Pyrintegrin
Chemical Name: N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide
Purity: ≥98%
Biological Activity
Pyrintegrin enhances survival of human embryonic stem cells (hESCs) following enzymatic dissociation. Thought to enhance cell-ECM adhesion and activate integrin signaling. Pyrintegrin increases adhesion of hESCs to matrigel- and laminin-coated plates, but not to gelatin-coated plates. Also podocyte-protective agent and prevents LPS-induced proteinuria in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules.
Xu et al.
Proc.Natl.Acad.Sci.USA, 2010;107:8129 -
A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules.
Lee et al.
J.Am.Soc.Nephrol, 2015;26:2741
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