Home / Neuregulin-1 beta 1/NRG1 beta 1 / Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain Protein

Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain Protein

Catalog #: 396-HB
78 Citations Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
396-HB-050/CF

With Carrier

Catalog # Availability Size / Price Qty
396-HB-050
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Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain Protein Bioactivity
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Citations (78)
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Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is 0.06-0.3 ng/mL.
Source
E. coli-derived human Neuregulin-1 beta 1/NRG1 beta 1 protein
Thr176-Lys246
Accession #
NP_039250
N-terminal Sequence
Analysis

Thr176

Predicted Molecular Mass
8 kDa
SDS-PAGE
8 kDa, reducing conditions

Product Datasheets

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396-HB (with carrier)

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396-HB/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

396-HB

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

396-HB/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain Protein Bioactivity View Larger

Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain (Catalog # 396-HB) stimulates cell proliferation of the MCF-7 human breast cancer cell line. The ED50 for this effect is 0.06-0.3 ng/mL.

SDS-PAGE Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 8 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Neuregulin-1 beta 1/NRG1 beta 1

The neuregulin family of structurally related glycoproteins comprises products from four distinct but related genes, Nrg-1, Nrg-2, Nrg-3, and Nrg-4. Through alternative splicing or the use of alternative promoters, Nrg-1 has been shown to encode more than 14 soluble or transmembrane proteins. The extracellular domain of the transmembrane NRG1 isoforms can be proteolytically cleaved to release soluble growth factors. All NRG1 isoforms contain an EGF-like domain ( alpha - or beta -splice variant that differ in their C-terminal region) that is required for their direct binding to the ErbB3 or ErbB4 receptor tyrosine kinases. The ErbB3 or ErbB4 subsequently recruits and heterodimerizes with ErbB2, resulting in tyrosine phosphorylation and NRG1 signaling. NRG1 isoforms can be classified into three major subtypes. Type I (Neu Differentiation Factor, NDF; Heregulin, HRG; Acetylcholine Receptor Inducing Activity, ARIA) and type II (Glial Growth Factor, GGF) NRG1s have an immunoglobulin (Ig)-like domain N-terminal to the EGF-like domain. Type I NRG1s differ from type II NRG1s by having a glycosylation-rich domain between the Ig-like and the EGF-like domains. Type III NRG1s (Sensory and Motor neuron-Derived Factor) lacks the Ig-like domain but has a cysteine rich domain (CRD) instead. NRG1 isoforms show distinct spatial and temporal expression patterns. These proteins play important roles during development of both the nervous system and the heart. They have been shown to regulate the selective expression of neurotransmitter receptors in neurons and at the neuromuscular junction, and promote the differentiation and development of Schwann cells from neural crest stem cells. NRG1s have also been shown to be involved in the establishment of the oligodendroglial lineage.

References
  1. Buonanno, A., and Fischbach, G.D. (2001) Curr. Opin. Neurobiol. 11:287.
  2. Adlkofer, K. and Lai, C. (2000) Glia 29:104.
  3. Garratt, A.N. et al. (2000) BioEssays 22:987.
Entrez Gene IDs
3084 (Human); 211323 (Mouse); 112400 (Rat)
Alternate Names
ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; neuregulin 1; Neuregulin1 beta 1; Neuregulin-1 beta 1; NRG1-IT2; SMDF

