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Recombinant Human NRG1 Isoform SMDF Protein

Catalog #: 378-SM
6 Citations Datasheet / COA / SDS

Discontinued Product

378-SM has been discontinued.
View all Neuregulin-1 Isoform SMDF products.
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Citations (6)
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Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human NRG1 Isoform SMDF Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is 1-5 ng/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human Neuregulin-1 Isoform SMDF protein
Leu117-Glu296, with a C-terminal 6-His tag
Accession #
NP_039253
N-terminal Sequence
Analysis
Leu117
Predicted Molecular Mass
20.2 kDa
SDS-PAGE
25-45 kDa, reducing conditions

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378-SM (with carrier)

Product Datasheet
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378-SM/CF (carrier free)

Discontinued Product

378-SM

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: Neuregulin-1 Isoform SMDF

The heregulin (also known as neuregulin) family of cytokines is comprised of multiple secreted or membrane-bound isoforms that are produced from the single heregulin gene by alternative splicing and/or usage of different promoters. All heregulin family members share an epidermal growth factor (EGF)-like domain ( alpha - or beta -variant) that interacts with the erbB family of tyrosine kinase receptors. NRG1 Isoform SMDF is a heregulin isoform containing a C-terminal EGF-like domain ( beta -variant) and a unique N-terminal sequence that lacks an Ig-like domain which is present in all other known heregulins. NRG1 Isoform SMDF also lacks a transmembrane domain and the cytoplasmic tail. NRG1 Isoform SMDF expression has been found to be restricted to the nervous system. It is likely that NRG1 Isoform SMDF may play an important role in neural-specific functions.

References
  1. Yarden, Y. and D. Wen (1994) in Guidebook to Cytokines and Their Receptors,
    2. N.A. Nicola, Ed., Oxford University Press, p. 146.
  2. Meyer, D. et al. (1997) Development 124:3575.
Entrez Gene IDs
3084 (Human); 211323 (Mouse); 112400 (Rat)
Alternate Names
ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; Neuregulin1 Isoform SMDF; Neuregulin-1 Isoform SMDF; NRG1-IT2; SMDF

Citations for Recombinant Human NRG1 Isoform SMDF Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
    Authors: Majd, H;Amin, S;Ghazizadeh, Z;Cesiulis, A;Arroyo, E;Lankford, K;Majd, A;Farahvashi, S;Chemel, AK;Okoye, M;Scantlen, MD;Tchieu, J;Calder, EL;Le Rouzic, V;Shibata, B;Arab, A;Goodarzi, H;Pasternak, G;Kocsis, JD;Chen, S;Studer, L;Fattahi, F;
    Cell stem cell
    Species: Human
    Sample Types: Whole Cells, Spheroid
    Applications: Bioassay
  2. Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival
    Authors: JC Pestoni, S Klingeman, OD Valdivia C, MA Fuse, M Onatunde, NA Sparrow, MA Karajannis, C Fernández-, MC Franco
    J. Biol. Chem., 2019-06-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation
    Authors: EA Newman, S Chukkapall, D Bashllari, TT Thomas, RA Van Noord, ER Lawlor, MJ Hoenerhoff, AW Opipari, VP Opipari
    Cell Death Dis, 2017-12-13;8(12):3208.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model
    Sci Rep, 2016-08-25;6(0):31692.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  5. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012-07-26;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.
    Authors: Wehrman TS, Raab WJ, Casipit CL, Doyonnas R, Pomerantz JH, Blau HM
    Proc. Natl. Acad. Sci. U.S.A., 2006-12-05;103(50):19063-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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