Recombinant Human TSPAN14-LEL Fc Chimera Protein, CF Summary
Product Specifications
| MD | Human IgG1 (Pro100-Lys330) | IEGR | Human TSPAN14-LEL (LEU114-Asn232) Accession # Q8NG11.1 |
| N-terminus | C-terminus | ||
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
11552-TS
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Reconstitution | Reconstitute at 500 μg/mL in PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Scientific Data
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2 μg/lane of Recombinant Human TSPAN14-LEL Fc Chimera Protein (Catalog # 11552-TS) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 43-54 kDa and 90-110 kDa, respectively.
Reconstitution Calculator
Background: TSPAN14
Tetraspanin 14, or TSPAN14, belongs to a superfamily of proteins that is characterized by four transmembrane domains, three intracellular domains and two extracellular loops: a small extracellular loop (SEL) and a large extracellular loop (LEL). The extracellular loops form molecular webs that bring together cell surface proteins, facilitating the formation of stable and functional signalling complexes. Tetraspanins form microdomains on the plasma membrane that mediate diverse biological processes including adhesion, cell fusion, immune response, and tumor development (1-4). Human TSPAN14 consists of 270 amino acids, with the LEL region spanning residues 114-232. Within the LEL, human TSPAN14 shares 98% aa sequence identity with mouse and rat TSPAN14-LEL.
- Charrin, S. et al. (2014) J. Cell Sci. 127:3641.
- Yang, J. et al. (2024) Cell. 13:193.
- Hemler, M.E. (2005) Nat. Rev. Mol. Cell Biol.6:801.
- Kim, T-K. et al. (2015) Biochem. Biophys. Res. Commun. 468:774.
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