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Recombinant Mouse CCL21/6Ckine Protein

Catalog #: 457-6C
56 Citations Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
457-6C-025/CF

With Carrier

Catalog # Availability Size / Price Qty
457-6C-025
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Citations (56)
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Recombinant Mouse CCL21/6Ckine Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to chemoattract 5-10 day cultured human peripheral blood lymphocytes (PBL). The ED50 for this effect is 50-200 ng/mL. Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR7. The ED50 for this effect is 3-15 ng/mL.
Source
E. coli-derived mouse CCL21/6Ckine protein
Ser24-Gly133
Accession #
P84444.1
N-terminal Sequence
Analysis
Ser24
Predicted Molecular Mass
12 kDa
SDS-PAGE
16-17 kDa, reducing conditions

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457-6C (with carrier)

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SDS

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457-6C/CF (carrier free)

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COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

457-6C

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

457-6C/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: CCL21/6Ckine

CCL21, also known as 6Ckine, TCA-4, SLC, Exodus-2, and A21, is a 12 kDa homeostatic chemokine that plays an important role in adaptive immune responses and inflammation (1). Unlike other CC chemokines, mouse CCL21 has a 36 amino acid (aa) C-terminal extension which mediates its attachment to carbohydrate structures and extracellular matrix components (2, 3). Mature mouse CCL21 shares 71% and 84% aa sequence identity with human and rat CCL21, respectively (4‑6). In mouse, three genes encode CCL21, with B and C forms being identical and the A form carrying serine at aa 65 instead of leucine. Both human and mouse CCL21 signal through the chemokine receptor CCR7, while mouse CCL21 additionally can signal through CXCR3 (7). CCL21 is constitutively presented on initial lymphatic vessels, high endothelial venules (HEV), and lymph node dendritic cells (DC) (8‑10). Immobilized CCL21 promotes the docking of DC to lymphatic vessels and the retention of T cells by lymph node DC, resulting in T cell priming for activation (8, 9). DC interaction with the anchored chemokine can induce CCL21 cleavage and release of an 8 kDa fragment that lacks the C‑terminal extension (10). During chronic inflammation or tissue damage, CCL21 is up‑regulated on local vascular endothelial cells, macrophages, T cells, and neurons (11‑14). In these settings, it promotes fibrosis, inflammatory cytokine production, and neuropathic pain (12‑14). The soluble chemokine is elevated in rheumatoid arthritis synovial fluid and in the serum of coronary artery disease patients (11, 13). CCL21 has been shown to exert either angiogenic or angiostatic effects (11, 15, 16). These effects, in combination with the ability of CCL21 to attract immune suppressor cells (Treg and MDSC) to a tumor site can have positive or negative effects on tumor progression (16, 17).

References
  1. Forster, R. et al. (2008) Nat. Rev. Immunol. 8:362.
  2. Yang, B.G. et al. (2007) J. Immunol. 179:4376.
  3. Rey-Gallardo, A. et al. (2010) Glycobiology 20:1139.
  4. Tanabe, S. et al. (1997) J. Immunol. 159:5671.
  5. Hromas, R. et al. (1997) J. Immunol. 159:2554.
  6. Hedrick, J.A. and A. Zlotnik (1997) J. Immunol. 159:1589.
  7. Jenh, C. et al. (1999) J. Immunol. 162:3765.
  8. Tal, O. et al. (2011) J. Exp. Med. 208:2141.
  9. Friedman, R.S. et al. (2006) Nat. Immunol. 7:1101.
  10. Schumann, K. et al. (2010) Immunity 32:703.
  11. Pickens, S.R. et al. (2012) Arthritis Rheum. 64:2471.
  12. Sakai, N. et al. (2006) Proc. Natl. Acad. Sci. USA 103:14098.
  13. Damas, J.K. et al. (2007) Arterioscler. Thromb. Vasc. Biol. 27:614.
  14. Biber, K. et al. (2011) EMBO J. 30:1864.
  15. Soto, H. et al. (1998) Proc. Natl. Acad. Sci. USA 95:8205.
  16. Vicari, A.P. et al. (2000) J. Immunol. 165:1992.
  17. Shields, J.D. et al. (2010) Science 328:749.
Entrez Gene IDs
6366 (Human); 18829 (Mouse); 298006 (Rat)
Alternate Names
6Ckine; 6CkineSmall-inducible cytokine A21; Beta-chemokine exodus-2; CCL21; chemokine (C-C motif) ligand 21; CKb9; exodus-2; member 21; SCYA21; SCYA21MGC34555; secondary lymphoid tissue chemokine; SLC; SLCSecondary lymphoid-tissue chemokine; TCA-4

Citations for Recombinant Mouse CCL21/6Ckine Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

