Home / FGF-8 / Recombinant Human/Mouse FGF-8b Protein

Recombinant Human/Mouse FGF-8b Protein

Catalog #: 423-F8
63 Citations 2 Reviews Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
423-F8-025/CF

With Carrier

Catalog # Availability Size / Price Qty
423-F8-025
423-F8-01M
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Recombinant Human/Mouse FGF-8b Protein Bioactivity
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Product Details
Citations (63)
FAQs
Reviews (2)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human/Mouse FGF-8b Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED50 for this effect is typically 6.5-40 ng/mL in the presence of 1 µg/mL heparin.
Source
E. coli-derived FGF-8 protein
Gln23-Arg215, with an N-terminal Met
Accession #
NP_006110 (human), NP_001159834 (mouse)
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
22.5 kDa
SDS-PAGE
23 kDa, reducing conditions

Product Datasheets

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423-F8 (with carrier)

Product Datasheet
COA
SDS

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423-F8/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

423-F8

Formulation Lyophilized from a 0.2 μm filtered solution in MOPS, Na2SO4 and Brij-35 with BSA as a carrier protein.
Reconstitution Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 3 months, 2 to 8 °C under sterile conditions after reconstitution.

423-F8/CF

Formulation Lyophilized from a 0.2 μm filtered solution in MOPS, Na2SO4 and Brij-35.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 3 months, 2 to 8 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Human/Mouse FGF-8b Protein Bioactivity View Larger

Recombinant Human/Mouse FGF-8b (Catalog # 423-F8) stimulates cell proliferation in the NR6R‑3T3 mouse fibroblast cell line. The ED50 for this effect is 6.5-40 ng/mL in the presence of 1 μg/mL heparin.

SDS-PAGE Recombinant Human/Mouse FGF-8b Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human/Mouse FGF-8b was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 23 kDa.

Cell Culture Staining of dopaminergic neurons with anti-tyrosine hydroxylase in green, anti-neuron-specific beta III tubulin Tuj1 in red and DAPI in blue View Larger

Dopaminergic neurons were generated from human pluripotent stem cells in media that included Bovine Fibronectin Protein (1030-FN) to support cell attachment and spreading, the ITS and N-2 Plus Media Supplements (AR013 and AR003, respectively) to select and enrich for neural stem cell populations, and a panel of growth factors for effective dopaminergic differentiation, including Recombinant Human FGF-basic, Recombinant Mouse FGF-8b (Catalog # 423-F8), and Recombinant Mouse Shh-N (464-SH). Cells were stained with a Mouse Anti-Human/Mouse Tyrosine Hydroxylase Monoclonal Antibody (MAB7566) followed by a NorthernLights™ 493-conjugated Donkey Anti-Mouse IgG Antigen Affinity-purified Secondary Antibody (NL009; green), and a Mouse Neuron-specific beta III Tubulin Tuj1 Monoclonal Antibody (MAB1195) followed by a NorthernLights 557-conjugated Donkey Anti-Mouse IgG Antigen Affinity-purified Secondary Antibody (NL007; red) and counterstained with DAPI (5748; blue).

Cell Culture Staining of dopaminergic neurons with anti-tyrosine hydroxylase in red, anti-neuron-specific beta III tubulin Tuj1 in green and DAPI in blue. View Larger

Dopaminergic neurons were generated from human pluripotent stem cells in media that included Bovine Fibronectin Protein (1030-FN) to support cell attachment and spreading, the ITS and N-2 Plus Media Supplements (AR013 and AR003, respectively), and a panel of growth factors for effective dopaminergic differentiation, including Recombinant Human FGF-basic, Recombinant Mouse FGF-8b (Catalog # 423-F8), and Recombinant Mouse Shh-N (464-SH). Tyrosine Hydroxylase was detected using a Mouse Anti-Human Tyrosine Hydroxylase Monoclonal Antibody (MAB7566). The cells were stained with the NorthernLights™ 557-conjugated Donkey Anti-Mouse IgG Antigen Affinity-purified Secondary Antibody (NL007; red). Neuron-specific beta-III Tubulin was detected using a Mouse Anti-Neuron-specific beta-III Tubulin (Clone Tuj-1) Monoclonal Antibody (MAB1195) followed by the NorthernLights™ 493-conjugated Donkey Anti-Mouse IgG Antigen Affinity-purified Secondary Antibody (NL009; green). Cells were counterstained with DAPI (5748; blue).

