(R)-(+)-HA-966

Catalog #: 0281
1 Citation Datasheet / COA / SDS

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(R)-(+)-HA-966 | CAS No. 123931-04-4 | NMDA Receptor Agonists

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Description: NMDA partial agonist/antagonist; acts at glycine site

Chemical Name: (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one

Purity: ≥98%

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Product Details

Citations (1)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier.

S-enantiomer also available.

Technical Data

M.Wt:

116.12

Formula:

C₄H₈N₂O₂

Solubility:

Soluble to 100 mM in water

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

123931-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of Merck Sharp and Dohme Ltd.

Other Product-Specific Information:

S-enantiomer Available

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-MthD.-aspartate receptor agonist responses in cat cultured cortical neurons.
Kemp and Priestley
Mol.Pharmacol., 1991;39:666
Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-MthD.-aspartate receptor complex.
Pullan et al.
J.Neurochem., 1990;55:1346
Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966).
Pullan et al.
Eur.J.Pharmacol., 1991;208:25

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for (R)-(+)-HA-966

The citations listed below are publications that use Tocris products. Selected citations for (R)-(+)-HA-966 include:

1 Citation: Showing 1 - 1

σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias.
Authors: Paquette Et al.
Elife 2008;19:111

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