Home / Apelin Receptor Agonists / [Pyr1]-Apelin-13

[Pyr1]-Apelin-13

Catalog #: 2420
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2420/1
[Pyr1]-Apelin-13
1 Image
Description: Potent peptide apelin agonist
Alternative Names: [pGlu1]-Apelin-13

Purity: ≥95%

Product Details
Citations (2)
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Biological Activity

[Pyr1]-Apelin-13 is a highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.

Technical Data

M.Wt:
1533.81
Formula:
C69H108N22O16S
Sequence:
XRPRLSHKGPMPF

(Modifications: X = Glp)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
217082-60-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Emerging roles of apelin in biology and medicine.
    Kleinz et al.
    Pharmacol.Ther., 2005;107:198
  2. [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man.
    Katugampola et al.
    Br.J.Pharmacol., 2001;132:1255
  3. Central and peripheral cardiovascular actions of apelin in conscious rats.
    Kagiyama et al.
    Regul.Pept., 2005;125:55
  4. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
    Tatemoto et al.
    Biochem.Biophys.Res.Comms., 1998;251:471

Product Datasheets

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Citations for [Pyr1]-Apelin-13

The citations listed below are publications that use Tocris products. Selected citations for [Pyr1]-Apelin-13 include:

2 Citations: Showing 1 - 2

  1. Apelin modulates murine gastric vagal afferent mechanosensitivity.
    Authors: Li
    Physiol Behav  2018;194:466
  2. Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth.
    Authors: Hall Et al.
    Cancer Lett  2017;386:179

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