Recombinant Human IL-4 Protein
Bigger Scale, More Savings. Try our NEW version of Human Recombinant IL-4 (Catalog # BT-004). Combining R&D Systems quality with scalability that allows for lower price points and a solid supply chain.
Recombinant Human IL-4 Protein Summary
Product Specifications
His25-Ser153, with an N-terminal Met
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
204-IL
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
Reconstitution | Reconstitute at 100-200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
204-IL/CF
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution | Reconstitute at 100-200 μg/mL in sterile PBS. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Scientific Data
As an alternative, please consider our next generation Recombinant Human IL-4 (BT-004). It has equivalent bioactivity to Recombinant Human IL-4 (Catalog # 204-IL). It combines R&D Systems quality with scalability that allows for a solid supply chain. Both Recombinant Human IL-4 proteins are measured in a cell proliferation assay using TF-1 human erythroleukemic cell line.
Reconstitution Calculator
Background: IL-4
Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13 kDa‑18 kDa Th2 cytokine that shows pleiotropic effects during immune responses (1‑3). It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha -helix structure (4). Human IL-4 is synthesized with a 24 aa signal sequence. Alternate splicing generates an isoform with a 16 aa internal deletion. Mature human IL-4 shares 55%, 39% and 43% aa sequence identity with bovine, mouse, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific in their activities (5‑7). IL-4 exerts its effects through two receptor complexes (8, 9). The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and ‑21). The type II receptor on nonhematopoietic cells consists of IL-4 R alpha and IL‑13 R alpha 1. The type II receptor also transduces IL-13 mediated signals. IL-4 is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils (1, 2). It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells (10‑13). IL-4 plays a dominant role in the development of allergic inflammation and asthma (12, 14).
- Benczik, M. and S.L. Gaffen (2004) Immunol. Invest. 33:109.
- Chomarat, P. and J. Banchereau (1998) Int. Rev. Immunol. 17:1.
- Yokota, T. et al. (1986) Proc. Natl. Acad. Sci. 83:5894.
- Redfield, C. et al. (1991) Biochemistry 30:11029.
- Ramirez, F. et al. (1988) J. Immunol. Meth. 221:141.
- Leitenberg, D. and T.L. Feldbush (1988) Cell. Immunol. 111:451.
- Mosman, T.R. et al. (1987) J. Immunol. 138:1813.
- Mueller, T.D. et al. (2002) Biochim. Biophys. Acta 1592:237.
- Nelms, K. et al. (1999) Annu. Rev. Immunol. 17:701.
- Paludan, S.R. (1998) Scand. J. Immunol. 48:459.
- Corthay, A. (2006) Scand. J. Immunol. 64:93.
- Ryan, J.J. et al. (2007) Crit. Rev. Immunol. 27:15.
- Grone, A. (2002) Vet. Immunol. Immunopathol. 88:1.
- Rosenberg, H.F. et al. (2007) J. Allergy Clin. Immunol. 119:1303.
Citations for Recombinant Human IL-4 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Tuberculosis in otherwise healthy adults with inherited TNF deficiency
Authors: Arias, AA;Neehus, AL;Ogishi, M;Meynier, V;Krebs, A;Lazarov, T;Lee, AM;Arango-Franco, CA;Yang, R;Orrego, J;Corcini Berndt, M;Rojas, J;Li, H;Rinchai, D;Erazo-Borrás, L;Han, JE;Pillay, B;Ponsin, K;Chaldebas, M;Philippot, Q;Bohlen, J;Rosain, J;Le Voyer, T;Janotte, T;Amarajeeva, K;Soudée, C;Brollo, M;Wiegmann, K;Marquant, Q;Seeleuthner, Y;Lee, D;Lainé, C;Kloos, D;Bailey, R;Bastard, P;Keating, N;Rapaport, F;Khan, T;Moncada-Vélez, M;Carmona, MC;Obando, C;Alvarez, J;Cataño, JC;Martínez-Rosado, LL;Sanchez, JP;Tejada-Giraldo, M;L'Honneur, AS;Agudelo, ML;Perez-Zapata, LJ;Arboleda, DM;Alzate, JF;Cabarcas, F;Zuluaga, A;Pelham, SJ;Ensser, A;Schmidt, M;Velásquez-Lopera, MM;Jouanguy, E;Puel, A;Krönke, M;Ghirardello, S;Borghesi, A;Pahari, S;Boisson, B;Pittaluga, S;Ma, CS;Emile, JF;Notarangelo, LD;Tangye, SG;Marr, N;Lachmann, N;Salvator, H;Schlesinger, LS;Zhang, P;Glickman, MS;Nathan, CF;Geissmann, F;Abel, L;Franco, JL;Bustamante, J;Casanova, JL;Boisson-Dupuis, S;
Nature
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Molecular mimicry in multisystem inflammatory syndrome in children
Authors: Bodansky, A;Mettelman, RC;Sabatino, JJ;Vazquez, SE;Chou, J;Novak, T;Moffitt, KL;Miller, HS;Kung, AF;Rackaityte, E;Zamecnik, CR;Rajan, JV;Kortbawi, H;Mandel-Brehm, C;Mitchell, A;Wang, CY;Saxena, A;Zorn, K;Yu, DJL;Pogorelyy, MV;Awad, W;Kirk, AM;Asaki, J;Pluvinage, JV;Wilson, MR;Zambrano, LD;Campbell, AP;Overcoming COVID-19 Network Investigators, ;Thomas, PG;Randolph, AG;Anderson, MS;DeRisi, JL;
Nature
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma
Authors: Yu, L;Deng, Y;Wang, X;Santos, C;Davis, IJ;Earp, HS;Liu, P;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Analysis of Intracellular Communication Reveals Consistent Gene Changes Associated with Early-Stage Acne Skin
Authors: Deng, M;Odhiambo, WO;Qin, M;To, TT;Brewer, GM;Kheshvadjian, AR;Cheng, C;Agak, GW;
Research square
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Engagement of CD99 activates distinct programs in Ewing sarcoma and macrophages
Authors: Manara, MC;Manferdini, C;Cristalli, C;Carrabotta, M;Santi, S;De Feo, A;Caldoni, G;Pasello, M;Landuzzi, L;Lollini, PL;Salamanna, F;Dominici, S;Fiori, V;Magnani, M;Lisignoli, G;Scotlandi, K;
Cancer immunology research
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface
Authors: Liu, J;Deng, Y;Wang, A;Liu, B;Zhou, X;Yin, T;Wang, Y;Tang, T;Qiu, Y;Chen, J;Yang, J;
Cell death & disease
Species: Human
Sample Types: Transduced Whole Cells, Whole Cells
Applications: Bioassay -
TIM-3 Expression and M2 Polarization of Macrophages in the TGF?-Activated Tumor Microenvironment in Colorectal Cancer
Authors: Katagata, M;Okayama, H;Nakajima, S;Saito, K;Sato, T;Sakuma, M;Fukai, S;Endo, E;Sakamoto, W;Saito, M;Saze, Z;Momma, T;Mimura, K;Kono, K;
Cancers
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Influence of Macrophages on Vascular Invasion of Inflammatory Breast Cancer Emboli Measured Using an In Vitro Microfluidic Multi-Cellular Platform
Authors: Gadde, M;Mehrabi-Dehdezi, M;Debeb, BG;Woodward, WA;Rylander, MN;
Cancers
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hydrogel-based molecular tension fluorescence microscopy for investigating receptor-mediated rigidity sensing
Authors: Wang, W;Chen, W;Wu, C;Zhang, C;Feng, J;Liu, P;Hu, Y;Li, H;Sun, F;Jiang, K;Zhang, X;Liu, Z;
Nature methods
Species: Mouse
Sample Types:
Applications: Cell Culture -
Molecular pathogenicity of 1-nonadecene and L-lactic acid, unique metabolites in radicular cysts and periapical granulomas
Authors: Altaie, AM;Mohammad, MG;Madkour, MI;AlSaegh, MA;Jayakumar, MN;K G, AR;Samsudin, AR;Halwani, R;Hamoudi, RA;Soliman, SSM;
Scientific reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Small-molecule PIK-93 modulates the tumor microenvironment to improve immune checkpoint blockade response
Authors: CY Lin, KY Huang, SH Kao, MS Lin, CC Lin, SC Yang, WC Chung, YH Chang, RJ Chein, PC Yang
Science Advances, 2023-04-07;9(14):eade9944.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Combination IFNbeta and membrane-stable CD40L maximize tumor dendritic cell activation and lymph node trafficking to elicit systemic T-cell immunity
Authors: H Zheng, X Yu, ML Ibrahim, D Foresman, M Xie, JO Johnson, TA Boyle, B Ruffell, BA Perez, SJ Antonia, N Ready, AN Saltos, MJ Cantwell, AA Beg
Cancer Immunology Research, 2023-04-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models
Authors: JY Li, Y Zhao, S Gong, MM Wang, X Liu, QM He, YQ Li, SY Huang, H Qiao, XR Tan, ML Ye, XH Zhu, SW He, Q Li, YL Liang, KL Chen, SW Huang, QJ Li, J Ma, N Liu
Nature Communications, 2023-02-16;14(1):865.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3
Authors: T Tate, S Matsumoto, K Nemoto, M Leisegang, S Nagayama, K Obama, Y Nakamura, K Kiyotani
Cancers, 2023-02-06;15(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
An alphavbeta3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity
Authors: ACH Szeto, ACF Ferreira, J Mannion, PA Clark, M Sivasubram, MWD Heycock, A Crisp, HE Jolin, P Kozik, MD Knolle, ANJ McKenzie
Nature Immunology, 2022-12-22;24(1):123-135.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity
Authors: E Cruz-Loren, NP Ramirez, J Lee, S Pandhe, L Wang, J Hernandez-, AM Spivak, V Planelles, T Petersen, MK Jain, ED Martinez, I D'Orso
Viruses, 2022-10-18;14(10):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation
Authors: SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen
Nature Communications, 2022-10-14;13(1):6069.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
Authors: AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler
Cells, 2022-08-19;11(16):.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation -
Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins
Authors: V Catalán, P Domench, J Gómez-Ambr, B Ramírez, S Becerril, A Mentxaka, A Rodríguez, V Valentí, R Moncada, J Baixauli, C Silva, J Escalada, G Frühbeck
International Journal of Molecular Sciences, 2022-08-17;23(16):.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation -
Mesenchymal Stem Cells Profile in Adult Atopic Dermatitis and Effect of IL4-IL13 Inflammatory Pathway Inhibition In Vivo: Prospective Case-Control Study
Authors: A Campanati, M Orciani, A Marani, M Di Vincenz, S Magi, S Gregoriou, F Diotallevi, E Martina, G Radi, A Offidani
Journal of Clinical Medicine, 2022-08-15;11(16):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Multifunctional hydrogel enhances bone regeneration through sustained release of Stromal Cell-Derived Factor-1alpha and exosomes
Authors: L Chen, C Yu, Y Xiong, K Chen, P Liu, AC Panayi, X Xiao, Q Feng, B Mi, G Liu
Bioactive materials, 2022-08-12;25(0):460-471.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns
Authors: SD van Haren, GK Pedersen, A Kumar, TJ Ruckwardt, S Moin, IN Moore, M Minai, M Liu, J Pak, F Borriello, S Doss-Golli, EMS Beijnen, S Ahmed, M Helmel, P Andersen, BS Graham, H Steen, D Christense, O Levy
Nature Communications, 2022-08-02;13(1):4234.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The nuclear lamina binds the EBV genome during latency and regulates viral gene expression
Authors: LB Caruso, R Guo, K Keith, J Madzo, D Maestri, S Boyle, J Wasserman, A Kossenkov, BE Gewurz, I Tempera
PloS Pathogens, 2022-04-14;18(4):e1010400.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Novel IL-15 dendritic cells have a potent immunomodulatory effect in immunotherapy of multiple myeloma
Authors: TH Chu, MC Vo, TJ Lakshmi, SY Ahn, M Kim, GY Song, DH Yang, JS Ahn, HJ Kim, SH Jung, JJ Lee
Translational Oncology, 2022-04-09;20(0):101413.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells
Authors: P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes
Cancers, 2022-03-11;14(6):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Soluble PD-L1 through alternative polyadenylation works as a decoy in lung cancer immunotherapy
Authors: R Sagawa, S Sakata, B Gong, Y Seto, A Takemoto, S Takagi, H Ninomiya, N Yanagitani, M Nakao, M Mun, K Uchibori, M Nishio, Y Miyazaki, Y Shiraishi, S Ogawa, K Kataoka, N Fujita, K Takeuchi, R Katayama
JCI Insight, 2022-01-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension
Authors: PL Chi, CC Cheng, CC Hung, MT Wang, HY Liu, MW Ke, MC Shen, KC Lin, SH Kuo, PP Hsieh, SR Wann, WC Huang
International journal of biological sciences, 2022-01-01;18(1):331-348.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
Authors: E Kim, H Um, J Park, JW Jung, JE Kim, H Lee, EA Shin, Y Pinanga, H Lee, SH Nam, JW Lee
Cell Reports, 2021-11-16;37(7):110018.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells.