Reconstitution Calculator

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Background: FGF-8

FGF-8 is a member of the fibroblast growth factor family that was originally discovered as a growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells (1-3). Alternate splicing of mouse FGF-8 mRNA generates eight secreted isoforms, designated a-h, but only FGF-8a, b, e and f exist in humans (4). FGF-8 contains a 22 amino acid (aa) signal sequence, an N‑terminal domain that varies according to the isoform (30 aa for FGF-8b; 20 aa for the shortest, FGF-8a), a 125 aa FGF domain and a 37 aa proline‑rich C‑terminal sequence. The FGF domain of FGF-8 shares the most aa identity with FGF17 (75%) and FGF-18 (67%), and the three form an FGF subfamily (2). Mouse FGF-8b shares 100% aa identity with human FGF-8b. FGF-8 is widely expressed during embryogenesis, and mediates epithelial-mesenchymal transitions. It plays an organizing and inducing role during gastrulation, and regulates patterning of the midbrain/hindbrain, eye, ear, limbs and heart in the embryo (2, 5 - 8). The isoforms may play different roles in development. FGF-8b shows the strongest receptor affinity and oncogenic transforming capacity although FGF-8a and FGF-8e are also transforming and have been found in human prostate, breast or ovarian tumors (1, 5, 9-12). FGF-8 shows limited expression in the normal adult, but low levels are found in the reproductive and genitourinary tract, peripheral leukocytes and bone marrow hematopoietic cells (3, 9, 13).

References
  1. Mattila, M.M. and P.L. Harkonen (2007) Cytokine Growth Factor Rev. 18:257.
  2. Reuss, B. and O. von Bohlen und Halbach (2003) Cell Tiss. Res. 313:139.
  3. Tanaka, A. et al. (1992) Proc. Natl. Acad. Sci. USA 89:8928.
  4. Gemel, J. et al. (1996) Genomics 35:253.
  5. Olsen, S.K. et al. (2006) Genes Dev. 20:185.
  6. Crossley, P.H. et al. (1996) Cell, 84:127.
  7. Heikinheimo, M. et al. (1994) Mech. Dev. 48:129.
  8. Sun, X. et al. (1999) Genes Dev. 13:1834.
  9. Ghosh, A.K. et al. (1996) Cell Growth Differ. 7:1425.
  10. Mattila, M.M. et al. (2001) Oncogene 20:2791.
  11. Valve, E. et al. (2000) Int. J. Cancer 88:718.
  12. Valve, E.M. et al. (2001) Lab. Invest. 81:815.
  13. Nezu, M. et al. (2005) Biochem. Biophys. Res. Commun. 335:843.
Long Name
Fibroblast Growth Factor 8
Entrez Gene IDs
2253 (Human); 14179 (Mouse); 29349 (Rat)
Alternate Names
AIGF; AIGFKAL6; Androgen-induced growth factor; FGF8; FGF-8; fibroblast growth factor 8 (androgen-induced); fibroblast growth factor 8; HBGF-8; Heparin-binding growth factor 8; MGC149376

Citations for Recombinant Human/Mouse FGF-8b Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