Citations for Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

78 Citations: Showing 1 - 10
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  1. TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells
    Authors: Priego, N;de Pablos-Aragoneses, A;Perea-García, M;Pieri, V;Hernandez-Oliver, C;Alvaro-Espinosa, L;Rojas, A;Sanchez, O;Steindl, A;Caleiras, E;Garcia, F;Garcia-Martin, S;Grana-Castro, O;Garcia-Mulero, S;Serrano, D;Velasco-Beltran, P;Jimenez-Lasheras, B;Egia-Mendikute, L;Rupp, L;Stammberger, A;Meinhardt, M;Chaachou-Charradi, A;Martínez-Saez, E;Bertero, L;Cassoni, P;Mangherini, L;Pellerino, A;Ruda, R;Soffietti, R;Al-Shahrour, F;Saftig, P;Sanz-Pamplona, R;Schmitz, M;Crocker, SJ;Calvo, A;Palazon, A;Group, R;Valiente, M;
    Cancer discovery
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Glucoselysine, a unique advanced glycation end-product of the polyol pathway and its association with vascular complications in type 2 diabetes
    Authors: Yamaguchi, H;Matsumura, T;Sugawa, H;Niimi, N;Sango, K;Nagai, R;
    The Journal of biological chemistry
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Chemokine platelet factor 4 accelerates peripheral nerve regeneration by regulating Schwann cell activation and axon elongation
    Authors: Gu, M;Cheng, X;Zhang, D;Wu, W;Cao, Y;He, J;
    Neural Regeneration Research
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  4. HER3 functions as an effective therapeutic target in triple negative breast cancer to potentiate the antitumor activity of gefitinib and paclitaxel
    Authors: Lyu, H;Shen, F;Ruan, S;Tan, C;Zhou, J;Thor, AD;Liu, B;
    Cancer cell international
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina
    Authors: Pruvost, M;Patzig, J;Yattah, C;Selcen, I;Hernandez, M;Park, HJ;Moyon, S;Liu, S;Morioka, MS;Shopland, L;Al-Dalahmah, O;Bendl, J;Fullard, JF;Roussos, P;Goldman, J;He, Y;Dupree, JL;Casaccia, P;
    Cell reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  6. Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis
    Authors: Wu, M;Li, M;Liu, W;Yan, M;Li, L;Ding, W;Nian, X;Dai, W;Sun, D;Zhu, Y;Huang, Q;Lu, X;Cai, Z;Hong, F;Li, X;Zhang, L;Liu, Z;Mo, W;Zhang, X;Zhang, L;
    Cell reports
    Species: Rat, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells
    Authors: Jovanovic, VM;Weber, C;Slamecka, J;Ryu, S;Chu, PH;Sen, C;Inman, J;De Sousa, JF;Barnaeva, E;Hirst, M;Galbraith, D;Ormanoglu, P;Jethmalani, Y;Mercado, JC;Michael, S;Ward, ME;Simeonov, A;Voss, TC;Tristan, CA;Singeç, I;
    Stem cell reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. ErbBs in Lens Cell Fibrosis and Secondary Cataract
    Authors: VanSlyke, JK;Boswell, BA;Musil, LS;
    Investigative ophthalmology & visual science
    Species: Avian - Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer
    Authors: Wang, F;Long, J;Li, L;Wu, ZX;Da, TT;Wang, XQ;Huang, C;Jiang, YH;Yao, XQ;Ma, HQ;Lian, ZX;Zhao, ZB;Cao, J;
    Science advances
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Efficacy of Nerve-Derived Hydrogels to Promote Axon Regeneration Is Influenced by the Method of Tissue Decellularization
    Authors: VK Kuna, A Lundgren, LO Anerillas, P Kelk, M Brohlin, M Wiberg, PJ Kingham, LN Novikova, G Andersson, LN Novikov
    International Journal of Molecular Sciences, 2022-08-06;23(15):.
    Species: Rats
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury
    Authors: M Ulrichsen, NP Gonçalves, S Mohseni, S Hjæresen, TL Lisle, S Molgaard, NK Madsen, OM Andersen, ÅF Svenningse, S Glerup, A Nykjær, CB Vægter
    Frontiers in Cellular Neuroscience, 2022-05-11;16(0):856734.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer
    Authors: S Madera, F Izzo, MF Chervo, A Dupont, VA Chiauzzi, S Bruni, E Petrillo, SS Merin, M De Martino, D Montero, C Levit, G Lebersztei, F Anfuso, A Roldán Dea, MF Mercoglian, CJ Proietti, R Schillaci, PV Elizalde, RI Cordo Russ
    Cell Death & Disease, 2022-05-09;13(5):447.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism
