Home / FGF-4 / Recombinant Human FGF-4 Protein

Recombinant Human FGF-4 Protein

Catalog #: 235-F4
75 Citations 2 Reviews Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
235-F4-025/CF

With Carrier

Catalog # Availability Size / Price Qty
235-F4-025
235-F4-01M
Recombinant Human FGF-4 Protein Bioactivity
2 Images
Product Details
Citations (75)
FAQs
Reviews (2)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human FGF-4 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED50 for this effect is 0.25-1.25 ng/mL.
Source
E. coli-derived human FGF-4 protein
Ser54-Leu206
Accession #
P08620
N-terminal Sequence
Analysis
Ser54 & Leu55
Predicted Molecular Mass
17 kDa
SDS-PAGE
16 kDa, reducing conditions

Product Datasheets

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235-F4 (with carrier)

Product Datasheet
COA
SDS

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235-F4/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

235-F4

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

235-F4/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Human FGF-4 Protein Bioactivity View Larger

Recombinant Human FGF-4 (Catalog # 235-F4) stimulates cell proliferation of the NR6R‑3T3 mouse fibroblast cell line. The ED50 for this effect is 0.25-1.25 ng/mL.

SDS-PAGE Recombinant Human FGF-4 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human FGF-4 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 16 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: FGF-4

FGF-4 (fibroblast growth factor-4), also known as FGF-K or K-FGF (Kaposi’s sarcoma-associated FGF), is a 25 kDa secreted, heparin-binding member of the FGF family (1, 2). The human FGF-4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus (2). Mature human FGF-4 (aa 71-206) shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF-4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development (1, 3). Its expression in the mouse trophoblast inner cell mass promotes expression of FGF R2, and is required for maintenance of the trophectoderm and primitive endoderm (3-5). Later in mouse development, FGF-4 works together with FGF-8 to mediate the activities of the apical ectodermal ridge, which direct the outgrowth and patterning of vertebrate limbs (3, 6-9). FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell self-renewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro (10-12). A C-terminally truncated 15 kDa isoform that opposes full-length FGF-4 and promotes differentiation is endogenously expressed in human embryonic stem cells. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential (13). It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease (14).

References
  1. Reuss, B. and O. von Bohlen und Halbach (2003) Cell Tiss. Res. 313:139.
  2. Hebert, J.M. et al. (1990) Dev. Biol. 138:454.
  3. Niswander, L. and G.R. Martin (1992) Development 114:755.
  4. Feldman, B. et al. (1995) Science 267:246.
  5. Goldin, S.N. and V.E. Papaioannou (2003) Genesis 36:40.
  6. Sun, X. et al. (2002) Nature 418:501.
  7. Boulet, A.M. et al. (2004) Dev. Biol. 273:361.
  8. Yu, K and D.M. Ornitz (2008) Development 135:483.
  9. Mariani, F.V. et al. (2008) Nature 453:401.
  10. Johannesson, M. et al. (2009) PLoS ONE 4:e4794.
  11. Kunath, T. et al. (2007) Development 134:2895.
  12. Mayshar, Y. et al. (2008) Stem Cells 26:767.
  13. Hajitou, A. et al. (1998) Oncogene 17:2059.
  14. Flynn, A. and T. O’Brien (2008) IDrugs 11:283.
Long Name
Fibroblast Growth Factor 4
Entrez Gene IDs
2249 (Human); 14175 (Mouse); 116499 (Rat)
Alternate Names
FGF4; FGF-4; fibroblast growth factor 4; HBGF-4; HBGF-4Transforming protein KS3; heparin secretory transforming protein 1; Heparin secretory-transforming protein 1; Heparin-binding growth factor 4; HST-1; HST-1HSTF-1; HSTF1fibroblast growth factor 4 splice isoform; HSTFGF-4; human stomach cancer, transforming factor from FGF-related oncogene; kaposi sarcoma oncogene; KFGF; K-FGF; KS3; oncogene HST

Citations for Recombinant Human FGF-4 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

