Quin C1
Chemical Name: 4-Butoxy-N-[1,4-dihydro-2-(4-methoxyphenyl)-4-oxo-3(2H)-quinazolinyl]benzamide
Purity: ≥98%
Biological Activity
Quin C1 is a potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1.
Zhou et al.
Mol.Pharmacol., 2007;72:976 -
FPR2/ALXR agonists and the resolution of inflammation.
Corminboeuf et al.
J.Med.Chem., 2014;58:537
Product Datasheets
Citation for Quin C1
The citations listed below are publications that use Tocris products. Selected citations for Quin C1 include:
1 Citation: Showing 1 - 1
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Agonist and antagonist effects of aripipr. on D2-like receptors controlling rat brain DA synthesis depend on the DArgic tone.
Authors: Ma Et al.
Int J Neuropsychopharmacol 2015;18
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