56 Citations: Showing 1 - 10
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  1. ILC2-derived LIF licences progress from tissue to systemic immunity
    Authors: Gogoi, M;Clark, PA;Ferreira, ACF;Rodriguez Rodriguez, N;Heycock, M;Ko, M;Murphy, JE;Chen, V;Luan, SL;Jolin, HE;McKenzie, ANJ;
    Nature
    Species: Transgenic Mouse
    Sample Types: Whole Cells, In Vivo
    Applications: Bioassay, In vivo assay
  2. Systematic identification of gene combinations to target in innate immune cells to enhance T cell activation
    Authors: Xia, L;Komissarova, A;Jacover, A;Shovman, Y;Arcila-Barrera, S;Tornovsky-Babeay, S;Jaya Prakashan, MM;Nasereddin, A;Plaschkes, I;Nevo, Y;Shiff, I;Yosefov-Levi, O;Izhiman, T;Medvedev, E;Eilon, E;Wilensky, A;Yona, S;Parnas, O;
    Nature communications
    Species: Transgenic Mouse, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. T cell receptor signaling strength establishes the chemotactic properties of effector CD8+ T cells that control tissue-residency
    Authors: Abdelbary, M;Hobbs, SJ;Gibbs, JS;Yewdell, JW;Nolz, JC;
    Nature communications
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Distinct bidirectional regulation of LFA1 and ?4?7 by Rap1 and integrin adaptors in T cells under shear flow
    Authors: Kamioka, Y;Ueda, Y;Kondo, N;Tokuhiro, K;Ikeda, Y;Bergmeier, W;Kinashi, T;
    Cell reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function
    Authors: Z Su, J Brooks, J Pelker, T Andreyeva, H Sobon, R Gifford, M Powers, J Wang, C Dower, M Hegen, D Messing, AD Sheehan, JJ Brennan
    PLoS ONE, 2023-01-20;18(1):e0280590.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  6. Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity
    Authors: J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao
    Cell Reports, 2023-01-18;42(1):111991.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE2-mediated amplification of CCR7-related trafficking of infected inflammatory monocytes
    Authors: EY Osorio, A Uscanga-Pa, GE Patterson, E Cordova, BL Travi, L Soong, PC Melby
    PloS Neglected Tropical Diseases, 2023-01-11;17(1):e0011040.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. GPR174 signals via Galphas to control a CD86-containing gene expression program in B cells
    Authors: EW Wolf, ZP Howard, L Duan, H Tam, Y Xu, JG Cyster
    Proceedings of the National Academy of Sciences of the United States of America, 2022-05-31;119(23):e2201794119.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration
    Authors: W Piao, L Li, V Saxena, J Iyyathurai, R Lakhan, Y Zhang, IT Lape, C Paluskievi, KL Hippen, Y Lee, E Silverman, MW Shirkey, LV Riella, BR Blazar, JS Bromberg
    Nature Communications, 2022-04-21;13(1):2176.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion
    Authors: X Sun, B Wu, HC Chiang, H Deng, X Zhang, W Xiong, J Liu, AM Rozeboom, BT Harris, E Blommaert, A Gomez, RE Garcia, Y Zhou, P Mitra, M Prevost, D Zhang, D Banik, C Isaacs, D Berry, C Lai, K Chaldekas, PS Latham, CA Brantner, A Popratilof, VX Jin, N Zhang, Y Hu, MA Pujana, TJ Curiel, Z An, R Li
    Nature, 2021-11-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II
    Authors: T Nakatani, K Tsujimoto, J Park, T Jo, T Kimura, Y Hayama, H Konaka, T Morita, Y Kato, M Nishide, S Koyama, S Nada, M Okada, H Takamatsu, A Kumanogoh
    Nature Communications, 2021-06-07;12(1):3333.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Helicobacter pylori-induced Rev-erb&alpha fosters gastric bacteria colonization by impairing host innate and adaptive defense
    Authors: FY Mao, YP Lv, CJ Hao, YS Teng, YG Liu, P Cheng, SM Yang, W Chen, T Liu, QM Zou, R Xie, JY Xu, Y Zhuang
    Cellular and Molecular Gastroenterology and Hepatology, 2021-03-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation
    Authors: T Koga, F Sasaki, K Saeki, S Tsuchiya, T Okuno, M Ohba, T Ichiki, S Iwamoto, H Uzawa, K Kitajima, C Meno, E Nakamura, N Tada, Y Fukui, J Kikuta, M Ishii, Y Sugimoto, M Nakao, T Yokomizo
    Cell Mol Immunol, 2020-10-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
    Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
    Cell Rep, 2020-06-30;31(13):107820.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. A mutation that blocks integrin alpha4beta7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis
    Authors: H Zhang, Y Zheng, Y Pan, C Lin, S Wang, Z Yan, L Lu, G Ge, J Li, YA Zeng, J Chen
    BMC Biol., 2020-06-10;18(1):64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Acidosis-Induced TGF-beta2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response
    Authors: N Trempolec, C Degavre, B Doix, D Brusa, C Corbet, O Feron
