777 ammonium salt | CAS No. 2122196-16-9 | Adenosine A2a Receptor Agonists
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Description: Potent adenosine A2A agonist

Chemical Name: 4-[2-[(6-Amino-9-b-D-ribofuranosyl-9H-purin-2-yl)thio]ethyl]benzenesulfonic acid ammonium salt

Purity: ≥97%

Product Details
Citations (2)
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Biological Activity

PSB 0777 ammonium salt is a potent adenosine A2A receptor full agonist (Ki = 44.4 nM for rat brain striatal A2A receptors). Exhibits subtype selectivity for A2A receptors over A1, A2B and A3 receptors (Ki ≥ 10 000 nM for rat A1, human A2B and human A3 receptors). Potentiates acetylcholine-induced contractions in ex vivo rat ileum/jejunum segments.

Technical Data

M.Wt:
500.55
Formula:
C18H20N5O7S2.NH4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at RT
CAS No:
2122196-16-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PSB 0777 ammonium salt

The citations listed below are publications that use Tocris products. Selected citations for PSB 0777 ammonium salt include:

2 Citations: Showing 1 - 2

  1. Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor.
    Authors: Gemma Et al.
    Comput Struct Biotechnol J  2020;18:2723-2732
  2. Adenosine Receptor Agonists Increase the Inhibition of Platelet Function by P2Y12 Antagonists in a cAMP- and Calcium-Dependent Manner.
    Authors: Cezary Et al.
    Pharmaceuticals (Basel)  2020;13

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