Recombinant Human IL-17RC Isoform 1 Fc Chimera Protein, CF Summary
Product Specifications
| Human IL-17 RC Isoform 1 (Leu21-His465) Accession # NP_703190.1 | IEGRMD | Human IgG1 (Pro100-Lys330) |
| N-terminus | C-terminus | |
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
9284-IL
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 500 μg/mL in PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Scientific Data
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When Recombinant Human IL-17 RC Isoform 1 Fc Chimera (Catalog # 9284-IL) is coated at 0.5 µg/mL, Recombinant Human IL-17/IL-17A (Catalog # 7955-IL) binds with an ED50 = 0.1-0.6 ng/mL.
Reconstitution Calculator
Background: IL-17RC
IL-17 receptor C (IL-17RC; also known as IL-17RL and IL-17Rhom) is an 85-110 kDa member of the IL-17 receptor family. IL-17 plays a key role in the development of autoimmunity and inflammation (1, 2). Human IL-17 RC is a type I transmembrane glycoprotein that is expressed on neutrophils, endothelial cells, chondrocytes and osteoblasts, breast and prostatic epithelium, fibroblasts, renal tubular epithelium, and skeletal muscle cells (3-5). Mature human IL-17 RC consists of a 518 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 232 aa cytoplasmic region (6). It is estimated that there are over 90 alternative splice forms, with transmembrane-containing isoforms predominating (4, 7). This recombinant protein corresponds to IL-17 RC isoform 1, the canonical form. Within the ECD, IL-17 RC isoform 1 shares 69% aa sequence identity with mouse IL-17 RC. IL-17 RC is the cognate receptor for IL-17F, and it binds IL-17A with similar affinity (8). IL-17 RC associates wiith IL-17 RA to form a receptor complex for both IL-17A and IL-17F (8-11).
- Song, X. and Y. Qian (2013) Cytokine 62:175.
- Weaver, C.T. et al. (2007) Annu. Rev. Immunol. 25:821.
- Taylor, P.R. et al. (2014) Nat. Immunol. 15:143.
- You, Z. et al. (2007) Neoplasia 9:464.
- Kokubu, T. et al. (2008) J. Hictochem. Cytochem. 56:89.
- Haudenschild, D. et al. (2002) J. Biol. Chem. 277:4309.
- Haudenschild, D.R. et al. (2006) Prostate 66:1268.
- Kuestner, R.E. et al. (2007) J. Immunol. 179:5462.
- Toy, D. et al. (2006) J. Immunol. 177:36.
- Kramer, J.M. et al. (2006) J. Immunol. 176:711.
- Kramer, J.M. et al. (2007) J. Immunol. 179:6379.
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