    Cancers (Basel), 2020-05-19;12(5):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. The lymph node stromal laminin alpha 5 shapes alloimmunity
    Authors: L Li, MW Shirkey, T Zhang, Y Xiong, W Piao, V Saxena, C Paluskievi, YS Lee, N Toney, BM Cerel, Q Li, T Simon, KD Smith, KL Hippen, BR Blazar, R Abdi, JS Bromberg
    J. Clin. Invest., 2020-05-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Photodynamic Therapy-Based Dendritic Cell Vaccination Suited to Treat Peritoneal Mesothelioma
    Authors: N Trempolec, B Doix, C Degavre, D Brusa, C Bouzin, O Riant, O Feron
    Cancers (Basel), 2020-02-27;12(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity
    Authors: S Sharif, N Ueda, Y Nakatani, LM Wise, S Clifton, Z Lateef, AA Mercer, SB Fleming
    Front Microbiol, 2019-06-25;10(0):1421.
    Species: Mouse
    Sample Types:
    Applications: Binding Assay
  20. Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling
    Authors: ML Capitano, N Mor-Vaknin, AK Saha, S Cooper, M Legendre, H Guo, R Contreras-, F Kappes, MA Sartor, CT Lee, X Huang, DM Markovitz, HE Broxmeyer
    J. Clin. Invest., 2019-05-20;130(0):2555-2570.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming
    Authors: L Simula, I Pacella, A Colamatteo, C Procaccini, V Cancila, M Bordi, C Tregnago, M Corrado, M Pigazzi, V Barnaba, C Tripodo, G Matarese, S Piconese, S Campello
    Cell Rep, 2018-12-11;25(11):3059-3073.e10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus
    Authors: FA Moretti, S Klapproth, R Ruppert, A Margraf, J Weber, R Pick, C Scheierman, M Sperandio, R Fässler, M Moser
    Elife, 2018-09-06;7(0):.
    Species: Mouse
    Sample Types: Whole Cells
  23. Regulation of T cell afferent lymphatic migration by targeting LT?R-mediated non-classical NF?B signaling
    Authors: W Piao, Y Xiong, K Famulski, CC Brinkman, L Li, N Toney, C Wagner, V Saxena, T Simon, JS Bromberg
    Nat Commun, 2018-08-01;9(1):3020.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1
    Authors: R Mashud, A Nomachi, A Hayakawa, K Kubouchi, S Danno, T Hirata, K Matsuo, T Nakayama, R Satoh, R Sugiura, M Abe, K Sakimura, S Wakana, H Ohsaki, S Kamoshida, H Mukai
    Sci Rep, 2017-08-09;7(1):7663.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. The Small Rho GTPase TC10 Modulates B Cell Immune Responses
    Authors: M Burbage, SJ Keppler, B Montaner, PK Mattila, FD Batista
    J. Immunol., 2017-07-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Occludin Expression in Epidermal ?? T Cells in Response to Epidermal Stress Causes Them To Migrate into Draining Lymph Nodes
    Authors: T Saito, M Yano, Y Ohki, M Tomura, N Nakano
    J. Immunol., 2017-05-31;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  27. DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction
    Authors: A Shiraishi, T Uruno, F Sanematsu, M Ushijima, D Sakata, T Hara, Y Fukui
    J. Biol. Chem, 2016-12-27;292(6):2191-2202.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Immunogenic Dendritic Cell Generation from Pluripotent Stem Cells by Ectopic Expression of Runx3
    Authors: Istvan Szatmari
    J. Immunol., 2016-11-16;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization
    Cell Rep, 2016-09-27;17(1):193-205.
    Species: Mouse
    Sample Types:
    Applications: Bioassay
  30. CCL19-CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima
    Nat Immunol, 2016-09-26;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  31. ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens
    J Leukoc Biol, 2016-09-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. WNK1 kinase balances T cell adhesion versus migration in vivo
    Nat Immunol, 2016-07-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration
    Authors: Tsun-Ho Lo
    J Immunol, 2016-06-17;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation.
    Authors: Gomez D, Diehl M, Crosby E, Weinkopff T, Debes G
    J Immunol, 2015-09-09;195(8):3531-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. TGF-beta1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.
    Authors: Pang M, Georgoudaki A, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander J, Nelson C, Jakobsson L, Betsholtz C, Sund M, Karlsson M, Fuxe J
    Oncogene, 2015-05-11;35(6):748-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFkappaB and ERK.
    Authors: Badr G, Sayed A, Abdel-Maksoud M, Mohamed A, El-Amir A, Abdel-Ghaffar F, Al-Quraishy S, Mahmoud M
    PLoS ONE, 2015-04-24;10(4):e0125340.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Induction and activation of latent transforming growth factor-beta1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1).