    Authors: C Monteiro, L Miarka, M Perea-Garc, N Priego, P García-Góm, L Álvaro-Esp, A de Pablos-, N Yebra, D Retana, P Baena, C Fustero-To, O Graña-Cast, K Troulé, E Caleiras, P Tezanos, P Muela, E Cintado, JL Trejo, JM Sepúlveda, P González-L, L Jiménez-Ro, LM Moreno, O Esteban, Á Pérez-Núñe, A Hernández-, J Mazarico G, I Ferrer, R Suárez, EM Garrido-Ma, L Paz-Ares, C Dalmasso, E Cohen-Jona, A Siegfried, A Hegarty, S Keelan, D Varešlija, LS Young, M Mohme, Y Goy, H Wikman, J Fernández-, G Blasco, L Alcázar, C Cabañuz, SI Grivenniko, A Ianus, N Shemesh, CC Faria, R Lee, P Lorigan, E Le Rhun, M Weller, R Soffietti, L Bertero, U Ricardi, J Bosch-Barr, E Sais, E Teixidor, A Hernández-, A Calvo, J Aristu, SM Martin, A Gonzalez, O Adler, N Erez, RENACER, M Valiente
    Nature Medicine, 2022-04-11;28(4):752-765.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  14. Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis
    Authors: H Han, Y Wang, J Curto, S Gurrapu, S Laudato, A Rumandla, G Chakrabort, X Wang, H Chen, Y Jiang, D Kumar, EG Caggiano, M Capogiri, B Zhang, Y Ji, SN Maity, M Hu, S Bai, AM Aparicio, E Efstathiou, CJ Logothetis, N Navin, NM Navone, Y Chen, FG Giancotti
    Cell Reports, 2022-04-05;39(1):110595.
    Species: Human
    Sample Types: Whole Cell
    Applications: Bioassay
  15. P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis
    Authors: J Patritti C, J Wu, RA Coover, TA Rizvi, KE Chaney, R Ravindran, JA Cancelas, RJ Spinner, N Ratner
    Elife, 2022-03-21;11(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  16. A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis
    Authors: L Zhu, D Retana, P García-Góm, L Álvaro-Esp, N Priego, M Masmudi-Ma, N Yebra, L Miarka, E Hernández-, C Blanco-Apa, S Martínez, C Sobrino, N Ajenjo, MJ Artiga, E Ortega-Pai, R Torres-Rui, S Rodríguez-, RENACER, R Soffietti, L Bertero, P Cassoni, T Weiss, J Muñoz, JM Sepúlveda, P González-L, L Jiménez-Ro, LM Moreno, O Esteban, Á Pérez-Núñe, A Hernández-, O Toldos, Y Ruano, L Alcázar, G Blasco, J Fernández-, E Caleiras, M Lafarga, D Megías, O Graña-Cast, C Nör, MD Taylor, LS Young, D Varešlija, N Cosgrove, FJ Couch, L Cussó, M Desco, S Mouron, M Quintela-F, M Weller, J Pastor, M Valiente
    Embo Molecular Medicine, 2022-02-17;0(0):e14552.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  17. ERBB3-dependent AKT and ERK pathways are essential for atrioventricular cushion development in mouse embryos
    Authors: K Kim, D Lee
    PLoS ONE, 2021-10-29;16(10):e0259426.
    Species: Chinese Hamster
    Sample Types: Whole Cells
    Applications: Bioassay
  18. SKP-SCs transplantation alleviates 6-OHDA-induced dopaminergic neuronal injury by modulating autophagy
    Authors: C Ma, W Zhang, W Wang, J Shen, K Cai, M Liu, M Cao
    Cell Death & Disease, 2021-07-05;12(7):674.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
    Authors: G Della-Flor, ER Wilson, LN Marziali, E Hurley, N Silvestri, B He, BW O'Malley, B Beirowski, Y Poitelon, L Wrabetz, ML Feltri
    Nature Communications, 2021-06-02;12(1):3285.
    Species: Mouse, Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Host interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex
    Authors: X Zheng, KJ Salinas, DXF Velez, T Nakayama, X Lin, D Banerjee, X Xu, SP Gandhi
    Nature Communications, 2021-02-08;12(1):862.
    Species: Mouse
    Sample Types:
    Applications: In Vivo
  21. Inhibitory Neural Network's Impairments at Hippocampal CA1 LTP in an Aged Transgenic Mouse Model of Alzheimer's Disease
    Authors: HJ Seo, JE Park, SM Choi, T Kim, SH Cho, KH Lee, WK Song, J Song, HS Jeong, DH Kim, BC Kim
    International Journal of Molecular Sciences, 2021-01-12;22(2):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Umbilical artery tissue contains p75 neurotrophin receptor-positive pericyte-like cells that possess neurosphere formation capacity and neurogenic differentiation potential
    Authors: R Fujii-Tezu, M Ishige-Wad, N Nagoshi, H Okano, H Mugishima, S Takahashi, I Morioka, T Matsumoto
    Regenerative Therapy, 2020-12-24;16(0):1-11.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  23. A Bioengineered Neuregulin-Hydrogel Therapy Reduces Scar Size and Enhances Post-Infarct Ventricular Contractility in an Ovine Large Animal Model
    Authors: JE Cohen, AB Goldstone, H Wang, BP Purcell, Y Shudo, JW MacArthur, AN Steele, MJ Paulsen, BB Edwards, CN Aribeana, NC Cheung, JA Burdick, YJ Woo
    J Cardiovasc Dev Dis, 2020-11-17;7(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  24. Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
