Recombinant Human TSPAN13-LEL Fc Chimera Protein, CF New

Recombinant Human TSPAN13-LEL Fc Chimera Protein, CF Summary

Product Specifications

Product Datasheets

Carrier Free

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

Background: TSPAN13

Tetraspanin 13, or TSPAN13, belongs to a superfamily of proteins that is characterized by four transmembrane domains, three intracellular domains and two extracellular loops: a small extracellular loop (SEL) and a large extracellular loop (LEL). The extracellular loops form molecular webs that bring together cell surface proteins, facilitating the formation of stable and functional signalling complexes. Tetraspanins form microdomains on the plasma membrane that mediate diverse biological processes including adhesion, cell fusion, immune response, and tumor development (1-4).  Human TSPAN13 consists of 204 amino acids, with the LEL region spanning residues 94-167.  Within the LEL, human TSPAN13 shares 89% aa 88% aa sequence identity with mouse and rat TSPAN13-LEL, respectively.

Related Research Areas

• Calcium Channels
• Ion Channels and Regulators
• Metalloproteases and Regulators