63 Citations: Showing 1 - 10
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  1. A tripartite circRNA/mRNA/miRNA interaction regulates glutamatergic signaling in the mouse brain
    Authors: Silenzi, V;D'Ambra, E;Santini, T;D'Uva, S;Setti, A;Salvi, N;Nicoletti, C;Scarfò, R;Cordella, F;Mongiardi, B;Cavezza, D;Liessi, N;Ferrucci, L;Ragozzino, D;Armirotti, A;Di Angelantonio, S;De Leonibus, E;Bozzoni, I;Morlando, M;
    Cell reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Ligand bias underlies differential signaling of multiple FGFs via FGFR1
    Authors: Karl, K;Del Piccolo, N;Light, T;Roy, T;Deduja, P;Ursachi, VC;Fafilek, B;Krejci, P;Hristova, K;
    eLife
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons
    Authors: Chen, Y;Kuang, J;Niu, Y;Zhu, H;Chen, X;So, KF;Xu, A;Shi, L;
    Neural regeneration research
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells
    Authors: Miwata, T;Suga, H;Mitsumoto, K;Zhang, J;Hamada, Y;Sakakibara, M;Soen, M;Ozaki, H;Asano, T;Miyata, T;Kawaguchi, Y;Yasuda, Y;Kobayashi, T;Sugiyama, M;Onoue, T;Hagiwara, D;Iwama, S;Oyadomari, S;Arima, H;
    Peptides
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Unconventional secretion of alpha-synuclein mediated by palmitoylated DNAJC5 oligomers
    Authors: S Wu, NC Hernandez, DW Sirkis, I Thomas-Wri, R Wade-Marti, R Schekman
    Elife, 2023-01-10;12(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. A reference human induced pluripotent stem cell line for large-scale collaborative studies
    Authors: CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendra, L Peng, H Oguro, J Kanaujiya, J Zou, D Sebesta, G Pratt, E Cross, J Blockwick, P Buxton, L Kinner-Bib, C Medura, C Tompkins, S Hughes, M Santiana, F Faghri, MA Nalls, D Vitale, S Ballard, YA Qi, DM Ramos, KM Anderson, J Stadler, P Narayan, J Papademetr, L Reilly, MP Nelson, S Aggarwal, LU Rosen, P Kirwan, V Pisupati, SL Coon, SW Scholz, T Priebe, M Öttl, J Dong, M Meijer, LJM Janssen, VS Lourenco, R van der Ka, D Crusius, D Paquet, AC Raulin, G Bu, A Held, BJ Wainger, RMC Gabriele, JM Casey, S Wray, D Abu-Bonsra, CL Parish, MS Beccari, DW Cleveland, E Li, IVL Rose, M Kampmann, C Calatayud, P Verstreken, L Heinrich, MY Chen, B Schüle, D Dou, ELF Holzbaur, MC Zanellati, R Basundra, M Deshmukh, S Cohen, R Khanna, M Raman, ZS Nevin, M Matia, J Van Lent, V Timmerman, BR Conklin, K Johnson Ch, K Zhang, S Funes, DA Bosco, L Erlebach, M Welzer, D Kronenberg, G Lyu, E Arenas, E Coccia, L Sarrafha, T Ahfeldt, JC Marioni, WC Skarnes, MR Cookson, ME Ward, FT Merkle
    Cell Stem Cell, 2022-12-01;29(12):1685-1702.e22.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  7. Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein
    Authors: JS Park, J Choi, L Cao, J Mohanty, Y Suzuki, A Park, D Baker, J Schlessing, S Lee
    Cell Reports, 2022-10-25;41(4):111545.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state
    Authors: H Ozaki, H Suga, M Sakakibara, M Soen, N Miyake, T Miwata, S Taga, T Nagai, M Kano, K Mitsumoto, T Miyata, T Kobayashi, M Sugiyama, T Onoue, H Takagi, D Hagiwara, S Iwama, R Banno, G Iguchi, Y Takahashi, K Muguruma, H Inoue, H Arima
    Scientific Reports, 2022-10-17;12(1):17381.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells
    Authors: DS Lee, YJ Song, HR Gug, JH Lee, HS Bae, JC Park
    Stem Cells International, 2022-09-27;2022(0):1092184.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Cell Culture
  10. Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer Progression
    Authors: L Yu, M Toriseva, S Afshan, M Cangiano, V Fey, A Erickson, H Seikkula, K Alanen, P Taimen, O Ettala, M Nurmi, PJ Boström, M Kallajoki, J Tuomela, T Mirtti, IJ Beumer, M Nees, P Härkönen
    Cancers, 2022-01-07;14(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Induction of gammadeltaT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cells
    Authors: N Hosaka, S Kanda, T Shimono, T Nishiyama
    Journal of Cellular and Molecular Medicine, 2021-10-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  12. 3D Bioprinting Mesenchymal Stem Cell-Derived Neural Tissues Using a Fibrin-Based Bioink
