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RA 2

Catalog #: 7129 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7129/50
7129/10
RA 2 | CAS No. 1867107-62-7 | Ca2+-Activated Potassium Channel Modulators
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Description: Potent negative modulator of KCa2.3 and KCa3.1 channels

Chemical Name: 1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate)

Purity: ≥98%

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Biological Activity

RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays >55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.

Technical Data

M.Wt:
414.36
Formula:
C22H16F2O6
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1867107-62-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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