Authors: Wellemans V, Benhassou H, Fuselier E, Bellesort F, Dury S, Lebargy F, Dormoy V, Fichel C, Naour R, Gounni A, Lamkhioued B
iScience, 2021-11-14;24(12):103433.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity
Authors: Y Qiao, Y Qiu, J Ding, N Luo, H Wang, X Ling, J Sun, Z Wu, Y Wang, Y Liu, F Guo, T Sun, W Shen, M Zhang, D Wu, B Chen, W Xu, X Wang
Nature Communications, 2021-11-04;12(1):6360.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris
Authors: S Shao, J Chen, WR Swindell, LC Tsoi, X Xing, F Ma, R Uppala, MK Sarkar, O Plazyo, AC Billi, R Wasikowski, KM Smith, P Honore, VE Scott, E Maverakis, JM Kahlenberg, G Wang, NL Ward, PW Harms, JE Gudjonsson
JCI Insight, 2021-10-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-33 receptor expression on myeloid and plasmacytoid dendritic cells after allergen challenge in patients with allergic rhinitis
Authors: YQ Peng, DH Chen, ZB Xu, SB Fang, BX He, XQ Liu, CA Akdis, QL Fu
International immunopharmacology, 2021-10-12;101(0):108233.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Neobavaisoflavone-mediated TH9 cell differentiation ameliorates bowel inflammation
Authors: J Guo, C Qiao, J Zhou, S Hu, X Lin, Y Shen, Z Li, J Liu
International immunopharmacology, 2021-10-01;101(0):108191.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Synthetic Hydrogel, VitroGel� ORGANOID-3, Improves Immune Cell-Epithelial Interactions in a Tissue Chip Co-Culture Model of Human Gastric Organoids and Dendritic Cells
Authors: MD Cherne, B Sidar, TA Sebrell, HS Sanchez, K Heaton, FJ Kassama, MM Roe, AB Gentry, CB Chang, ST Walk, M Jutila, JN Wilking, D Bimczok
Frontiers in Pharmacology, 2021-09-06;12(0):707891.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vgamma9Vdelta2 T cells independently of HMBPP production
Authors: AF Alice, G Kramer, S Bambina, KS Bahjat, MJ Gough, MR Crittenden
Scientific Reports, 2021-08-11;11(1):16347.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation of glucocorticoid-resistant SARS-CoV-2 T�cells for adoptive cell therapy
Authors: R Basar, N Uprety, E Ensley, M Daher, K Klein, F Martinez, F Aung, M Shanley, B Hu, E Gokdemir, AK Nunez Cort, M Mendt, F Reyes Silv, S Acharya, T Laskowski, L Muniz-Feli, PP Banerjee, Y Li, S Li, L Melo Garci, P Lin, H Shaim, SG Yates, D Marin, I Kaur, S Rao, D Mak, A Lin, Q Miao, J Dou, K Chen, RE Champlin, EJ Shpall, K Rezvani
Cell Reports, 2021-07-07;36(3):109432.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
Authors: R Song, Y Gao, I Dozmorov, V Malladi, I Saha, MM McDaniel, S Parameswar, C Liang, C Arana, B Zhang, B Wakeland, J Zhou, MT Weirauch, LC Kottyan, EK Wakeland, C Pasare
Cell Reports, 2021-03-23;34(12):108891.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responses
Authors: H Gunawardan, T Romero, N Yao, S Heidt, A Mulder, DA Elashoff, NM Valenzuela
Scientific Reports, 2021-01-21;11(1):1949.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes
Authors: TM Garcia-Bat, ML Palma, RR Anderko, DC Hsu, J Ananworani, BT Korber, GD Gaiha, N Phanuphak, R Thomas, S Tovanabutr, BD Walker, JW Mellors, PA Piazza, E Kroon, SA Riddler, NL Michael, CR Rinaldo, RB Mailliard, I4C and RV
EBioMedicine, 2021-01-12;63(0):103175.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors.
Authors: Roudko V, Bozkus C, Orfanelli T, McClain C, Carr C, O'Donnell T, Chakraborty L, Samstein R, Huang K, Blank S, Greenbaum B, Bhardwaj N
Cell, 2020-11-30;183(6):1634-1649.e17.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients
Authors: I Hwang, JW Kim, K Ylaya, EJ Chung, H Kitano, C Perry, J Hanaoka, J Fukuoka, JY Chung, SM Hewitt
J Transl Med, 2020-11-23;18(1):443.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
The Human Leukocyte Antigen Class II Immunopeptidome of the SARS-CoV-2 Spike Glycoprotein
Authors: MD Knierman, MB Lannan, LJ Spindler, CL McMillian, RJ Konrad, RW Siegel
Cell Reports, 2020-11-13;33(9):108454.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
CD73 contributes to anti-inflammatory properties of afferent lymphatic endothelial cells in humans and mice
Authors: D Eichin, A Pessia, A Takeda, J Laakkonen, L Bellmann, M Kankainen, BA Imhof, P Stoitzner, J Tang, M Salmi, S Jalkanen
Eur. J. Immunol., 2020-10-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2
Authors: F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen
Res Sq, 2020-09-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The use of patient-derived breast tissue explants to study macrophage polarization and the effects of environmental chemical exposure
Authors: KJ Gregory, SM Morin, A Kubosiak, J Ser-Dolans, B Schalet, DJ Jerry, SS Schneider
Immunol. Cell Biol., 2020-09-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Tetrameric glycoprotein complex gH/gL/gQ1/gQ2 is a promising vaccine candidate for human herpesvirus 6B
Authors: B Wang, K Hara, A Kawabata, M Nishimura, A Wakata, LH Tjan, AL Poetranto, C Yamamoto, Y Haseda, T Aoshi, L Munakata, R Suzuki, M Komatsu, R Tsukamoto, T Itoh, C Nishigori, Y Saito, T Matozaki, Y Mori
PLoS Pathog., 2020-07-23;16(7):e1008609.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
Cell Rep, 2020-06-30;31(13):107820.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization
Authors: K Shan, N Feng, J Cui, S Wang, H Qu, G Fu, J Li, H Chen, X Wang, R Wang, Y Qi, Z Gu, YQ Chen
J. Cell. Mol. Med., 2020-05-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
NADPH oxidase 1 is highly expressed in human large and small bowel cancers
Authors: J Lu, G Jiang, Y Wu, S Antony, JL Meitzler, A Juhasz, H Liu, K Roy, H Makhlouf, R Chuaqui, D Butcher, MM Konaté, JH Doroshow
PLoS ONE, 2020-05-19;15(5):e0233208.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibiting Monocyte Recruitment to Prevent the Pro-Tumoral Activity of Tumor-Associated Macrophages in Chondrosarcoma
Authors: M Minopoli, S Sarno, G Di Carlucc, R Azzaro, S Costantini, F Fazioli, M Gallo, G Apice, L Cannella, D Rea, MP Stoppelli, D Boraschi, A Budillon, K Scotlandi, A De Chiara, MV Carriero
Cells, 2020-04-24;9(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dermatopontin, A Novel Adipokine Promoting Adipose Tissue Extracellular Matrix Remodelling and Inflammation in Obesity
Authors: X Unamuno, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán
J Clin Med, 2020-04-09;9(4):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment
Authors: YD Kim, SM Park, HC Ha, AR Lee, H Won, H Cha, S Cho, JM Cho
J Cancer, 2020-04-06;11(14):4059-4072.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
Authors: H Gan, T Shen, DP Chupp, JR Taylor, HN Sanchez, X Li, Z Xu, H Zan, P Casali
Sci Adv, 2020-04-01;6(14):eaay2793.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Antifibrotic Effects of the Thiazolidinediones in Eosinophilic Esophagitis Pathologic Remodeling: A Preclinical Evaluation
Authors: QM Nhu, L Hsieh, L Dohil, R Dohil, RO Newbury, R Kurten, FJ Moawad, SS Aceves
Clin Transl Gastroenterol, 2020-04-01;11(4):e00164.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor
Authors: B ?y?y?ska-G, B Trzaskowsk, M Dutkiewicz, O Zegrocka-S, M Machci?ska, K Bocian, M Kowalewska, K Koziak
Sci Rep, 2020-02-19;10(1):2886.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial
Authors: S Somanathan, R Calcedo, JM Wilson
Mol. Ther., 2020-02-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Mesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine
Authors: A Papait, E Vertua, M Magatti, S Ceccarigli, S De Munari, AR Silini, M Sheleg, R Ofir, O Parolini
Cells, 2020-01-06;9(1):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients
Authors: MH Chen, MT Huang, WK Yu, SS Lee, JH Wang, TR Cheng, MR Bowman, SL Hsieh
J. Biomed. Sci., 2019-12-20;26(1):97.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures
Authors: SC Lee, MS Tang, AV Easton, JC Devlin, LL Chua, I Cho, FM Moy, TF Khang, YAL Lim, P Loke
PLoS Pathog., 2019-12-16;15(12):e1008066.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Alpha-linolenic acid enhances the phagocytic and secretory functions of alternatively activated macrophages in part via changes to the oxylipin profile
Authors: SD Pauls, LA Rodway, T Winter, CG Taylor, P Zahradka, HM Aukema
Int. J. Biochem. Cell Biol., 2019-12-04;119(0):105662.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hydrogel based protein biochip for parallel detection of biomarkers for diagnosis of a Systemic Inflammatory Response Syndrome (SIRS) in human serum
Authors: A Stumpf, T Brandstett, J Hübner, J Rühe
PLoS ONE, 2019-12-02;14(12):e0225525.
Species: Human
Sample Types: Serum
Applications: ELISA Standard -
Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR
Authors: W Nowak, LN Grendas, LM Sanmarco, IG Estecho, ÁR Arena, N Eberhardt, DE Rodante, MP Aoki, FM Daray, EA Carrera Si, AE Errasti
EBioMedicine, 2019-11-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
Authors: N Berges, MS Nawaz, T Børresdatt, L Hagen, M Bjørås, JK Laerdahl, I Alseth
PLoS ONE, 2019-11-08;14(11):e0225081.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
HIV-Specific T Cells Can Be Generated against Non-escaped T Cell Epitopes with a GMP-Compliant Manufacturing Platform
Authors: S Patel, R Hanajiri, M Grant, D Saunders, S Van Pelt, M Keller, PJ Hanley, G Simon, DF Nixon, D Hardy, RB Jones, CM Bollard
Mol Ther Methods Clin Dev, 2019-10-11;16(0):11-20.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy
Authors: LNS Andrade, AH Otake, SGB Cardim, FI da Silva, MM Ikoma Saka, TK Furuya, M Uno, FS Pasini, R Chammas
Sci Rep, 2019-10-09;9(1):14482.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components
Authors: P Dolzani, E Assirelli, L Pulsatelli, R Meliconi, E Mariani, S Neri
PLoS ONE, 2019-09-24;14(9):e0222947.