75 Citations: Showing 1 - 10
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  1. Reprogramming human urine cells into intestinal organoids with long-term expansion ability and barrier function
    Authors: Zhang, R;Chen, Y;Feng, Z;Cai, B;Cheng, Y;Du, Y;Ou, S;Chen, H;Pan, M;Liu, H;Pei, D;Cao, S;
    Heliyon
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Non-pituitary growth hormone enables colon cell senescence evasion
    Authors: Chesnokova, V;Zonis, S;Apaydin, T;Barrett, R;Melmed, S;
    Aging cell
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production
    Authors: O'Connell, AE;Raveenthiraraj, S;Oliveira, LFS;Adegboye, C;Dasuri, VS;Qi, W;Khetani, RS;Singh, A;Sundaram, N;Lin, J;Nandivada, P;Rincón-Cruz, L;Goldsmith, JD;Thiagarajah, JR;Carlone, DL;Turner, JR;Agrawal, PB;Helmrath, M;Breault, DT;
    Cellular and molecular gastroenterology and hepatology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Ligand bias underlies differential signaling of multiple FGFs via FGFR1
    Authors: Karl, K;Del Piccolo, N;Light, T;Roy, T;Deduja, P;Ursachi, VC;Fafilek, B;Krejci, P;Hristova, K;
    eLife
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)
    Authors: Hanaoka, K;Ikeno, T;Iwaki, S;Deguchi, S;Takayama, K;Mizuguchi, H;Tao, F;Kojima, N;Ohno, H;Sasaki, E;Komatsu, T;Ueno, T;Maeda, K;Kusuhara, H;Urano, Y;
    Science advances
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse
    Authors: Kruger, RE;Frum, T;Brumm, AS;Hickey, SL;Niakan, KK;Aziz, F;Shammami, MA;Roberts, JG;Ralston, A;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Embryo
    Applications: Bioassay
  7. Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon
    Authors: Múnera, JO;Kechele, DO;Bouffi, C;Qu, N;Jing, R;Maity, P;Enriquez, JR;Han, L;Campbell, I;Mahe, MM;McCauley, HA;Zhang, X;Sundaram, N;Hudson, JR;Zarsozo-Lacoste, A;Pradhan, S;Tominaga, K;Sanchez, JG;Weiss, AA;Chatuvedi, P;Spence, JR;Hachimi, M;North, T;Daley, GQ;Mayhew, CN;Hu, YC;Takebe, T;Helmrath, MA;Wells, JM;
    Cell stem cell
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  8. pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells
    Authors: Farahani, PE;Yang, X;Mesev, EV;Fomby, KA;Brumbaugh-Reed, EH;Bashor, CJ;Nelson, CM;Toettcher, JE;
    eLife
    Species: Mouse
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  9. Dynamic antagonism between key repressive pathways maintains the placental epigenome
    Authors: R Weigert, S Hetzel, N Bailly, C Haggerty, IA Ilik, PYK Yung, C Navarro, A Bolondi, AS Kumar, C Anania, B Brändl, D Meierhofer, DG Lupiáñez, FJ Müller, T Aktas, SJ Elsässer, H Kretzmer, ZD Smith, A Meissner
    Nature Cell Biology, 2023-04-06;25(4):579-591.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Modulation of Reoviral Cytolysis (II): Cellular Stemness
    Authors: Bourhill, T;Rohani, L;Kumar, M;Bose, P;Rancourt, D;Johnston, R;
    Viruses
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7
    Authors: A Rössig, K Hill, W Nörenberg, S Weidenbach, S Zierler, M Schaefer, T Gudermann, V Chubanov
    Cell Calcium, 2022-08-17;106(0):102640.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  12. Epiblast inducers capture mouse trophectoderm stem cells in�vitro and pattern blastoids for implantation in utero
    Authors: J Seong, J Frias-Alde, V Holzmann, H Kagawa, G Sestini, H Heidari Kh, Y Scholte Op, M Kip, SJ Pradhan, L Verwegen, J Vivié, L Li, A Alemany, J Korving, F Darmis, A van Oudena, D Ten Berge, N Geijsen, NC Rivron
    Cell Stem Cell, 2022-07-07;29(7):1102-1118.e8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids
    Authors: J Jeong, TH Kim, M Kim, YK Jung, KS Kim, S Shim, H Jang, WI Jang, SB Lee, D Choi
    Biology, 2022-03-23;11(4):.
    Species: Human
    Sample Types: Transduced Whole Cells
    Applications: Bioassay
  14. Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage
    Authors: V Chesnokova, S Zonis, A Apostolou, HQ Estrada, S Knott, K Wawrowsky, K Michelsen, A Ben-Shlomo, R Barrett, V Gorbunova, K Karalis, S Melmed
    Cell Reports, 2021-12-14;37(11):110068.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids
    Authors: S Xia, Z Bozóky, M Di Paola, O Laselva, S Ahmadi, JX Jiang, AL Pitstick, C Jiang, D Rotin, CN Mayhew, NL Jones, CE Bear
    Cells, 2021-12-04;10(12):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  16. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells
    Authors: AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells
    Cell Stem Cell, 2021-12-01;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  17. Apoptotic endocrinal toxic effects of perchlorate in human placental cells
    Authors: MM Ali, SA Khater, AA Fayed, D Sabry, SF Ibrahim
