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PZ 3022

Catalog #: 7876 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7876/10
7876/50
PZ 3022 | CAS No. 2170608-85-0 | Enzyme Activators
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Description: PanK Activator

Chemical Name: 6-[4-[2-(4-Cyclopropylphenyl)acetyl]-1-piperazinyl]-3-pyridazinecarbonitrile

Purity: ≥98%

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Biological Activity

PZ 3022 is a potent allosteric pantothenate kinase (PanK) activator (EC50=5.3 nM for PanK3). In a mouse model of propionic acidemia, treatment with PZ 3022 increases hepatic CoASH and C2-CoA, and decreases C3-CoA, improving intracellular C3:C2-CoA ratio and plasma C3:C2-carnitine ratios. PZ 3022 is orally bioavailable.

Technical Data

M.Wt:
347.42
Formula:
C20H21N5O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2170608-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from St. Jude Children's Research Hospital

Product Datasheets

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