Recombinant Human CTRP3/C1qTNF3/CORS26 Protein, CF
Recombinant Human CTRP3/C1qTNF3/CORS26 Protein, CF Summary
Product Specifications
Gln23-Lys246
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
9398-TN/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 250 μg/mL in PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Scientific Data
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When Recombinant Human CTRP3/C1qTNF3/CORS26 (Catalog # 9398-TN) is immobilized at 4 µg/mL, Recombinant Human CD36/SR-B3 Fc Chimera (Catalog # 1955-CD) binds with an ED50 of 1.5-7.5 μg/mL.
Reconstitution Calculator
Background: CTRP3/C1qTNF3/CORS26
CORS-26 (collagenous repeat-containing sequence of 26 kDa protein) also known as C1qTNF3 (complement C1q TNF-related protein 3/CTRP3), cartonectin, cartducin, is a 30-32 kDa, secreted member of the C1q and TNF-related (CTRP) superfamily of molecules (1). The mature protein is 224 aa in length. It contains an N-terminal collagen-like domain followed by a C-terminal globular region. Human CORS26 shares 99% aa sequence identity with the mouse CORS26 (2). Like other CTRP members, CORS26 has a trimeric structure and can assemble into hexameric or higher order molecular forms (3). It is expressed by a variety of cells, including adipocytes, cartilage, fibroblasts, monocytes and proliferating chondrocytes (4). The inflammatory effects of LPS, TLR-4 and fatty acids have been shown to be inhibited by CORS26 in adipocytes and monocytes (5). In mouse models, CORS26 has been shown to lower glucose levels and decrease gluconeogenic gene expression (6). Inhibition of 3T3-L1 pre-adipocyte differentiation to adipocytes is associated with CORS26 treatment, demonstrating potential anti-obesity effects (7). Treatment with CORS26 results in the proliferation of skeletal muscle C2C12 cells and inhibition of C2C12 myotube differentiation, mediated by the ERK pathway (8). Due to the variety of functions in metabolism and inflammation, CORS26 is a potential new target of type 2 diabetes treatment.
- Wong, G.W. et al. (2004) Proc. Natl. Acad. Sci. U.S.A. 101:10302.
- Schaffler A. et al. (2003). Biochim Biophys Acta.1630:123.
- Suzuki S. et al. (2007) FEBS Lett. 581: 809.
- Weigert J. et al. (2005) FEBS Lett. 579: 5565.
- Kopp, A. et al. (2010) Endocrinology. 151:5267.
- Peterson J. M. et al. (2010) J Biol Chem. 285:39691.
- Nishimoto, H. et al. (2017) Cell Bio Int. 41:197.
- Otani M. et al. (2015) Mol Cell Biochem. 409:271.
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