    Toxicology reports, 2021-04-17;8(0):863-870.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. Farnesyl dimethyl chromanol targets colon cancer stem cells and prevents colorectal cancer metastasis
    Authors: K Husain, D Coppola, CS Yang, MP Malafa
    Scientific Reports, 2021-01-26;11(1):2185.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  19. Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
    Authors: SK Sarvestani, S Signs, B Hu, Y Yeu, H Feng, Y Ni, DR Hill, RC Fisher, S Ferrandon, RK DeHaan, J Stiene, M Cruise, TH Hwang, X Shen, JR Spence, EH Huang
    Nature Communications, 2021-01-11;12(1):262.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Evaluating totipotency using criteria of increasing stringency
    Authors: E Posfai, JP Schell, A Janiszewsk, I Rovic, A Murray, B Bradshaw, T Yamakawa, T Pardon, M El Bakkali, I Talon, N De Geest, P Kumar, SK To, S Petropoulo, A Jurisicova, V Pasque, F Lanner, J Rossant
    Nature Cell Biology, 2021-01-08;23(1):49-60.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells
    Authors: H Fang, S Geng, M Hao, Q Chen, M Liu, C Liu, Z Tian, C Wang, T Takebe, JL Guan, Y Chen, Z Guo, W He, J Diao
    Nature Communications, 2021-01-04;12(1):109.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis
    Authors: C Sangokoya, R Blelloch
    Proc. Natl. Acad. Sci. U.S.A., 2020-08-11;117(34):20625-20635.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Generation of intestinal organoids derived from human pluripotent stem cells for drug testing
    Authors: S Yoshida, H Miwa, T Kawachi, S Kume, K Takahashi
    Sci Rep, 2020-04-06;10(1):5989.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice
    Authors: MJ Jeyarajah, G Jaju Bhatt, DM Hillier, SJ Renaud
    Cells, 2020-03-31;9(4):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance
    Authors: Y Toba, S Deguchi, N Mimura, A Sakamoto, K Harada, K Hirata, K Takayama, H Mizuguchi
    PLoS ONE, 2020-02-27;15(2):e0229654.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
    Authors: NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman
    Nat. Biotechnol., 2020-02-24;0(0):.
    Species: Human
    Sample Types: cell culture
    Applications: Cell Culture
  27. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells
    Authors: Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban
    Nat. Immunol., 2020-02-17;21(3):274-286.
    Species: Human
    Sample Types: Cells
    Applications: Cell Culture
  28. ER stress reliever enhances functionalities of in vitro cultured hepatocytes
    Authors: JS Kim, SI Hwang, JL Ryu, HS Hong, JM Lee, SM Lee, X Jin, C Han, JH Kim, J Han, MR Lee, DH Woo
    Stem Cell Res, 2020-02-12;43(0):101732.
    Species: Human
    Sample Types: cell culture
    Applications: Bioassay
  29. MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State
    Authors: H Zhang, LTP Khoa, F Mao, H Xu, B Zhou, Y Han, M O'Leary, A Nusrat, L Wang, TL Saunders, Y Dou
    Cell Rep, 2019-11-26;29(9):2659-2671.e6.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Cell Culture
  30. Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells
    Authors: KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son
    J Clin Med, 2019-07-04;8(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development
    Authors: RMJ Genga, EM Kernfeld, KM Parsi, TJ Parsons, MJ Ziller, R Maehr
    Cell Rep, 2019-04-16;27(3):708-718.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. FGF signal is not required for hepatoblast differentiation of human iPS cells
    Authors: Y Toba, A Kiso, S Nakamae, F Sakurai, K Takayama, H Mizuguchi
    Sci Rep, 2019-03-06;9(1):3713.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Excess growth hormone suppresses DNA damage repair in epithelial cells
    Authors: V Chesnokova, S Zonis, R Barrett, H Kameda, K Wawrowsky, A Ben-Shlomo, M Yamamoto, J Gleeson, C Bresee, V Gorbunova, S Melmed
    JCI Insight, 2019-02-07;4(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Generation of human antral and fundic gastric organoids from pluripotent stem cells
    Authors: TR Broda, KW McCracken, JM Wells
    Nat Protoc, 2019-01-01;14(1):28-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Transfection of Peripheral Blood Monocytes with SOX2 Enhances Multipotency, Proliferation, and Redifferentiation into Neohepatocytes and Insulin-Producing Cells
    Authors: A Hyder, S Ehnert, F Fändrich, H Ungefroren
    Stem Cells Int, 2018-10-04;2018(0):4271875.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. The COPII cargo adapter SEC24C is essential for neuronal homeostasis
    Authors: B Wang, JH Joo, R Mount, BJW Teubner, A Krenzer, AL Ward, VP Ichhaporia, EJ Adams, R Khoriaty, ST Peters, SM Pruett-Mil, SS Zakharenko, D Ginsburg, M Kundu