Species: Human
Sample Types: Tissue Explant
Applications: Bioassay -
NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling
Authors: X Unamuno, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán
Cell. Mol. Immunol., 2019-09-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells
Authors: Y Wu, MM Konaté, J Lu, H Makhlouf, R Chuaqui, S Antony, JL Meitzler, MJ Difilippan, H Liu, A Juhasz, G Jiang, I Dahan, K Roy, JH Doroshow
J. Immunol., 2019-09-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
In Vivo Administration of Recombinant Human Granulocyte Colony-Stimulating Factor Increases the Immune Effectiveness of Dendritic Cell-Based Cancer Vaccination
Authors: S Shimodaira, R Yanagisawa, T Koya, K Hirabayash, Y Higuchi, T Sakamoto, M Togi, T Kato, T Kobayashi, T Koizumi, S Koido, H Sugiyama
Vaccines (Basel), 2019-09-19;7(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dissection of the Effects of JAK and BTK Inhibitors on the Functionality of Healthy and Malignant Lymphocytes
Authors: T Hofland, I de Weerdt, H Ter Burg, R de Boer, S Tannheimer, SH Tonino, AP Kater, E Eldering
J. Immunol., 2019-09-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TNF-α and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes
Authors: S Sugihara, S Sugimoto, K Tachibana, M Kobashi, H Nomura, T Miyake, Y Hirai, O Yamasaki, S Morizane
J. Dermatol. Sci., 2019-08-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance
Authors: SR Levan, KA Stamnes, DL Lin, AR Panzer, E Fukui, K McCauley, KE Fujimura, M McKean, DR Ownby, EM Zoratti, HA Boushey, MD Cabana, CC Johnson, SV Lynch
Nat Microbiol, 2019-07-22;4(11):1851-1861.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Novel MRGPRX2 antagonists inhibit IgE-independent activation of human umbilical cord blood-derived mast cells
Authors: H Ogasawara, M Furuno, K Edamura, M Noguchi
J. Leukoc. Biol., 2019-07-12;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies
Authors: JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles
Nat. Immunol., 2019-07-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Boiling Histotripsy-induced Partial Mechanical Ablation Modulates Tumour Microenvironment by Promoting Immunogenic Cell Death of Cancers
Authors: KJ Pahk, CH Shin, IY Bae, Y Yang, SH Kim, K Pahk, H Kim, SJ Oh
Sci Rep, 2019-06-21;9(1):9050.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TRIM5? Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation
Authors: AI Chiramel, NR Meyerson, KL McNally, RM Broeckel, VR Montoya, O Méndez-Sol, SJ Robertson, GL Sturdevant, KJ Lubick, V Nair, BH Youseff, RM Ireland, CM Bosio, K Kim, J Luban, VM Hirsch, RT Taylor, F Bouamr, SL Sawyer, SM Best
Cell Rep, 2019-06-11;27(11):3269-3283.e6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Deubiquitinase Inhibitor b-AP15 and Its Effect on Phenotype and Function of Monocyte-Derived Dendritic Cells
Authors: M Schmidt, V Altdörfer, S Schnitte, AR Fuchs, KN Kropp, S Maurer, MR Müller, HR Salih, SM Rittig, F Grünebach, D Dörfel
Neoplasia, 2019-05-25;21(7):653-664.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Efficient HIV-1 Trans Infection of CD4+ T Cells Occurs in the Presence of Antiretroviral Therapy
Authors: G Rappocciol, N Sluis-Crem, CR Rinaldo
Open Forum Infect Dis, 2019-05-24;6(7):ofz253.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
DNA from virulent M. tuberculosis induces TNF-? production and autophagy in M1 polarized macrophages
Authors: A Ruiz, S Guzmán-Bel, LE Carreto-Bi, Y Gonzalez, E Juárez
Microb. Pathog., 2019-05-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition
Authors: VA Jennings, GB Scott, AMS Rose, KJ Scott, G Migneco, B Keller, K Reilly, O Donnelly, H Peach, D Dewar, KJ Harrington, H Pandha, A Samson, RG Vile, AA Melcher, F Errington-
Mol. Ther., 2019-04-14;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns
Authors: S Márquez, JJ Fernández, C Mancebo, C Herrero-Sá, S Alonso, TA Sandoval, M Rodríguez, JR Cubillos-R, O Montero, N Fernández, M Sánchez Cr
Cell Rep, 2019-04-09;27(2):525-536.e4.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPAR?-Dependent NF-?B Signaling Pathway In Vivo and In Vitro
Authors: T Zhu, Z Chen, G Chen, D Wang, S Tang, H Deng, J Wang, S Li, J Lan, J Tong, H Li, X Deng, W Zhang, J Sun, Y Tu, W Luo, C Li
Mediators Inflamm., 2019-04-03;2019(0):4927430.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1
Authors: J Kristoff, ML Palma, TM Garcia-Bat, C Shen, N Sluis-Crem, P Gupta, CR Rinaldo, RB Mailliard
EBioMedicine, 2019-04-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists
Authors: R Gramlich, E Aliahmadi, M Peiser
Int J Mol Sci, 2019-03-19;20(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Novel Gastric Spheroid Co-Culture Model Reveals Chemokine-Dependent Recruitment of Human Dendritic Cells to the Gastric Epithelium
Authors: TA Sebrell, M Hashimi, B Sidar, R Wilkinson, L Kirpotina, MT Quinn, Z Malkoç, PJ Taylor, JN Wilking, D Bimczok
Cell Mol Gastroenterol Hepatol, 2019-03-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis
Authors: X Qin, M Liu, S Zhang, C Wang, T Zhang
Cytokine, 2019-03-01;117(0):84-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Identification of P2Y receptors involved in oleamide-suppressing inflammatory responses in murine microglia and human dendritic cells
Authors: M Kita, Y Ano, A Inoue, J Aoki
Sci Rep, 2019-02-28;9(1):3135.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+ Cells
Authors: F Feng, J Zhao, P Li, R Li, L Chen, C Sun
Viruses, 2019-02-13;11(2):.
Species: Human
Sample Types:
Applications: Bioassay -
An essential role for the Zn2+ transporter ZIP7 in B cell development
Authors: C Anzilotti, DJ Swan, B Boisson, M Deobagkar-, C Oliveira, P Chabosseau, KR Engelhardt, X Xu, R Chen, L Alvarez, R Berlinguer, KR Bull, E Cawthorne, AP Cribbs, TL Crockford, TS Dang, A Fearn, EJ Fenech, SJ de Jong, BC Lagerholm, CS Ma, D Sims, B van den Be, Y Xu, AJ Cant, G Kleiner, TR Leahy, MT de la More, JM Puck, RS Shapiro, M van der Bu, JR Chapman, JC Christians, B Davies, JA McGrath, S Przyborski, M Santibanez, SG Tangye, A Werner, GA Rutter, S Padilla-Pa, JL Casanova, RJ Cornall, ME Conley, S Hambleton
Nat. Immunol., 2019-02-04;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets
Authors: K Gettler, M Giri, E Kenigsberg, J Martin, LS Chuang, NY Hsu, LA Denson, JS Hyams, A Griffiths, JD Noe, WV Crandall, DR Mack, R Kellermaye, C Abraham, G Hoffman, S Kugathasan, JH Cho
Genes Immun., 2019-01-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling
Authors: X Liu, P Zhang, Y Zhang, Z Wang, S Xu, Y Li, W Huai, Q Zhou, X Chen, X Chen, N Li, P Wang, Y Li, X Cao
Cell Res., 2018-12-04;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Brucella canis induces canine CD4+ T cells multi-cytokine Th1/Th17 production via dendritic cell activation
Authors: M Pujol, C Borie, M Montoya, A Ferreira, R Vernal
Comp. Immunol. Microbiol. Infect. Dis., 2018-11-30;62(0):68-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Eomesodermin controls a unique differentiation program in human IL-10 and IFN-? co-producing regulatory T-cells
Authors: P Gruarin, S Maglie, M De Simone, B Häringer, C Vasco, V Ranzani, R Bosotti, JS Noddings, P Larghi, F Facciotti, ML Sarnicola, M Martinovic, MC Crosti, M Moro, RL Rossi, ME Bernardo, F Caprioli, F Locatelli, G Rossetti, S Abrignani, M Pagani, J Geginat
Eur. J. Immunol., 2018-11-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells
Authors: C Kim, B Hu, RR Jadhav, J Jin, H Zhang, MM Cavanagh, RS Akondy, R Ahmed, CM Weyand, JJ Goronzy
Cell Rep, 2018-11-20;25(8):2148-2162.e5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages
Authors: DA Bejarano, MC Puertas, K Börner, J Martinez-P, B Müller, HG Kräusslich
Viruses, 2018-11-10;10(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Attenuation of CD47-SIRP? Signal in Cholangiocarcinoma Potentiates Tumor-Associated Macrophage-Mediated Phagocytosis and Suppresses Intrahepatic Metastasis
Authors: K Vaeteewoot, R Kariya, P Pothipan, S Fujikawa, C Pairojkul, S Waraasawap, K Kuwahara, C Wongkham, S Wongkham, S Okada
Transl Oncol, 2018-11-09;12(2):217-225.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis
Authors: P Järver, A Dondalska, C Poux, A Sandberg, J Bergenstrå, AE Sköld, N Dereuddre-, F Martinon, S Pålsson, E Zaghloul, D Brodin, B Sander, KA Lennox, MA Behlke, S El-Andalou, J Lehtiö, J Lundeberg, R LeGrand, AL Spetz
Sci Rep, 2018-10-26;8(1):15841.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Decreased allergy incidence in children supplemented with E. coli O83:K24:H31 and its possible modes of action
Authors: J Hrdý, K Vlasáková, V ?erný, L Súkeníková, O Novotná, P Petrásková, K Boráková, R Lodinová-Ž, L Kolá?ová, L Prokešová
Eur. J. Immunol., 2018-10-21;0(0):.
Species: Human
Sample Types: Plasma
-
Co-culture of dendritic cells and cytokine-induced killer cells effectively suppresses liver cancer stem cell growth by inhibiting pathways in the immune system
Authors: T Yang, W Zhang, L Wang, C Xiao, L Wang, Y Gong, D Huang, B Guo, Q Li, Y Xiang, Y Nan
BMC Cancer, 2018-10-16;18(1):984.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumor-associated macrophages derived CCL18 promotes metastasis in squamous cell carcinoma of the head and neck
Authors: L She, Y Qin, J Wang, C Liu, G Zhu, G Li, M Wei, C Chen, G Liu, D Zhang, X Chen, Y Wang, Y Qiu, Y Tian, X Zhang, Y Liu, D Huang
Cancer Cell Int., 2018-08-28;18(0):120.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation
Authors: CH Lu, DW Yeh, CY Lai, YL Liu, LR Huang, AY Lee, SC Jin, TH Chuang
Oncogene, 2018-07-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Proton irradiation orchestrates macrophage reprogramming through NF?B signaling
Authors: G Genard, AC Wera, C Huart, B Le Calve, S Penninckx, A Fattacciol, T Tabarrant, C Demazy, N Ninane, AC Heuskin, S Lucas, C Michiels
Cell Death Dis, 2018-06-27;9(7):728.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inefficient HIV-1 trans infection of CD4+ T cells by macrophages from HIV-1 nonprogressors is associated with altered membrane cholesterol and DC-SIGN
Authors: DC DeLucia, CR Rinaldo, G Rappocciol
J. Virol., 2018-06-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Anisakis pegreffii impacts differentiation and function of human dendritic cells
Authors: C Napoletano, S Mattiucci, A Colantoni, F Battisti, IG Zizzari, H Rahimi, M Nuti, A Rughetti
Parasite Immunol., 2018-05-01;0(0):e12527.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activated dendritic cells modulate proliferation and differentiation of human myoblasts
Authors: L Ladislau, DM Portilho, T Courau, A Solares-Pé, E Negroni, J Lainé, D Klatzmann, A Bonomo, Y Allenbach, O Benveniste, I Riederer, W Savino, V Mouly, G Butler-Bro, CF Benjamim
Cell Death Dis, 2018-05-01;9(5):551.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cross-sectional analysis of CD8 T cell immunity to human herpesvirus 6B
Authors: LK Martin, A Hollaus, A Stahuber, C Hübener, A Fraccaroli, J Tischer, A Schub, A Moosmann
PLoS Pathog., 2018-04-26;14(4):e1006991.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages
Authors: I Pop?na, A ?bols, L Saul?te, K Pleiko, E Zandberga, K J?kabsons, E Endzeli?š, A Llorente, A Lin?, U Rieksti?a
Cell Commun. Signal, 2018-04-24;16(1):17.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation -
Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia
Authors: MK Hasan, J Yu, GF Widhopf, LZ Rassenti, L Chen, Z Shen, SP Briggs, DS Neuberg, TJ Kipps
Blood, 2018-04-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages
Authors: EY Huang, JC Chang, HH Chen, CY Hsu, HC Hsu, KL Wu
BMC Cancer, 2018-03-27;18(1):321.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin 35: Inhibitory regulator in monocyte-derived dendritic cell maturation and activation
Authors: X Chen, S Hao, Z Zhao, J Liu, Q Shao, F Wang, D Sun, Y He, W Gao, H Mao
Cytokine, 2018-03-20;108(0):43-52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Lipid abnormalities in atopic skin are driven by type 2 cytokines
Authors: E Berdyshev, E Goleva, I Bronova, N Dyjack, C Rios, J Jung, P Taylor, M Jeong, CF Hall, BN Richers, KA Norquest, T Zheng, MA Seibold, DY Leung
JCI Insight, 2018-02-22;3(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Somatic IL4R Mutations in Primary Mediastinal Large B-cell lymphoma lead to constitutive JAK-STAT signaling activation
Authors: E Viganò, J Gunawardan, A Mottok, T Van Tol, K Mak, FC Chan, L Chong, E Chavez, B Woolcock, K Takata, D Twa, HP Shulha, A Telenius, O Kutovaya, SS Hung, S Healy, S Ben-Neriah, K Leroy, P Gaulard, A Diepstra, R Kridel, KJ Savage, L Rimsza, R Gascoyne, C Steidl
Blood, 2018-02-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1? and MCP-1 in cultured human retinal pigment epithelial cells
Authors: ZM Bian, MG Field, SG Elner, JM Kahlenberg, VM Elner
Exp. Eye Res., 2018-02-16;170(0):29-39.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Efficacy of intracellular immune checkpoint-silenced DC vaccine
Authors: D Wang, XF Huang, B Hong, XT Song, L Hu, M Jiang, B Zhang, H Ning, Y Li, C Xu, X Lou, B Li, Z Yu, J Hu, J Chen, F Yang, H Gao, G Ding, L Liao, L Rollins, L Jones, SY Chen, H Chen
JCI Insight, 2018-02-08;3(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum
Authors: L Bin, X Li, B Richers, JE Streib, JW Hu, P Taylor, DYM Leung
J. Allergy Clin. Immunol., 2018-01-31;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Trichinella spiralis Excretory-Secretory Products Induce Tolerogenic Properties in Human Dendritic CellsviaToll-Like Receptors 2 and 4
Authors: N Ilic, A Gruden-Mov, J Cvetkovic, S Tomic, DB Vucevic, C Aranzamend, M Colic, E Pinelli, L Sofronic-M
Front Immunol, 2018-01-24;9(0):11.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells
Authors: T Kato, T Matsuda, Y Ikeda, JH Park, M Leisegang, S Yoshimura, T Hikichi, M Harada, M Zewde, S Sato, K Hasegawa, K Kiyotani, Y Nakamura
Oncotarget, 2018-01-13;9(13):11009-11019.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
NF-?B inducing kinase is a therapeutic target for systemic lupus erythematosus
Authors: HD Brightbill, E Suto, N Blaquiere, N Ramamoorth, S Sujatha-Bh, EB Gogol, GM Castanedo, BT Jackson, YC Kwon, S Haller, J Lesch, K Bents, C Everett, PB Kohli, S Linge, L Christian, K Barrett, A Jaochico, LM Berezhkovs, PW Fan, Z Modrusan, K Veliz, MJ Townsend, J DeVoss, AR Johnson, R Godemann, WP Lee, CD Austin, BS McKenzie, JA Hackney, JJ Crawford, ST Staben, MH Alaoui Ism, LC Wu, N Ghilardi
Nat Commun, 2018-01-12;9(1):179.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells
Authors: YJ Choi, SJ Park, YS Park, HS Park, KM Yang, K Heo
PLoS ONE, 2018-01-03;13(1):e0190638.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-? and Engagement of CD85j
Authors: SY Nuñez, A Ziblat, F Secchiari, NI Torres, JM Sierra, XL Raffo Irao, RE Araya, CI Domaica, MB Fuertes, NW Zwirner
J. Immunol., 2017-12-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
An Activating Janus Kinase-3 Mutation Is Associated with Cytotoxic T Lymphocyte Antigen-4-Dependent Immune Dysregulation Syndrome
Authors: H Sic, M Speletas, V Cornacchio, M Seidl, M Beibel, B Linghu, F Yang, E Sevdali, AE Germenis, EJ Oakeley, E Vangreveli, AW Sailer, E Traggiai, H Gram, H Eibel
Front Immunol, 2017-12-15;8(0):1824.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Analysis of CTCL cell lines reveals important differences between mycosis fungoides/S�zary syndrome vs. HTLV-1+ leukemic cell lines
Authors: E Netchiporo, J Gantchev, M Tsang, P Thibault, AK Watters, JM Hughes, FM Ghazawi, A Woetmann, N Ødum, D Sasseville, IV Litvinov
Oncotarget, 2017-10-07;8(56):95981-95998.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
GATA3 regulates FLG and FLG2 expression in human primary keratinocytes
Authors: J Zeitvogel, N Jokmin, S Rieker, I Klug, C Brandenber, T Werfel
Sci Rep, 2017-09-19;7(1):11847.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A niche that triggers aggressiveness within BRCA1-IRIS overexpressing triple negative tumors is supported by reciprocal interactions with the microenvironment
Authors: D Ryan, D Bogan, J Davies, J Koziol, WM ElShamy
Oncotarget, 2017-09-14;8(61):103182-103206.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency
Authors: M Yoshida, Y Ishioka, T Ozawa, H Okuyama, M Iguchi, T Ota, T Ito, M Nagira, A Morita, H Tanaka, H Naito, H Kidoya, N Takakura
Sci Rep, 2017-09-11;7(1):11137.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy
Authors: L Sarmiento, J De Rosa, A Machicote, LA Billordo, P Baz, PM Fernández, I Kaimen Mac, A Blanco, EI Arana
Sci Rep, 2017-09-11;7(1):11077.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients
Authors: M Matsushita, K Ozawa, T Suzuki, M Nakamura, N Nakano, S Kanchi, D Ichikawa, E Matsuki, M Sakurai, D Karigane, H Kasahara, N Tsukamoto, T Shimizu, T Mori, H Nakajima, S Okamoto, Y Kawakami, Y Hattori
Blood Cancer J, 2017-09-01;7(9):e601.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors
Authors: J Helft, F Anjos-Afon, AG van der Ve, P Chakravart, D Bonnet, C Reis E Sou
Cell Rep, 2017-07-18;20(3):529-537.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dexamethasone induced inhibition of Dectin-1 activation of antigen presenting cells is mediated via STAT-3 and NF-?B signaling pathways.