    Authors: PG Mazzara, S Muggeo, M Luoni, L Massimino, M Zaghi, PT Valverde, S Brusco, MJ Marzi, C Palma, G Colasante, A Iannielli, M Paulis, C Cordiglier, SG Giannelli, P Podini, C Gellera, F Taroni, F Nicassio, M Rasponi, V Broccoli
    Nat Commun, 2020-08-21;11(1):4178.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair
    Authors: J Wang, J Wang, L Yang, C Zhao, LN Wu, L Xu, F Zhang, Q Weng, M Wegner, QR Lu
    Nat Commun, 2020-08-17;11(1):4133.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies
    Authors: AJ Davies, J Fehmi, M Senel, H Tumani, J Dorst, S Rinaldi
    J Clin Med, 2020-06-27;9(7):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  27. Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation
    Authors: BE Fornasari, M El Soury, G Nato, A Fucini, G Carta, G Ronchi, A Crosio, I Perroteau, S Geuna, S Raimondo, G Gambarotta
    Cells, 2020-06-01;9(6):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  28. A novel anti-HER2 antibody GB235 reverses Trastuzumab resistance in HER2-expressing tumor cells in vitro and in vivo
    Authors: M Shu, H Yan, C Xu, Y Wu, Z Chi, W Nian, Z He, J Xiao, H Wei, Q Zhou, JX Zhou
    Sci Rep, 2020-02-19;10(1):2986.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer
    Authors: MJ Baker, MC Abba, R Garcia-Mat, MG Kazanietz
    Cancers (Basel), 2020-02-19;12(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  30. Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
    Authors: S De, C Campbell, AR Venkitaram, A Esposito
    Cell Rep, 2020-02-18;30(7):2083-2093.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Claudin-15 overexpression inhibits proliferation and promotes apoptosis of Schwann cells in vitro
    Authors: JN Li, Z Zhang, GZ Wu, DB Yao, SS Cui
    Neural Regen Res, 2020-01-01;15(1):169-177.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory
    Authors: S Domínguez, CC Rey, L Therreau, A Fanton, D Massotte, L Verret, RA Piskorowsk, V Chevaleyre
    Cell Rep, 2019-10-29;29(5):1099-1112.e4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma
    Authors: T Sato, S Yoo, R Kong, A Sinha, P Chandraman, A Patel, M Fridrikh, O Nagano, T Masuko, MB Beasley, CA Powell, J Zhu, H Watanabe
    Cancer Res., 2019-09-24;79(24):6084-6100.
    Species: Human
    Sample Types: Whole Cells
    Applications: Stimulation
  34. Neuregulin1 β improves both spatial and associative learning and memory in Alzheimer model of rats possibly through signaling pathways other than Erk1/2
    Authors: M Jalilzad, A Jafari, P Babaei
    Neuropeptides, 2019-09-07;0(0):101963.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  35. Dataset on the effect of knockout of KLK8 in social memory
    Authors: H Nakazawa, Y Suzuki, Y Ishikawa, Y Bando, S Yoshida, S Shiosaka
    Data Brief, 2019-08-30;26(0):104458.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  36. HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma
    Authors: KS Meister, NR Godse, NI Khan, ML Hedberg, C Kemp, S Kulkarni, D Alvarado, T LaVallee, S Kim, JR Grandis, U Duvvuri
    Sci Rep, 2019-06-24;9(1):9130.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Organoid culture media formulated with growth factors of defined cellular activity
    Authors: M Urbischek, H Rannikmae, T Foets, K Ravn, M Hyvönen, M de la Roch
    Sci Rep, 2019-04-17;9(1):6193.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Methods of olfactory ensheathing cell harvesting from the olfactory mucosa in dogs
    Authors: D Ito, D Carwardine, J Prager, LF Wong, M Kitagawa, N Jeffery, N Granger
    PLoS ONE, 2019-03-06;14(3):e0213252.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response
    Authors: JP Turowec, EWT Lau, X Wang, KR Brown, FA Fellouse, KK Jawanda, J Pan, J Moffat, S Sidhu
    J. Biol. Chem., 2018-12-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites: A role for the ETS-1 transcription factor
    Authors: MC Surles-Zei, Y Li, TJ Distel, H Omotayo, S Ge, BD Ford
    PLoS ONE, 2018-06-01;13(6):e0197092.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  41. Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody
    Authors: V Oganesyan, L Peng, JS Bee, J Li, SR Perry, F Comer, L Xu, K Cook, K Senthil, L Clarke, K Rosenthal, C Gao, M Damschrode, H Wu, WF Dall'Acqua
    J. Biol. Chem., 2018-04-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Heparanase attenuates axon degeneration following sciatic nerve transection