    J. Clin. Invest., 2018-06-25;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages
    Authors: J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao
    Cell Transplant, 2018-06-13;0(0):9636897187803.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B
    Authors: R Okamoto, K Takayama, N Akita, Y Nagamoto, D Hosokawa, S Iizuka, F Sakurai, H Suemizu, K Ohashi, H Mizuguchi
    Cell Transplant, 2018-02-01;27(2):299-309.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.
    Authors: Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett
    Cellular and Molecular Gastroenterology and Hepatology, 2017-12-29;0(0):2352-345X.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver
    Authors: WS Fagg, N Liu, MJ Yang, K Cheng, E Chung, JS Kim, G Wu, J Fair
    Cell Transplant, 2017-12-01;26(12):1868-1877.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling
    Authors: JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, JE Vallance, NF Shroyer, KL Sinagoga, A Zarzoso-La, JR Hudson, JC Howell, P Chatuvedi, JR Spence, JM Shannon, AM Zorn, MA Helmrath, JM Wells
    Cell Stem Cell, 2017-06-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2
    Authors: M Kang, V Garg, AK Hadjantona
    Dev. Cell, 2017-05-25;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling
    Authors: S Mitani, K Takayama, Y Nagamoto, K Imagawa, F Sakurai, M Tachibana, R Sumazaki, H Mizuguchi
    Mol. Ther., 2017-04-24;25(6):1420-1433.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. HER2-overexpressing breast cancers amplify FGFR signaling upon acquisition of resistance to dual therapeutic blockade of HER2
    Authors: AB Hanker, JG Garrett, MV Estrada, PD Moore, PG Ericsson, JP Koch, E Langley, S Singh, PS Kim, GM Frampton, EM Sanford, P Owns, J Becker, MR Groseclose, S Castellino, H Joensuu, J Huober, JC Brase, M Samira, S Brohée, D Venet, D Brown, J Baselga, M Piccart, C Sotiriou, CL Arteaga
    Clin. Cancer Res., 2017-04-05;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Simplified 3D protocol capable of generating early cortical neuroepithelium
    Authors: DB Holmes, VM Heine
    Biol Open, 2017-03-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Wnt/?-catenin promotes gastric fundus specification in mice and humans
    Authors: KW McCracken, E Aihara, B Martin, CM Crawford, T Broda, J Treguier, X Zhang, JM Shannon, MH Montrose, JM Wells
    Nature, 2017-01-04;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst
    Nat Commun, 2016-11-18;7(0):13463.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  48. Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis
    Authors: DA Elberry, SN Amin, RS Esmail, LA Rashed, MM Gamal
    EXCLI J, 2016-11-07;15(0):652-670.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Growth hormone is permissive for neoplastic colon growth
    Proc Natl Acad Sci USA, 2016-05-25;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Convergence of cMyc and beta-catenin on Tcf7l1 enables endoderm specification.
    Authors: Morrison G, Scognamiglio R, Trumpp A, Smith A
    EMBO J, 2015-12-16;35(3):356-68.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1.
    Authors: Tamminen K, Balboa D, Toivonen S, Pakarinen M, Wiener Z, Alitalo K, Otonkoski T
    PLoS ONE, 2015-07-31;10(7):e0134551.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. In vitro generation of human pluripotent stem cell derived lung organoids.
    Authors: Dye, Briana R, Hill, David R, Ferguson, Michael, Tsai, Yu-Hwai, Nagy, Melinda, Dyal, Rachel, Wells, James M, Mayhew, Christop, Nattiv, Roy, Klein, Ophir D, White, Eric S, Deutsch, Gail H, Spence, Jason R
    Elife, 2015-03-24;4(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
    Authors: Tabata T, Petitt M, Zydek M, Fang-Hoover J, Larocque N, Tsuge M, Gormley M, Kauvar L, Pereira L
    J Virol, 2015-03-04;89(9):5134-47.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.
    Authors: Krawchuk D, Anani S, Honma-Yamanaka N, Polito S, Shafik M, Yamanaka Y
    J Cell Sci, 2015-01-14;128(5):1011-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Identification and characterization of mesenchymal-epithelial progenitor-like cells in normal and injured rat liver.
    Authors: Liu D, Yovchev M, Zhang J, Alfieri A, Tchaikovskaya T, Laconi E, Dabeva M
    Am J Pathol, 2014-11-06;185(1):110-28.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.
    Authors: Leslie J, Huang S, Opp J, Nagy M, Kobayashi M, Young V, Spence J
    Infect Immun, 2014-10-13;83(1):138-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Differentiation-dependent requirement of Tsix long non-coding RNA in imprinted X-chromosome inactivation.