Authors: Philipp Kotthoff, Annkristin Heine, Stefanie Andrea Erika Held, Peter Brossart
Scientific Reports, 2017-07-03;0(0):2045-2322.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RNase 7 downregulates TH2 cytokine production by activated human T-cells
Authors: V Kopfnagel, S Wagenknech, L Brand, J Zeitvogel, J Harder, K Hofmann, M Kleine, T Werfel
Allergy, 2017-06-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The IGH locus relocalizes to a recombination compartment in the perinucleolar region of differentiating B-lymphocytes
Authors: A Pichugin, OV Iarovaia, A Gavrilov, I Sklyar, N Barinova, A Barinov, E Ivashkin, G Caron, S Aoufouchi, SV Razin, T Fest, M Lipinski, YS Vassetzky
Oncotarget, 2017-06-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differential Th17 response induced by the two clades of the pandemic ST258 Klebsiella pneumoniae clonal lineages producing KPC-type carbapenemase
Authors: AM Clemente, G Castronovo, A Antonelli, MM D'Andrea, M Tanturli, E Perissi, S Paccosi, A Parenti, F Cozzolino, GM Rossolini, MG Torcia
PLoS ONE, 2017-06-06;12(6):e0178847.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activated Natural Killer Cells Mediate the Suppressive Effect of Interleukin-4 on Tumor Development via STAT6 Activation in an Atopic Condition Melanoma Model
Authors: DJ Son, YY Jung, MH Park, HL Lee, MJ Song, HS Yoo, DY Hwang, SB Han, JT Hong
Neoplasia, 2017-06-03;19(7):537-548.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis
Authors: F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai
Scand. J. Immunol., 2017-06-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Colony-stimulating factor 1 receptor blockade inhibits tumor growth by altering the polarization of tumor-associated macrophages in hepatocellular carcinoma
Authors: JY Ao, XD Zhu, ZT Chai, H Cai, YY Zhang, KZ Zhang, LQ Kong, N Zhang, BG Ye, DN Ma, HC Sun
Mol. Cancer Ther., 2017-06-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases
Authors: CSB Viegas, RM Costa, L Santos, PA Videira, Z Silva, N Araújo, AL Macedo, AP Matos, C Vermeer, DC Simes
PLoS ONE, 2017-05-18;12(5):e0177829.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells
Authors: SC Silva-Card, AJ Affandi, L Spel, M Cossu, JAG van Roon, M Boes, TRDJ Radstake
J. Immunol., 2017-05-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A phase II trial of autologous dendritic cell vaccination and radiochemotherapy following fluorescence-guided surgery in newly diagnosed glioblastoma patients
Authors: S Inogés, S Tejada, AL de Cerio, JG Pérez-Larr, J Espinós, MA Idoate, PD Domínguez, RG de Eulate, J Aristu, M Bendandi, F Pastor, M Alonso, E Andreu, FP Cardoso, RD Valle
J Transl Med, 2017-05-12;15(1):104.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells
Authors: F Kawamura, M Inaki, A Katafuchi, Y Abe, N Tsuyama, Y Kurosu, A Yanagi, M Higuchi, S Muto, T Yamaura, H Suzuki, H Noji, S Suzuki, MA Yoshida, M Sasatani, K Kamiya, M Onodera, A Sakai
Sci Rep, 2017-05-10;7(1):1659.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Oil-Soluble Contrast Medium (OSCM) for Hysterosalpingography Modulates Dendritic Cell and Regulatory T Cell Profiles in the Peritoneal Cavity: A Possible Mechanism by Which OSCM Enhances Fertility
Authors: G Izumi, K Koga, M Takamura, W Bo, M Nagai, M Miyashita, M Harada, T Hirata, Y Hirota, O Yoshino, T Fujii, Y Osuga
J. Immunol., 2017-04-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer
Authors: S Mehrotra, CD Britten, S Chin, E Garrett-Ma, CA Cloud, M Li, G Scurti, ML Salem, MH Nelson, MB Thomas, CM Paulos, AM Salazar, MI Nishimura, MP Rubinstein, Z Li, DJ Cole
J Hematol Oncol, 2017-04-07;10(1):82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-? induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps
Authors: BF Wang, PP Cao, ZC Wang, ZY Li, ZZ Wang, J Ma, B Liao, YK Deng, XB Long, K Xu, H Wang, H Wang, M Zeng, X Lu, Z Liu
Allergy, 2017-04-04;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs
Authors: J Wang, H Ye, D Zhang, K Cheng, Y Hu, X Yu, L Lu, J Hu, C Zuo, B Qian, Y Yu, S Liu, G Liu, C Mao, S Liu
Theranostics, 2017-03-24;7(6):1407-1421.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
BET proteins are a key component of immunoglobulin gene expression
Authors: JM Shim, JS Lee, KE Russell, CH Wiegman, PJ Barnes, D Fear, IM Adcock, AL Durham
Epigenomics, 2017-03-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transmembrane TNF-dependent uptake of anti-TNF antibodies
Authors: A Deora, S Hegde, J Lee, CH Choi, Q Chang, C Lee, L Eaton, H Tang, D Wang, D Lee, M Michalak, M Tomlinson, Q Tao, N Gaur, B Harvey, S McLoughlin, B Labkovsky, T Ghayur
MAbs, 2017-03-21;0(0):0.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations
Authors: C Guntermann, A Piaia, ML Hamel, D Theil, T Rubic-Schn, A Del Rio-Es, L Dong, A Billich, K Kaupmann, J Dawson, K Hoegenauer, D Orain, S Hintermann, R Stringer, DD Patel, A Doelemeyer, M Deurinck, J Schümann
JCI Insight, 2017-03-09;2(5):e91127.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation
Authors: MA Schumacher, M Hedl, C Abraham, JK Bernard, PR Lozano, JJ Hsieh, D Almohazey, EB Bucar, S Punit, PJ Dempsey, MR Frey
Cell Death Dis, 2017-02-23;8(2):e2622.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Th1high in tumor microenvironment is an indicator of poor prognosis for patients with NSCLC
Authors: J Huang, F Shen, H Huang, C Ling, G Zhang
Oncotarget, 2017-02-21;8(8):13116-13125.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes
Authors: Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang
Am J Transl Res, 2017-02-15;9(2):454-465.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells
Authors: M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney
Clin. Cancer Res, 2017-02-09;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
Authors: H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali
Nat Commun, 2017-02-08;8(0):14244.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cell MST1 inhibits Th17 differentiation
Authors: C Li, Y Bi, Y Li, H Yang, Q Yu, J Wang, Y Wang, H Su, A Jia, Y Hu, L Han, J Zhang, S Li, W Tao, G Liu
Nat Commun, 2017-02-01;8(0):14275.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators
Authors: A Dyer, Y Di, H Calderon, S Illingwort, G Kueberuwa, A Tedcastle, P Jakeman, SL Chia, A Brown, MA Silva, D Barlow, J Beadle, T Hermiston, DJ Ferguson, B Champion, KD Fisher, LW Seymour
Mol Ther Oncolytics, 2016-12-10;4(0):18-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Usage of Murine T-cell Hybridoma Cells as Responder Cells Reveals Interference of Helicobacter Pylori with Human Dendritic Cell-mediated Antigen Presentation
Authors: Michael Fehlings
Eur J Microbiol Immunol (Bp), 2016-12-01;6(4):306-311.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Procyanidin A2 Modulates IL-4-Induced CCL26 Production in Human Alveolar Epithelial Cells
Int J Mol Sci, 2016-11-12;17(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients
Authors: Veerle Somers
J. Immunol., 2016-11-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models
Authors: Nathalie Castex-Riz
Clin Cosmet Investig Dermatol, 2016-11-10;9(0):421-434.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine
Sci Rep, 2016-11-02;6(0):36355.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Comparative analysis of the interaction of HSPs in dendritic cells, macrophages, RGM-1 cells infected by Helicobacter pylori
Authors: Guangxin Li
Am J Transl Res, 2016-10-15;8(10):4184-4194.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages
J Immunol, 2016-09-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD11c/CD18 Dominates Adhesion of Human Monocytes, Macrophages and Dendritic Cells over CD11b/CD18
PLoS ONE, 2016-09-22;11(9):e0163120.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells
Elife, 2016-09-20;5(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytokines TNF-?, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells.
Authors: Angela P Bastidas-C, Astrid D Bakker, Behrouz Zandieh-D, Cornelis J Kleverlaa, Nathalie Bravenboe, Tim Forouzanf, Jenneke Klein-Nul
Stem Cells International, 2016-09-07;0(0):1687-966X.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Posttranscriptional upregulation of p53 by reactive oxygen species in chronic lymphocytic leukemia
Cancer Res, 2016-09-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Thymic stromal chemokine TSLP acts through Th2 cytokine production to induce cutaneous T cell lymphoma
Cancer Res, 2016-09-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17
PLoS ONE, 2016-09-02;11(9):e0161759.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MiR-146a modulates macrophage polarization in systemic juvenile idiopathic arthritis by targeting INHBA
Mol Immunol, 2016-08-16;77(0):205-212.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
Circ Res, 2016-07-14;0(0):.