    Authors: M Restan Per, R Sharma, NZ Masri, SM Willerth
    Biomolecules, 2021-08-21;11(8):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex
    Authors: C Zhou, D Chen, J Ren, D Huang, R Li, H Luo, C Guan, Y Cao, W Wang
    Journal of Cellular and Molecular Medicine, 2021-02-13;0(0):.
    Species: Human, Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Bioassay
  14. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use
    Authors: TW Kim, J Piao, SY Koo, S Kriks, SY Chung, D Betel, ND Socci, SJ Choi, S Zabierowsk, BN Dubose, EJ Hill, EV Mosharov, S Irion, MJ Tomishima, V Tabar, L Studer
    Cell Stem Cell, 2021-02-04;28(2):343-355.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Control of mesenchymal cell fate via application of FGF-8b in vitro
    Authors: T Otsuka, PY Mengsteab, CT Laurencin
    Stem Cell Research, 2021-01-07;51(0):102155.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations
    Authors: KX Liang, CK Kristianse, S Mostafavi, GH Vatne, GA Zantingh, A Kianian, C Tzoulis, LE Høyland, M Ziegler, RM Perez, J Furriol, Z Zhang, N Balafkan, Y Hong, R Siller, GJ Sullivan, LA Bindoff
    EMBO Mol Med, 2020-08-25;0(0):e12146.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson's disease
    Authors: JL Goggi, L Qiu, MC Liao, S Khanapur, L Jiang, R Boominatha, SV Hartimath, P Cheng, FF Yong, V Soh, X Deng, YM Lin, A Haslop, PW Tan, X Zeng, JWL Lee, Z Zhang, P Sadasivam, EK Tan, SK Luthra, WD Shingleton, SKW Oh, L Zeng, EG Robins
    Stem Cell Res Ther, 2020-08-08;11(1):347.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Combined Dendritic and Axonal Deterioration Are Responsible for Motoneuronopathy in Patient-Derived Neuronal Cell Models of Chorea-Acanthocytosis
    Authors: H Gla beta, P Neumann, A Pal, P Reinhardt, A Storch, J Sternecker, A Hermann
    Int J Mol Sci, 2020-03-05;21(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  19. Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors
    Authors: S Mahajani, A Raina, C Fokken, S Kügler, M Bähr
    Cell Death Dis, 2019-11-27;10(12):898.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  20. Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes
    Authors: S Westphal, T Gantert, C Kless, K Hüttinger, M Klingenspo, T Fromme
    Sci Rep, 2019-06-11;9(1):8470.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Modeling Motor Neuron Resilience in ALS Using Stem Cells
    Authors: I Allodi, J Nijssen, JA Benitez, C Schweingru, A Fuchs, G Bonvicini, M Cao, O Kiehn, E Hedlund
    Stem Cell Reports, 2019-05-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients
    Authors: M Elkouris, G Kouroupi, A Vourvoukel, N Papagianna, V Kaltezioti, R Matsas, L Stefanis, M Xilouri, PK Politis
    Front Cell Neurosci, 2019-02-22;13(0):58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages
    Authors: J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao
    Cell Transplant, 2018-06-13;0(0):9636897187803.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons
    Authors: G Collo, L Cavalleri, M Zoli, U Maskos, E Ratti, E Merlo Pich
    Front Pharmacol, 2018-06-01;9(0):572.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Efficient induction of functional ameloblasts from human keratinocyte stem cells
    Authors: X Hu, JW Lee, X Zheng, J Zhang, X Lin, Y Song, B Wang, X Hu, HH Chang, Y Chen, CP Lin, Y Zhang
    Stem Cell Res Ther, 2018-05-02;9(1):126.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Effects of Passage Number and Differentiation Protocol on the Generation of Dopaminergic Neurons from Rat Bone Marrow-Derived Mesenchymal Stem Cells
    Authors: G Shall, M Menosky, S Decker, P Nethala, R Welchko, X Leveque, M Lu, M Sandstrom, U Hochgeschw, J Rossignol, G Dunbar
    Int J Mol Sci, 2018-03-02;19(3):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling
    Authors: G Collo, L Cavalleri, F Bono, C Mora, S Fedele, RW Invernizzi, M Gennarelli, G Piovani, T Kunath, MJ Millan, E Merlo Pich, P Spano
    Neural Plast., 2018-02-04;2018(0):4196961.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  28. Chromosomal instability during neurogenesis in Huntington's disease