    Authors: MJ Whitehead, R McGonigal, HJ Willison, SC Barnett
    Sci Rep, 2018-03-26;8(1):5219.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  43. A predominantly glial origin of axonal ribosomes after nerve injury
    Authors: K Müller, A Schnatz, M Schillner, S Woertge, C Müller, I von Graeve, A Waisman, J van Minnen, CF Vogelaar
    Glia, 2018-03-25;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Modulation of the Neuregulin 1/ErbB system after skeletal muscle denervation and reinnervation
    Authors: M Morano, G Ronchi, V Nicolò, BE Fornasari, A Crosio, I Perroteau, S Geuna, G Gambarotta, S Raimondo
    Sci Rep, 2018-03-22;8(1):5047.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma
    Authors: E Capone, A Lamolinara, D D'Agostino, C Rossi, V De Laurenz, M Iezzi, S Iacobelli, G Sala
    J Control Release, 2018-03-14;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. NeurotropinAccelerates the Differentiation of Schwann Cells and Remyelination in a Rat Lysophosphatidylcholine-Induced Demyelination Model
    Authors: H Matsuoka, H Tanaka, J Sayanagi, T Iwahashi, K Suzuki, S Nishimoto, K Okada, T Murase, H Yoshikawa
    Int J Mol Sci, 2018-02-08;19(2):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Remyelination improvement after neurotrophic factors secreting cells transplantation in rat spinal cord injury
    Authors: S Razavi, N Ghasemi, M Mardani, H Salehi
    Iran J Basic Med Sci, 2017-04-01;20(4):392-398.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells
    Authors: H Uchida, M Machida, T Miura, T Kawasaki, T Okazaki, K Sasaki, S Sakamoto, N Ohuchi, M Kasahara, A Umezawa, H Akutsu
    JCI Insight, 2017-01-12;2(1):e86492.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Developmental pruning of excitatory synaptic inputs to parvalbumin interneurons in monkey prefrontal cortex
    Authors: DW Chung, ZP Wills, KN Fish, DA Lewis
    Proc. Natl. Acad. Sci. U.S.A, 2017-01-10;114(4):E629-E637.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer
    Oncogene, 2016-12-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4
    Authors: Benedetta Elena Fornasari
    Mol. Cell. Neurosci, 2016-10-27;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Neuregulin-1 Regulates Cortical Inhibitory Neuron Dendrite and Synapse Growth through DISC1
    Authors: Karun K Singh
    Neural Plast., 2016-10-25;2016(0):7694385.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Myelinating glia differentiation is regulated by extracellular matrix elasticity
    Sci Rep, 2016-09-20;6(0):33751.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway
    J Neuroinflammation, 2016-09-06;13(1):237.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Heregulin-1� and HER3 in hepatocellular carcinoma: status and regulation by insulin
    J Exp Clin Cancer Res, 2016-08-11;35(1):126.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. The reemergence of long-term potentiation in aged Alzheimer's disease mouse model
    Sci Rep, 2016-07-05;6(0):29152.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  57. Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination
    Authors: Lai Man Natalie Wu
    Nat Neurosci, 2016-06-13;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Activation of endothelial ?-catenin signaling induces heart failure
    Sci Rep, 2016-05-05;6(0):25009.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  59. Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury.
    Authors: Li Y, Lein P, Ford G, Liu C, Stovall K, White T, Bruun D, Tewolde T, Gates A, Distel T, Surles-Zeigler M, Ford B
    J Neuroinflammation, 2015-04-02;12(1):64.
    Species: Rat
    Sample Types: In Vivo
  60. Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice.
    Authors: Reuter S, Soonpaa M, Firulli A, Chang A, Field L
    PLoS ONE, 2014-12-29;9(12):e115871.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  61. Label-free imaging of Schwann cell myelination by third harmonic generation microscopy.
    Authors: Lim H, Sharoukhov D, Kassim I, Zhang Y, Salzer J, Melendez-Vasquez C
    Proc Natl Acad Sci U S A, 2014-12-01;111(0):18025.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance.
    Authors: Cordo Russo R, Beguelin W, Diaz Flaque M, Proietti C, Venturutti L, Galigniana N, Tkach M, Guzman P, Roa J, O'Brien N, Charreau E, Schillaci R, Elizalde P