Species: Human
Sample Types: Plasma
Applications: Bioassay -
JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE
Authors: Edaire Cheng
PLoS ONE, 2016-06-16;11(6):e0157376.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2
PLoS ONE, 2016-05-24;11(5):e0155771.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD99 isoforms regulate CD1a expression in human monocyte-derived DCs through ATF-2/CREB-1 phosphorylation
Authors: K Mahiddine, A Mallaviall, H Bziouech, F Larbret, A Bernard, G Bernard
Eur J Immunol, 2016-05-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7
Authors: MM Halpert, V Konduri, D Liang, Y Chen, JB Wing, S Paust, JM Levitt, WK Decker
Stem Cells Dev., 2016-05-02;25(10):774-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1
Authors: TM Garcia-Bat, E Kim, F Concha-Ben, S Trivedi, RB Mailliard, A Gambotto, RL Ferris
J. Immunol, 2016-02-05;196(6):2870-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cryptococcus gattii Capsule Blocks Surface Recognition Required for Dendritic Cell Maturation Independent of Internalization and Antigen Processing.
Authors: Huston S, Ngamskulrungroj P, Xiang R, Ogbomo H, Stack D, Li S, Timm-McCann M, Kyei S, Oykhman P, Kwon-Chung K, Mody C
J Immunol, 2016-01-06;196(3):1259-71.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma.
Authors: Chai S, Yap Y, Foo Y, Yap L, Ponniah S, Teo S, Cheong S, Patel V, Lim K
PLoS ONE, 2015-11-04;10(11):e0130464.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression.
Authors: Makela S, Osterlund P, Westenius V, Latvala S, Diamond M, Gale M, Julkunen I
J Virol, 2015-09-16;89(23):12014-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells.
Authors: Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, Deng L, Zanvit P, Tu E, Jin W, Abbatiello B, Goldberg N, Chen Q, Sun L, Zhao K, Chen W
Nat Immunol, 2015-08-31;16(10):1077-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes.
Authors: Eigenbrod T, Pelka K, Latz E, Kreikemeyer B, Dalpke A
J Immunol, 2015-06-22;195(3):1092-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma.
Authors: Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D
J Transl Med, 2015-06-20;13(0):197.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1.
Authors: Shipkowski K, Taylor A, Thompson E, Glista-Baker E, Sayers B, Messenger Z, Bauer R, Jaspers I, Bonner J
PLoS ONE, 2015-06-19;10(6):e0128888.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo.
Authors: Ptaschinski C, Mukherjee S, Moore M, Albert M, Helin K, Kunkel S, Lukacs N
PLoS Pathog, 2015-06-17;11(6):e1004978.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.
Authors: Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, Lidov H, Hopkins G, DU L, Belkadi A, Chrabieh M, Itan Y, Picard C, Fournet J, Eibel H, Tsitsikov E, Pai S, Abel L, Al-Herz W, Casanova J, Israel A, Notarangelo L
J Exp Med, 2015-05-25;212(6):939-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Functional loss of IkappaBepsilon leads to NF-kappaB deregulation in aggressive chronic lymphocytic leukemia.
Authors: Mansouri L, Sutton L, Ljungstrom V, Bondza S, Arngarden L, Bhoi S, Larsson J, Cortese D, Kalushkova A, Plevova K, Young E, Gunnarsson R, Falk-Sorqvist E, Lonn P, Muggen A, Yan X, Sander B, Enblad G, Smedby K, Juliusson G, Belessi C, Rung J, Chiorazzi N, Strefford J, Langerak A, Pospisilova S, Davi F, Hellstrom M, Jernberg-Wiklund H, Ghia P, Soderberg O, Stamatopoulos K, Nilsson M, Rosenquist R
J Exp Med, 2015-05-18;212(6):833-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mechanism of the antigen-independent cytokinergic SPE-7 IgE activation of human mast cells in vitro.
Authors: Bax H, Bowen H, Dodev T, Sutton B, Gould H
Sci Rep, 2015-04-20;5(0):9538.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Wear particles derived from metal hip implants induce the generation of multinucleated giant cells in a 3-dimensional peripheral tissue-equivalent model.
Authors: Dutta D, Potnis P, Rhodes K, Wood S
PLoS ONE, 2015-04-20;10(4):e0124389.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation.
Authors: Bachle S, Sauter D, Sibitz S, Sandberg J, Kirchhoff F, Moll M
Sci Rep, 2015-04-15;5(0):9675.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin.
Authors: Florsheim E, Yu S, Bragatto I, Faustino L, Gomes E, Ramos R, Barbuto J, Medzhitov R, Russo M
J Immunol, 2015-04-15;194(10):4621-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Histamine promotes the development of monocyte-derived dendritic cells and reduces tumor growth by targeting the myeloid NADPH oxidase.
Authors: Martner A, Wiktorin H, Lenox B, Ewald Sander F, Aydin E, Aurelius J, Thoren F, Stahlberg A, Hermodsson S, Hellstrand K
J Immunol, 2015-04-13;194(10):5014-21.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human umbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-beta1 alleviate atopic dermatitis by reducing mast cell degranulation.
Authors: Kim H, Yun J, Shin T, Lee S, Lee B, Yu K, Seo Y, Lee S, Kang T, Choi S, Seo K, Kang K
Stem Cells, 2015-04-01;33(4):1254-66.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Paracoccidioides brasiliensis interferes on dendritic cells maturation by inhibiting PGE2 production.
Authors: Fernandes R, Bachiega T, Rodrigues D, Golim M, Dias-Melicio L, Balderramas H, Kaneno R, Soares A
PLoS ONE, 2015-03-20;10(3):e0120948.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model.
Authors: Yao, Xiujuan, Wang, Wei, Li, Yan, Huang, Ping, Zhang, Qian, Wang, Jingjing, Wang, Wen, Lv, Zhe, An, Yunqing, Qin, Jianguo, Corrigan, Chris J, Huang, Kewu, Sun, Yongchan, Ying, Sun
Respir Res, 2015-03-18;16(0):39.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.
Authors: Curtis J, Luo Y, Zenner H, Cuchet-Lourenco D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu J, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer C, Nurnberg P, Horstmann R, Drobniewski F, Plagnol V, Barrett J, Nejentsev S
Nat Genet, 2015-03-16;47(5):523-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of CD4+ T cells through IL-12 and TGF-beta1.
Authors: Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R
Proc Natl Acad Sci U S A, 2015-02-17;112(9):E957-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
Authors: Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C
Respir Res, 2015-02-07;16(0):14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
Authors: Herova M, Schmid M, Gemperle C, Hersberger M
J Immunol, 2015-01-30;194(5):2330-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.
Authors: Ranzani, Valeria, Rossetti, Grazisa, Panzeri, Ilaria, Arrigoni, Alberto, Bonnal, Raoul J, Curti, Serena, Gruarin, Paola, Provasi, Elena, Sugliano, Elisa, Marconi, Maurizio, De Francesco, Raffaele, Geginat, Jens, Bodega, Beatrice, Abrignani, Sergio, Pagani, Massimil
Nat Immunol, 2015-01-26;16(3):318-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Association of antigen-specific T-cell responses with antigen expression and immunoparalysis in multiple myeloma.
Authors: Fichtner S, Hose D, Engelhardt M, Meissner T, Neuber B, Krasniqi F, Raab M, Schonland S, Ho A, Goldschmidt H, Hundemer M
Clin Cancer Res, 2015-01-21;21(7):1712-21.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Viral semaphorin inhibits dendritic cell phagocytosis and migration but is not essential for gammaherpesvirus-induced lymphoproliferation in malignant catarrhal fever.
Authors: Myster F, Palmeira L, Sorel O, Bouillenne F, DePauw E, Schwartz-Cornil I, Vanderplasschen A, Dewals B
J Virol, 2015-01-14;89(7):3630-47.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay -
CD40L induces functional tunneling nanotube networks exclusively in dendritic cells programmed by mediators of type 1 immunity.
Authors: Zaccard C, Watkins S, Kalinski P, Fecek R, Yates A, Salter R, Ayyavoo V, Rinaldo C, Mailliard R
J Immunol, 2014-12-29;194(3):1047-56.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT.
Authors: Holmes T, Wilson E, Black E, Benest A, Vaz C, Tan B, Tanavde V, Cook G
Proc Natl Acad Sci U S A, 2014-12-15;111(52):E5688-96.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
Cancer Res, 2014-12-09;75(2):306-15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.
Authors: Lam, Sharon, Sung, Julia, Cruz, Conrad, Castillo-Caro, Paul, Ngo, Minhtran, Garrido, Carolina, Kuruc, Joann, Archin, Nancie, Rooney, Cliona, Margolis, David, Bollard, Catherin
Mol Ther, 2014-11-04;23(2):387-95.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytotoxicity of human endogenous retrovirus K-specific T cells toward autologous ovarian cancer cells.
Authors: Rycaj K, Plummer J, Yin B, Li M, Garza J, Radvanyi L, Ramondetta L, Lin K, Johanning G, Tang D, Wang-Johanning F
Clin Cancer Res, 2014-11-04;21(2):471-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Low molecular weight hyaluronan-pulsed human dendritic cells showed increased migration capacity and induced resistance to tumor chemoattraction.
Authors: Rizzo M, Bayo J, Piccioni F, Malvicini M, Fiore E, Peixoto E, Garcia M, Aquino J, Gonzalez Campana A, Podesta G, Terres M, Andriani O, Alaniz L, Mazzolini G
PLoS ONE, 2014-09-19;9(9):e107944.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.
Authors: Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L
J Clin Invest, 2014-09-17;124(10):4657-67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
Authors: Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L
PLoS ONE, 2014-09-03;9(9):e106673.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.
Authors: Hedl M, Abraham C
Proc Natl Acad Sci U S A, 2014-09-02;111(37):13451-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dengue virus-infected human dendritic cells reveal hierarchies of naturally expressed novel NS3 CD8 T cell epitopes.
Authors: Piazza P, Campbell D, Marques E, Hildebrand W, Buchli R, Mailliard R, Rinaldo C
Clin Exp Immunol, 2014-09-01;177(3):696-702.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Immunopathogenesis of HIV infection in cocaine users: role of arachidonic acid.
Authors: Samikkannu T, Rao K, Ding H, Agudelo M, Raymond A, Yoo C, Nair M
PLoS ONE, 2014-08-29;9(8):e106348.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant.
Authors: Saenz R, Futalan D, Leutenez L, Eekhout F, Fecteau J, Sundelius S, Sundqvist S, Larsson M, Hayashi T, Minev B, Carson D, Esener S, Messmer B, Messmer D
J Transl Med, 2014-08-14;12(0):211.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nitric oxide enhances Th9 cell differentiation and airway inflammation.
Authors: Niedbala W, Besnard A, Nascimento D, Donate P, Sonego F, Yip E, Guabiraba R, Chang H, Fukada S, Salmond R, Schmitt E, Bopp T, Ryffel B, Liew F
Nat Commun, 2014-08-07;5(0):4575.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy.
Authors: Berlin C, Kowalewski D, Schuster H, Mirza N, Walz S, Handel M, Schmid-Horch B, Salih H, Kanz L, Rammensee H, Stevanovic S, Stickel J
Leukemia, 2014-08-05;29(3):647-59.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.
Authors: Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K
J Immunol, 2014-07-30;193(5):2297-305.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10.
Authors: Engler D, Reuter S, van Wijck Y, Urban S, Kyburz A, Maxeiner J, Martin H, Yogev N, Waisman A, Gerhard M, Cover T, Taube C, Muller A
Proc Natl Acad Sci U S A, 2014-07-29;111(32):11810-5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Treatment with chemotherapy and dendritic cells pulsed with multiple Wilms' tumor 1 (WT1)-specific MHC class I/II-restricted epitopes for pancreatic cancer.
Authors: Koido S, Homma S, Okamoto M, Takakura K, Mori M, Yoshizaki S, Tsukinaga S, Odahara S, Koyama S, Imazu H, Uchiyama K, Kajihara M, Arakawa H, Misawa T, Toyama Y, Yanagisawa S, Ikegami M, Kan S, Hayashi K, Komita H, Kamata Y, Ito M, Ishidao T, Yusa S, Shimodaira S, Gong J, Sugiyama H, Ohkusa T, Tajiri H
Clin Cancer Res, 2014-07-23;20(16):4228-39.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.
Authors: Deng B, Wang C, Arnardottir H, Li Y, Cheng C, Dalli J, Serhan C
PLoS ONE, 2014-07-18;9(7):e102362.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The regulation and role of c-FLIP in human Th cell differentiation.
Authors: Kylaniemi M, Kaukonen R, Myllyviita J, Rasool O, Lahesmaa R
PLoS ONE, 2014-07-14;9(7):e102022.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Monocyte-derived dendritic cells from Crohn's disease patients exhibit decreased ability to activate T helper type 17 responses in memory cells.
Authors: Nieminen J, Sipponen T, Farkkila M, Vaarala O
Clin Exp Immunol, 2014-07-01;177(1):190-202.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Live attenuated B. pertussis BPZE1 rescues the immune functions of Respiratory Syncytial virus infected human dendritic cells by promoting Th1/Th17 responses.
Authors: Schiavoni I, Fedele G, Quattrini A, Bianco M, Schnoeller C, Openshaw P, Locht C, Ausiello C
PLoS ONE, 2014-06-26;9(6):e100166.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
NK cells are primed by ANRS MVA(HIV)-infected DCs, via a mechanism involving NKG2D and membrane-bound IL-15, to control HIV-1 infection in CD4+ T cells.
Authors: Moreno-Nieves U, Didier C, Levy Y, Barre-Sinoussi F, Scott-Algara D
Eur J Immunol, 2014-06-24;44(8):2370-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cells restore CD8+ T cell reactivity to autologous HIV-1.