    Authors: A Ruzo, GF Croft, JJ Metzger, S Galgoczi, LJ Gerber, C Pellegrini, H Wang, M Fenner, S Tse, A Marks, C Nchako, AH Brivanlou
    Development, 2018-01-29;145(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  29. Comparative Analysis of Spontaneous and Stimulus-Evoked Calcium Transients in Proliferating and Differentiating Human Midbrain-Derived Stem Cells
    Authors: T Johansen, C Krabbe, SI Schmidt, AM Serrano, M Meyer
    Stem Cells Int, 2017-10-22;2017(0):9605432.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells
    Authors: AR Rodrigues, N Yakushiji-, Y Atsuta, G Andrey, P Schorderet, D Duboule, CJ Tabin
    Proc. Natl. Acad. Sci. U.S.A, 2017-03-07;0(0):.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Neurotoxic reactive astrocytes are induced by activated microglia
    Authors: SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer, ML Bennett, AE Mnch, WS Chung, TC Peterson, DK Wilton, A Frouin, BA Napier, N Panicker, M Kumar, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson, B Stevens, BA Barres
    Nature, 2017-01-18;541(7638):481-487.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization
    Authors: Florian Wegner
    J. Neurosci., 2016-11-23;36(47):12027-12043.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: Effects on Embryo Survival
    J Biol Chem, 2016-07-08;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  34. N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data
    Authors: Daniel A Monti
    PLoS ONE, 2016-06-16;11(6):e0157602.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors
    Authors: Eva Hedlund
    Sci Rep, 2016-06-01;6(0):26448.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.
    Authors: Chan W, Howe K, Clegg J, Guimond S, Price D, Turnbull J, Pratt T
    PLoS ONE, 2015-06-15;10(6):e0130147.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  37. Collective cell migration of the nephric duct requires FGF signaling.
    Authors: Attia L, Schneider J, Yelin R, Schultheiss T
    Dev Dyn, 2014-12-30;244(2):157-67.
    Species: Chicken
    Sample Types: In Vivo
    Applications: Bioassay
  38. Susceptibility of human embryonic stem cell-derived neural cells to Japanese encephalitis virus infection.
    Authors: Shen, Shih-Che, Shen, Ching-I, Lin, Ho, Chen, Chun-Jun, Chang, Chia-Yu, Chen, Sheng-Me, Lee, Hsiu-Chi, Lai, Ping-Sha, Su, Hong-Lin
    PLoS ONE, 2014-12-17;9(12):e114990.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Etv1 and Ewsr1 cooperatively regulate limb mesenchymal Fgf10 expression in response to apical ectodermal ridge-derived fibroblast growth factor signal.
    Authors: Yamamoto-Shiraishi Y, Higuchi H, Yamamoto S, Hirano M, Kuroiwa A
    Dev Biol, 2014-08-07;394(1):181-90.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Manipulating gene expression and signaling activity in cultured mouse limb bud cells.
    Authors: Lewandowski J, Pursell T, Rabinowitz A, Vokes S
    Dev Dyn, 2014-04-17;243(7):928-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells.
    Authors: Mong J, Panman L, Alekseenko Z, Kee N, Stanton L, Ericson J, Perlmann T
    Stem Cells, 2014-03-01;32(3):609-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture.
    Authors: Ni, Na, Hu, Yaohua, Ren, Huixia, Luo, Chuanmin, Li, Peng, Wan, Jian-Bo, Su, Huanxing
    PLoS ONE, 2013-12-20;8(12):e84504.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish.
    Authors: McCarroll, Matthew, Nechiporuk, Alex V
    PLoS ONE, 2013-12-17;8(12):e85087.
    Species: Zebrafish
    Sample Types: Whole Cells
    Applications: In Vivo
  44. MicroRNA-based promotion of human neuronal differentiation and subtype specification.
    Authors: Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O
    PLoS ONE, 2013-03-18;8(3):e59011.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
    Authors: Tomlinson DC, Knowles MA
    Am. J. Pathol., 2010-10-01;177(5):2379-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
    Authors: Roelandt P, Pauwelyn KA, Sancho-Bru P
    PLoS ONE, 2010-08-11;5(8):e12101.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  47. FGFs, Wnts and BMPs mediate induction of VEGFR-2 (Quek-1) expression during avian somite development.
