Recombinant Human FGF-6 (aa 67-208) Protein Summary
Product Specifications
Gly67-Ile208
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
6829-F6
| Formulation | Lyophilized from a 0.2 μm filtered solution in MES, Na2S04, NaCl and CHAPS with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 100 μg/mL in PBS containing at least 0.1% human or bovine serum albumin. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
6829-F6/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in MES, Na2S04, NaCl and CHAPS. |
| Reconstitution | Reconstitute at 100 μg/mL in PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: FGF-6
Fibroblast Growth Factor-6 (FGF-6), also known as HST-2, is a 25-28 kDa member of the FGF family of heparin binding polypeptides which are potent regulators of cell proliferation, differentiation, and function. FGF proteins contain a 120 amino acid (aa) core FGF domain that exhibits a beta -trefoil structure (1, 2). Mature human FGF-6 is a 171 aa protein that shares 94% aa sequence identity with mouse and rat FGF-6 (3). It binds and signals primarily through FGF R1c, 2c, and 4 (4). FGF-6 functions as a mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells, and N-linked glycosylation is required for the full mitogenic effect (5‑7). FGF-6 expression is restricted to skeletal muscle during development, although it can be upregulated in prostate cancer and Kaposi sarcoma (7-9). In the adult, FGF-6 is upregulated in injured skeletal muscle and is required for muscle regeneration (10). FGF-6 inhibits the terminal differentiation of myoblasts and also cooperates with TGF-beta 2 to promote chondrogenesis in embryonic somites (8, 11).
- Wiedlocha, A. and V. Sorensen (2004) Curr. Top. Microbiol. Immunol. 286:45.
- Mohammadi, M. et al. (2005) Cytokine Growth Factor Rev. 16:107.
- Marics, I. et al. (1989) Oncogene 4:335.
- Ornitz, D.M. et al. (1996) J. Biol. Chem. 271:15292.
- Pizette, S. et al. (1991) Cell Growth Differ. 2:561.
- Asada, M. et al. (1999) Growth Factors 16:293.
- Ropiquet, F. et al. (2000) Cancer Res. 60:4245.
- de Lapeyriere, O. et al. (1993) Development 118:601.
- Li, J. et al. (1993) Cancer 72:2253.
- Floss, T. et al. (1997) Genes Dev. 11:2040.
- Grass, S. et al. (1996) Development 122:141.
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