Authors: Smith K, Mailliard R, Larsen B, Wong K, Gupta P, Mullins J, Rinaldo C
J Virol, 2014-06-18;88(17):9976-90.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Biological activities and phytochemical profiles of extracts from different parts of bamboo (Phyllostachys pubescens).
Authors: Tanaka, Akinobu, Zhu, Qinchang, Tan, Hui, Horiba, Hiroki, Ohnuki, Koichiro, Mori, Yasuhiro, Yamauchi, Ryoko, Ishikawa, Hiroya, Iwamoto, Akira, Kawahara, Hiroharu, Shimizu, Kuniyosh
Molecules, 2014-06-18;19(6):8238-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Combinatorial flexibility of cytokine function during human T helper cell differentiation.
Authors: Touzot M, Grandclaudon M, Cappuccio A, Satoh T, Martinez-Cingolani C, Servant N, Manel N, Soumelis V
Nat Commun, 2014-05-28;5(0):3987.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.
Authors: Hedl M, Zheng S, Abraham C
J Immunol, 2014-05-19;192(12):5924-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Analysis of somatic hypermutations in the IgM switch region in human B cells.
Authors: Horiuchi K, Imai K, Mitsui-Sekinaka K, Yeh T, Ochs H, Durandy A, Nonoyama S
J Allergy Clin Immunol, 2014-05-15;134(2):411-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1beta-stimulated production of chemokines and matrix-degrading enzymes in vitro.
Authors: Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, Trisolino G, Facchini A, Borzi R, Meliconi R
PLoS ONE, 2014-05-12;9(5):e96925.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
Authors: Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D
J Clin Invest, 2014-05-08;124(6):2513-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Novel avian influenza A (H7N9) virus induces impaired interferon responses in human dendritic cells.
Authors: Arilahti V, Makela S, Tynell J, Julkunen I, Osterlund P
PLoS ONE, 2014-05-07;9(5):e96350.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair.
Authors: MacLeod A, Rudolph R, Corriden R, Ye I, Garijo O, Havran W
J Immunol, 2014-05-07;192(12):5695-702.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Alterations in cholesterol metabolism restrict HIV-1 trans infection in nonprogressors.
Authors: Rappocciolo, Giovanna, Jais, Mariel, Piazza, Paolo, Reinhart, Todd A, Berendam, Stella J, Garcia-Exposito, Laura, Gupta, Phalguni, Rinaldo, Charles
MBio, 2014-04-29;5(3):e01031-13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia.
Authors: Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R
Eur J Immunol, 2014-04-15;44(7):2175-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neuropeptide Y induces potent migration of human immature dendritic cells and promotes a Th2 polarization.
Authors: Buttari B, Profumo E, Domenici G, Tagliani A, Ippoliti F, Bonini S, Businaro R, Elenkov I, Rigano R
FASEB J, 2014-04-03;28(7):3038-49.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Reversal of tumor immune inhibition using a chimeric cytokine receptor.
Authors: Leen A, Sukumaran S, Watanabe N, Mohammed S, Keirnan J, Yanagisawa R, Anurathapan U, Rendon D, Heslop H, Rooney C, Brenner M, Vera J
Mol Ther, 2014-03-20;22(6):1211-20.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia.
Authors: Walsby E, Buggins A, Devereux S, Jones C, Pratt G, Brennan P, Fegan C, Pepper C
Blood, 2014-03-17;123(23):3607-17.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate B cell growth.
Authors: Caccuri, Francesc, Giagulli, Cinzia, Reichelt, Joachim, Martorelli, Debora, Marsico, Stefania, Bugatti, Antonell, Barone, Ines, Rusnati, Marco, Guzman, Carlos A, Dolcetti, Riccardo, Caruso, Arnaldo
J Virol, 2014-03-12;88(10):5706-17.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The molecule of DC-SIGN captures enterovirus 71 and confers dendritic cell-mediated viral trans-infection.
Authors: Ren X, Ma L, Liu Q, Li C, Huang Z, Wu L, Xiong S, Wang J, Wang H
Virol J, 2014-03-12;11(0):47.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human metapneumovirus M2-2 protein inhibits innate immune response in monocyte-derived dendritic cells.
Authors: Ren J, Liu G, Go J, Kolli D, Zhang G, Bao X
PLoS ONE, 2014-03-11;9(3):e91865.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response.
Authors: Chu H, Zhou J, Wong B, Li C, Cheng Z, Lin X, Poon V, Sun T, Lau C, Chan J, To K, Chan K, Lu L, Zheng B, Yuen K
Virology, 2014-03-07;454(0):197-205.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation.
Authors: Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L
Eur J Immunol, 2014-02-18;44(5):1330-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma.
Authors: Gunawardana J, Chan F, Telenius A, Woolcock B, Kridel R, Tan K, Ben-Neriah S, Mottok A, Lim R, Boyle M, Rogic S, Rimsza L, Guiter C, Leroy K, Gaulard P, Haioun C, Marra M, Savage K, Connors J, Shah S, Gascoyne R, Steidl C
Nat Genet, 2014-02-16;46(4):329-35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Adenovirus-based vaccines against rhesus lymphocryptovirus EBNA-1 induce expansion of specific CD8+ and CD4+ T cells in persistently infected rhesus macaques.
Authors: Leskowitz, R, Fogg, M H, Zhou, X Y, Kaur, A, Silveira, E L V, Villinger, F, Lieberman, P M, Wang, F, Ertl, H C
J Virol, 2014-02-12;88(9):4721-35.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses.
Authors: Herath S, Benlahrech A, Papagatsias T, Athanasopoulos T, Bouzeboudjen Z, Hervouet C, Klavinskis L, Meiser A, Kelleher P, Dickson G, Patterson S
PLoS ONE, 2014-02-05;9(2):e88327.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis.
Authors: Liu J, Harberts E, Tammaro A, Girardi N, Filler R, Fishelevich R, Temann A, Licona-Limon P, Girardi M, Flavell R, Gaspari A
J Invest Dermatol, 2014-01-31;134(7):1903-11.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of the structure and immunostimulatory activity of a vaccine adjuvant, de-O-acylated lipooligosaccharide.
Authors: Han, Ji Eun, Wui, Seo Ri, Kim, Kwang Su, Cho, Yang Je, Cho, Wan Je, Lee, Na Gyong
PLoS ONE, 2014-01-22;9(1):e85838.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human CD19 and CD40L deficiencies impair antibody selection and differentially affect somatic hypermutation.
Authors: van Zelm M, Bartol S, Driessen G, Mascart F, Reisli I, Franco J, Wolska-Kusnierz B, Kanegane H, Boon L, van Dongen J, van der Burg M
J Allergy Clin Immunol, 2014-01-11;134(1):135-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Novel regulation of CD80/CD86-induced phosphatidylinositol 3-kinase signaling by NOTCH1 protein in interleukin-6 and indoleamine 2,3-dioxygenase production by dendritic cells.
Authors: Koorella C, Nair J, Murray M, Carlson L, Watkins S, Lee K
J Biol Chem, 2014-01-10;289(11):7747-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes.
Authors: Suzuki, Hitoshi, Raska, Milan, Yamada, Koshi, Moldoveanu, Zina, Julian, Bruce A, Wyatt, Robert J, Tomino, Yasuhiko, Gharavi, Ali G, Novak, Jan
J Biol Chem, 2014-01-07;289(8):5330-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype.
Authors: Garcia S, Krausz S, Ambarus C, Fernandez B, Hartkamp L, van Es I, Hamann J, Baeten D, Tak P, Reedquist K
PLoS ONE, 2014-01-03;9(1):e82088.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The IL-23/Th17 axis is involved in the adaptive immune response to Bacillus anthracis in humans.
Authors: Harris K, Ramachandran G, Basu S, Rollins S, Mann D, Cross A
Eur J Immunol, 2014-01-02;44(3):752-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cocaine enhances HIV-1 infectivity in monocyte derived dendritic cells by suppressing microRNA-155.
Authors: Napuri, Jessica, Pilakka-Kanthikeel, Sudheesh, Raymond, Andrea, Agudelo, Marisela, Yndart-Arias, Adriana, Saxena, Shailend, Nair, Madhavan
PLoS ONE, 2013-12-31;8(12):e83682.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Identification of novel human leukocyte antigen-A*0201-restricted, cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy.
Authors: Ji, Jianfei, Judkowski, Valeria, Liu, Gentao, Wang, Hongqian, Bunying, Alcinett, Li, Zhenhua, Xu, Minlin, Bender, James, Pinilla, Clemenci, Yu, John S
Stem Cells Transl Med, 2013-12-27;3(3):356-64.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18.
Authors: Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H
PLoS ONE, 2013-12-20;8(12):e82586.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
PaCS is a novel cytoplasmic structure containing functional proteasome and inducible by cytokines/trophic factors.
Authors: Sommi, Patrizia, Necchi, Vittorio, Vitali, Agostina, Montagna, Daniela, De Luigi, Ada, Salmona, Mario, Ricci, Vittorio, Solcia, Enrico
PLoS ONE, 2013-12-17;8(12):e82560.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.
Authors: Sharquie I, Al-Ghouleh A, Fitton P, Clark M, Armour K, Sewell H, Shakib F, Ghaemmaghami A
BMC Immunol, 2013-12-13;14(0):54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains.
Authors: Cavrois, Marielle, Neidleman, Jason, Santiago, Mario L, Derdeyn, Cynthia, Hunter, Eric, Greene, Warner C
J Virol, 2013-12-11;88(4):2083-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Serum level of IL-10 is increased in patients with endometriosis, and IL-10 promotes the growth of lesions in a murine model.
Authors: Suen J, Chang Y, Chiu P, Hsieh T, Hsi E, Chen Y, Chen Y, Tsai E
Am J Pathol, 2013-12-08;184(2):464-71.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2.
Authors: Engstrom A, Erlandsson A, Delbro D, Wijkander J
Int J Oncol, 2013-12-02;44(2):385-92.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Two wheat decapeptides prevent gliadin-dependent maturation of human dendritic cells.
Authors: Giordani L, Del Pinto T, Vincentini O, Felli C, Silano M, Viora M
Exp Cell Res, 2013-11-19;321(2):248-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD169 mediates the capture of exosomes in spleen and lymph node.
Authors: Saunderson S, Dunn A, Crocker P, McLellan A
Blood, 2013-11-19;123(2):208-16.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression.
Authors: Otsuka A, Doi H, Egawa G, Maekawa A, Fujita T, Nakamizo S, Nakashima C, Nakajima S, Watanabe T, Miyachi Y, Narumiya S, Kabashima K
J Allergy Clin Immunol, 2013-09-20;133(1):139-46.e1-10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines.
Authors: Spiess C, Bevers J, Jackman J, Chiang N, Nakamura G, Dillon M, Liu H, Molina P, Elliott J, Shatz W, Scheer J, Giese G, Persson J, Zhang Y, Dennis M, Giulianotti J, Gupta P, Reilly D, Palma E, Wang J, Stefanich E, Scheerens H, Fuh G, Wu L
J Biol Chem, 2013-07-23;288(37):26583-93.
Species: Human, Rat
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, Immunization -
Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization.
Authors: Hawkins R, Larjo A, Tripathi S, Wagner U, Luu Y, Lonnberg T, Raghav S, Lee L, Lund R, Ren B, Lahdesmaki H, Lahesmaa R
Immunity, 2013-06-20;38(6):1271-84.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease.
Authors: Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume M, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, Koganei K, Sugita A, Kanai T, Hibi T
Immunology, 2013-05-01;139(1):19-29.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells.
Authors: Cai, Minchao, Wu, Jing, Mao, Chaoming, Ren, Jianmin, Li, Pu, Li, Xiao, Zhong, Jiuchang, Xu, Chundi, Zhou, Tong
J Transl Med, 2013-04-29;11(0):103.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Genome-wide analysis of alternative splicing during dendritic cell response to a bacterial challenge.
Authors: Rodrigues R, Grosso A, Moita L
PLoS ONE, 2013-04-17;8(4):e61975.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Griffithsin protects mice from genital herpes by preventing cell-to-cell spread.
Authors: Nixon, Briana, Stefanidou, Martha, Mesquita, Pedro M, Fakioglu, Esra, Segarra, Theodore, Rohan, Lisa, Halford, William, Palmer, Kenneth, Herold, Betsy C
J Virol, 2013-03-27;87(11):6257-69.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway.
Authors: Chen, Qian, Swaminathan, Sanjay, Yang, De, Dai, Lue, Sui, Hongyan, Yang, Jun, Hornung, Ronald L, Wang, Yanmei, Huang, Da Wei, Hu, Xiaojun, Lempicki, Richard, Imamichi, Tomozumi
PLoS ONE, 2013-03-20;8(3):e59194.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells.
Authors: Madsen J, Gaiha G, Palaniyar N, Dong T, Mitchell D, Clark H
PLoS ONE, 2013-03-18;8(3):e59047.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans.
Authors: Oosterhoff D, Heusinkveld M, Lougheed S, Kosten I, Lindstedt M, Bruijns S, van Es T, van Kooyk Y, van der Burg S, de Gruijl T
J Immunol, 2013-03-06;190(7):3338-45.
Species: Human
Sample Types: Whole Tissue
Applications: Ex Vivo -
Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes.
