Recombinant Mouse FSH alpha/beta Protein Summary
Product Specifications
| Mouse FSH beta (His20-Glu130) Accession # Q60687 |
GGGSGGGSGGGS | Mouse FSH alpha (Leu25-Ser120) Accession # P01216 |
| N-terminus | C-terminus | |
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
8576-FS
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 100 μg/mL in PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
8576-FS/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 100 μg/mL in PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: FSH alpha/beta
Follicle-Stimulating Hormone (FSH) beta is one of the components of the heterodimeric glycoprotein hormone FSH. FSH is composed of noncovalently linked glycosylated alpha and beta chains. The alpha subunit is also a component of Luteinizing Hormone (LH), Thyroid-Stimulating Hormone, and Chorionic Gonadotropin. The unique beta subunit confers the protein’s specific biological action and is responsible for the interaction with the FSH Receptor (1-3). The approximately 21 kDa mouse FSH beta subunit shares 85% and 95% aa sequence identity with the human and rat orthologs, respectively. FSH is produced and secreted by the anterior pituitary gland. Its secretion is controlled by Gonadotropin-Releasing Hormone from the hypothalamus; however, FSH secretion can also be stimulated by activins and inhibited by inhibins (4-6). FSH works in concert with LH to regulate female reproduction; FSH stimulates follicular growth and LH induces ovulation (7). FSH can also regulate estrogen formation by inducing the aromatase enzyme that converts androgen to estradiol (7, 8). In addition, it has been suggested to have a role in postmenopausal bone loss and in the neovascularization surrounding malignant tumors (9-11). In males, FSH is critical for sperm production (12). Mutations in the human FSH and FSHR genes are associated with reduced reproductive functioning in females (2, 11). Additionally, increased production of autoantibodies directed against FSH beta has been suggested to contribute to certain types of female infertility (2). Assisted reproductive technology commonly uses recombinant FSH to induce follicle growth (7).
- Fox, K.M. et al. (2001) Mol. Endocrinol. 15:378.
- Haller-Kikkatalo, K. et al. (2012) Clin. Dev. Immunol. 2012:762541.
- Jiang, X. et al. (2014) Mol. Cell. Endocrinol. 382:424.
- Findlay, J.K. (1993) Biol. Reprod. 48:15.
- Marshall, J.C. et al. (1993) Trans. Am. Clin. Climatol. Assoc. 104:31.
- Bernard, D.J. and S. Tran (2013) Biol. Reprod. 88:1.
- Raju, G.A. et al. (2013) J. Hum. Reprod. Sci. 6:227.
- Erickson, G.F. and A.J. Hsueh (1978) Endocrinology 102:1275.
- Sun, L. et al. (2006) Cell 125:247.
- Radu, A. et al. (2010) N. Engl. J. Med. 363:1621.
- Laan, M. et al. (2012) Curr. Opin. Endocrinol. Diabetes Obes. 19:220.
- Franchimont, P. et al. (1975) J. Reprod. Fertil. 44:335.
Citations for Recombinant Mouse FSH alpha/beta Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Post-thaw viability of mouse preantral follicles after cryopreservation with cryotube freezing and OPS vitrification procedures
Authors: L Bordás, B Somosk?i, D Török, BN Vincze, S Cseh
Reproductive biology, 2023-03-09;23(2):100752.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Low WIP1 Expression Accelerates Ovarian Aging by Promoting Follicular Atresia and Primordial Follicle Activation
Authors: S Zhou, Y Xi, Y Chen, F Fu, W Yan, M Li, Y Wu, A Luo, Y Li, S Wang
Cells, 2022-12-03;11(23):.
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture -
Construction of Artificial Ovaries with Decellularized Porcine Scaffold and Its Elicited Immune Response after Xenotransplantation in Mice
Authors: T Wu, YY Gao, XN Tang, JJ Zhang, SX Wang
Journal of functional biomaterials, 2022-09-28;13(4):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Follicle-stimulating hormone worsens osteoarthritis by causing inflammation and chondrocyte dedifferentiation
Authors: Z Huan, Y Wang, M Zhang, X Zhang, Y Liu, L Kong, J Xu
FEBS Open Bio, 2021-06-27;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
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