(R)-MG 132
Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide
Purity: ≥98%
Biological Activity
(R)-MG 132 is a potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach.
Mroczkiewicz et al.
J.Med.Chem., 2010;53:1509
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Citations for (R)-MG 132
The citations listed below are publications that use Tocris products. Selected citations for (R)-MG 132 include:
3 Citations: Showing 1 - 3
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Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes.
Authors: Armando A Et al.
Cells 2022;11
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Calcineurin Controls Expression of EAAT1/GLAST in Mouse and Human Cultured Astrocytes through Dynamic Regulation of Protein Synthesis and Degradation.
Authors: Eleonora Et al.
Int J Mol Sci 2020;21
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Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas.
Authors: C David Et al.
Cancer Res 2019;79:4026-4041
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