Authors: Dong J, Chang H, Ivascu C, Qian Y, Rezai S, Okhrimenko A, Cosmi L, Maggi L, Eckhardt F, Wu P, Sieper J, Alexander T, Annunziato F, Gossen M, Li J, Radbruch A, Thiel A
Eur J Immunol, 2013-03-01;43(3):793-804.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes.
Authors: Hirayama M, Nishikawa H, Nagata Y, Tsuji T, Kato T, Kageyama S, Ueda S, Sugiyama D, Hori S, Sakaguchi S, Ritter G, Old L, Gnjatic S, Shiku H
Eur J Immunol, 2013-02-26;43(4):989-1000.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
Authors: Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R
Clin Cancer Res, 2013-02-26;19(7):1858-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IFN-alpha induces APOBEC3G, F, and A in immature dendritic cells and limits HIV-1 spread to CD4+ T cells.
Authors: Mohanram V, Skold A, Bachle S, Pathak S, Spetz A
J Immunol, 2013-02-20;190(7):3346-53.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency.
Authors: Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A
J Allergy Clin Immunol, 2013-02-10;131(4):1146-56, 1156.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
Authors: Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B
Sci Rep, 2013-01-01;3(0):1540.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages.
Authors: Gemperle C, Schmid M, Herova M, Marti-Jaun J, Wuest S, Loretz C, Hersberger M
PLoS ONE, 2012-11-21;7(11):e50195.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients.
Authors: Brusic, Ana, Hainz, Ursula, Wadleigh, Martha, Neuberg, Donna, Su, Mei, Canning, Christin, Deangelo, Daniel J, Stone, Richard, Lee, Jeng-Shi, Mulligan, Richard, Ritz, Jerome, Dranoff, Glenn, Sasada, Tetsuro, Wu, Catherin
Oncoimmunology, 2012-10-01;1(7):1095-1103.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma.
Authors: Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J
PLoS ONE, 2012-10-01;7(10):e46117.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
PLoS Biol, 2012-09-25;10(9):e1001395.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
AAV2/IL-12 gene delivery into dendritic cells (DC) enhances CTL stimulation above other IL-12 applications: Evidence for IL-12 intracrine activity in DC.
Authors: You C, Shi M, Liu Y, Cao M, Luo R, Hermonat P
Oncoimmunology, 2012-09-01;1(6):847-855.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase.
Authors: Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Hornsell WG, Guler R, Campanero-Rhodes MA, Palma AS, Feizi T, Kim SK, Sobieszczuk P, Willment JA, Brown GD
J. Biol. Chem., 2012-06-11;287(31):25964-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
PLoS ONE, 2012-04-18;7(4):e34965.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
Authors: Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M
Eur. J. Immunol., 2012-04-01;42(4):936-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Antigen-independent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway.
Authors: Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA
J. Immunol., 2012-03-14;188(8):3745-56.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A.
Authors: Nielsen N, Odum N, Urso B, Lanier LL, Spee P
PLoS ONE, 2012-02-22;7(2):e31959.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency.
Authors: Kawamura T, Ogawa Y, Nakamura Y
J. Clin. Invest., 2012-01-03;122(2):722-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry.
Authors: Osterlund P, Strengell M, Sarin L, Poranen M, Fagerlund R, Melen K, Julkunen I
J Virol, 2012;86(20):11183-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Measles virus causes immunogenic cell death in human melanoma.
Authors: Donnelly, O G, Errington-Mais, F, Steele, L, Hadac, E, Jennings, V, Scott, K, Peach, H, Phillips, R M, Bond, J, Pandha, H, Harrington, K, Vile, R, Russell, S, Selby, P, Melcher, A A
Gene Ther, 2011-12-15;20(1):7-15.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Expression and regulation of CCL15 by human airway smooth muscle cells.
Authors: Joubert P, Lajoie-Kadoch S, Wellemans V, Létuvé S, Tulic MK, Halayko AJ, Hamid Q
Clin. Exp. Allergy, 2011-11-09;42(1):85-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission.
Authors: Beck B, Dorfel D, Lichtenegger FS, Geiger C, Lindner L, Merk M, Schendel DJ, Subklewe M
J Transl Med, 2011-09-13;9(0):151.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
Authors: Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W
J. Immunol., 2011-06-10;187(2):748-59.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae.
Authors: Novotny LA, Clements JD, Bakaletz LO
Mucosal Immunol, 2011-02-16;4(4):456-67.
Species: Chinchilla
Sample Types: Whole Cells
Applications: Bioassay -
HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.
Authors: Song W, Tai YT, Tian Z, Hideshima T, Chauhan D, Nanjappa P, Exley MA, Anderson KC, Munshi NC
Leukemia, 2010-11-19;25(1):161-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression.
Authors: Xu H, Wang X, Pahar B
J. Immunol., 2010-11-08;185(12):7340-8.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
The implication of aberrant GM-CSF expression in decidual cells in the pathogenesis of preeclampsia.
Authors: Huang SJ, Zenclussen AC, Chen CP, Basar M, Yang H, Arcuri F, Li M, Kocamaz E, Buchwalder L, Rahman M, Kayisli U, Schatz F, Toti P, Lockwood CJ
Am. J. Pathol., 2010-09-09;177(5):2472-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration.
Authors: Johnson LA, Jackson DG
Int. Immunol., 2010-08-25;22(10):839-49.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of dynamin-dependent endocytosis interferes with type III IFN expression in bacteria-infected human monocyte-derived DCs.
Authors: Pietila TE, Latvala S, Osterlund P, Julkunen I
J. Leukoc. Biol., 2010-07-07;88(4):665-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma.
Authors: Miyagaki T, Sugaya M, Fujita H
J. Invest. Dermatol., 2010-05-27;130(9):2304-11.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.
Authors: Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH
Nat. Immunol., 2010-05-02;11(6):527-34.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis.
Authors: Ha CT, Wu JA, Irmak S, Lisboa FA, Dizon AM, Warren JW, Ergun S, Dveksler GS
Biol. Reprod., 2010-03-24;83(1):27-35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-4 enhances IFN-lambda1 (IL-29) production by plasmacytoid DCs via monocyte secretion of IL-1Ra.
Authors: Megjugorac NJ, Gallagher GE, Gallagher G
Blood, 2010-03-16;115(21):4185-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TSLP and downstream molecules in experimental mouse allergic conjunctivitis.
Authors: Zheng X, Ma P, De Paiva CS, Cunningham MA, Hwang CS, Pflugfelder SC, Li DQ
Invest. Ophthalmol. Vis. Sci., 2010-01-27;51(6):3076-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.
Authors: Kishuku M, Nishioka Y, Abe S, Kishi J, Ogino H, Aono Y, Azuma M, Kinoshita K, Batmunkh R, Rentsenhand B, Makino H, Ranjan P, Minakuchi K, Sone S
J. Immunol., 2009-12-15;183(12):8176-85.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
Authors: Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW
Mucosal Immunol, 2009-10-07;3(1):40-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms.
Authors: Correale J, Farez M
J. Immunol., 2009-10-07;183(9):5999-6012.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses.
Authors: Duraisingham SS, Hornig J, Gotch F, Patterson S
J. Immunol., 2009-07-22;183(4):2242-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Autologous melanoma vaccine induces antitumor and self-reactive immune responses that affect patient survival and depend on MHC class II expression on vaccine cells.
Authors: Lotem M, Machlenkin A, Hamburger T, Nissan A, Kadouri L, Frankenburg S, Gimmon Z, Elias O, David IB, Kuznetz A, Shiloni E, Peretz T
Clin. Cancer Res., 2009-07-14;15(15):4968-77.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.
Authors: Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT
Clin. Immunol., 2009-06-25;133(1):27-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
Authors: Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
Eur. J. Immunol., 2009-05-01;39(5):1221-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
JNK is constitutively active in mantle cell lymphoma: cell cycle deregulation and polyploidy by JNK inhibitor SP600125.
Authors: Wang M, Atayar C, Rosati S, Bosga-Bouwer A, Kluin P, Visser L
J. Pathol., 2009-05-01;218(1):95-103.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids.
Authors: Le TA, Takai T, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H
Allergy, 2009-03-27;64(8):1231-2.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Epitope specificity and clonality of EBV-specific CTLs used to treat posttransplant lymphoproliferative disease.
Authors: McAulay KA, Haque T, Urquhart G, Bellamy C, Guiretti D, Crawford DH
J. Immunol., 2009-03-15;182(6):3892-901.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation.
Authors: Ogawa Y, Kawamura T, Kimura T, Ito M, Blauvelt A, Shimada S
Blood, 2009-03-11;113(21):5157-66.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
In vitro neutralization of tumor necrosis factor-alpha during Chlamydia pneumoniae infection impairs dendritic cells maturation/function and increases chlamydial progeny.
Authors: Njau F, Wittkop U, Rohde M, Haller H, Klos A, Wagner AD
FEMS Immunol. Med. Microbiol., 2009-03-01;55(2):215-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
FcepsilonRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells.
Authors: Okayama Y, Okumura S, Sagara H, Yuki K, Sasaki T, Watanabe N, Fueki M, Sugiyama K, Takeda K, Fukuda T, Saito H, Ra C
Eur. Respir. J., 2009-01-22;34(2):425-35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.
Authors: Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ
Invest. Ophthalmol. Vis. Sci., 2009-01-17;50(6):2702-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.
Authors: Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H
J. Allergy Clin. Immunol., 2008-12-03;123(1):179-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells.
Authors: Hirosako S, Goto E, Fujii K, Tsumori K, Hirata N, Tsumura S, Kamohara H, Kohrogi H
Clin. Exp. Immunol., 2008-11-26;155(2):266-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Redox regulation of interleukin-4 signaling.
Authors: Sharma P, Chakraborty R, Wang L, Min B, Tremblay ML, Kawahara T, Lambeth JD, Haque SJ
Immunity, 2008-10-17;29(4):551-64.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway.
Authors: Aoudjehane L, Pissaia A, Scatton O, Podevin P, Massault PP, Chouzenoux S, Soubrane O, Calmus Y, Conti F
Lab. Invest., 2008-07-14;88(9):973-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Adenosine receptors in regulation of dendritic cell differentiation and function.
Authors: Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
Blood, 2008-06-17;112(5):1822-31.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation.
Authors: Jasny E, Eisenblatter M, Matz-Rensing K, Tenner-Racz K, Tenbusch M, Schrod A, Stahl-Hennig C, Moos V, Schneider T, Racz P, Uberla K, Kaup FJ, Ignatius R
J. Immunol., 2008-05-15;180(10):6629-39.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12.
Authors: Lamhamedi-Cherradi SE, Martin RE, Ito T, Kheradmand F, Corry DB, Liu YJ, Moyle M
J. Immunol., 2008-05-01;180(9):6000-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RNA-loaded CD40-activated B cells stimulate antigen-specific T-cell responses in dogs with spontaneous lymphoma.
Authors: Mason NJ, Coughlin CM, Overley B, Cohen JN, Mitchell EL, Colligon TA, Clifford CA, Zurbriggen A, Sorenmo KU, Vonderheide RH
Gene Ther., 2008-03-13;15(13):955-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62.
Applications: ELISA (Standard) -
Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes.
Authors: Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R
J. Leukoc. Biol., 2008-02-15;83(5):1181-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua.
Authors: Huang SJ, Chen CP, Schatz F, Rahman M, Abrahams VM, Lockwood CJ
J. Pathol., 2008-02-01;214(3):328-36.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.
Authors: Christophi GP, Hudson CA, Gruber RC, Christophi CP, Mihai C, Mejico LJ, Jubelt B, Massa PT
Lab. Invest., 2008-01-21;88(3):243-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression and regulation of CCR1 by airway smooth muscle cells in asthma.
Authors: Joubert P, Lajoie-Kadoch S, Welman M, Dragon S, Letuvee S, Tolloczko B, Halayko AJ, Gounni AS, Maghni K, Hamid Q
J. Immunol., 2008-01-15;180(2):1268-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia.
Authors: Baskar S, Kwong KY, Hofer T, Levy JM, Kennedy MG, Lee E, Staudt LM, Wilson WH, Wiestner A, Rader C
Clin. Cancer Res., 2008-01-15;14(2):396-404.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.
Authors: Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F
J. Clin. Invest., 2007-12-01;117(12):3868-3878.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling.
Authors: Liotta F, Angeli R, Cosmi L, Fili L, Manuelli C, Frosali F, Mazzinghi B, Maggi L, Pasini A, Lisi V, Santarlasci V, Consoloni L, Angelotti ML, Romagnani P, Parronchi P, Krampera M, Maggi E, Romagnani S, Annunziato F
Stem Cells, 2007-10-25;26(1):279-89.
Applications: ELISA (Standard) -
Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays.
Authors: Pfleger C, Schloot N, ter Veld F
J. Immunol. Methods, 2007-10-22;329(1):214-8.
Applications: ELISA (Standard) -
Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
Authors: Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW
Transplantation, 2007-07-27;84(2):196-206.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells.
Authors: Kato A, Favoreto S, Avila PC, Schleimer RP
J. Immunol., 2007-07-15;179(2):1080-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL.
Authors: He B, Xu W, Santini PA
Immunity, 2007-06-01;26(6):812-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transcriptional response of human dendritic cells to Borrelia garinii--defective CD38 and CCR7 expression detected.
