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Recombinant Human BMP-9 Protein, CF

Catalog #: 3209-BP/CF
49 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3209-BP-010/CF
Recombinant Human BMP-9 Protein Bioactivity
2 Images
Product Details
Citations (49)
FAQs
Reviews
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human BMP-9 Protein, CF Summary

Product Specifications

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351. The ED50 for this effect is 0.4-1.6 ng/mL.
Source
Chinese Hamster Ovary cell line, CHO-derived human BMP-9 protein
Ser320-Arg429
Accession #
Q9UK05
N-terminal Sequence
Analysis
Ser320
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
12.1 kDa (monomer)
SDS-PAGE
13 kDa, reducing conditions

Product Datasheets

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3209-BP/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

3209-BP/CF

Formulation Supplied as a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution

It is recommended that sterile 4 mM HCl be added to the vial to prepare a working stock solution of no less than 100 μg/mL. The carrier-free protein should be used immediately upon dilution to avoid losses in activity due to non-specific binding to the inside surface of the vial. For long term storage as a dilute solution, a carrier protein (e.g. 0.1% HSA or BSA) should be added to the vial.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after opening.

Scientific Data

Bioactivity Recombinant Human BMP-9 Protein Bioactivity View Larger

Recombinant Human BMP-9 (Catalog # 3209-BP/CF) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED50 for this effect is 0.4-1.6 ng/mL.

SDS-PAGE Recombinant Human BMP-9 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human BMP-9 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 13 kDa and 23 kDa, respectively.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: BMP-9

Human BMP-9, also known as growth and differentiation factor 2 (GDF-2), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. BMP-9 regulates the development and function of a variety of embryonal and adult tissues (1, 2). The human BMP-9 cDNA encodes a 429 amino acid (aa) precursor that includes a 22 aa signal sequence, a 298 aa propeptide, and a 111 aa mature protein (3). Unlike with other BMP family proteins, the propeptide does not interfere with the biological activity of BMP-9 and remains associated with the mature peptide after proteolytic cleavage (4). Human and mouse BMP-9 share 96% aa sequence identity. Within the mature protein, human BMP-9 shares 64% aa sequence identity with human BMP-10 and less than 50% aa sequence identity with other BMPs. BMP-9 is expressed by non-parenchymal cells in the liver, (5, 6) where it promotes lipid metabolism and inhibits glucose production (7). BMP-9 exerts a prolonged hypoglycemic effect which may be due to an enhancement of insulin release (7). BMP-9 interacts with a high affinity specific heteromeric receptor expressed on liver endothelial cells that has been identified as ALK-1 (4 - 6). In the embryonal CNS, BMP-9 functions in the development and maintenance of the cholinergic neuronal phenotype (8 - 10). BMP-9 also induces the differentiation of mesenchymal stem cells into the chondrogenic lineage (11, 12). At low concentrations, BMP-9 is a proliferative factor for hematopoietic progenitor cells, but at higher concentrations, it enhances TGF-beta 1 production and inhibits hematopoietic progenitor colony formation (13).

References
  1. Chen, D. et al. (2004) Growth Factors 22:233.
  2. Miyazono, K. et al. (2005) Cytokine Growth Factor Rev. 16:251.
  3. Celeste, A.J. et al. (1994) J. Bone Miner. Res. 9:S136.
  4. Brown, M.A. et al. (2005) J. Biol. Chem. 280:25111.
  5. Song, J.J. et al. (1995) Endocrinology 136:4293.
  6. Miller, A.F. et al. (2000) J. Biol. Chem. 275:17937.
  7. Chen, C. et al. (2003) Nat. Biotechnol. 21:294.
  8. Lopez-Coviella, I. et al. (2000) Science 289:313.
  9. Lopez-Coviella, I. et al. (2005) Proc. Natl. Acad. Sci. 102:6984.
  10. Lopez-Coviella, I. et al. (2002) J. Physiol. Paris 96:53.
  11. Majumdar, M.K. et al. (2001) J. Cell. Physiol. 189:275.
  12. Hills, R.L. et al. (2005) J. Orthoped. Res. 23:611.
  13. Ploemacher, R.E. et al. (1999) Leukemia 13:428.
Long Name
Bone Morphogenetic Protein 9
Entrez Gene IDs
2658 (Human); 12165 (Mouse)
Alternate Names
BMP9; BMP-9; BMP9BMP-9Bone morphogenetic protein 9; GDF2; GDF-2; growth differentiation factor 2; growth/differentiation factor 2

