R 59-022

Discontinued Product

2194 has been discontinued.
View all Lipid Metabolism Inhibitors products.
R 59-022 | CAS No. 93076-89-2 | Lipid Metabolism Inhibitors
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Description: Diacylglycerol kinase inhibitor; increases PKC activity

Chemical Name: 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

R 59-022 is a diacylglycerol (DAG) kinase inhibitor (IC50 = 2.8 μM); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.

Technical Data

M.Wt:
459.58
Formula:
C27H26FN3OS
Solubility:
Soluble to 20 mM in ethanol and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
93076-89-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for R 59-022

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