    Authors: Nimmagadda S, Geetha-Loganathan P, Scaal M, Christ B, Huang R
    Dev. Biol., 2007-03-01;305(2):421-9.
    Species: Avian - Quail
    Sample Types: In Vivo
    Applications: In Vivo
  48. Differentiation of ES cells into cerebellar neurons.
    Authors: Salero E, Hatten ME
    Proc. Natl. Acad. Sci. U.S.A., 2007-02-09;104(8):2997-3002.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue.
    Authors: Shimizu T, Bae YK, Hibi M
    Development, 2006-11-01;133(23):4709-19.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: Bioassay
  50. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm.
    Authors: Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM
    Development, 2006-08-30;133(19):3787-96.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements.
    Authors: Tiecke E, Bangs F, Blaschke R, Farrell ER, Rappold G, Tickle C
    Dev. Biol., 2006-07-12;298(2):585-96.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  52. Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.
    Authors: Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, Amano T, Yagi T, Sakai N, Kohriyama T, Matsumoto M
    J. Neurochem., 2006-07-01;98(1):45-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx.
    Authors: Hutson MR, Zhang P, Stadt HA, Sato AK, Li YX, Burch J, Creazzo TL, Kirby ML
    Dev. Biol., 2006-06-12;295(2):486-97.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion.
    Authors: Castelo-Branco G, Sousa KM, Bryja V, Pinto L, Wagner J, Arenas E
    Mol. Cell. Neurosci., 2005-10-21;31(2):251-62.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Control of the segmentation process by graded MAPK/ERK activation in the chick embryo.
    Authors: Delfini MC, Dubrulle J, Malapert P, Chal J, Pourquie O
    Proc. Natl. Acad. Sci. U.S.A., 2005-07-29;102(32):11343-8.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  56. Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos.
    Authors: Reversade B, Kuroda H, Lee H, Mays A, De Robertis EM
    Development, 2005-06-23;132(15):3381-92.
    Species: Xenopus
    Sample Types: In Vivo
    Applications: In Vivo
  57. Derivation of midbrain dopamine neurons from human embryonic stem cells.
    Authors: Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L
    Proc. Natl. Acad. Sci. U.S.A., 2004-08-13;101(34):12543-8.
    Species: Human, Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  58. vhnf1 and Fgf signals synergize to specify rhombomere identity in the zebrafish hindbrain.
    Authors: Wiellette EL, Sive H
    Development, 2003-08-01;130(16):3821-9.
    Species: Zebrafish
    Sample Types: In Vivo
    Applications: In Vivo
  59. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling.
    Authors: Gunhaga L, Marklund M, Sjodal M, Hsieh JC, Jessell TM, Edlund T
    Nat. Neurosci., 2003-07-01;6(7):701-7.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  60. Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein.
    Authors: Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R
    Int. J. Dev. Biol., 2003-02-01;47(1):15-29.
    Species: Xenopus
    Sample Types: In Vivo
    Applications: In Vivo
  61. FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit.
    Authors: Fischer A, Viebahn C, Blum M
    Curr. Biol., 2002-10-29;12(21):1807-16.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse.
    Authors: Abu-Issa R, Smyth G, Smoak I, Yamamura K, Meyers EN
    Development, 2002-10-01;129(19):4613-25.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  63. Regulation of avian cardiogenesis by Fgf8 signaling.
    Authors: Alsan BH, 2019, Schultheiss TM
    e0007247, 2002-04-01;129(8):1935-43.
    Species: Chicken
    Sample Types: In Ovo
    Applications: In Ovo

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Recombinant Human/Mouse FGF-8b Protein
By Sameehan Mahajani on 05/26/2017
Application: Stem/Immune cell maintenance or differentiation

It would be helpful to have larger aliquots.

Recombinant Human/Mouse FGF-8b Protein
By Marco Onorati on 08/03/2016
Application: CellProlif