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Quetiapine hemifumarate

Catalog #: 4735 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4735/50
Quetiapine hemifumarate | CAS No. 111974-72-2 | Non-selective 5-HT2 Receptor Antagonists
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Description: 5-HT2 antagonist; also D2 antagonist; atypical antipsychotic
Alternative Names: ICI 204,636

Chemical Name: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate

Purity: ≥99%

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Biological Activity

Quetiapine hemifumarate is an atypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors.

Technical Data

M.Wt:
441.54
Formula:
C21H25N3O2S.0.5C4H4O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
111974-72-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Seroquel: biochemical profile of a potential atypical antipsychotic.
    Saller and Salama
    Psychopharmacology (Berl.), 1993;112:285
  2. Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with cloz.
    Ellenbroek et al.
    Neuropsychopharmacology, 1996;15:406

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