Authors: Hartiala P, Hytonen J, Pelkonen J, Kimppa K, West A, Penttinen MA, Suhonen J, Lahesmaa R, Viljanen MK
J. Leukoc. Biol., 2007-04-17;82(1):33-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells.
Authors: Bayry J, Triebel F, Kaveri SV, Tough DF
J. Immunol., 2007-04-01;178(7):4184-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Lewis X oligosaccharides targeting to DC-SIGN enhanced antigen-specific immune response.
Authors: Wang J, Zhang Y, Wei J, Zhang X, Zhang B, Zhu Z, Zou W, Wang Y, Mou Z, Ni B, Wu Y
Immunology, 2007-03-20;121(2):174-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells.
Authors: Ettinger R, Sims GP, Robbins R, Withers D, Fischer RT, Grammer AC, Kuchen S, Lipsky PE
J. Immunol., 2007-03-01;178(5):2872-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD28-mediated regulation of multiple myeloma cell proliferation and survival.
Authors: Bahlis NJ, King AM, Kolonias D, Carlson LM, Liu HY, Hussein MA, Terebelo HR, Byrne GE, Levine BL, Boise LH, Lee KP
Blood, 2007-02-20;109(11):5002-10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
Blood, 2007-02-08;109(10):4272-9.
Applications: ELISA (Standard) -
Interleukin-4 induces human hepatocyte apoptosis through a Fas-independent pathway.
Authors: Aoudjehane L, Podevin P, Scatton O, Jaffray P, Dusanter-Fourt I, Feldmann G, Massault PP, Grira L, Bringuier A, Dousset B, Chouzenoux S, Soubrane O, Calmus Y, Conti F
FASEB J., 2007-02-05;21(7):1433-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells.
Authors: De Fanis U, Mori F, Kurnat RJ, Lee WK, Bova M, Adkinson NF, Casolaro V
Blood, 2007-01-18;109(10):4343-50.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.
Authors: Pietila TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I
J. Immunol., 2007-01-01;178(1):253-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.
Authors: Kurooka M, Kaneda Y
Cancer Res., 2007-01-01;67(1):227-36.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
Authors: Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
AIDS, 2007;21(10):1263-72.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard) -
C-reactive protein impairs human CD14+ monocyte-derived dendritic cell differentiation, maturation and function.
Authors: Zhang R, Becnel L, Li M, Chen C, Yao Q
Eur. J. Immunol., 2006-11-01;36(11):2993-3006.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Der p, IL-4, and TGF-beta cooperatively induce EGFR-dependent TARC expression in airway epithelium.
Authors: Heijink IH, Marcel Kies P, van Oosterhout AJ, Postma DS, Kauffman HF, Vellenga E
Am. J. Respir. Cell Mol. Biol., 2006-10-05;36(3):351-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naive CD4+ T cells.
Authors: Mesturini R, Nicola S, Chiocchetti A, Bernardone IS, Castelli L, Bensi T, Ferretti M, Comi C, Dong C, Rojo JM, Yagi J, Dianzani U
Eur. J. Immunol., 2006-10-01;36(10):2601-12.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Allergic airway inflammation inhibits pulmonary antibacterial host defense.
Authors: Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R
J. Immunol., 2006-08-01;177(3):1833-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cells can turn CD4+ T lymphocytes into vascular endothelial growth factor-carrying cells by intercellular neuropilin-1 transfer.
Authors: Bourbie-Vaudaine S, Blanchard N, Hivroz C, Romeo PH
J. Immunol., 2006-08-01;177(3):1460-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modification of TLR-induced activation of human dendritic cells by type I IFN: synergistic interaction with TLR4 but not TLR3 agonists.
Authors: Walker J, Tough DF
Eur. J. Immunol., 2006-07-01;36(7):1827-36.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Diesel exhaust exposure favors TH2 cell recruitment in nonatopic subjects by differentially regulating chemokine production.
Authors: Chang Y, Senechal S, de Nadai P, Chenivesse C, Gilet J, Vorng H, Legendre B, Tonnel AB, Wallaert B, Lassalle P, Tsicopoulos A
J. Allergy Clin. Immunol., 2006-06-21;118(2):354-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines.
Authors: Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B
Clin. Immunol., 2006-06-16;120(2):220-31.
Applications: ELISA (Standard) -
IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.
Authors: Vaknin-Dembinsky A, Balashov K, Weiner HL
J. Immunol., 2006-06-15;176(12):7768-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumor-derived TGFbeta-1 induces dendritic cell apoptosis in the sentinel lymph node.
Authors: Ito M, Minamiya Y, Kawai H, Saito S, Saito H, Nakagawa T, Imai K, Hirokawa M, Ogawa J
J. Immunol., 2006-05-01;176(9):5637-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
Authors: Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R
Eur. J. Immunol., 2006-05-01;36(5):1309-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.
Authors: Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson PM, Bhardwaj N
Blood, 2006-04-13;108(3):947-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus.
Authors: Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY
Immunity, 2006-03-01;24(3):341-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes.
Authors: Koelle DM, Huang J, Hensel MT, McClurkan CL
J. Virol., 2006-03-01;80(6):2863-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection.
Authors: Das S, Suarez G, Beswick EJ, Sierra JC, Graham DY, Reyes VE
J. Immunol., 2006-03-01;176(5):3000-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Th2 cytokine response in Major Depressive Disorder patients before treatment.
Authors: Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G
J. Neuroimmunol., 2006-02-02;172(1):156-65.
Applications: ELISA (Standard) -
Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes.
Authors: Mortara L, Ploquin MJ, Faye A, Scott-Algara D, Vaslin B, Butor C, Hosmalin A, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC
J. Immunol. Methods, 2005-11-21;308(1):138-55.
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: Bioassay -
Effect of piceatannol in human monocyte-derived dendritic cells in vitro.
Authors: Takei M, Umeyama A, Arihara S, Matsumoto H
J Pharm Sci, 2005-05-01;94(5):974-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus.
Authors: Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bunemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B
Arthritis Rheum., 2005-05-01;52(5):1504-16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
J. Cell. Physiol., 2005-04-01;203(1):35-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.
Authors: Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM
Arthritis Rheum., 2005-03-01;52(3):770-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13.
Authors: Fujitsu Y, Fukuda K, Kimura K, Seki K, Kumagai N, Nishida T
Invest. Ophthalmol. Vis. Sci., 2005-03-01;46(3):797-802.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma.
Authors: Pound JD, Batth BK, Johannessen I, Wood K
J. Immunol., 2005-03-01;174(5):3015-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism.
Authors: Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D
J. Immunol., 2005-02-15;174(4):2376-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1.
Authors: Yamamoto H, Nagata M, Sakamoto Y
Ann. Allergy Asthma Immunol., 2005-02-01;94(2):292-300.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Bioassay -
The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation.
Authors: Kyriakides TR, Foster MJ, Keeney GE, Tsai A, Giachelli CM, Clark-Lewis I, Rollins BJ, Bornstein P
Am. J. Pathol., 2004-12-01;165(6):2157-66.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure.
Authors: Pivarcsi A, Gombert M, Dieu-Nosjean MC, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A
J. Immunol., 2004-11-01;173(9):5810-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
Authors: Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB
Blood, 2004-09-16;105(2):750-8.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Bioassay -
IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
J. Immunol., 2004-09-01;173(5):3482-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effects of antiasthmatic agents on the functions of peripheral blood monocyte-derived dendritic cells from atopic patients.
Authors: Saeki S, Matsuse H, Kondo Y, Machida I, Kawano T, Tomari S, Obase Y, Fukushima C, Kohno S
J. Allergy Clin. Immunol., 2004-09-01;114(3):538-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-22 increases the innate immunity of tissues.
Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
Immunity, 2004-08-01;21(2):241-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
Authors: Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L
Blood, 2004-07-08;104(10):3267-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells.
Authors: Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T
Immunology, 2004-06-01;112(2):274-89.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
Authors: Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G
Blood, 2004-03-25;104(2):314-20.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.
Authors: Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB
Blood, 2004-03-18;104(2):453-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differential effect of IL-4 and IL-13 on the expression of recombination-activating genes in mature B cells from human peripheral blood.
Authors: Kajiwara K, Shinazawa M, Morishima H, Yanagihara Y
Cell. Immunol., 2004-02-01;227(2):121-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
Authors: Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI
Am. J. Respir. Cell Mol. Biol., 2004-01-12;30(6):816-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines.
Authors: Copeland S, Siddiqui J, Remick D
J. Immunol. Methods, 2004-01-01;284(1):99-106.
Applications: ELISA (Standard) -
BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.
Authors: Moreaux J, Legouffe E, Jourdan E, Quittet P, Reme T, Lugagne C, Moine P, Rossi JF, Klein B, Tarte K
Blood, 2003-12-04;103(8):3148-57.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis.
Authors: Uchida K, Nakata K, Trapnell BC, Terakawa T, Hamano E, Mikami A, Matsushita I, Seymour JF, Oh-Eda M, Ishige I, Eishi Y, Kitamura T, Yamada Y, Hanaoka K, Keicho N
Blood, 2003-09-25;103(3):1089-98.
Species: Human
Sample Types: Serum
Applications: SDS-Page -
DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells.
Authors: Tailleux L, Schwartz O, Herrmann JL, Pivert E, Jackson M, Amara A, Legres L, Dreher D, Nicod LP, Gluckman JC, Lagrange PH, Gicquel B, Neyrolles O
J. Exp. Med., 2003-01-06;197(1):121-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells.
Authors: Messmer D, Jacque JM, Santisteban C, Bristow C, Han SY, Villamide-Herrera L, Mehlhop E, Marx PA, Steinman RM, Gettie A, Pope M
J. Immunol., 2002-10-15;169(8):4172-82.
Species: Human, Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Increased macrophage infection upon subcutaneous inoculation of rhesus macaques with simian immunodeficiency virus-loaded dendritic cells or T cells but not with cell-free virus.
Authors: Ignatius R, 107336, Tenner-Racz K, Messmer D, Gettie A, Blanchard J, Luckay A, Russo C, Smith S, Marx PA, Steinman RM, Racz P, Pope M
Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage, 2002-10-01;76(19):9787-97.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization.
Authors: van der Kleij D, Latz E, Brouwers JF, Kruize YC, Schmitz M, Kurt-Jones EA, Espevik T, de Jong EC, Kapsenberg ML, Golenbock DT, Tielens AG, Yazdanbakhsh M
J. Biol. Chem., 2002-09-30;277(50):48122-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cutting edge: immune cells as sources and targets of the IL-10 family members?
Authors: Wolk K, Kunz S, Asadullah K, Sabat R
J. Immunol., 2002-06-01;168(11):5397-402.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
Authors: Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI
Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Oncostatin M production by human dendritic cells in response to bacterial products.
Authors: Suda T, 146, Chida K, Todate A, Ide K, Asada K, Nakamura Y, Suzuki K, Kuwata H, Nakamura H
2002-03-21;17(6):335-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN.
Authors: Wu L, 107253, Bashirova AA, Martin TD, Villamide L, Mehlhop E, Chertov AO, Unutmaz D, Pope M, Carrington M, KewalRamani VN
IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in Sweden, 2002-01-29;99(3):1568-73.
Species: Human, Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis.
Authors: Ong PY, Hamid QA, Travers JB, Strickland I, Al Kerithy M, Boguniewicz M, Leung DY
J. Immunol., 2002-01-01;168(1):505-10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases.
Authors: Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzani S, Girolomoni G
J. Leukoc. Biol., 2001-10-01;70(4):617-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-11 induces Th2 polarization of human CD4(+) T cells.
Authors: Curti A, Ratta M, Corinti S, Girolomoni G, Ricci F, Tazzari P, Siena M, Grande A, Fogli M, Tura S, Lemoli RM
Blood, 2001-05-01;97(9):2758-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Proliferating dendritic cell progenitors in human blood.
Authors: Romani N, Gruner S, Brang D, Kampgen E, Lenz A, Trockenbacher B, Konwalinka G, Fritsch P, Steinman R, Schuler G
J Exp Med, 1994-07-01;180(1):83-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
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Average Rating: 4.6 (Based on 22 Reviews)
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Reason for Rating: We have been using R&D IL-4 for several years in our lab to differentiate monocytic (CD14+) cells into dendritic cells with high levels of success.
We used IL4 to differentiate THP cells to Dendritic cells.
Reason for Rating: We used IL4, GMCSF, TNF ALPHA to differentiate THP1 cells to mature DC.
Reason for Rating: We use RnD Recombinant Human IL-4 Protein and GM-CSF to differentiate CD14+ PBMC to classical dendritic cells from patients. It works well.
Fast DC protocol. 24 hour GM-CSF + IL-4
Reason for Rating: Cells supplied with 20ng/ml IL-4 and 100ng/ml of GM-CSF to differentiate dendritic cells
Reason for Rating: Cells were supplied with the cytokinetreatments: 50 ng /ml GM-CSF and 10 ng/ ml1 of IL-4 to differentiate DC cells
Used to prepare DCs from monocytes
Reason for Rating: 50ng/ml of this cytokine for 5 days helped to differentiate cells from CD14+ monocytes into CD14negative dendritic cells.
Reason for Rating: Always get consistent result with this cytokine