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Recombinant Mouse IFN-beta Protein

Catalog #: 12400-1
21 Citations Datasheet / COA / SDS
Newer Version Available: 8234-MB
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12400-1
R&D Systems Recombinant Proteins and Enzymes
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Citations (21)
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Recombinant Mouse IFN-beta Protein Summary

Product Specifications

Accession #
K00020

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12400-1

Product Datasheet
COA
SDS

12400-1

Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
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Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name
Interferon beta
Entrez Gene IDs
3456 (Human); 15977 (Mouse); 24481 (Rat)
Alternate Names
Fibroblast interferon; IFB; IFBIFNB; IFF; IFNB; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

Citations for Recombinant Mouse IFN-beta Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

21 Citations: Showing 1 - 10
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  1. Inhibiting Type I arginine methyltransferase activity promotes the T cell mediated antitumor immune response
    Authors: A Fedoriw, L Shi, S O'Brien, KN Smitheman, Y Wang, J Hou, C Sherk, S Rajapurkar, J Laraio, LJ Williams, C Xu, G Han, Q Feng, MT Bedford, L Wang, O Barbash, RG Kruger, P Hwu, HP Mohammad, W Peng
    Cancer Immunology Research, 2022-04-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice
    Authors: A Wang, SD Pope, JS Weinstein, S Yu, C Zhang, CJ Booth, R Medzhitov
    Proc. Natl. Acad. Sci. U.S.A., 2019-01-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
    Authors: S Li, Z Hong, Z Wang, F Li, J Mei, L Huang, X Lou, S Zhao, L Song, W Chen, Q Wang, H Liu, Y Cai, H Yu, H Xu, G Zeng, Q Wang, J Zhu, X Liu, N Tan, C Wang
    Cell Rep, 2018-12-18;25(12):3405-3421.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages
    Authors: H Cui, S Banerjee, S Guo, N Xie, G Liu
    J. Immunol., 2018-03-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation
    Authors: JC Santos, MS Dick, B Lagrange, D Degrandi, K Pfeffer, M Yamamoto, E Meunier, P Pelczar, T Henry, P Broz
    EMBO J., 2018-02-19;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Ischemia/Reperfusion Induces Interferon Stimulated Gene Expression in Microglia
    Authors: A McDonough, RV Lee, S Noor, C Lee, T Le, M Iorga, JLH Phillips, S Murphy, T Möller, JR Weinstein
    J. Neurosci., 2017-07-26;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  7. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection
    Authors: MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles
    J. Immunol., 2017-06-02;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Bioassay
  8. ATF3 Is a Key Regulator of Macrophage IFN Responses.
    Authors: Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D
    J Immunol, 2015-09-28;195(9):4446-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii.
    Authors: Majumdar, Tanmay, Chattopadhyay, Saurabh, Ozhegov, Evgeny, Dhar, Jayeeta, Goswami, Ramansu, Sen, Ganes C, Barik, Sailen
    PLoS Pathog, 2015-03-26;11(3):e1004779.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation.
    Authors: Welsby I, Hutin D, Gueydan C, Kruys V, Rongvaux A, Leo O
    J Biol Chem, 2014-08-01;289(38):26642-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.
    Authors: Duong S, Condotta S, Rai D, Martin M, Griffith T, Badovinac V
    J Immunol, 2014-03-19;192(8):3618-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
    Authors: Lu B, Antoine D, Kwan K, Lundback P, Wahamaa H, Schierbeck H, Robinson M, Van Zoelen M, Yang H, Li J, Erlandsson-Harris H, Chavan S, Wang H, Andersson U, Tracey K
    Proc Natl Acad Sci U S A, 2014-01-27;111(8):3068-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Optineurin insufficiency impairs IRF3 but not NF-kappaB activation in immune cells.
    Authors: Munitic I, Giardino Torchia M, Meena N, Zhu G, Li C, Ashwell J
    J Immunol, 2013-11-15;191(12):6231-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  14. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Evaluating vaccinia virus cytokine co-expression in TLR GKO mice.
    Authors: Sutherland DB, Ranasinghe C, Regner M, Phipps S, Matthaei KI, Day SL, Ramshaw IA
    Immunol. Cell Biol., 2010-12-21;89(0):706-15.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Developmet
  16. TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis.
    Authors: Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H
    J. Immunol., 2010-11-22;186(1):556-62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. IFN-gamma down-regulates Secretoglobin 3A1 gene expression.
    Authors: Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly RP, Itabe H, Yamamoto M, Kimura S, Kamijo R
    Biochem. Biophys. Res. Commun., 2009-01-09;379(4):964-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
    Authors: Guo B, Chang EY, Cheng G
    J. Clin. Invest., 2008-05-01;118(5):1680-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3.
    Authors: Molle C, Nguyen M, Flamand V, Renneson J, Trottein F, De Wit D, Willems F, Goldman M, Goriely S
    J. Immunol., 2007-06-15;178(12):7607-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
    Authors: Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
    Blood, 2006-05-23;108(6):2041-4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Differential Growth of IFN-beta-Engineered Tumor Cells in Nude and IFN Receptor-Null Mice.
    Authors: Zhang F, Lee J, Wang D, Dong Z
    J. Interferon Cytokine Res., 2006-02-01;26(2):108-18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. What are the differences between Recombinant Mouse IFN-beta Protein (Catalog # 8234-MB) and Recombinant Mouse IFN-beta Protein (Catalog # 12400-1)?

    • Catalog # 12400-1 is raised in E. coli and has an endotoxin specification of <1 EU/ug. Catalog # 8234-MB is raised in HEK293 cells, and it has a lower endotoxin specification of <0.10 EU per 1 ug of protein.

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