    Authors: Ballesteros A, Mentink-Kane M, Warren J, Kaplan G, Dveksler G
    J Biol Chem, 2014-12-29;290(7):4422-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Control of lymphocyte egress from lymph nodes through beta2-adrenergic receptors.
    Authors: Nakai A, Hayano Y, Furuta F, Noda M, Suzuki K
    J Exp Med, 2014-11-24;211(13):2583-98.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Regulation of T cell motility in vitro and in vivo by LPA and LPA2.
    Authors: Knowlden S, Capece T, Popovic M, Chapman T, Rezaee F, Kim M, Georas S
    PLoS ONE, 2014-07-08;9(7):e101655.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Autotaxin produced by stromal cells promotes LFA-1-independent and Rho-dependent interstitial T cell motility in the lymph node paracortex.
    Authors: Katakai T, Kondo N, Ueda Y, Kinashi T
    J Immunol, 2014-06-16;193(2):617-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
    Authors: Geherin, Skye A, Wilson, R Paul, Jennrich, Silke, Debes, Gudrun F
    PLoS ONE, 2014-04-21;9(4):e95626.
    Species: Mouse, Ovine
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Dendritic cell motility and T cell activation requires regulation of Rho-cofilin signaling by the Rho-GTPase activating protein myosin IXb.
    Authors: Xu Y, Pektor S, Balkow S, Hemkemeyer S, Liu Z, Grobe K, Hanley P, Shen L, Bros M, Schmidt T, Bahler M, Grabbe S
    J Immunol, 2014-03-19;192(8):3559-68.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling.
    Authors: Willinger T, Ferguson S, Pereira J, De Camilli P, Flavell R
    J Exp Med, 2014-03-17;211(4):685-700.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Moesin controls clathrin-mediated S1PR1 internalization in T cells.
    Authors: Nomachi, Akira, Yoshinaga, Masanori, Liu, Jaron, Kanchanawong, Pakorn, Tohyama, Kiyoshi, Thumkeo, Dean, Watanabe, Takeshi, Narumiya, Shuh, Hirata, Takako
    PLoS ONE, 2013-12-16;8(12):e82590.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.
    Authors: Luckashenak N, Wahe A, Breit K, Brakebusch C, Brocker T
    J Immunol, 2012-12-03;190(1):27-35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  46. Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.
    Authors: Hyun YM, Sumagin R, Sarangi PP
    J. Exp. Med., 2012-06-18;209(7):1349-62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.
    Authors: Ippagunta SK, Malireddi RK, Shaw PJ
    Nat. Immunol., 2011-09-04;12(10):1010-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs.
    Authors: Rehm A, Mensen A, Schradi K, Gerlach K, Wittstock S, Winter S, Buchner G, Dorken B, Lipp M, Hopken UE
    Blood, 2011-05-17;118(4):1020-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development.
    Authors: Biber K, Tsuda M, Tozaki-Saitoh H
    EMBO J., 2011-03-25;30(9):1864-73.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  50. Macrophage mannose receptor on lymphatics controls cell trafficking.
    Authors: Marttila-Ichihara F, Turja R, Miiluniemi M, Karikoski M, Maksimow M, Niemela J, Martinez-Pomares L, Salmi M, Jalkanen S
    Blood, 2008-04-23;112(1):64-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress.
    Authors: Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG
    Immunity, 2007-12-27;28(1):122-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells.
    Authors: Kabashima K, Shiraishi N, Sugita K, Mori T, Onoue A, Kobayashi M, Sakabe J, Yoshiki R, Tamamura H, Fujii N, Inaba K, Tokura Y
    Am. J. Pathol., 2007-09-06;171(4):1249-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells.
    Authors: Fujita H, Asahina A, Komine M, Tamaki K
    Cell. Immunol., 2007-05-15;245(2):70-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. The role of CCL21 in recruitment of T-precursor cells to fetal thymi.
    Authors: Ueno T, Kuse S, Saito F, Nitta T, Kakiuchi T, Hollander GA, Takahama Y
    Blood, 2004-09-09;105(1):31-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Local delivery of recombinant vaccinia virus expressing secondary lymphoid chemokine (SLC) results in a CD4 T-cell dependent antitumor response.
    Authors: Flanagan K, Glover RT, Horig H, Yang W, Kaufman HL
    Vaccine, 2004-07-29;22(21):2894-903.
    Applications: Western Blot
  56. Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity.
    Authors: Tolba KA, D†­ÃÅê†Ò, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD
    Îζ)Š4wJ]¾b.ŠKd•ÿ¶fäMò&¨k³, 2002-11-15;62(22):6545-51.
    Species: Human
    Sample Types: Cell Culture Supernates, N/A
    Applications: Bioassay, ELISA (Standard)

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