    Oncogene, 2014-09-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood.
    Authors: Paterson, Clare, Law, Amanda J
    PLoS ONE, 2014-08-05;9(8):e104172.
    Species: Mouse
    Sample Types: In Vivo, Whole Tissue
    Applications: Enzyme Assay, In Vivo
  64. The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.
    Authors: Kirkegaard T, Yde C, Kveiborg M, Lykkesfeldt A
    Int J Oncol, 2014-05-09;45(1):393-400.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination.
    Authors: Da Silva T, Eira J, Lopes A, Malheiro A, Sousa V, Luoma A, Avila R, Wanders R, Just W, Kirschner D, Sousa M, Brites P
    J Clin Invest, 2014-04-24;124(6):2560-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1.
    Authors: Forster N, Saladi S, van Bragt M, Sfondouris M, Jones F, Li Z, Ellisen L
    Dev Cell, 2014-01-09;28(2):147-60.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  67. The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.
    Authors: Mimura, Kousaku, Shiraishi, Kensuke, Mueller, Anja, Izawa, Shinichi, Kua, Ley-Fang, So, Jimmy, Yong, Wei-Peng, Fujii, Hideki, Seliger, Barbara, Kiessling, Rolf, Kono, Koji
    J Immunol, 2013-11-15;191(12):6261-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  68. Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.
    Authors: Fleck D, van Bebber F, Colombo A, Galante C, Schwenk B, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler S, Schmid B, Willem M, Haass C
    J Neurosci, 2013-05-01;33(18):7856-69.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. An efficient method for dorsal root ganglia neurons purification with a one-time anti-mitotic reagent treatment.
    Authors: Liu, Rui, Lin, Gou, Xu, Hanpeng
    PLoS ONE, 2013-04-02;8(4):e60558.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Cellular Effects of HER3-Specific Affibody Molecules.
    Authors: Gostring L, Malm M, Hoiden-Guthenberg I, Frejd FY, Stahl S, Lofblom J, Gedda L
    PLoS ONE, 2012-06-29;7(6):e40023.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Subchronic peripheral neuregulin-1 increases ventral hippocampal neurogenesis and induces antidepressant-like effects.
    Authors: Mahar I, Tan S, Davoli MA, Dominguez-Lopez S, Qiang C, Rachalski A, Turecki G, Mechawar N
    PLoS ONE, 2011-10-19;6(10):e26610.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  72. Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts.
    Authors: Sarup J, Jin P, Turin L, Bai X, Beryt M, Brdlik C, Higaki JN, Jorgensen B, Lau FW, Lindley P, Liu J, Ni I, Rozzelle J, Kumari R, Watson SA, Zhang J, Shepard HM
    Mol. Cancer Ther., 2008-10-01;7(10):3223-36.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors.
    Authors: Kwon OB, Paredes D, Gonzalez CM, Neddens J, Hernandez L, Vullhorst D, Buonanno A
    Proc. Natl. Acad. Sci. U.S.A., 2008-10-01;105(40):15587-92.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  74. Identification of neuregulin as a factor required for formation of aligned spermatogonia.
    Authors: Hamra FK, Chapman KM, Nguyen D, Garbers DL
    J. Biol. Chem., 2006-11-10;282(1):721-30.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Central administration of transforming growth factor-alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters.
    Authors: Snodgrass-Belt P, Gilbert JL, Davis FC
    Brain Res., 2005-03-21;1038(2):171-82.
    Species: Hamster
    Sample Types: In Vivo
    Applications: In Vivo
  76. Prolactin and heregulin override DNA damage-induced growth arrest and promote phosphatidylinositol-3 kinase-dependent proliferation in breast cancer cells.
    Authors: Chakravarti P, Henry MK, Quelle FW
    Int. J. Oncol., 2005-02-01;26(2):509-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke.
    Authors: Xu Z, Jiang J, Ford G, Ford BD
    Biochem. Biophys. Res. Commun., 2004-09-17;322(2):440-6.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  78. Heregulin ameliorates the dystrophic phenotype in mdx mice.
    Authors: Krag TO, Bogdanovich S, Jensen CJ, Fischer MD, Hansen-Schwartz J, Javazon EH, Flake AW, Edvinsson L, Khurana TS
    Proc. Natl. Acad. Sci. U.S.A., 2004-09-13;101(38):13856-60.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

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