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Rat alpha 2u-Globulin Antibody

Catalog #: AF586
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF586
AF586-SP
alpha 2u-Globulin in Rat Liver.
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Citations (2)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Rat alpha 2u-Globulin Antibody Summary

Species Reactivity
Rat
Specificity
Detects rat alpha 2u-Globulin in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Rat urine-derived alpha 2u-Globulin
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Rat alpha 2u-Globulin
Immunohistochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry a<sub>2u</sub>-Globulin antibody in Rat Liver by Immunohistochemistry (IHC-Fr). View Larger

alpha 2u-Globulin in Rat Liver. a2u-Globulin was detected in perfusion fixed frozen sections of rat liver using 5 µg/mL Goat Anti-Rat a2u-Globulin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF586) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: alpha 2u-Globulin

Rat alpha 2u-Globulin (AUG), also known as major urinary protein, belongs to the lipocalin protein family. Under complex hormonal control, alpha 2u-globulin is a low molecular weight protein expressed in a tissue-, age-, and sex-specific fashion. Circulating alpha 2u-globulin is expressed by the liver. It is removed from the plasma by the kidney and excreted.

Rodent studies have employed alpha 2u-globulin nephropathy as an experimental model for the development of kidney tumors. Induction of alpha 2u-globulin nephropathy alters the number, size and shape of hyaline droplets in the proximal tubules. Intra-cellular accumulation of alpha 2u-globulin induces cell death and necrosis of tubular epithelial cells.

Alternate Names
alpha 2u-Globulin; AUG; Mup; PGCL1

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Citations for Rat alpha 2u-Globulin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Drug-induced Obstructive and Retrograde Nephropathy Associated with alpha 2u-globulin in Male Rats
    Authors: Björn Jacobsen, Christian Freichel, Anne Eichinger-Chapelon, Andreas Brink, Jean-Christophe Hoflack, Mudher Albassam et al.
    Toxicologic Pathology
  2. Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
    Authors: Yoshiyuki Tago, Min Wei, Naomi Ishii, Anna Kakehashi, Hideki Wanibuchi
    Journal of Toxicologic Pathology

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