Citations for Recombinant Human BMP-9 Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

49 Citations: Showing 1 - 10
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  1. BMP-9 Improves the Osteogenic Differentiation Ability over BMP-2 through p53 Signaling In Vitro in Human Periosteum-Derived Cells
    Authors: Park, JH;Koh, EB;Seo, YJ;Oh, HS;Byun, JH;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models
    Authors: M Morita, A Yoneda, N Tokunoh, T Masaki, K Shirakura, M Kinoshita, R Hashimoto, N Shigesada, J Takahashi, M Tachibana, S Tanaka, M Obana, N Hino, M Ikawa, K Tsujikawa, C Ono, Y Matsuura, H Kidoya, N Takakura, Y Kubota, T Doi, K Takayama, Y Yoshioka, Y Fujio, Y Okada
    Proceedings of the National Academy of Sciences of the United States of America, 2023-01-12;120(3):e2213317120.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Oxidative stress-induced MMP- and gamma-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10
    Authors: C Ivaldo, M Passalacqu, AL Furfaro, C d'Abramo, S Ruiz, PK Chatterjee, CN Metz, M Nitti, P Marambaud
    Scientific Reports, 2023-01-11;13(1):597.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  4. Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
    Authors: Z Shonibare, M Monavarian, K O'Connell, D Altomare, A Shelton, S Mehta, R Jaskula-Sz, R Phaeton, MD Starr, R Whitaker, A Berchuck, AB Nixon, RC Arend, NY Lee, CR Miller, N Hempel, K Mythreye
    Oncogene, 2022-07-26;40(4):111066.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Dynamic Visualization of TGF-beta/SMAD3 Transcriptional Responses in Single Living Cells
    Authors: DL Marvin, L You, L Bornes, M van Dinthe, N Peters, H Dang, SK Hakuno, M Hornsveld, O Kranenburg, J van Rheene, JHT Rohling, MP Chien, P Ten Dijke, L Ritsma
    Cancers, 2022-05-19;14(10):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  6. Preclinical Evaluation of BMP-9-Treated Human Bone-like Substitutes for Alveolar Ridge Preservation following Tooth Extraction
    Authors: F Kawecki, J Jann, M Fortin, FA Auger, N Faucheux, J Fradette
    International Journal of Molecular Sciences, 2022-03-18;23(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  7. BMP9 Promotes an Epithelial Phenotype and a Hepatocyte-like Gene Expression Profile in Adult Hepatic Progenitor Cells
    Authors: A Addante, C González-C, C Roncero, N Lazcanoitu, J García-Sáe, B Herrera, A Sánchez
    Cells, 2022-01-21;11(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Osteoinductive potential of recombinant BMP-9 in bone defects of mice treated with antiresorptive agents
    Authors: M Fujioka-Ko, SD Marjanowsk, M Kono, S Hino, N Saulacic, B Schaller
    International journal of oral and maxillofacial surgery, 2021-08-26;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  9. BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-&kapppaB dependent macrophage polarization
    Authors: Q Jiang, Q Li, B Liu, G Li, G Riedemann, H Gaitantzi, K Breitkopf-, A Zeng, H Ding, K Xu
    International immunopharmacology, 2021-03-31;96(0):107591.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells
    Authors: B Tao, JR Kraehling, S Ghaffari, CM Ramirez, S Lee, JW Fowler, WL Lee, C Fernandez-, A Eichmann, WC Sessa
    J Biol Chem, 2020-10-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Both Human Hematoma Punctured from Pelvic Fractures and Serum Increase Muscle Resident Stem Cells Response to BMP9: A Multivariate Statistical Approach
    Authors: Y Alinejad, MA Lauzon, G Grenier, F Balg, N Faucheux
    J Clin Med, 2020-04-19;9(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. A Signaling Crosstalk between BMP9 and HGF/c-Met Regulates Mouse Adult Liver Progenitor Cell Survival
    Authors: A Addante, C Roncero, N Lazcanoitu, R Méndez, L Almalé, M García-Álv, P Ten Dijke, I Fabregat, B Herrera, A Sánchez
    Cells, 2020-03-19;9(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  13. CD105 overexpression mediates drug-resistance in choriocarcinoma cells through BMP9/Smad pathway