    Authors: Maclary E, Buttigieg E, Hinten M, Gayen S, Harris C, Sarkar M, Purushothaman S, Kalantry S
    Nat Commun, 2014-06-30;5(0):4209.
    Species: Mouse
    Sample Types: Embryo
    Applications: Bioassay
  58. HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin.
    Authors: Watanabe, Hitoshi, Takayama, Kazuo, Inamura, Mitsuru, Tachibana, Masashi, Mimura, Natsumi, Katayama, Kazufumi, Tashiro, Katsuhis, Nagamoto, Yasuhito, Sakurai, Fuminori, Kawabata, Kenji, Furue, Miho Kus, Mizuguchi, Hiroyuki
    PLoS ONE, 2014-03-20;9(3):e90791.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
    Authors: Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J
    J Am Soc Nephrol, 2013-12-19;25(6):1211-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. CCAAT/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision.
    Authors: Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue M, Mizuguchi H
    Development, 2013-11-27;141(1):91-100.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes.
    Authors: Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K, Mizuguchi H
    Stem Cell Reports, 2013-10-03;1(4):322-35.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Derivation of cerebellar neurons from human pluripotent stem cells.
    Authors: Erceg S, Lukovic D, Moreno-Manzano V, Stojkovic M, Bhattacharya S
    Curr Protoc Stem Cell Biol, 2012-03-01;20(0):1H.51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells.
    Authors: Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang H, Kim S
    Stem Cells Dev, 2012-02-29;21(12):2273-87.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
    Authors: Tomlinson DC, Knowles MA
    Am. J. Pathol., 2010-10-01;177(5):2379-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
    Authors: Roelandt P, Pauwelyn KA, Sancho-Bru P
    PLoS ONE, 2010-08-11;5(8):e12101.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  66. Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specification.
    EMBO J., 2009-10-22;29(1):55-67.
    Species: Xenopus
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells.
    Authors: Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ
    Biol. Reprod., 2009-06-24;81(5):833-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Differentiation of ES cells into cerebellar neurons.
    Authors: Salero E, Hatten ME
    Proc. Natl. Acad. Sci. U.S.A., 2007-02-09;104(8):2997-3002.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Role for amplification and expression of glypican-5 in rhabdomyosarcoma.
    Authors: Williamson D, Selfe J, Lu YJ, Pritchard-Jones K, Murai K, Jones P, Workman P, Shipley J
    Cancer Res., 2007-01-01;67(1):57-65.
    Species: Xenopus
    Sample Types: Whole Tissue
    Applications: Bioassay
  70. FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc.
    Authors: Nakayama T, Mutsuga N, Tosato G
    Blood, 2006-10-31;109(4):1363-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Multipotent adult progenitor cells from swine bone marrow.
    Authors: Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C
    Stem Cells, 2006-08-24;24(11):2355-66.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements.
    Authors: Tiecke E, Bangs F, Blaschke R, Farrell ER, Rappold G, Tickle C
    Dev. Biol., 2006-07-12;298(2):585-96.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  73. An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity.
    Authors: Nordstrom U, Maier E, Jessell TM, Edlund T
    PLoS Biol., 2006-07-01;4(8):e252.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  74. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis.
    Authors: Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP
    Development, 2005-02-16;132(6):1223-34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Heparin-binding secretory transforming gene (hst) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription.
    Authors: Shimon I, Huttner A, Said J, Spirina OM, Melmed S
    J. Clin. Invest., 1996-01-01;97(1):187-95.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay

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Recombinant Human FGF-4 Protein
By Ricardo Malvicini on 09/26/2021
Application: Stem/Immune cell maintenance or differentiation

Used for the differentiation of iPSC into intestinal organoids.

Recombinant Human FGF-4 Protein
By Anonymous on 01/19/2016
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: This growth factor worked perfectly for the maintenance of trophoblast stem cells.

Trophoblast stem cells are maintained in the presence of growth factors including FGF-4 (cat # 235-F4). When the growth factors are removed, the cells differentiate into giant cells (see image).