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Puromycin dihydrochloride

Catalog #: 4089
16 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4089/50
Puromycin dihydrochloride | CAS No. 58-58-2 | DNA, RNA and Protein Synthesis Inhibitors
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Description: Protein synthesis inhibitor

Chemical Name: 3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride

Purity: ≥98%

Product Details
Citations (16)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Puromycin dihydrochloride is a protein synthesis inhibitor; leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Aminonucleoside antibiotic. Inhibits translation in both in vitro and in vivo systems. Also inhibits the transport of proteins into the mitochondria in vitro.

Technical Data

M.Wt:
544.43
Formula:
C22H29N7O5.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
58-58-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
    Dasgupta S, Castro L, Dulman R, Yang C, Schmidt M, Ferro E, Fricker L
    PLoS ONE, 2014;9(7):e103604.
  2. AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.
    Ma S, Mao L, Deng W, Li Y, Bu L, Yu G, Zhang W, Sun Z
    Am J Transl Res, 0;9(2):507-519.
  3. Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
    M Varela-Eir, A Varela-Váz, A Guitián-Ca, CL Paíno, V Mato, R Largo, T Aasen, A Tabernero, E Fonseca, M Kandouz, JR Caeiro, A Blanco, MD Mayán
    Cell Death Dis, 2018;9(12):1166.
  4. Up-regulation of syncytin-1 contributes to TNF-�-enhanced fusion between OSCC and HUVECs partly via Wnt/?-catenin-dependent pathway
    TL Yan, M Wang, Z Xu, CM Huang, XC Zhou, EH Jiang, XP Zhao, Y Song, K Song, Z Shao, K Liu, ZJ Shang
    Sci Rep, 2017;7(0):40983.
  5. Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction.
    Price and Verner
    Biochim.Biophys.Acta., 1993;1150:89

Product Datasheets

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Citations for Puromycin dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Puromycin dihydrochloride include:

16 Citations: Showing 1 - 10

  1. Two distinct trophectoderm lineage stem cells from human pluripotent stem cells.
    Authors: Balaji M Et al.
    J Biol Chem  2021;296:100386
  2. PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.
    Authors: Nabil G Et al.
    Stem Cell Reports  2021;16:2958-2972
  3. CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through β-catenin.
    Authors: Tao Et al.
    Cell Death Dis  2021;12:650
  4. Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation.
    Authors: Mark L Et al.
    Cell Rep  2020;31:107785
  5. FUS contributes to mTOR-dependent inhibition of translation.
    Authors: Chantelle F Et al.
    J Biol Chem  2020;295:18459-18473
  6. FUS contributes to mTOR-dependent inhibition of translation.
    Authors: Chantelle F Et al.
    J Biol Chem  2020;295:18459-18473
  7. An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells.
    Authors: Philipp Et al.
    Cancers (Basel)  2020;12
  8. SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance.
    Authors: Yang Et al.
    Autophagy  2019;:1
  9. Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.
    Authors: Yu Et al.
    PLoS One  2019;14:e0210608
  10. AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.
    Authors: Ma Et al.
    Am J Transl Res.  2017;9:507

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