    Authors: X Wang, L Zong, W Wang, J Yang, Y Xiang
    J Cancer, 2020-01-01;11(2):272-283.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  14. Muscle injury-induced hypoxia alters the proliferation and differentiation potentials of muscle resident stromal cells
    Authors: G Drouin, V Couture, MA Lauzon, F Balg, N Faucheux, G Grenier
    Skelet Muscle, 2019-06-19;9(1):18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives
    Authors: X Cao, GK Yakala, FE van den Hi, A Cochrane, CL Mummery, VV Orlova
    Stem Cell Reports, 2019-06-11;12(6):1282-1297.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. BMP9 stimulates joint regeneration at digit amputation wounds in mice
    Authors: L Yu, LA Dawson, M Yan, K Zimmel, YL Lin, CP Dolan, M Han, K Muneoka
    Nat Commun, 2019-02-05;10(1):424.
    Species: Mouse
    Sample Types: Beads
    Applications: In Vivo
  17. Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation
    Authors: M Subileau, G Merdzhanov, D Ciais, V Collin-Fau, JJ Feige, S Bailly, D Vittet
    Stem Cell Reports, 2018-12-27;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma
    Authors: E Tillet, M Ouarné, A Desroches-, C Mallet, M Subileau, R Didier, A Lioutsko, G Belthier, JJ Feige, S Bailly
    J. Biol. Chem., 2018-05-22;0(0):.
    Applications: Western Blot
  19. The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium
    Authors: K Schlereth, D Weichenhan, T Bauer, T Heumann, E Giannakour, D Lipka, S Jaeger, M Schlesner, P Aloy, R Eils, C Plass, HG Augustin
    Elife, 2018-05-11;7(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Endoglin interacts with VEGFR2 to promote angiogenesis
    Authors: H Tian, JJ Huang, C Golzio, X Gao, M Hector-Gre, N Katsanis, GC Blobe
    FASEB J., 2018-01-11;0(0):fj201700867RR.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
    Authors: SR Pasricha, PJ Lim, TL Duarte, C Casu, D Oosterhuis, K Mleczko-Sa, M Suciu, AR Da Silva, K Al-Hourani, J Arezes, K McHugh, S Gooding, JN Frost, K Wray, A Santos, G Porto, E Repapi, N Gray, SJ Draper, N Ashley, E Soilleux, P Olinga, MU Muckenthal, JR Hughes, S Rivella, TA Milne, AE Armitage, H Drakesmith
    Nat Commun, 2017-09-01;8(1):403.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  22. Peptides derived from the knuckle epitope of BMP-9 induce the cholinergic differentiation and inactivate GSk3beta in human SH-SY5Y neuroblastoma cells
    Authors: MA Lauzon, O Drevelle, N Faucheux
    Sci Rep, 2017-07-05;7(1):4695.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Bone morphogenetic protein (BMP) 9 and BMP10 enhance tumor necrosis factor-?-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2
    Authors: CG Mitrofan, SL Appleby, GB Nash, Z Mallat, ER Chilvers, PD Upton, NW Morrell
    J. Biol. Chem., 2017-06-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology
    Authors: K Sakamoto, Y Kanematsu-, Y Kamada, M Oka, T Ohnishi, M Miwa, T Asami, H Inooka
    Biochem Biophys Rep, 2017-06-10;11(0):33-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier via the activin receptor-like kinase-1 receptor
    Authors: W Abdullahi, H Brzica, K Ibbotson, TP Davis, PT Ronaldson
    J. Cereb. Blood Flow Metab., 2017-04-07;0(0):271678X177029.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  26. BMP-9 interferes with liver regeneration and promotes liver fibrosis
    Authors: K Breitkopf-, C Meyer, C König, H Gaitantzi, A Addante, M Thomas, E Wiercinska, C Cai, Q Li, F Wan, C Hellerbran, NA Valous, M Hahnel, C Ehlting, JG Bode, S Müller-Boh, U Klingmülle, J Altenöder, I Ilkavets, MJ Goumans, LJ Hawinkels, SJ Lee, M Wieland, C Mogler, MP Ebert, B Herrera, H Augustin, A Sánchez, S Dooley, P Ten Dijke
    Gut, 2017-03-23;0(0):.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay, ELISA (Standard)
  27. Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells
    Authors: Y Tachida, N Izumi, T Sakurai, H Kobayashi
    Biol Open, 2017-03-15;6(3):370-380.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis
    Authors: Y Akatsu, Y Yoshimatsu, T Tomizawa, K Takahashi, A Katsura, K Miyazono, T Watabe
    Cancer Sci, 2017-01-01;108(1):151-155.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential
    J Clin Med, 2016-11-30;5(12):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9)
    PLoS ONE, 2016-11-22;11(11):e0166382.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium
    J Immunol, 2016-09-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis
    Authors: BR Yoon, YH Chung, SJ Yoo, K Kawara, J Kim, IS Yoo, CG Park, SW Kang, WW Lee
    J. Biol. Chem, 2015-12-23;291(8):4048-57.
    Species: Human
    Sample Types:
    Applications: Bioassay
  33. BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus.
    Authors: Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S
    Proc Natl Acad Sci U S A, 2015-06-08;112(25):E3207-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology.
    Authors: Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, Ricci-Vitiani L, D'Alessandris Q, Morgante L, Giannetti S, Larocca L, Todaro M, Benfante A, Colorito M, Stassi G, De Maria R, Rowlinson S, Stancato L
    PLoS ONE, 2015-04-28;10(4):e0125697.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses.
    Authors: Young K, Tweedie E, Conley B, Ames J, FitzSimons M, Brooks P, Liaw L, Vary C
    PLoS ONE, 2015-04-24;10(4):e0122892.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells.
    Authors: Woltje K, Jabs M, Fischer A
    PLoS ONE, 2015-03-23;10(3):e0120547.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis.
    Authors: Pan C, Kumar S, Shah N, Hoyt D, Hawinkels L, Mythreye K, Lee N
    J Biol Chem, 2014-07-28;289(37):25486-96.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.
    Authors: Olsen O, Wader K, Misund K, Vatsveen T, Ro T, Mylin A, Turesson I, Stordal B, Moen S, Standal T, Waage A, Sundan A, Holien T
    Blood Cancer J, 2014-03-21;4(0):e196.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits.
    Authors: Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, Zhou G, Ayala M, Zhang S
    Nat Biotechnol, 2013-04-21;31(5):440-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs).
    Authors: Wu, Qifang, Sun, Chia Chi, Lin, Herbert, Babitt, Jodie L
    PLoS ONE, 2012-09-27;7(9):e46307.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  41. BMP9 regulates endoglin-dependent chemokine responses in endothelial cells.
    Authors: Young, Kira, Conley, Barbara, Romero, Diana, Tweedie, Eric, O'Neill, Christin, Pinz, Ilka, Brogan, Louise, Lindner, Volkhard, Liaw, Lucy, Vary, Calvin P
    Blood, 2012-09-26;120(20):4263-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012-07-26;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. BMP9 and BMP10 are critical for postnatal retinal vascular remodeling.
    Blood, 2012-05-07;119(25):6162-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium.
    Authors: Yao Y, Jumabay M, Ly A, Radparvar M, Wang AH, Abdmaulen R, Bostrom KI
    Blood, 2012-04-03;119(21):5037-47.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Bioassay
  45. Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
    Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
    J. Biol. Chem., 2011-07-07;286(34):30034-46.
    Species: Human, Mouse
    Sample Types: Recombinant Protein, Whole Cells
    Applications: Bioassay, Surface Plasmon Resonance
  46. Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations.
    Authors: Ricard N, Bidart M, Mallet C
    Blood, 2010-05-25;116(9):1604-12.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum.
    Authors: Herrera B, Inman GJ
    BMC Cell Biol., 2009-03-19;10(0):20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.
    Authors: Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T
    Blood, 2007-05-31;110(6):2182-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.
    Authors: David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S
    Blood, 2006-10-26;109(5):1953-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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